JP4597532B2 - Ｎ−［フェニル（ピペリジン−２−イル）メチル］ベンズアミド誘導体類、それらの製造方法および治療におけるそれらの使用 - Google Patents

Ｎ−［フェニル（ピペリジン−２−イル）メチル］ベンズアミド誘導体類、それらの製造方法および治療におけるそれらの使用 Download PDF

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Publication number
JP4597532B2
JP4597532B2 JP2003586132A JP2003586132A JP4597532B2 JP 4597532 B2 JP4597532 B2 JP 4597532B2 JP 2003586132 A JP2003586132 A JP 2003586132A JP 2003586132 A JP2003586132 A JP 2003586132A JP 4597532 B2 JP4597532 B2 JP 4597532B2
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JP
Japan
Prior art keywords
group
chloro
general formula
phenyl
methyl
Prior art date
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Expired - Fee Related
Application number
JP2003586132A
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English (en)
Japanese (ja)
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JP2005527593A5 (https=
JP2005527593A (ja
Inventor
ダルガザンリ，ジハド
エステン−ブートウ，ジュヌヴィエーヴ
マガ，パスカル
マラブ，ブノワ
メダイスコ，フロレンス
ロゲル，ピエール
セヴラン，ミレーユ
ヴェロニク，コリン
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Sanofi Aventis France
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Sanofi Synthelabo SA
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Publication of JP2005527593A5 publication Critical patent/JP2005527593A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2003586132A 2002-04-19 2003-04-17 Ｎ−［フェニル（ピペリジン−２−イル）メチル］ベンズアミド誘導体類、それらの製造方法および治療におけるそれらの使用 Expired - Fee Related JP4597532B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0204916A FR2838739B1 (fr) 2002-04-19 2002-04-19 Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique
PCT/FR2003/001232 WO2003089411A1 (fr) 2002-04-19 2003-04-17 Derives de n-[phenyl(piperidin-2-yl)methyl] benzamide, leur preparation et leur application en therapeutique

Publications (3)

Publication Number Publication Date
JP2005527593A JP2005527593A (ja) 2005-09-15
JP2005527593A5 JP2005527593A5 (https=) 2006-06-08
JP4597532B2 true JP4597532B2 (ja) 2010-12-15

Family

ID=28686193

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003586132A Expired - Fee Related JP4597532B2 (ja) 2002-04-19 2003-04-17 Ｎ−［フェニル（ピペリジン−２−イル）メチル］ベンズアミド誘導体類、それらの製造方法および治療におけるそれらの使用

Country Status (35)

Country Link
US (2) US7326722B2 (https=)
EP (1) EP1499589B1 (https=)
JP (1) JP4597532B2 (https=)
KR (2) KR20040103973A (https=)
CN (1) CN100482646C (https=)
AR (1) AR039413A1 (https=)
AT (1) ATE361279T1 (https=)
AU (1) AU2003262420B2 (https=)
BR (1) BR0309397A (https=)
CA (1) CA2481461C (https=)
CO (1) CO5631432A2 (https=)
CY (1) CY1108025T1 (https=)
DE (1) DE60313602T2 (https=)
DK (1) DK1499589T3 (https=)
EA (1) EA007225B1 (https=)
EC (1) ECSP045369A (https=)
ES (1) ES2286444T3 (https=)
FR (1) FR2838739B1 (https=)
HR (1) HRP20040977B1 (https=)
IL (2) IL164400A0 (https=)
IS (1) IS2540B (https=)
MA (1) MA27192A1 (https=)
ME (1) MEP25608A (https=)
MX (1) MXPA04010326A (https=)
NO (1) NO329065B1 (https=)
NZ (1) NZ536015A (https=)
PL (1) PL373195A1 (https=)
PT (1) PT1499589E (https=)
RS (1) RS51888B (https=)
SI (1) SI1499589T1 (https=)
TN (1) TNSN04208A1 (https=)
TW (1) TWI306402B (https=)
UA (1) UA78025C2 (https=)
WO (1) WO2003089411A1 (https=)
ZA (1) ZA200408154B (https=)

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FR2842804B1 (fr) 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861073B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861070B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
WO2005044810A1 (en) * 2003-10-30 2005-05-19 Janssen Pharmaceutica, N.V. Glyt2 modulators
US20050209317A1 (en) * 2004-03-22 2005-09-22 Apkarian A V Method and compositions for treatment of chronic neuropathic pain
ES2520015T3 (es) * 2005-04-08 2014-11-11 Pfizer Products Inc. [3.1.0]Heteroaril amidas bicíclicas como inhibidores de transporte de glicina de tipo 1
JP2009179562A (ja) * 2006-08-11 2009-08-13 Taisho Pharmaceutical Co Ltd グリシントランスポーター阻害剤
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
TW200911808A (en) * 2007-07-23 2009-03-16 Astrazeneca Ab Novel compounds
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MX2010010773A (es) 2008-04-01 2011-04-11 Abbott Gmbh & Co Kg Tetrahidroisoquinolinas, composiciones farmaceuticas que las contienen y su uso en terapia.
WO2010087761A1 (en) * 2009-01-28 2010-08-05 Astrazeneca Ab 2-aza-bicyclo[2.2.2]octane compounds and uses thereof
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TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
JP5618047B2 (ja) * 2010-01-29 2014-11-05 国立大学法人千葉大学 ポジトロン断層撮影法およびポジトロン放出化合物
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US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
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US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
US8710043B2 (en) 2011-06-24 2014-04-29 Amgen Inc. TRPM8 antagonists and their use in treatments
CA2844275A1 (en) 2011-08-05 2013-02-14 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2014006004A (es) 2011-11-18 2015-04-16 Abbvie Deutschland Derivados de aminobenzociclohepteno, aminotetralina, aminoindano y fenalcilamina n-sustituidas, composiciones farmaceuticas que los contienen, y su uso en terapia.
FR2983197B1 (fr) * 2011-11-29 2014-07-25 Assist Publ Hopitaux De Paris Utilisation de phacetoperane pour traiter un trouble deficit de l'attention hyperactivite
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
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Also Published As

Publication number Publication date
HRP20040977A2 (en) 2004-12-31
US20050159450A1 (en) 2005-07-21
CO5631432A2 (es) 2006-04-28
ES2286444T3 (es) 2007-12-01
AU2003262420A1 (en) 2003-11-03
NO329065B1 (no) 2010-08-09
WO2003089411A1 (fr) 2003-10-30
TW200306830A (en) 2003-12-01
MXPA04010326A (es) 2005-07-05
CA2481461C (en) 2010-01-12
IL164400A0 (en) 2005-12-18
HRP20040977B1 (hr) 2008-04-30
DK1499589T3 (da) 2007-09-10
IS2540B (is) 2009-09-15
SI1499589T1 (sl) 2007-10-31
EA007225B1 (ru) 2006-08-25
IS7479A (is) 2004-09-30
CN100482646C (zh) 2009-04-29
EA200401172A1 (ru) 2005-04-28
IL164400A (en) 2010-11-30
US7326722B2 (en) 2008-02-05
ECSP045369A (es) 2005-03-10
CA2481461A1 (en) 2003-10-30
NZ536015A (en) 2006-11-30
US20070197601A1 (en) 2007-08-23
ZA200408154B (en) 2005-10-10
AR039413A1 (es) 2005-02-16
JP2005527593A (ja) 2005-09-15
KR20040103973A (ko) 2004-12-09
EP1499589B1 (fr) 2007-05-02
RS51888B (sr) 2012-02-29
PL373195A1 (en) 2005-08-22
NO20044388L (no) 2005-01-19
DE60313602T2 (de) 2008-01-10
KR101019313B1 (ko) 2011-03-07
BR0309397A (pt) 2005-03-01
KR20080075236A (ko) 2008-08-14
TNSN04208A1 (fr) 2007-03-12
RS91404A (sr) 2007-02-05
TWI306402B (en) 2009-02-21
EP1499589A1 (fr) 2005-01-26
MA27192A1 (fr) 2005-01-03
PT1499589E (pt) 2007-08-10
DE60313602D1 (de) 2007-06-14
UA78025C2 (en) 2007-02-15
FR2838739B1 (fr) 2004-05-28
MEP25608A (en) 2010-06-10
AU2003262420B2 (en) 2009-02-19
ATE361279T1 (de) 2007-05-15
FR2838739A1 (fr) 2003-10-24
CN1662497A (zh) 2005-08-31
CY1108025T1 (el) 2013-09-04

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