JP4761683B2 - 置換５−オキソ−５，６，７，８−テトラヒドロ−４ｈ−１−ベンゾピランおよびベンゾチオピランならびにそのａｍｐａ増強剤としての使用 - Google Patents
置換５−オキソ−５，６，７，８−テトラヒドロ−４ｈ−１−ベンゾピランおよびベンゾチオピランならびにそのａｍｐａ増強剤としての使用 Download PDFInfo
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- JP4761683B2 JP4761683B2 JP2001502407A JP2001502407A JP4761683B2 JP 4761683 B2 JP4761683 B2 JP 4761683B2 JP 2001502407 A JP2001502407 A JP 2001502407A JP 2001502407 A JP2001502407 A JP 2001502407A JP 4761683 B2 JP4761683 B2 JP 4761683B2
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- Prior art keywords
- amino
- cyano
- tetrahydro
- benzopyran
- oxo
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- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
- 125000004933 β-carbolinyl group Chemical group C1(=NC=CC=2C3=CC=CC=C3NC12)* 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13750199P | 1999-06-04 | 1999-06-04 | |
| US60/137,501 | 1999-06-04 | ||
| PCT/US2000/015307 WO2000075123A1 (en) | 1999-06-04 | 2000-06-05 | Substituted 5-oxo-5,6,7,8-tetrahydro-4h-1-benzopyrans and benzothiopyrans and the use thereof as potentiators of ampa |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003501422A JP2003501422A (ja) | 2003-01-14 |
| JP2003501422A5 JP2003501422A5 (de) | 2007-07-26 |
| JP4761683B2 true JP4761683B2 (ja) | 2011-08-31 |
Family
ID=22477711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001502407A Expired - Fee Related JP4761683B2 (ja) | 1999-06-04 | 2000-06-05 | 置換５−オキソ−５，６，７，８−テトラヒドロ−４ｈ−１−ベンゾピランおよびベンゾチオピランならびにそのａｍｐａ増強剤としての使用 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1189896A1 (de) |
| JP (1) | JP4761683B2 (de) |
| AU (1) | AU5318300A (de) |
| WO (1) | WO2000075123A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4237639B2 (ja) * | 2002-04-10 | 2009-03-11 | ドンブ ハンノン ケミカル カンパニー リミテッド | テトラゾールを含む二次アミンで置換されたベンゾピラン誘導体、その製造方法及びそれを含む製薬組成物 |
| WO2010066253A1 (en) * | 2008-12-12 | 2010-06-17 | Bunch, Lennart | Selective inhibitors of excitatory amino acid transporter subtype 1 (eaat1 /glast) |
| CN102424675B (zh) * | 2011-11-07 | 2014-04-16 | 镇江市高等专科学校 | 制备2-氨基-3-氰基苯并吡喃衍生物的方法 |
| BR112015031249A2 (pt) | 2013-06-13 | 2017-07-25 | Veroscience Llc | método de tratamento, método para tratar um distúrbio metabólico ou um elemento chave do mesmo, método para normalizar um ritmo diário de liberação de dopamina no sumn, método para estimular a liberação de dopamina de neurônios dopaminérgicos no sumn de um indivíduo e composição farmacêutica |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09509484A (ja) * | 1994-02-08 | 1997-09-22 | エヌピーエス・ファルマシューティカルズ，インコーポレイテッド | 神経障害および神経病の治療に有用な受容体作動性カルシウムチャネル上の新規部位で活性な化合物 |
| JP2000511518A (ja) * | 1996-05-14 | 2000-09-05 | グラクソ、グループ、リミテッド | 時間生物学的薬剤としてのベンゾフランおよびベンゾピラン |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4430639A1 (de) * | 1994-08-29 | 1996-03-07 | Bayer Ag | Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten |
-
2000
- 2000-06-05 JP JP2001502407A patent/JP4761683B2/ja not_active Expired - Fee Related
- 2000-06-05 AU AU53183/00A patent/AU5318300A/en not_active Abandoned
- 2000-06-05 WO PCT/US2000/015307 patent/WO2000075123A1/en not_active Application Discontinuation
- 2000-06-05 EP EP00938095A patent/EP1189896A1/de not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09509484A (ja) * | 1994-02-08 | 1997-09-22 | エヌピーエス・ファルマシューティカルズ，インコーポレイテッド | 神経障害および神経病の治療に有用な受容体作動性カルシウムチャネル上の新規部位で活性な化合物 |
| JP2000511518A (ja) * | 1996-05-14 | 2000-09-05 | グラクソ、グループ、リミテッド | 時間生物学的薬剤としてのベンゾフランおよびベンゾピラン |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1189896A1 (de) | 2002-03-27 |
| WO2000075123A1 (en) | 2000-12-14 |
| AU5318300A (en) | 2000-12-28 |
| JP2003501422A (ja) | 2003-01-14 |
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