JP4642476B2 - （ｒ）および（ｓ）−アミノカルニチンおよびその誘導体のｄ−およびｌ−アスパラギン酸からの合成 - Google Patents

（ｒ）および（ｓ）−アミノカルニチンおよびその誘導体のｄ−およびｌ−アスパラギン酸からの合成 Download PDF

Info

Publication number
JP4642476B2
JP4642476B2 JP2004566248A JP2004566248A JP4642476B2 JP 4642476 B2 JP4642476 B2 JP 4642476B2 JP 2004566248 A JP2004566248 A JP 2004566248A JP 2004566248 A JP2004566248 A JP 2004566248A JP 4642476 B2 JP4642476 B2 JP 4642476B2
Authority
JP
Japan
Prior art keywords
compound
group
converting
alkyl
straight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004566248A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006513243A (ja
JP2006513243A5 (OSRAM
Inventor
ファビオ・ジャンネッシ
ナタリーナ・デルオモ
マリア・オルネッラ・ティンティ
フランチェスコ・デ・アンジェリス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/338,045 external-priority patent/US20030153783A1/en
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of JP2006513243A publication Critical patent/JP2006513243A/ja
Publication of JP2006513243A5 publication Critical patent/JP2006513243A5/ja
Application granted granted Critical
Publication of JP4642476B2 publication Critical patent/JP4642476B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2004566248A 2003-01-08 2003-12-19 （ｒ）および（ｓ）−アミノカルニチンおよびその誘導体のｄ−およびｌ−アスパラギン酸からの合成 Expired - Fee Related JP4642476B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/338,045 US20030153783A1 (en) 1999-06-30 2003-01-08 Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US10/372,627 US6822115B2 (en) 1999-06-30 2003-02-25 Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
PCT/IT2003/000846 WO2004063143A1 (en) 2003-01-08 2003-12-19 Synthesis fo (r) and (s)-aminocarnitine and derivatives thereof from d-and l-aspartic acid

Publications (3)

Publication Number Publication Date
JP2006513243A JP2006513243A (ja) 2006-04-20
JP2006513243A5 JP2006513243A5 (OSRAM) 2007-02-08
JP4642476B2 true JP4642476B2 (ja) 2011-03-02

Family

ID=32716886

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004566248A Expired - Fee Related JP4642476B2 (ja) 2003-01-08 2003-12-19 （ｒ）および（ｓ）−アミノカルニチンおよびその誘導体のｄ−およびｌ−アスパラギン酸からの合成

Country Status (18)

Country Link
US (1) US6822115B2 (OSRAM)
EP (1) EP1581475B1 (OSRAM)
JP (1) JP4642476B2 (OSRAM)
KR (1) KR20050092398A (OSRAM)
CN (1) CN1735588B (OSRAM)
AT (1) ATE443039T1 (OSRAM)
AU (1) AU2003295219B2 (OSRAM)
BR (1) BR0317956A (OSRAM)
CA (1) CA2512679A1 (OSRAM)
CY (1) CY1109545T1 (OSRAM)
DE (1) DE60329325D1 (OSRAM)
DK (1) DK1581475T3 (OSRAM)
ES (1) ES2333523T3 (OSRAM)
MX (1) MXPA05007315A (OSRAM)
PL (1) PL378538A1 (OSRAM)
PT (1) PT1581475E (OSRAM)
SI (1) SI1581475T1 (OSRAM)
WO (1) WO2004063143A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
ITRM20050090A1 (it) * 2005-03-02 2006-09-03 Sigma Tau Ind Farmaceutiche Riunite Spa Derivati dell'acido ammino-butanoico inibitore della cpt.
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
US8410150B2 (en) * 2007-03-09 2013-04-02 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
CA2677049A1 (en) * 2007-08-01 2009-02-05 Sionex Corporation Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
IT1261489B (it) 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US20030153783A1 (en) * 1999-06-30 2003-08-14 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
IT1306162B1 (it) * 1999-06-30 2001-05-30 Sigma Tau Ind Farmaceuti Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.

Also Published As

Publication number Publication date
DK1581475T3 (da) 2010-01-25
BR0317956A (pt) 2006-06-13
WO2004063143A1 (en) 2004-07-29
JP2006513243A (ja) 2006-04-20
PT1581475E (pt) 2009-11-09
EP1581475A1 (en) 2005-10-05
CN1735588B (zh) 2010-05-26
AU2003295219A1 (en) 2004-08-10
CY1109545T1 (el) 2014-08-13
ES2333523T3 (es) 2010-02-23
EP1581475B1 (en) 2009-09-16
KR20050092398A (ko) 2005-09-21
US20030153784A1 (en) 2003-08-14
HK1086254A1 (en) 2006-09-15
DE60329325D1 (de) 2009-10-29
AU2003295219B2 (en) 2010-08-12
PL378538A1 (pl) 2006-05-02
MXPA05007315A (es) 2005-09-30
SI1581475T1 (sl) 2009-12-31
ATE443039T1 (de) 2009-10-15
CN1735588A (zh) 2006-02-15
CA2512679A1 (en) 2004-07-29
US6822115B2 (en) 2004-11-23

Similar Documents

Publication Publication Date Title
CN110300756B (zh) 7H-吡咯并[2,3-d]嘧啶衍生物的制备方法及其合成中间体
CN101563312A (zh) 阿塞那平合成中间体的制备方法
JPH07304770A (ja) 新規ベンゾアゼピノン誘導体
JP4642476B2 (ja) （ｒ）および（ｓ）−アミノカルニチンおよびその誘導体のｄ−およびｌ−アスパラギン酸からの合成
US6528684B1 (en) Synthesis of (R) and (S) -aminocarnitine and their derivatives starting from D- and L-aspartic acid
KR20020005630A (ko) 삼환성 아미노알콜 유도체의 신규 제조 방법
CA2793129A1 (en) Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
US8063244B2 (en) Process for the synthesis of pregabalin
CN111410622A (zh) L-胱硫醚盐酸盐的合成方法
US20030153783A1 (en) Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
JP4491412B2 (ja) Ｌ−γ−メチレングルタミン酸とその類似化合物の合成方法
US7217835B2 (en) Production method of O-substituted tyrosine compound
HK1086254B (en) Synthesis fo (r) and (s) -aminocarnitine and derivatives thereof from d-and l-aspartic acid
JP4042060B2 (ja) アミノジカルボン酸のω−ベンジルエステルの製造方法、このエステルのアルカンスルホネートの製造方法および得られたアルカンスルホネート
CA2694320C (en) Method of producing optically active n-(halopropyl)amino acid derivative
EP1078919B1 (en) Synthesis of alpha-amino-alpha',alpha'-dihaloketones and process for the preparation of beta)-amino acid derivatives by the use of the same
JP2005041854A (ja) 光学活性ｎ−（２−置換−３−ハロプロピオニル）アミノ酸類及びその製造方法、並びにそれを用いた光学活性ｎ−（２−置換−３−アシルチオプロピオニル）アミノ酸類の製造方法
JPH10291979A (ja) １，２，３，４−テトラヒドロイソキノリン−３−カルボン酸ターシャリーブチルアミドの製造方法
WO2017122822A1 (ja) デプシペプチド類化合物の製造中間体及びその製造方法
FR2943666A1 (fr) Metallophore derive de nicotianamine et ses procedes de fabrication
JPH10130284A (ja) メタンジホスホン酸化合物の製造法
KR20000035350A (ko) Ｎ-알콕시카보닐-ｎ-시아노에틸 아미노산 알킬에스테르의제조 방법
IE20000060A1 (en) Novel Process for Producing AMPA Antagonist Compounds

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061218

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061218

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100105

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100405

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100412

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100506

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100513

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100607

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100706

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101006

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20101102

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20101201

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131210

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees