JP4688498B2 - Ｊａｋインヒビターとしてのヘテロアリール−ピリミジン誘導体 - Google Patents

Ｊａｋインヒビターとしてのヘテロアリール−ピリミジン誘導体 Download PDF

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Publication number
JP4688498B2
JP4688498B2 JP2004550483A JP2004550483A JP4688498B2 JP 4688498 B2 JP4688498 B2 JP 4688498B2 JP 2004550483 A JP2004550483 A JP 2004550483A JP 2004550483 A JP2004550483 A JP 2004550483A JP 4688498 B2 JP4688498 B2 JP 4688498B2
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aliphatic
substituted
phenyl
nitrogen
hydrogen
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Japanese (ja)
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JP2006514006A5 (enExample
JP2006514006A (ja
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ランディー エス． ベティエル，
マーク レデボウア，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
JP2004550483A 2002-11-04 2003-11-04 Ｊａｋインヒビターとしてのヘテロアリール−ピリミジン誘導体 Expired - Fee Related JP4688498B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42357902P 2002-11-04 2002-11-04
US60/423,579 2002-11-04
PCT/US2003/035163 WO2004041814A1 (en) 2002-11-04 2003-11-04 Heteroaryl-pyramidine derivatives as jak inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010211038A Division JP2011016839A (ja) 2002-11-04 2010-09-21 Ｊａｋインヒビターとしてのヘテロアリール−ピリミジン誘導体

Publications (3)

Publication Number Publication Date
JP2006514006A JP2006514006A (ja) 2006-04-27
JP2006514006A5 JP2006514006A5 (enExample) 2010-06-03
JP4688498B2 true JP4688498B2 (ja) 2011-05-25

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ID=32312681

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004550483A Expired - Fee Related JP4688498B2 (ja) 2002-11-04 2003-11-04 Ｊａｋインヒビターとしてのヘテロアリール−ピリミジン誘導体
JP2010211038A Pending JP2011016839A (ja) 2002-11-04 2010-09-21 Ｊａｋインヒビターとしてのヘテロアリール−ピリミジン誘導体

Family Applications After (1)

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JP2010211038A Pending JP2011016839A (ja) 2002-11-04 2010-09-21 Ｊａｋインヒビターとしてのヘテロアリール−ピリミジン誘導体

Country Status (9)

Country Link
US (1) US7259161B2 (enExample)
EP (1) EP1562938B1 (enExample)
JP (2) JP4688498B2 (enExample)
AT (1) ATE371656T1 (enExample)
AU (1) AU2003295396B2 (enExample)
CA (1) CA2506773A1 (enExample)
DE (1) DE60316013T2 (enExample)
ES (1) ES2289349T3 (enExample)
WO (1) WO2004041814A1 (enExample)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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US6638926B2 (en) * 2000-09-15 2003-10-28 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
IL166241A0 (en) 2002-07-29 2006-01-15 Rigel Pharmaceuticals Inc Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds
US8178671B2 (en) 2003-07-30 2012-05-15 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds
RU2007107177A (ru) * 2004-07-28 2008-09-10 Айрм Ллк (Bm) Соединения и композиции, как модуляторы ядерных рецепторов стероидных гормонов
WO2006047492A2 (en) 2004-10-22 2006-05-04 Amgen Inc. Substituted nitrogen-containing heterocycles as vanilloid receptor ligands and their uses as medicament
EP1814878B1 (en) 2004-11-24 2012-01-04 Rigel Pharmaceuticals, Inc. Spiro-2, 4-pyrimidinediamine compounds and their uses
JP5154231B2 (ja) * 2005-02-14 2013-02-27 ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド 快適な眼科用具およびその製造法
CA2604551A1 (en) * 2005-05-03 2007-03-08 Rigel Pharmaceuticals, Inc. Jak kinase inhibitors and their uses
CN105348203B (zh) 2005-06-08 2018-09-18 里格尔药品股份有限公司 抑制jak途径的组合物和方法
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US8604042B2 (en) 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
US8133900B2 (en) 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
DK1951684T3 (en) 2005-11-01 2016-10-24 Targegen Inc BIARYLMETAPYRIMIDIN kinase inhibitors
AU2006316322B2 (en) * 2005-11-22 2011-08-25 Merck Canada Inc. Tricyclic compounds useful as inhibitors of kinases
DK3184526T3 (en) 2005-12-13 2019-01-14 Incyte Holdings Corp PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES AS A JANUS-KINASE INHIBITOR
WO2007089768A2 (en) * 2006-01-30 2007-08-09 Exelixis, Inc. 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and pharmaceutical compositions containing them
US9052529B2 (en) 2006-02-10 2015-06-09 Johnson & Johnson Vision Care, Inc. Comfortable ophthalmic device and methods of its production
US8962643B2 (en) 2006-02-24 2015-02-24 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
CA2650140A1 (en) * 2006-04-14 2007-10-25 Mriganka Sur Identifying and modulating molecular pathways that mediate nervous system plasticity
CA2673125C (en) 2006-10-19 2015-04-21 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US8513270B2 (en) 2006-12-22 2013-08-20 Incyte Corporation Substituted heterocycles as Janus kinase inhibitors
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