JP4568726B2 - 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物 - Google Patents

鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物 Download PDF

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JP4568726B2
JP4568726B2 JP2006534463A JP2006534463A JP4568726B2 JP 4568726 B2 JP4568726 B2 JP 4568726B2 JP 2006534463 A JP2006534463 A JP 2006534463A JP 2006534463 A JP2006534463 A JP 2006534463A JP 4568726 B2 JP4568726 B2 JP 4568726B2
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composition
analgesic
opioid
opioid analgesic
formula
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JP2006534463A
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Japanese (ja)
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JP2007508325A5 (enExample
JP2007508325A (ja
Inventor
ニコラス ジー． バザン，
アンソニー バッカリーノ，
カルロス サンケル，
ジュリオ アルバレス ブイラ，
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Louisiana State University
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Louisiana State University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006534463A 2003-10-09 2004-10-12 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物 Expired - Fee Related JP4568726B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/682,744 US6806291B1 (en) 2003-10-09 2003-10-09 Analgesic compounds, their synthesis and pharmaceutical compositions containing them
PCT/US2004/033609 WO2005035485A2 (en) 2003-10-09 2004-10-12 Analgesic compounds, their synthesis and pharmaceutical compositions containing them

Related Child Applications (1)

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JP2010124856A Division JP2010195826A (ja) 2003-10-09 2010-05-31 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物

Publications (3)

Publication Number Publication Date
JP2007508325A JP2007508325A (ja) 2007-04-05
JP2007508325A5 JP2007508325A5 (enExample) 2007-11-15
JP4568726B2 true JP4568726B2 (ja) 2010-10-27

Family

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Family Applications (2)

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JP2006534463A Expired - Fee Related JP4568726B2 (ja) 2003-10-09 2004-10-12 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物
JP2010124856A Withdrawn JP2010195826A (ja) 2003-10-09 2010-05-31 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物

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JP2010124856A Withdrawn JP2010195826A (ja) 2003-10-09 2010-05-31 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物

Country Status (9)

Country Link
US (1) US6806291B1 (enExample)
EP (1) EP1682496B1 (enExample)
JP (2) JP4568726B2 (enExample)
AT (1) ATE427931T1 (enExample)
AU (1) AU2004279880B2 (enExample)
CA (1) CA2544648C (enExample)
DE (1) DE602004020494D1 (enExample)
ES (1) ES2325163T3 (enExample)
WO (1) WO2005035485A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1009407B1 (en) * 1997-09-04 2004-04-28 Novoneuron, Inc. Noribogaine in the treatment of pain and drug addiction
US20070083185A1 (en) * 2005-09-30 2007-04-12 Darrick Carter Iontophoretic device and method of delivery of active agents to biological interface
WO2008021896A2 (en) * 2006-08-08 2008-02-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Therapeutic methods for neuropathic pain
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
UA111065C2 (uk) 2010-07-23 2016-03-25 Демеркс, Інк. Композиції норибогаїну
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
JP2015500833A (ja) 2011-12-09 2015-01-08 デメレックス， インコーポレイテッド ノルイボガインのリン酸エステル
US8242158B1 (en) * 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
WO2013112673A1 (en) 2012-01-25 2013-08-01 Demerx, Inc. Synthetic voacangine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
EP2934541A4 (en) 2012-12-20 2016-08-03 Demerx Inc NORIBOGAINE SUBSTITUTE
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
MX2020002147A (es) * 2017-08-25 2022-10-03 The Board Of Supervisors Of Louisiana State Univ And Agricultural And Mechanical College Composiciones útiles para la mejora del dolor.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700773A (en) * 1969-06-25 1972-10-24 Merck & Co Inc Substituted phenylsulfamyl salicyclic acids and derivatives thereof in the treatment of inflammation
DE4010536A1 (de) * 1990-04-02 1991-10-10 Boehringer Mannheim Gmbh Pharmazeutische waessrige loesung von 4-(2-(benzolsulfonylamino)-ethyl)-phenoxyessigsaeure
US5554636A (en) 1995-04-21 1996-09-10 Lsu Medical Center Foundation N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them
JP2000103778A (ja) * 1997-05-15 2000-04-11 Ono Pharmaceut Co Ltd ベンゼンスルフォンアミド化合物、それらの製造方法およびそれらを有効成分として含有するプロスタグランジンｅ２受容体拮抗剤
IL138686A0 (en) * 1999-10-01 2001-10-31 Pfizer Prod Inc α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS
TWI239942B (en) * 2001-06-11 2005-09-21 Dainippon Pharmaceutical Co N-arylphenylacetamide derivative and pharmaceutical composition containing the same

Also Published As

Publication number Publication date
JP2010195826A (ja) 2010-09-09
EP1682496B1 (en) 2009-04-08
ES2325163T3 (es) 2009-08-27
CA2544648A1 (en) 2005-04-21
EP1682496A2 (en) 2006-07-26
DE602004020494D1 (de) 2009-05-20
WO2005035485A2 (en) 2005-04-21
AU2004279880A1 (en) 2005-04-21
AU2004279880B2 (en) 2010-09-16
CA2544648C (en) 2011-05-24
ATE427931T1 (de) 2009-04-15
US6806291B1 (en) 2004-10-19
WO2005035485A3 (en) 2005-06-09
JP2007508325A (ja) 2007-04-05

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