JP4841054B2 - 新規インスリン／ｉｇｆ／リラキシンファミリーポリペプチドおよびそのｄｎａ - Google Patents

新規インスリン／ｉｇｆ／リラキシンファミリーポリペプチドおよびそのｄｎａ Download PDF

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Publication number
JP4841054B2
JP4841054B2 JP2001123210A JP2001123210A JP4841054B2 JP 4841054 B2 JP4841054 B2 JP 4841054B2 JP 2001123210 A JP2001123210 A JP 2001123210A JP 2001123210 A JP2001123210 A JP 2001123210A JP 4841054 B2 JP4841054 B2 JP 4841054B2
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Japan
Prior art keywords
polypeptide
dna
seq
present
amino acid
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Expired - Fee Related
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JP2001123210A
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English (en)
Japanese (ja)
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JP2002345468A5 (enExample
JP2002345468A (ja
Inventor
康明 伊藤
伸宏 鈴木
一紀 西
秀樹 木澤
征隆 原田
和宏 大儀
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Priority to JP2001123210A priority Critical patent/JP4841054B2/ja
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Publication of JP2002345468A5 publication Critical patent/JP2002345468A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/64—Relaxins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
JP2001123210A 2000-04-21 2001-04-20 新規インスリン／ｉｇｆ／リラキシンファミリーポリペプチドおよびそのｄｎａ Expired - Fee Related JP4841054B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2001123210A JP4841054B2 (ja) 2000-04-21 2001-04-20 新規インスリン／ｉｇｆ／リラキシンファミリーポリペプチドおよびそのｄｎａ

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
JP2000126340 2000-04-21
JP2000126340 2000-04-21
JP2000-126340 2000-04-21
JP2000205587 2000-07-03
JP2000-205587 2000-07-03
JP2000205587 2000-07-03
JP2000-247962 2000-08-10
JP2000247962 2000-08-10
JP2000247962 2000-08-10
JP2000395050 2000-12-22
JP2000-395050 2000-12-22
JP2000395050 2000-12-22
JP2001123210A JP4841054B2 (ja) 2000-04-21 2001-04-20 新規インスリン／ｉｇｆ／リラキシンファミリーポリペプチドおよびそのｄｎａ

Publications (3)

Publication Number Publication Date
JP2002345468A JP2002345468A (ja) 2002-12-03
JP2002345468A5 JP2002345468A5 (enExample) 2008-05-29
JP4841054B2 true JP4841054B2 (ja) 2011-12-21

Family

ID=27481250

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001123210A Expired - Fee Related JP4841054B2 (ja) 2000-04-21 2001-04-20 新規インスリン／ｉｇｆ／リラキシンファミリーポリペプチドおよびそのｄｎａ

Country Status (8)

Country Link
US (2) US7049403B2 (enExample)
EP (1) EP1283260A4 (enExample)
JP (1) JP4841054B2 (enExample)
KR (1) KR20020093053A (enExample)
CN (1) CN1633498A (enExample)
AU (2) AU4880901A (enExample)
CA (1) CA2406855A1 (enExample)
WO (1) WO2001081562A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1317538A4 (en) * 2000-09-13 2005-04-06 Smithkline Beecham NOVEL CONNECTIONS
AUPR814401A0 (en) * 2001-10-08 2001-11-01 Howard Florey Institute Of Experimental Physiology And Medicine Human 3 relaxin
CA2517283A1 (en) * 2003-03-04 2004-09-30 Janssen Pharmaceutica N.V. Relaxin3-gpcr135 complexes and their production and use
WO2005075641A1 (ja) 2004-02-09 2005-08-18 Eisai R & D Management Co., Ltd. スクリーニング方法
EP1789452B1 (en) * 2004-08-25 2012-04-25 Janssen Pharmaceutica NV Relaxin-chimeric polypeptides and their preparation and use
ATE549351T1 (de) * 2007-01-30 2012-03-15 Janssen Pharmaceutica Nv Chimärer peptidantagonist für gpcr135 oder gpcr142
US9767495B2 (en) * 2008-12-19 2017-09-19 Sap Se Different sales and planning product options
US20100161366A1 (en) * 2008-12-19 2010-06-24 Achim Clemens Product requirement specification in production model
CN116773828B (zh) 2023-08-21 2023-10-31 成都大熊猫繁育研究基地 一种大熊猫rln3酶联免疫检测方法及单克隆抗体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2051375C (en) * 1989-05-04 2000-09-12 Dennis J. Henner Process and compositions for the isolation of human relaxin
AU9037898A (en) * 1997-09-24 1999-04-12 Genentech Inc. Insulin-like polypeptide and uses therefor
KR100448427B1 (ko) * 1998-10-13 2004-09-16 제넨테크, 인크. 신생 세포 성장을 억제하기 위한 방법 및 조성물
CA2347835A1 (en) 1998-12-01 2000-06-08 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
AU3228500A (en) * 1999-02-12 2000-08-29 Zymogenetics Inc. Insulin-family homolog localized to chromosome 1
EP1294887A1 (en) * 2000-03-10 2003-03-26 ZymoGenetics, Inc. Insulin homolog polypeptide zins4
US20020012967A1 (en) * 2000-03-10 2002-01-31 Holloway James L. Insulin homolog polypeptide zins4
EP1317538A4 (en) * 2000-09-13 2005-04-06 Smithkline Beecham NOVEL CONNECTIONS

Also Published As

Publication number Publication date
KR20020093053A (ko) 2002-12-12
CN1633498A (zh) 2005-06-29
EP1283260A1 (en) 2003-02-12
US7049403B2 (en) 2006-05-23
US20030158381A1 (en) 2003-08-21
AU2001248809B2 (en) 2005-05-19
WO2001081562A1 (en) 2001-11-01
AU4880901A (en) 2001-11-07
US7410641B2 (en) 2008-08-12
JP2002345468A (ja) 2002-12-03
CA2406855A1 (en) 2001-11-01
US20060073567A1 (en) 2006-04-06
EP1283260A4 (en) 2004-08-18

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