RU2339640C2 - БИЦИКЛИЧЕСКИЕ 6-АЛКИЛИДЕНПЕНЕМЫ В КАЧЕСТВЕ ИНГИБИТОРОВ β-ЛАКТАМАЗ - Google Patents
БИЦИКЛИЧЕСКИЕ 6-АЛКИЛИДЕНПЕНЕМЫ В КАЧЕСТВЕ ИНГИБИТОРОВ β-ЛАКТАМАЗ Download PDFInfo
- Publication number
- RU2339640C2 RU2339640C2 RU2004135082/04A RU2004135082A RU2339640C2 RU 2339640 C2 RU2339640 C2 RU 2339640C2 RU 2004135082/04 A RU2004135082/04 A RU 2004135082/04A RU 2004135082 A RU2004135082 A RU 2004135082A RU 2339640 C2 RU2339640 C2 RU 2339640C2
- Authority
- RU
- Russia
- Prior art keywords
- oxo
- thia
- azabicyclo
- hept
- carboxylic acid
- Prior art date
Links
- 0 BC=C([C@]1SC=C(C(O)O*)N11)C1=O Chemical compound BC=C([C@]1SC=C(C(O)O*)N11)C1=O 0.000 description 1
- UCDIXJKWUCLMJK-XQRVVYSFSA-N CC(C)O/C=C(/C=O)\Br Chemical compound CC(C)O/C=C(/C=O)\Br UCDIXJKWUCLMJK-XQRVVYSFSA-N 0.000 description 1
- VHIKJKZKKOBMAA-UHFFFAOYSA-N CC1C(C=O)=CN(CCSC2)C2=CC1 Chemical compound CC1C(C=O)=CN(CCSC2)C2=CC1 VHIKJKZKKOBMAA-UHFFFAOYSA-N 0.000 description 1
- STAFPBSYZHFMOB-UHFFFAOYSA-N CSC1=NCCSC1 Chemical compound CSC1=NCCSC1 STAFPBSYZHFMOB-UHFFFAOYSA-N 0.000 description 1
- KLCGUDSBFDKXCQ-UHFFFAOYSA-N NC1=NCCSC1 Chemical compound NC1=NCCSC1 KLCGUDSBFDKXCQ-UHFFFAOYSA-N 0.000 description 1
- HBDDRESWUAFAHY-UHFFFAOYSA-N O=C1NCCSC1 Chemical compound O=C1NCCSC1 HBDDRESWUAFAHY-UHFFFAOYSA-N 0.000 description 1
- RKHPMFNLYOWIRY-UHFFFAOYSA-N O=Cc1cnc2[n]1CCSC2 Chemical compound O=Cc1cnc2[n]1CCSC2 RKHPMFNLYOWIRY-UHFFFAOYSA-N 0.000 description 1
- CAQSLXADSMAWHL-UHFFFAOYSA-N S=C1NCCSC1 Chemical compound S=C1NCCSC1 CAQSLXADSMAWHL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37705202P | 2002-05-01 | 2002-05-01 | |
| US60/377,052 | 2002-05-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004135082A RU2004135082A (ru) | 2006-01-20 |
| RU2339640C2 true RU2339640C2 (ru) | 2008-11-27 |
Family
ID=29401437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004135082/04A RU2339640C2 (ru) | 2002-05-01 | 2003-04-30 | БИЦИКЛИЧЕСКИЕ 6-АЛКИЛИДЕНПЕНЕМЫ В КАЧЕСТВЕ ИНГИБИТОРОВ β-ЛАКТАМАЗ |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7112582B2 (https=) |
| EP (2) | EP1499621A1 (https=) |
| JP (2) | JP4602759B2 (https=) |
| KR (1) | KR20050007368A (https=) |
| CN (2) | CN101570545A (https=) |
| AR (1) | AR039774A1 (https=) |
| AU (1) | AU2003231205A1 (https=) |
| BR (1) | BR0309757A (https=) |
| CA (1) | CA2483538A1 (https=) |
| CR (3) | CR7508A (https=) |
| EC (1) | ECSP045397A (https=) |
| IL (1) | IL164899A0 (https=) |
| MX (1) | MXPA04010663A (https=) |
| NO (1) | NO20044549L (https=) |
| NZ (1) | NZ536182A (https=) |
| RU (1) | RU2339640C2 (https=) |
| SG (1) | SG162614A1 (https=) |
| TW (1) | TW200307687A (https=) |
| UA (1) | UA79117C2 (https=) |
| WO (1) | WO2003093279A1 (https=) |
| ZA (1) | ZA200409686B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040132708A1 (en) * | 2002-05-01 | 2004-07-08 | Wyeth | Process for preparing 6-alkylidene penem derivatives |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| AR039476A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | Proceso para preparar derivados de 6-alquiliden penem |
| JP2007503447A (ja) * | 2003-08-25 | 2007-02-22 | リヴァアックス ファーマスーティカルズ，エルエルシー | 神経治療セファゾリン経口投与組成物 |
| TW200716102A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| TW200716104A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| EP1909786A2 (en) * | 2005-07-27 | 2008-04-16 | Wyeth a Corporation of the State of Delaware | TRICYCLIC 6-ALKYLIDENE-PENEM ß-LACTAMASE INHIBITORS AND ß-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC |
| JP2009502934A (ja) * | 2005-07-27 | 2009-01-29 | ワイス | 二環式６−アルキリデンペネムβ−ラクタマーゼインヒビターおよびβ−ラクタム抗生物質の組み合わせ：広範なスペクトルの抗生物質 |
| GT200600380A (es) * | 2005-08-24 | 2007-03-29 | Proceso para la preparacion de inhibidores de beta-lactamasa | |
| US20090018332A1 (en) * | 2007-06-28 | 2009-01-15 | Wyeth | Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors |
| CN104119857A (zh) * | 2013-04-27 | 2014-10-29 | 海洋王照明科技股份有限公司 | 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件 |
| CN104119858A (zh) * | 2013-04-27 | 2014-10-29 | 海洋王照明科技股份有限公司 | 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件 |
| SG11201806383TA (en) | 2016-02-23 | 2018-09-27 | Pfizer | 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds |
| EP3448861B1 (en) * | 2016-04-28 | 2021-04-21 | F. Hoffmann-La Roche AG | A process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one |
| MA45918A (fr) | 2016-08-15 | 2019-06-19 | Bayer Ag | Dérivés hétérocycliques bicycliques condensés utilisés comme pesticides |
| CN114957258A (zh) * | 2021-02-25 | 2022-08-30 | 华东理工大学 | 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用 |
| CN117279917A (zh) * | 2021-05-21 | 2023-12-22 | 成都百裕制药股份有限公司 | 哌嗪衍生物及其在医药上的应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
| US4206067A (en) * | 1978-10-02 | 1980-06-03 | Chevron Research Company | Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base |
| DE3176517D1 (en) | 1980-04-24 | 1987-12-17 | Beecham Group Plc | Beta-lactam compounds, their preparation and use |
| EP0120613A1 (en) | 1983-03-02 | 1984-10-03 | Beecham Group Plc | Penem derivatives and precursors |
| GB8402086D0 (en) | 1984-01-26 | 1984-02-29 | Beecham Group Plc | Compounds |
| FI82471C (fi) | 1984-01-26 | 1991-03-11 | Beecham Group Plc | Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater. |
| EP0150984B1 (en) | 1984-01-30 | 1991-09-11 | Pfizer Inc. | 6-(substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof |
| EP0167050A1 (en) * | 1984-06-21 | 1986-01-08 | Beecham Group Plc | Clavulanate compounds, their preparation and use and intermediates thereof |
| GB8518421D0 (en) | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
| GB8518422D0 (en) | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
| GB8518416D0 (en) | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
| ATE159021T1 (de) | 1986-01-17 | 1997-10-15 | Beecham Group Plc | Verfahren zur herstellung von penem derivaten und zwischenprodukte zu dieser herstellung |
| US4891369A (en) * | 1986-12-03 | 1990-01-02 | Taiho Pharmaceutical Company, Limited | 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof |
| DE3725375A1 (de) * | 1987-07-31 | 1989-02-09 | Bayer Ag | Stabile oxapenem-3-carbonsaeuren |
| GB8724566D0 (en) | 1987-10-20 | 1987-11-25 | Roussel Lab Ltd | Chemical compounds |
| GB8729614D0 (en) | 1987-12-18 | 1988-02-03 | Beecham Group Plc | Novel compounds |
| GB8729613D0 (en) | 1987-12-18 | 1988-02-03 | Beecham Group Plc | Novel compounds |
| NZ237202A (en) | 1990-02-23 | 1994-01-26 | Bristol Myers Squibb Co | Composition containing beta-lactam antibiotic and cationic oligopeptide |
| EP0447704A1 (en) | 1990-03-21 | 1991-09-25 | Smithkline Beecham Farmaceutici S.p.A. | N-Acylated azacyclic compounds, processes for their preparations and their use as medications |
| GB9116236D0 (en) | 1991-07-27 | 1991-09-11 | Smithkline Beecham Plc | Novel compounds |
| GB9222700D0 (en) * | 1992-10-29 | 1992-12-09 | Smithkline Beecham Plc | Chemical compounds |
| US5349045A (en) | 1993-01-26 | 1994-09-20 | United States Surgical Corporation | Polymer derived from cyclic amide and medical devices manufactured therefrom |
| GB9326248D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Plc | Pharmaceutical formulations |
| BR9507521A (pt) | 1994-04-25 | 1997-09-16 | Smithkline Beecham Plc | Formulação farmacêutica método para o tratemento de infecções bacterianas em seres humanos e animais uso de uma formulação e processo para sua preparação |
| US5629322A (en) | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| AU1705400A (en) * | 1998-10-15 | 2000-05-01 | Sarawak Medichem Pharmaceuticals, Inc. | Method and composition for treating and preventing tuberculosis |
| GB9928290D0 (en) * | 1999-12-01 | 2000-01-26 | Univ Belfast | Process for preparing ambient temperature ionic liquids |
| EP1199077A1 (en) * | 2000-10-19 | 2002-04-24 | Amura Limited | Stable compositions of oxapenem-3-carboxylic acids by Co-lyophilisation with pharmaceutical carriers |
| GB0106428D0 (en) * | 2001-03-15 | 2001-05-02 | Amura Ltd | Antibacterial composition |
| AR039476A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | Proceso para preparar derivados de 6-alquiliden penem |
| AR039774A1 (es) * | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| US20040132708A1 (en) * | 2002-05-01 | 2004-07-08 | Wyeth | Process for preparing 6-alkylidene penem derivatives |
| AR039475A1 (es) * | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| AR046041A1 (es) * | 2003-10-03 | 2005-11-23 | Aventis Pharma Inc | Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos |
| TW200716104A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| TW200716102A (en) * | 2005-06-01 | 2007-05-01 | Wyeth Corp | Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
| JP2009502934A (ja) * | 2005-07-27 | 2009-01-29 | ワイス | 二環式６−アルキリデンペネムβ−ラクタマーゼインヒビターおよびβ−ラクタム抗生物質の組み合わせ：広範なスペクトルの抗生物質 |
-
2003
- 2003-04-28 AR ARP030101471A patent/AR039774A1/es unknown
- 2003-04-29 TW TW092110033A patent/TW200307687A/zh unknown
- 2003-04-30 JP JP2004501418A patent/JP4602759B2/ja not_active Expired - Fee Related
- 2003-04-30 KR KR10-2004-7017597A patent/KR20050007368A/ko not_active Ceased
- 2003-04-30 RU RU2004135082/04A patent/RU2339640C2/ru not_active IP Right Cessation
- 2003-04-30 NZ NZ536182A patent/NZ536182A/en not_active IP Right Cessation
- 2003-04-30 CN CNA2009101331547A patent/CN101570545A/zh active Pending
- 2003-04-30 UA UA20041109833A patent/UA79117C2/uk unknown
- 2003-04-30 EP EP03724340A patent/EP1499621A1/en not_active Ceased
- 2003-04-30 EP EP08004917A patent/EP1988093A1/en not_active Withdrawn
- 2003-04-30 CA CA002483538A patent/CA2483538A1/en not_active Abandoned
- 2003-04-30 SG SG200607462-9A patent/SG162614A1/en unknown
- 2003-04-30 BR BR0309757-9A patent/BR0309757A/pt not_active IP Right Cessation
- 2003-04-30 CN CN038097338A patent/CN1649883B/zh not_active Expired - Fee Related
- 2003-04-30 AU AU2003231205A patent/AU2003231205A1/en not_active Abandoned
- 2003-04-30 WO PCT/US2003/013428 patent/WO2003093279A1/en not_active Ceased
- 2003-04-30 MX MXPA04010663A patent/MXPA04010663A/es active IP Right Grant
- 2003-05-01 US US10/427,380 patent/US7112582B2/en not_active Expired - Fee Related
-
2004
- 2004-10-06 CR CR7508A patent/CR7508A/es not_active Application Discontinuation
- 2004-10-22 NO NO20044549A patent/NO20044549L/no not_active Application Discontinuation
- 2004-10-28 IL IL16489904A patent/IL164899A0/xx unknown
- 2004-10-29 EC EC2004005397A patent/ECSP045397A/es unknown
- 2004-11-30 ZA ZA200409686A patent/ZA200409686B/xx unknown
-
2006
- 2006-06-06 US US11/447,814 patent/US20060217361A1/en not_active Abandoned
-
2008
- 2008-08-21 US US12/195,706 patent/US7812014B2/en not_active Expired - Fee Related
-
2009
- 2009-08-21 CR CR10983A patent/CR10983A/es not_active Application Discontinuation
- 2009-08-21 CR CR10986A patent/CR10986A/es not_active Application Discontinuation
-
2010
- 2010-06-02 JP JP2010127126A patent/JP2010215652A/ja active Pending
Non-Patent Citations (2)
| Title |
|---|
| BENNET I.S. et al. 6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial β-lactamase. IV. Kidney stability, serum binding and additional biological evaluation of racemic derivatives. The J. of Antibiot. 1991, 44(3):338-43. * |
| BROOM N.J.P. et al. 6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial β-lactamase. II. Racemic furyl and thienyl derivatives. The J. of Antibiot. 1990, 43(1):76-82. BENNET I.S. et al. 6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial β-lactamase. III. Structure-activity relationships of the 5-membered heterocyclic derivatives. The J. of Antibiot. 1991, 44(3):331-7. BENNET I.S. et al. 6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial β-lactamase. V. Chiral 1,2,3-triazolyl derivatives. The J. of Antibiot. 1991, 44(9):969-78. * |
Also Published As
| Publication number | Publication date |
|---|---|
| US7112582B2 (en) | 2006-09-26 |
| EP1988093A1 (en) | 2008-11-05 |
| US20080312203A1 (en) | 2008-12-18 |
| JP4602759B2 (ja) | 2010-12-22 |
| CN1649883B (zh) | 2010-05-26 |
| RU2004135082A (ru) | 2006-01-20 |
| NO20044549L (no) | 2005-01-25 |
| IL164899A0 (en) | 2005-12-18 |
| AU2003231205A1 (en) | 2003-11-17 |
| CN101570545A (zh) | 2009-11-04 |
| TW200307687A (en) | 2003-12-16 |
| AR039774A1 (es) | 2005-03-02 |
| KR20050007368A (ko) | 2005-01-17 |
| SG162614A1 (en) | 2010-07-29 |
| NZ536182A (en) | 2006-10-27 |
| US7812014B2 (en) | 2010-10-12 |
| CR7508A (es) | 2005-01-05 |
| BR0309757A (pt) | 2005-03-08 |
| JP2005533017A (ja) | 2005-11-04 |
| WO2003093279A1 (en) | 2003-11-13 |
| MXPA04010663A (es) | 2005-04-20 |
| CN1649883A (zh) | 2005-08-03 |
| EP1499621A1 (en) | 2005-01-26 |
| ZA200409686B (en) | 2007-09-26 |
| ECSP045397A (es) | 2005-01-03 |
| UA79117C2 (en) | 2007-05-25 |
| US20040077622A1 (en) | 2004-04-22 |
| CR10983A (es) | 2009-09-09 |
| CA2483538A1 (en) | 2003-11-13 |
| CR10986A (es) | 2009-09-09 |
| US20060217361A1 (en) | 2006-09-28 |
| JP2010215652A (ja) | 2010-09-30 |
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