JP4613158B2 - 皮膚係合面形状を形成された皮内送出デバイス - Google Patents
皮膚係合面形状を形成された皮内送出デバイス Download PDFInfo
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- JP4613158B2 JP4613158B2 JP2006503197A JP2006503197A JP4613158B2 JP 4613158 B2 JP4613158 B2 JP 4613158B2 JP 2006503197 A JP2006503197 A JP 2006503197A JP 2006503197 A JP2006503197 A JP 2006503197A JP 4613158 B2 JP4613158 B2 JP 4613158B2
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- Prior art keywords
- skin
- engaging surface
- needle cannula
- skin engaging
- protrusion
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- Expired - Lifetime
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- 238000012377 drug delivery Methods 0.000 claims description 5
- 230000002500 effect on skin Effects 0.000 claims description 3
- 230000035515 penetration Effects 0.000 claims description 3
- 210000003491 skin Anatomy 0.000 description 134
- 238000002347 injection Methods 0.000 description 24
- 239000007924 injection Substances 0.000 description 24
- 208000024780 Urticaria Diseases 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 9
- 230000002093 peripheral effect Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 210000004207 dermis Anatomy 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000003825 pressing Methods 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
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- 208000026935 allergic disease Diseases 0.000 description 2
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- 230000008859 change Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 210000003813 thumb Anatomy 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001442495 Mantophasmatodea Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 description 1
- 229940124736 hepatitis-B vaccine Drugs 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 230000037368 penetrate the skin Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/3257—Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6063—Optical identification systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
Description
Claims (13)
- 薬物送出デバイスであって、
前端を有する尖った遠位端を有する針カニューレと;
前記針カニューレの周囲に配置され、針カニューレに対し横向でかつ少なくとも部分的に前記針カニューレの周囲に配置された皮膚係合面を画成する遠位端を有するリミッタとを具え、
前記皮膚係合面は、概ね同一平面の部分を備えて概ね非平面であり、
前記皮膚係合面内に画成された凹所は、前記同一平面に隣接し、前記皮膚係合面の境界まで延びるくぼみであって、前記皮膚係合面が患者の皮膚に押し付けられた時に患者の皮膚の部分が変形して入り得るくぼみを画成し、
前記皮膚係合面が、前記針カニューレの前記前端の貫通を患者の皮膚の真皮層に制限するように、前記針カニューレの前記前端は、前記同一平面の部分によって画成された面から約0.5mmから、3.0mmの範囲の距離、間隔をあけられており、前記皮膚係合面は、前記針カニューレに近接する第1部分と前記第1部分から遠位に延び、前記同一平面の部分が形成された環状の突部とを含むことを特徴とするデバイス。 - 前記突部は、自由遠位端に終結し、前記同一平面の部分は前記自由遠位端上に画成されることを特徴とする請求項1に記載のデバイス。
- 前記突部は前記針カニューレを取り囲むことを特徴とする請求項1に記載のデバイス。
- 前記突部は多角形の横断面を有することを特徴とする請求項1に記載のデバイス。
- 前記突部は概ね長方形の横断面を有することを特徴とする請求項4に記載のデバイス。
- 前記突部は概ね台形の横断面を有することを特徴とする請求項4に記載のデバイス。
- 前記突部は概ね四角形の横断面を有することを特徴とする請求項4に記載のデバイス。
- 前記突部は0.2mmから1.0mmの範囲の高さを有し、前記突部は自由遠位端に終結し、前記自由遠位端は0.2mmから0.6mmの範囲の幅に画成されることを特徴とする請求項4に記載のデバイス。
- 前記突部はそれぞれ0.2mmから0.5mmの、高さと幅を有することを特徴とする請求項5に記載のデバイス。
- 前記突部は0.5mmから1.0mmの範囲の高さを有し、前記突部は自由遠位端に終結し、前記自由遠位端は0.35mmから0.6mmの範囲の幅に画成することを特徴とする請求項6に記載のデバイス。
- 前記突部はそれぞれ0.2mmから0.5mmの、高さと幅を有することを特徴とする請求項7に記載のデバイス。
- 前記突部の横断面の少なくとも一部はアーチ状であることを特徴とする請求項1に記載のデバイス。
- 薬物送出デバイスであって、
前端を有する尖った遠位端を有する針カニューレと;
前記針カニューレの周囲に配置され、針カニューレに対し横向でかつ少なくとも部分的に前記針カニューレの周囲に配置された皮膚係合面を画成する遠位端を有するリミッタとを具え、
前記皮膚係合面は、概ね同一平面の部分を備えて概ね非平面であり、
前記皮膚係合面内に画成された凹所は、前記同一平面に隣接し、前記皮膚係合面の境界まで延びるくぼみであって、前記皮膚係合面が患者の皮膚に押し付けられた時に患者の皮膚の部分が変形して入り得るくぼみを画成し、
前記皮膚係合面が、前記針カニューレの前記前端の貫通を患者の皮膚の真皮層に制限するように、前記針カニューレの前記前端は、前記同一平面部分によって画成される平面から約0.5mmから、3.0mmの範囲の距離、間隔をあけられており、前記皮膚係合面は、前記針カニューレに近接する第1部分と前記第1部分から遠位に延び、前記同一平面の部分が形成された環状の突部とを含み、前記突部の横断面の少なくとも一部はアーチ状であることを特徴とするデバイス。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44382603P | 2003-01-30 | 2003-01-30 | |
PCT/US2004/002699 WO2004069301A2 (en) | 2003-01-30 | 2004-01-30 | Intradermal delivery device with contoured skin engaging surface geometry |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006517129A JP2006517129A (ja) | 2006-07-20 |
JP4613158B2 true JP4613158B2 (ja) | 2011-01-12 |
Family
ID=37114529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006503197A Expired - Lifetime JP4613158B2 (ja) | 2003-01-30 | 2004-01-30 | 皮膚係合面形状を形成された皮内送出デバイス |
Country Status (9)
Country | Link |
---|---|
US (1) | US8267890B2 (ja) |
EP (1) | EP1596910B1 (ja) |
JP (1) | JP4613158B2 (ja) |
CN (1) | CN1756573B (ja) |
AU (1) | AU2004209917B8 (ja) |
CA (1) | CA2514503C (ja) |
ES (1) | ES2611428T3 (ja) |
MX (1) | MXPA05007963A (ja) |
WO (1) | WO2004069301A2 (ja) |
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2004
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- 2004-01-30 JP JP2006503197A patent/JP4613158B2/ja not_active Expired - Lifetime
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- 2004-01-30 CN CN2004800056340A patent/CN1756573B/zh not_active Expired - Lifetime
- 2004-01-30 ES ES04706988.5T patent/ES2611428T3/es not_active Expired - Lifetime
- 2004-01-30 US US10/543,714 patent/US8267890B2/en active Active
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CN1756573A (zh) | 2006-04-05 |
CN1756573B (zh) | 2011-06-08 |
BRPI0407086A (pt) | 2006-01-24 |
CA2514503A1 (en) | 2004-08-19 |
MXPA05007963A (es) | 2005-09-20 |
AU2004209917A1 (en) | 2004-08-19 |
AU2004209917B2 (en) | 2010-01-14 |
US8267890B2 (en) | 2012-09-18 |
EP1596910B1 (en) | 2016-10-19 |
AU2004209917B8 (en) | 2010-05-06 |
CA2514503C (en) | 2011-09-27 |
US20080045900A1 (en) | 2008-02-21 |
WO2004069301A2 (en) | 2004-08-19 |
EP1596910A4 (en) | 2006-12-06 |
EP1596910A2 (en) | 2005-11-23 |
WO2004069301A3 (en) | 2005-06-09 |
JP2006517129A (ja) | 2006-07-20 |
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