JP4671574B2 - 志賀毒素様毒素及び血管内皮成長因子断片を含有する組換えたんぱく質 - Google Patents
志賀毒素様毒素及び血管内皮成長因子断片を含有する組換えたんぱく質 Download PDFInfo
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- JP4671574B2 JP4671574B2 JP2001569328A JP2001569328A JP4671574B2 JP 4671574 B2 JP4671574 B2 JP 4671574B2 JP 2001569328 A JP2001569328 A JP 2001569328A JP 2001569328 A JP2001569328 A JP 2001569328A JP 4671574 B2 JP4671574 B2 JP 4671574B2
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| US09/796,861 US20010031485A1 (en) | 2000-03-22 | 2001-03-01 | Recombinant proteins containing Shiga-like toxin and vascular endothelial growth factor fragments |
| US09/796,861 | 2001-03-01 | ||
| PCT/US2001/008798 WO2001070945A1 (en) | 2000-03-22 | 2001-03-19 | Recombinant proteins containing shiga-like toxin and vascular endothelial growth factor fragments |
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| JP2003533980A JP2003533980A (ja) | 2003-11-18 |
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| EP2286843A3 (de) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Arzneimitteln zur Zielgerichtung von Endothelzellen |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7794693B2 (en) * | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| EP1587944A4 (de) | 2002-03-01 | 2007-03-21 | Dyax Corp | Kdr und vegf/kdr-bindende peptide und ihre diagnostische und therapeutische veranwendung bei der diagnose und therapie |
| DE10210284A1 (de) * | 2002-03-08 | 2003-10-02 | Medigene Ag | Verfahren zum Identifizieren von spezifischen RNA-Inhibitoren |
| DK2949658T3 (en) | 2003-03-03 | 2018-10-01 | Dyax Corp | Peptides that specifically bind HGF receptor (cMet) and uses thereof |
| ATE504312T1 (de) * | 2003-07-21 | 2011-04-15 | Intervet Int Bv | Hybrid-toxine mit shiga-artigen toxin- untereinheiten, verbunden mit escherichia coli wärmeinstabilen enterotoxin-untereinheiten und vakzine daraus |
| CN103045633A (zh) * | 2012-12-11 | 2013-04-17 | 中国科学院广州生物医药与健康研究院 | 重组人血管内皮细胞生长因子-165蛋白及其生产方法 |
| PT2970487T (pt) | 2013-03-12 | 2020-06-17 | Molecular Templates Inc | Proteínas citotóxicas compreendendo regiões de ligação de direcionamento para células e regiões de subunidades de toxina a shiga para a morte seletiva de tipos específicos de células |
| AU2015209063C1 (en) * | 2014-01-27 | 2020-06-25 | Molecular Templates, Inc. | MHC class I epitope delivering polypeptides |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| ES2919749T3 (es) | 2014-06-11 | 2022-07-28 | Molecular Templates Inc | Moléculas dirigidas a células citotóxicas resistentes a la escisión por proteasa |
| AU2016215205B2 (en) | 2015-02-05 | 2021-10-21 | Molecular Templates, Inc. | Multivalent CD20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof |
| LT3303373T (lt) | 2015-05-30 | 2020-07-10 | Molecular Templates, Inc. | Deimunizuoto shiga toksino a subvieneto karkasai ir juos apimančios ląstelės taikinio molekulės |
| IL293710B2 (en) | 2016-12-07 | 2024-10-01 | Molecular Templates Inc | Shiga toxin A subunit activator polypeptides, Shiga toxin activator scaffolds and cell-targeting molecules for site-specific conjugation |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US20200024312A1 (en) | 2017-01-25 | 2020-01-23 | Molecular Templates, Inc. | Cell-targeting molecules comprising de-immunized, shiga toxin a subunit effectors and cd8+ t-cell epitopes |
| CN110612117B (zh) | 2018-04-17 | 2024-04-12 | 分子模板公司 | 包含去免疫化的志贺毒素a亚基支架的her2靶向分子 |
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- 2001-03-19 JP JP2001569328A patent/JP4671574B2/ja not_active Expired - Lifetime
- 2001-03-19 EP EP01918834A patent/EP1268760B1/de not_active Expired - Lifetime
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| DE60143382D1 (de) | 2010-12-16 |
| ATE486934T1 (de) | 2010-11-15 |
| WO2001070945A1 (en) | 2001-09-27 |
| EP1268760A4 (de) | 2004-07-14 |
| US20010031485A1 (en) | 2001-10-18 |
| JP2003533980A (ja) | 2003-11-18 |
| EP1268760A1 (de) | 2003-01-02 |
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