JP4776780B2 - ミトコンドリア病の治療方法 - Google Patents

ミトコンドリア病の治療方法 Download PDF

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Publication number
JP4776780B2
JP4776780B2 JP2000600654A JP2000600654A JP4776780B2 JP 4776780 B2 JP4776780 B2 JP 4776780B2 JP 2000600654 A JP2000600654 A JP 2000600654A JP 2000600654 A JP2000600654 A JP 2000600654A JP 4776780 B2 JP4776780 B2 JP 4776780B2
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composition
formula
mitochondrial
mitochondrial disease
synthesis pathway
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Japanese (ja)
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JP2002537340A (ja
JP2002537340A5 (zh
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ナヴィアックス、ロバート、ケイ．
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University of California
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University of California
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
JP2000600654A 1999-02-23 2000-02-23 ミトコンドリア病の治療方法 Expired - Lifetime JP4776780B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12158899P 1999-02-23 1999-02-23
US60/121,588 1999-02-23
PCT/US2000/004663 WO2000050043A1 (en) 1999-02-23 2000-02-23 Methods of treatment of mitochondrial disorders

Publications (3)

Publication Number Publication Date
JP2002537340A JP2002537340A (ja) 2002-11-05
JP2002537340A5 JP2002537340A5 (zh) 2007-04-12
JP4776780B2 true JP4776780B2 (ja) 2011-09-21

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JP2000600654A Expired - Lifetime JP4776780B2 (ja) 1999-02-23 2000-02-23 ミトコンドリア病の治療方法

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US (2) US7638501B1 (zh)
EP (2) EP1808177B1 (zh)
JP (1) JP4776780B2 (zh)
KR (2) KR100879559B1 (zh)
CN (2) CN100379426C (zh)
AT (1) ATE381935T1 (zh)
AU (1) AU776437B2 (zh)
BR (1) BR0008447A (zh)
CA (1) CA2362925C (zh)
DE (1) DE60037578T2 (zh)
DK (1) DK1171137T3 (zh)
ES (1) ES2298130T3 (zh)
HU (1) HU230191B1 (zh)
IL (3) IL144964A0 (zh)
MX (1) MXPA01008549A (zh)
NZ (1) NZ513926A (zh)
PT (1) PT1171137E (zh)
RU (2) RU2268732C2 (zh)
WO (1) WO2000050043A1 (zh)
ZA (1) ZA200107727B (zh)

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EP1171137B1 (en) 2007-12-26
EP1808177A2 (en) 2007-07-18
AU2004235661A1 (en) 2005-01-27
KR100758712B1 (ko) 2007-09-14
PT1171137E (pt) 2008-03-17
WO2000050043A1 (en) 2000-08-31
RU2001125913A (ru) 2005-02-20
EP1171137A4 (en) 2004-04-07
KR20020031331A (ko) 2002-05-01
EP1171137A1 (en) 2002-01-16
RU2005121711A (ru) 2007-01-20
CN1191835C (zh) 2005-03-09
RU2268732C2 (ru) 2006-01-27
HUP0400914A2 (hu) 2004-08-30
DE60037578T2 (de) 2009-01-08
RU2394580C2 (ru) 2010-07-20
JP2002537340A (ja) 2002-11-05
CN1626107A (zh) 2005-06-15
IL180528A0 (en) 2007-06-03
US20100098678A1 (en) 2010-04-22
ES2298130T3 (es) 2008-05-16
DK1171137T3 (da) 2008-03-31
DE60037578D1 (de) 2008-02-07
ATE381935T1 (de) 2008-01-15
CN100379426C (zh) 2008-04-09
US7638501B1 (en) 2009-12-29
IL144964A0 (en) 2002-06-30
ZA200107727B (en) 2007-10-31
NZ513926A (en) 2001-09-28
CA2362925C (en) 2011-04-12
AU3243400A (en) 2000-09-14
US8748408B2 (en) 2014-06-10
IL144964A (en) 2013-11-28
CN1341024A (zh) 2002-03-20
AU776437B2 (en) 2004-09-09
EP1808177A3 (en) 2010-07-28
IL180528A (en) 2013-11-28
EP1808177B1 (en) 2018-08-08
CA2362925A1 (en) 2000-08-31
KR20070085864A (ko) 2007-08-27
HU230191B1 (hu) 2015-09-28
MXPA01008549A (es) 2003-06-06
KR100879559B1 (ko) 2009-01-22
BR0008447A (pt) 2002-01-15
HUP0400914A3 (en) 2007-05-29

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