AR039774A1 - 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas - Google Patents

6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas

Info

Publication number
AR039774A1
AR039774A1 ARP030101471A ARP030101471A AR039774A1 AR 039774 A1 AR039774 A1 AR 039774A1 AR P030101471 A ARP030101471 A AR P030101471A AR P030101471 A ARP030101471 A AR P030101471A AR 039774 A1 AR039774 A1 AR 039774A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
aryl
heteroaryl
bicyclic
Prior art date
Application number
ARP030101471A
Other languages
English (en)
Spanish (es)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR039774A1 publication Critical patent/AR039774A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D499/00Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D503/00Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ARP030101471A 2002-05-01 2003-04-28 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas AR039774A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37705202P 2002-05-01 2002-05-01

Publications (1)

Publication Number Publication Date
AR039774A1 true AR039774A1 (es) 2005-03-02

Family

ID=29401437

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101471A AR039774A1 (es) 2002-05-01 2003-04-28 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas

Country Status (21)

Country Link
US (3) US7112582B2 (https=)
EP (2) EP1988093A1 (https=)
JP (2) JP4602759B2 (https=)
KR (1) KR20050007368A (https=)
CN (2) CN101570545A (https=)
AR (1) AR039774A1 (https=)
AU (1) AU2003231205A1 (https=)
BR (1) BR0309757A (https=)
CA (1) CA2483538A1 (https=)
CR (3) CR7508A (https=)
EC (1) ECSP045397A (https=)
IL (1) IL164899A0 (https=)
MX (1) MXPA04010663A (https=)
NO (1) NO20044549L (https=)
NZ (1) NZ536182A (https=)
RU (1) RU2339640C2 (https=)
SG (1) SG162614A1 (https=)
TW (1) TW200307687A (https=)
UA (1) UA79117C2 (https=)
WO (1) WO2003093279A1 (https=)
ZA (1) ZA200409686B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
MXPA06002125A (es) * 2003-08-25 2006-05-31 Revaax Pharmaceuticals Llc Composiciones orales de cefazolin neuroterapeutico.
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
BRPI0613928A2 (pt) * 2005-07-27 2011-02-15 Wyeth Corp método para o tratamento de uma infecção ou doença bacteriana; composição; produto; e uso de cefepima ou de um sal farmaceuticamente aceitável da mesma e um composto de fórmula i ou um sal farmaceuticamente aceitável ou éster hidrolisável in vivo do mesmo
TW200727897A (en) * 2005-07-27 2007-08-01 Wyeth Corp Bicyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN104119857A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN104119858A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN113332292A (zh) 2016-02-23 2021-09-03 辉瑞公司 6,7-二氢-5H-吡唑并[5,1-b][1,3]噁嗪-2-甲酰胺化合物
JP6983813B2 (ja) * 2016-04-28 2021-12-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 2−ピラゾロ[1,5−a]ピラジン−2−イルピリド[1,2−a]ピリミジン−4−オンの調製のためのプロセス
MX2019001918A (es) 2016-08-15 2019-09-06 Bayer Cropscience Ag Derivados del heterociclo biciclico condensado como agentes de control de plagas.
CN114957258A (zh) * 2021-02-25 2022-08-30 华东理工大学 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用
KR20240012534A (ko) * 2021-05-21 2024-01-29 청두 바이위 파머수티컬 씨오., 엘티디 피페라진 유도체 및 이의 의학적 용도

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US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
US4206067A (en) * 1978-10-02 1980-06-03 Chevron Research Company Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base
EP0041768B1 (en) 1980-04-24 1987-11-11 Beecham Group Plc Beta-lactam compounds, their preparation and use
EP0120613A1 (en) 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors
GB8402086D0 (en) 1984-01-26 1984-02-29 Beecham Group Plc Compounds
FI82471C (fi) 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
EP0150984B1 (en) 1984-01-30 1991-09-11 Pfizer Inc. 6-(substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof
EP0167050A1 (en) * 1984-06-21 1986-01-08 Beecham Group Plc Clavulanate compounds, their preparation and use and intermediates thereof
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
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ATE159021T1 (de) 1986-01-17 1997-10-15 Beecham Group Plc Verfahren zur herstellung von penem derivaten und zwischenprodukte zu dieser herstellung
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
GB8724566D0 (en) 1987-10-20 1987-11-25 Roussel Lab Ltd Chemical compounds
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NZ237202A (en) 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
EP0447704A1 (en) 1990-03-21 1991-09-25 Smithkline Beecham Farmaceutici S.p.A. N-Acylated azacyclic compounds, processes for their preparations and their use as medications
GB9116236D0 (en) 1991-07-27 1991-09-11 Smithkline Beecham Plc Novel compounds
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
US5349045A (en) 1993-01-26 1994-09-20 United States Surgical Corporation Polymer derived from cyclic amide and medical devices manufactured therefrom
GB9326248D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Plc Pharmaceutical formulations
ATE252906T1 (de) 1994-04-25 2003-11-15 Smithkline Beecham Plc Pharmazeutische formulierung, die ein beta- lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
AU1705400A (en) * 1998-10-15 2000-05-01 Sarawak Medichem Pharmaceuticals, Inc. Method and composition for treating and preventing tuberculosis
GB9928290D0 (en) * 1999-12-01 2000-01-26 Univ Belfast Process for preparing ambient temperature ionic liquids
EP1199077A1 (en) * 2000-10-19 2002-04-24 Amura Limited Stable compositions of oxapenem-3-carboxylic acids by Co-lyophilisation with pharmaceutical carriers
GB0106428D0 (en) * 2001-03-15 2001-05-02 Amura Ltd Antibacterial composition
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200727897A (en) * 2005-07-27 2007-08-01 Wyeth Corp Bicyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic

Also Published As

Publication number Publication date
JP4602759B2 (ja) 2010-12-22
UA79117C2 (en) 2007-05-25
SG162614A1 (en) 2010-07-29
US20040077622A1 (en) 2004-04-22
TW200307687A (en) 2003-12-16
CN1649883A (zh) 2005-08-03
US20060217361A1 (en) 2006-09-28
JP2010215652A (ja) 2010-09-30
MXPA04010663A (es) 2005-04-20
US7812014B2 (en) 2010-10-12
RU2339640C2 (ru) 2008-11-27
CR10986A (es) 2009-09-09
IL164899A0 (en) 2005-12-18
EP1499621A1 (en) 2005-01-26
CN101570545A (zh) 2009-11-04
BR0309757A (pt) 2005-03-08
CR7508A (es) 2005-01-05
NZ536182A (en) 2006-10-27
AU2003231205A1 (en) 2003-11-17
US7112582B2 (en) 2006-09-26
CA2483538A1 (en) 2003-11-13
CR10983A (es) 2009-09-09
CN1649883B (zh) 2010-05-26
KR20050007368A (ko) 2005-01-17
EP1988093A1 (en) 2008-11-05
US20080312203A1 (en) 2008-12-18
NO20044549L (no) 2005-01-25
ZA200409686B (en) 2007-09-26
ECSP045397A (es) 2005-01-03
RU2004135082A (ru) 2006-01-20
WO2003093279A1 (en) 2003-11-13
JP2005533017A (ja) 2005-11-04

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