JP4602759B2 - β−ラクタマーゼ阻害剤としての二環式６−アルキリデン−ペネム - Google Patents

β−ラクタマーゼ阻害剤としての二環式６−アルキリデン−ペネム Download PDF

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Publication number
JP4602759B2
JP4602759B2 JP2004501418A JP2004501418A JP4602759B2 JP 4602759 B2 JP4602759 B2 JP 4602759B2 JP 2004501418 A JP2004501418 A JP 2004501418A JP 2004501418 A JP2004501418 A JP 2004501418A JP 4602759 B2 JP4602759 B2 JP 4602759B2
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oxo
thia
carboxylic acid
ene
ylmethylene
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Japanese (ja)
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JP2005533017A (ja
JP2005533017A5 (https=
Inventor
アラナパカム・ムドゥンバイ・ベンカテサン
タレック・スハイル・マンサワー
阿部　　隆夫
一記 山村
毅 高崎
アトゥル・アガルワル
オスバルド・ドス・サントス
フク−ワー・スム
ヤン−イ・リン
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ワイス・エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004501418A 2002-05-01 2003-04-30 β−ラクタマーゼ阻害剤としての二環式６−アルキリデン−ペネム Expired - Fee Related JP4602759B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37705202P 2002-05-01 2002-05-01
PCT/US2003/013428 WO2003093279A1 (en) 2002-05-01 2003-04-30 BICYCLIC 6-ALKYLIDENE-PENEMS AS ß-LACTAMASES INHIBITORS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010127126A Division JP2010215652A (ja) 2002-05-01 2010-06-02 β−ラクタマーゼ阻害剤としての二環式６−アルキリデン−ペネム

Publications (3)

Publication Number Publication Date
JP2005533017A JP2005533017A (ja) 2005-11-04
JP2005533017A5 JP2005533017A5 (https=) 2006-03-23
JP4602759B2 true JP4602759B2 (ja) 2010-12-22

Family

ID=29401437

Family Applications (2)

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JP2004501418A Expired - Fee Related JP4602759B2 (ja) 2002-05-01 2003-04-30 β−ラクタマーゼ阻害剤としての二環式６−アルキリデン−ペネム
JP2010127126A Pending JP2010215652A (ja) 2002-05-01 2010-06-02 β−ラクタマーゼ阻害剤としての二環式６−アルキリデン−ペネム

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JP2010127126A Pending JP2010215652A (ja) 2002-05-01 2010-06-02 β−ラクタマーゼ阻害剤としての二環式６−アルキリデン−ペネム

Country Status (21)

Country Link
US (3) US7112582B2 (https=)
EP (2) EP1499621A1 (https=)
JP (2) JP4602759B2 (https=)
KR (1) KR20050007368A (https=)
CN (2) CN101570545A (https=)
AR (1) AR039774A1 (https=)
AU (1) AU2003231205A1 (https=)
BR (1) BR0309757A (https=)
CA (1) CA2483538A1 (https=)
CR (3) CR7508A (https=)
EC (1) ECSP045397A (https=)
IL (1) IL164899A0 (https=)
MX (1) MXPA04010663A (https=)
NO (1) NO20044549L (https=)
NZ (1) NZ536182A (https=)
RU (1) RU2339640C2 (https=)
SG (1) SG162614A1 (https=)
TW (1) TW200307687A (https=)
UA (1) UA79117C2 (https=)
WO (1) WO2003093279A1 (https=)
ZA (1) ZA200409686B (https=)

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AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
JP2007503447A (ja) * 2003-08-25 2007-02-22 リヴァアックス ファーマスーティカルズ，エルエルシー 神経治療セファゾリン経口投与組成物
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
EP1909786A2 (en) * 2005-07-27 2008-04-16 Wyeth a Corporation of the State of Delaware TRICYCLIC 6-ALKYLIDENE-PENEM ß-LACTAMASE INHIBITORS AND ß-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC
JP2009502934A (ja) * 2005-07-27 2009-01-29 ワイス 二環式６−アルキリデンペネムβ−ラクタマーゼインヒビターおよびβ−ラクタム抗生物質の組み合わせ：広範なスペクトルの抗生物質
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN104119857A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN104119858A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
SG11201806383TA (en) 2016-02-23 2018-09-27 Pfizer 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
EP3448861B1 (en) * 2016-04-28 2021-04-21 F. Hoffmann-La Roche AG A process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one
MA45918A (fr) 2016-08-15 2019-06-19 Bayer Ag Dérivés hétérocycliques bicycliques condensés utilisés comme pesticides
CN114957258A (zh) * 2021-02-25 2022-08-30 华东理工大学 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用
CN117279917A (zh) * 2021-05-21 2023-12-22 成都百裕制药股份有限公司 哌嗪衍生物及其在医药上的应用

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US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
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TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
JP2009502934A (ja) * 2005-07-27 2009-01-29 ワイス 二環式６−アルキリデンペネムβ−ラクタマーゼインヒビターおよびβ−ラクタム抗生物質の組み合わせ：広範なスペクトルの抗生物質

Also Published As

Publication number Publication date
US7112582B2 (en) 2006-09-26
EP1988093A1 (en) 2008-11-05
US20080312203A1 (en) 2008-12-18
CN1649883B (zh) 2010-05-26
RU2004135082A (ru) 2006-01-20
NO20044549L (no) 2005-01-25
IL164899A0 (en) 2005-12-18
AU2003231205A1 (en) 2003-11-17
CN101570545A (zh) 2009-11-04
TW200307687A (en) 2003-12-16
AR039774A1 (es) 2005-03-02
RU2339640C2 (ru) 2008-11-27
KR20050007368A (ko) 2005-01-17
SG162614A1 (en) 2010-07-29
NZ536182A (en) 2006-10-27
US7812014B2 (en) 2010-10-12
CR7508A (es) 2005-01-05
BR0309757A (pt) 2005-03-08
JP2005533017A (ja) 2005-11-04
WO2003093279A1 (en) 2003-11-13
MXPA04010663A (es) 2005-04-20
CN1649883A (zh) 2005-08-03
EP1499621A1 (en) 2005-01-26
ZA200409686B (en) 2007-09-26
ECSP045397A (es) 2005-01-03
UA79117C2 (en) 2007-05-25
US20040077622A1 (en) 2004-04-22
CR10983A (es) 2009-09-09
CA2483538A1 (en) 2003-11-13
CR10986A (es) 2009-09-09
US20060217361A1 (en) 2006-09-28
JP2010215652A (ja) 2010-09-30

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