JP4837663B2 - 造影画像化のためのガス充填微小胞組成物 - Google Patents

造影画像化のためのガス充填微小胞組成物 Download PDF

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Publication number
JP4837663B2
JP4837663B2 JP2007526459A JP2007526459A JP4837663B2 JP 4837663 B2 JP4837663 B2 JP 4837663B2 JP 2007526459 A JP2007526459 A JP 2007526459A JP 2007526459 A JP2007526459 A JP 2007526459A JP 4837663 B2 JP4837663 B2 JP 4837663B2
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Prior art keywords
microvesicles
gas
particle size
microvesicle
composition
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Japanese (ja)
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JP2008509970A5 (OSRAM
JP2008509970A (ja
Inventor
フィリップ・ビュサ
ペーテル・フリンキング
クリスティアン・ギヨ
ミシェル・シュナイダー
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Bracco Suisse SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP2007526459A 2004-08-18 2005-08-17 造影画像化のためのガス充填微小胞組成物 Expired - Fee Related JP4837663B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04019557.0 2004-08-18
EP04019557 2004-08-18
PCT/EP2005/054041 WO2006018433A1 (en) 2004-08-18 2005-08-17 Gas-filled microvesicles composition for contrast imaging

Publications (3)

Publication Number Publication Date
JP2008509970A JP2008509970A (ja) 2008-04-03
JP2008509970A5 JP2008509970A5 (OSRAM) 2008-05-15
JP4837663B2 true JP4837663B2 (ja) 2011-12-14

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JP2007526459A Expired - Fee Related JP4837663B2 (ja) 2004-08-18 2005-08-17 造影画像化のためのガス充填微小胞組成物

Country Status (7)

Country Link
US (2) US9248204B2 (OSRAM)
EP (1) EP1784228B1 (OSRAM)
JP (1) JP4837663B2 (OSRAM)
CN (2) CN103120799A (OSRAM)
AU (1) AU2005273865B2 (OSRAM)
CA (1) CA2575677C (OSRAM)
WO (1) WO2006018433A1 (OSRAM)

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DE602004029010D1 (de) 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
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WO2007054561A1 (en) * 2005-11-10 2007-05-18 Bracco Research Sa Instantaneous visualization of contrast agent concentration in imaging applications
EP1951124B1 (en) 2005-11-10 2017-01-04 Bracco Suisse SA Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
JP5313915B2 (ja) 2006-12-21 2013-10-09 ブラッコ・シュイス・ソシエテ・アノニム 医用画像用途における固定化された造影剤の脱離の検知
US9072492B2 (en) 2007-12-28 2015-07-07 Bracco Suisse Sa Quantification analysis of immobilized contrast agent in medical imaging applications
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
CN101745126B (zh) * 2008-12-10 2012-04-25 温州医学院 一种包载水溶性药物超声造影剂的制备方法
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES
US20130101521A1 (en) * 2010-05-01 2013-04-25 The Trustees Of Columbia University In The City Of New York Methods devices and systems of preparing targeted microbubble shells
WO2011149985A1 (en) * 2010-05-24 2011-12-01 Nanovalent Pharmaceuticals, Inc. Polymerized shell lipid microbubbles and uses thereof
JP6333287B2 (ja) 2012-12-21 2018-05-30 ブラッコ・シュイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ 時間に対する統計的分析に基づく画像診断応用におけるセグメンテーション
US10368842B2 (en) 2014-04-07 2019-08-06 Bracco Suisse S.A. Estimation of acoustic level in-situ with non-fundamental analysis
CN108289654B (zh) 2015-12-10 2021-03-30 博莱科瑞士股份有限公司 通过动态阈值化来检测固定化造影剂
CN111132732B (zh) * 2017-06-29 2021-09-21 医视特有限公司 增强对靶组织的治疗同时限制对非靶组织的损伤的系统
US11035740B1 (en) * 2017-07-31 2021-06-15 Prasidiux, Llc Stimulus indicating device employing thermoreversible amphiphilic gels
WO2019170606A1 (en) * 2018-03-07 2019-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles
JP7539380B2 (ja) * 2018-12-21 2024-08-23 ブラッコ・スイス・ソシエテ・アノニム リガンドを含むガス充填微小胞
US11246945B2 (en) 2019-06-07 2022-02-15 National Defense Medical Center Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer
CN116917029A (zh) * 2021-03-01 2023-10-20 国立大学法人东京大学 微颗粒和微颗粒分散液
NL2033467B1 (en) 2022-11-04 2024-05-24 Demcon Curonix B V System for generating microvesicles having a predefined size and/or size distribution
NL2037565B1 (en) 2024-04-26 2025-11-11 Demcon Curonix B V Fluid delivery system for providing a flow of microvesicle containing liquid to a subject
CN121107681A (zh) * 2025-11-07 2025-12-12 陕西新天地固体废物综合处置有限公司 一种污泥脱水处理用高效复合絮凝剂及其制备方法

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Also Published As

Publication number Publication date
CN101005858A (zh) 2007-07-25
US20080008657A1 (en) 2008-01-10
WO2006018433A1 (en) 2006-02-23
EP1784228A1 (en) 2007-05-16
AU2005273865B2 (en) 2011-02-24
CA2575677C (en) 2013-01-22
AU2005273865A1 (en) 2006-02-23
US20160184464A1 (en) 2016-06-30
US10076580B2 (en) 2018-09-18
JP2008509970A (ja) 2008-04-03
CN103120799A (zh) 2013-05-29
US9248204B2 (en) 2016-02-02
CA2575677A1 (en) 2006-02-23
EP1784228B1 (en) 2016-10-05

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