JP4726296B2 - 創傷治癒のためのマトリックスタンパク質組成物 - Google Patents

創傷治癒のためのマトリックスタンパク質組成物 Download PDF

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Publication number
JP4726296B2
JP4726296B2 JP2000533139A JP2000533139A JP4726296B2 JP 4726296 B2 JP4726296 B2 JP 4726296B2 JP 2000533139 A JP2000533139 A JP 2000533139A JP 2000533139 A JP2000533139 A JP 2000533139A JP 4726296 B2 JP4726296 B2 JP 4726296B2
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Prior art keywords
enamel matrix
wound
enamel
kda
composition
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Expired - Lifetime
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JP2000533139A
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English (en)
Japanese (ja)
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JP2002504520A5 (https=
JP2002504520A (ja
Inventor
スティナ ゲストレリウス
ラルス ハンマーストローム
ペーター リンスタッダス
クライスター アンダーソン
イワン スラビー
トマス ハンマーグレン
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インスティチュート ストローマン アーゲー
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Priority claimed from PCT/IB1999/000337 external-priority patent/WO1999043344A2/en
Publication of JP2002504520A publication Critical patent/JP2002504520A/ja
Publication of JP2002504520A5 publication Critical patent/JP2002504520A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/108Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dental Preparations (AREA)
JP2000533139A 1998-02-27 1999-02-26 創傷治癒のためのマトリックスタンパク質組成物 Expired - Lifetime JP4726296B2 (ja)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DK27098 1998-02-27
DK0270/98 1998-02-27
US8155198P 1998-04-13 1998-04-13
US60/081,551 1998-04-13
DK199800270 1998-07-21
DK60/081,551 1998-10-16
DKPA199801328 1998-10-16
DK199801328 1998-10-16
DKPA199801328 1998-10-16
PCT/IB1999/000337 WO1999043344A2 (en) 1998-02-27 1999-02-26 Matrix protein compositions for wound healing

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007131100A Division JP5024866B2 (ja) 1998-02-27 2007-05-17 創傷治癒のためのマトリックスタンパク質組成物

Publications (3)

Publication Number Publication Date
JP2002504520A JP2002504520A (ja) 2002-02-12
JP2002504520A5 JP2002504520A5 (https=) 2005-07-21
JP4726296B2 true JP4726296B2 (ja) 2011-07-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000533139A Expired - Lifetime JP4726296B2 (ja) 1998-02-27 1999-02-26 創傷治癒のためのマトリックスタンパク質組成物

Country Status (6)

Country Link
US (3) US6503539B2 (https=)
JP (1) JP4726296B2 (https=)
AR (1) AR020055A1 (https=)
BR (1) BRPI9908182C1 (https=)
PL (1) PL204797B1 (https=)
RU (1) RU2241489C2 (https=)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL137869A0 (en) * 1998-02-27 2001-10-31 Biora Bioex Ab Matrix protein compositions for wound healing
US6884427B1 (en) * 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
US20030096740A1 (en) * 1999-03-10 2003-05-22 Lars Hammarstrom Matrix protein compositions for induction of apoptosis
US6979670B1 (en) * 1999-03-10 2005-12-27 Biora Bioex Ab Matrix protein compositions for grafting
HU230030B1 (hu) 1999-10-08 2015-05-28 Debiopharm International Sa Fab I inhibitorok
US6821953B1 (en) * 1999-12-16 2004-11-23 University Of Southern California Methods for treating and preventing damage to mucosal tissue
US7304030B2 (en) * 2000-06-20 2007-12-04 Biora Ab Matrix protein composition for dentin regeneration
JP5095063B2 (ja) * 2000-06-20 2012-12-12 ストローマン ホールディング アーゲー 象牙質再生に用いる基質タンパク質組成物
JP4017977B2 (ja) * 2000-08-08 2007-12-05 アデランス リサーチ インスティテュート インコーポレイテッド 組織工学で処置した毛髪用の台
US7144729B2 (en) * 2000-09-01 2006-12-05 Dfb Pharmaceuticals, Inc. Methods and compositions for tissue regeneration
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
CA2434254C (en) * 2001-01-12 2013-08-13 Board Of Regents, The University Of Texas System Novel antiseptic derivatives with broad spectrum antimicrobial activity for the impregnation of surfaces
US7033611B2 (en) * 2001-02-23 2006-04-25 Biora Bioex Ab Matrix protein compositions for guided connective tissue growth
EP1560584B1 (en) * 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab i inhibitors
CN100346823C (zh) * 2001-09-14 2007-11-07 比奥拉比奥埃克斯公司 用于调节免疫反应的釉质基质蛋白组合物
CA2473931C (en) * 2002-01-23 2010-10-26 Dentsply International, Inc. Irrigation solution and methods for use
US20040068284A1 (en) * 2002-01-29 2004-04-08 Barrows Thomas H. Method for stimulating hair growth and kit for carrying out said method
JP4948744B2 (ja) * 2002-10-04 2012-06-06 允 深江 歯周組織再生剤、その有効成分抽出法、およびプラスミド
EP1575951B1 (en) * 2002-12-06 2014-06-25 Debiopharm International SA Heterocyclic compounds, methods of making them and their use in therapy
JP2004307454A (ja) * 2003-02-21 2004-11-04 Seikagaku Kogyo Co Ltd 生理活性ペプチド及びこれを含有する薬剤
US7494980B2 (en) * 2003-03-10 2009-02-24 The United States Of America As Represented By The Secretary Of The Army Antimicrobial peptide and methods of use thereof
US8778889B2 (en) * 2003-03-10 2014-07-15 The United States Of America As Represented By The Secretary Of The Army Antimicrobial decapeptide oral hygiene treatment
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
HUE045608T2 (hu) * 2003-06-06 2020-01-28 Univ Texas Antimikrobiális öblítõoldatok
WO2005000837A1 (en) * 2003-06-19 2005-01-06 Janssen Pharmaceutica N.V. Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
EP1680148A1 (en) * 2003-10-21 2006-07-19 Bioartificial Gel Technologies Inc. Hydrogel-containing medical articles and methods of using and making the same
US20050125015A1 (en) * 2003-12-04 2005-06-09 Mcnally-Heintzelman Karen M. Tissue-handling apparatus, system and method
US20050125033A1 (en) * 2003-12-04 2005-06-09 Mcnally-Heintzelman Karen M. Wound closure apparatus
JP2007522835A (ja) * 2004-01-20 2007-08-16 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 医療装置に消毒組成物をコーティングする、および含浸させる方法
US7597885B2 (en) * 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
US20050220821A1 (en) * 2004-03-31 2005-10-06 Allergan, Inc. Pressure sore treatment
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
AR050212A1 (es) * 2004-08-13 2006-10-04 Aderans Res Inst Inc Organogenesis a partir de celulas disociadas
RU2277933C2 (ru) * 2004-09-21 2006-06-20 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма цефазолина для профилактики послеоперационных инфекционных осложнений в оториноларингологии
US7766658B2 (en) * 2004-11-30 2010-08-03 Align Technology, Inc. Systems and methods for intra-oral diagnosis
US20060115782A1 (en) * 2004-11-30 2006-06-01 Chunhua Li Systems and methods for coating a dental appliance
US20060115785A1 (en) * 2004-11-30 2006-06-01 Chunhua Li Systems and methods for intra-oral drug delivery
US7947508B2 (en) * 2004-11-30 2011-05-24 Align Technology, Inc. Systems and methods for intra-oral diagnosis
SE0403014D0 (sv) * 2004-12-10 2004-12-10 Straumann Holding Ag New protein formulation
EP1830863A2 (en) * 2004-12-10 2007-09-12 Straumann Holding AG Protein formulation
US7722900B2 (en) * 2005-04-09 2010-05-25 Yukiko Tanabe, legal representative Effect of porcine sheath proteins on the regeneration activity of periodontal ligament
US20070048356A1 (en) * 2005-08-31 2007-03-01 Schorr Phillip A Antimicrobial treatment of nonwoven materials for infection control
US20070048344A1 (en) * 2005-08-31 2007-03-01 Ali Yahiaoui Antimicrobial composition
US20070048345A1 (en) * 2005-08-31 2007-03-01 Kimberly-Clark Worldwide, Inc. Antimicrobial composition
US20070048358A1 (en) * 2005-08-31 2007-03-01 Schorr Phillip A Antimicrobial substrates
US20070154621A1 (en) 2005-11-18 2007-07-05 Issam Raad Methods for coating surfaces with antimicrobial agents
TW200803877A (en) * 2005-11-22 2008-01-16 Aderans Res Inst Inc Hair grafts derived from plucked hair
WO2007062386A2 (en) * 2005-11-22 2007-05-31 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
KR20080075027A (ko) * 2005-12-05 2008-08-13 아피늄 파마슈티컬스, 인크. Fabi 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물
US20070135706A1 (en) * 2005-12-13 2007-06-14 Shimko Daniel A Debridement method, device and kit
US20070148187A1 (en) * 2005-12-27 2007-06-28 Intact Enterprises, Inc. Mastic gum composition for use as a dietary supplement in humans and animals
WO2008006083A2 (en) 2006-07-07 2008-01-10 Surmodics, Inc. Beaded wound spacer device
JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ, インク. Fabiインヒビターとしてのアクリルアミド誘導体
US7772213B2 (en) * 2006-07-27 2010-08-10 Nathan Strick Composition for the treatment of inflammatory conditions
US8623842B2 (en) * 2006-09-27 2014-01-07 Hemostasis, Llc Hemostatic agent and method
EP2125802A4 (en) 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
EP2120561A4 (en) 2007-02-19 2012-11-21 Plurogen Therapeutics Inc COMPOSITIONS FOR TREATING BIOFILMS, AND METHODS FOR THEIR USE
US7985537B2 (en) * 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
US20090202609A1 (en) * 2008-01-06 2009-08-13 Keough Steven J Medical device with coating composition
US20100291160A1 (en) * 2009-05-13 2010-11-18 Carver David R Pharmaceutical system for trans-membrane delivery
US8980243B2 (en) 2009-05-19 2015-03-17 Neal Koller Surface active agent compositions and methods for enhancing oxygenation, reducing bacteria and improving wound healing at a site of treatment
US9192626B2 (en) * 2009-06-10 2015-11-24 American Silver, Llc Dental uses of silver hydrosol
CN101991688A (zh) * 2009-08-20 2011-03-30 徐荣祥 药物组合物在制备治疗糖尿病溃疡药物中的用途
US8790613B2 (en) * 2010-02-24 2014-07-29 Erachem Comilog, Inc. Treated electrolytic manganese dioxide and method for its production
JP5671618B2 (ja) 2010-10-15 2015-02-18 ストラウマン ホールディング アーゲー Pgaを含んでなる新しいemd製剤
BR112013030381B1 (pt) 2011-05-27 2021-10-26 University Of Washington Through Its Center For Commercialization Produto de cuidado oral
AU2013279021C1 (en) 2012-06-19 2017-03-16 Debiopharm International Sa Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
US20140023979A1 (en) * 2012-07-18 2014-01-23 Maha Mohamed Fouad Mounir Regeneration of ameloblast cells and dental enamel in vivo
JP6298468B2 (ja) 2012-10-16 2018-03-20 サーモディクス,インコーポレイテッド 創傷充填デバイスおよび方法
US20140186273A1 (en) * 2012-12-27 2014-07-03 University Of Southern California Chitosan -Amelogenin Hydrogel for In Situ Enamel Growth
US20140272803A1 (en) * 2013-03-14 2014-09-18 Alan Nevins Root canal for tissue in-growth
WO2014177602A1 (en) * 2013-04-30 2014-11-06 Straumann Holding Ag Trap 63
JP6483139B2 (ja) * 2014-01-17 2019-03-13 ストラウマン ホールディング アーゲー 増強した安定性のemdの製造方法
US10201457B2 (en) 2014-08-01 2019-02-12 Surmodics, Inc. Wound packing device with nanotextured surface
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
AU2016209327A1 (en) 2015-01-20 2017-08-10 Plurogen Therapeutics, Llc Compositions and methods of treating microbes
US9962465B2 (en) 2015-07-07 2018-05-08 University Of Southern California Amelogenin-chitosan hydrogel for dentin hypersensitivity
US10952940B2 (en) 2016-01-15 2021-03-23 University Of Washington Reagents and methods for mineralization of tooth enamel
RU2732224C9 (ru) 2016-01-31 2021-06-18 Медивунд Лтд. Раноочищающая композиция для лечения ран
RS61312B1 (sr) 2016-02-26 2021-02-26 Debiopharm Int Sa Lek za lečenje infekcija dijabetskog stopala
WO2017183018A1 (en) * 2016-04-18 2017-10-26 Mediwound Ltd Methods of debridement of chronic wounds
TN2021000159A1 (en) 2019-02-14 2023-04-04 Debiopharm Int Sa Afabicin formulation, method for making the same and uses thereof
SG11202113174SA (en) 2019-06-14 2021-12-30 Debiopharm Int Sa Medicament and use thereof for treating bacterial infections involving biofilm
US11457996B2 (en) * 2019-09-12 2022-10-04 King Abdulaziz University Dental pulp capping composition and method of preserving and regenerating capped pulp and dentin bridge
CZ308980B6 (cs) 2020-01-24 2021-11-03 Contipro A.S. Dentální přípravek z vláken na bázi kyseliny hyaluronové s regulovatelnou biodegradabilitou
US20240269167A1 (en) * 2020-12-21 2024-08-15 Biointelligent Technology Systems Slu A mucosal re-epithelialization composition
KR102802100B1 (ko) * 2023-07-14 2025-05-02 주식회사 티앤알바이오팹 흡수성 체내 지혈 키트 및 흡수성 체내 지혈제

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU98529A1 (ru) * 1952-04-04 1953-11-30 Конструкторское Бюро Особое Рабочее колесо центробежного погружного насоса
SU1398869A1 (ru) * 1985-10-31 1988-05-30 Московский медицинский стоматологический институт им.Н.А.Семашко Способ лечени зв желудка и двенадцатиперстной кишки
SE454480B (sv) 1986-09-25 1988-05-09 Lars Hammarstrom Bindningsinducerande komposition
SE461313B (sv) 1988-03-17 1990-02-05 Biora Ab Bindningsinducerande komposition
SE503096C2 (sv) 1994-09-22 1996-03-25 Biora Ab Komposition innehållande EDTA för användning vid konditionering av tandrötter
WO1997002730A2 (en) 1995-07-13 1997-01-30 Biora Ab Enamel matrix related polypeptide

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US6720009B2 (en) 2004-04-13
US20020169105A1 (en) 2002-11-14
BRPI9908182C1 (pt) 2021-05-25
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US7294352B2 (en) 2007-11-13
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BRPI9908182B1 (pt) 2017-09-26
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