JP2007508325A5 - - Google Patents
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- Publication number
- JP2007508325A5 JP2007508325A5 JP2006534463A JP2006534463A JP2007508325A5 JP 2007508325 A5 JP2007508325 A5 JP 2007508325A5 JP 2006534463 A JP2006534463 A JP 2006534463A JP 2006534463 A JP2006534463 A JP 2006534463A JP 2007508325 A5 JP2007508325 A5 JP 2007508325A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- analgesic
- opioid analgesic
- formula
- opioid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 18
- 239000000014 opioid analgesic Substances 0.000 claims 9
- 230000000202 analgesic effect Effects 0.000 claims 5
- 229940121367 non-opioid analgesics Drugs 0.000 claims 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000000730 antalgic agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- 206010019851 Hepatotoxicity Diseases 0.000 claims 1
- 229940099433 NMDA receptor antagonist Drugs 0.000 claims 1
- 239000008896 Opium Substances 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 231100000334 hepatotoxic Toxicity 0.000 claims 1
- 230000003082 hepatotoxic effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229940126403 monoamine reuptake inhibitor Drugs 0.000 claims 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 claims 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 1
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 229960001027 opium Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229930015710 phenanthrene alkaloid Natural products 0.000 claims 1
- 125000001792 phenanthrenyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 claims 1
- 150000003053 piperidines Chemical class 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical class C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/682,744 US6806291B1 (en) | 2003-10-09 | 2003-10-09 | Analgesic compounds, their synthesis and pharmaceutical compositions containing them |
| PCT/US2004/033609 WO2005035485A2 (en) | 2003-10-09 | 2004-10-12 | Analgesic compounds, their synthesis and pharmaceutical compositions containing them |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010124856A Division JP2010195826A (ja) | 2003-10-09 | 2010-05-31 | 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007508325A JP2007508325A (ja) | 2007-04-05 |
| JP2007508325A5 true JP2007508325A5 (enExample) | 2007-11-15 |
| JP4568726B2 JP4568726B2 (ja) | 2010-10-27 |
Family
ID=33132107
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534463A Expired - Fee Related JP4568726B2 (ja) | 2003-10-09 | 2004-10-12 | 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物 |
| JP2010124856A Withdrawn JP2010195826A (ja) | 2003-10-09 | 2010-05-31 | 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010124856A Withdrawn JP2010195826A (ja) | 2003-10-09 | 2010-05-31 | 鎮痛性化合物、それらの合成およびそれらを含む薬学的組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6806291B1 (enExample) |
| EP (1) | EP1682496B1 (enExample) |
| JP (2) | JP4568726B2 (enExample) |
| AT (1) | ATE427931T1 (enExample) |
| AU (1) | AU2004279880B2 (enExample) |
| CA (1) | CA2544648C (enExample) |
| DE (1) | DE602004020494D1 (enExample) |
| ES (1) | ES2325163T3 (enExample) |
| WO (1) | WO2005035485A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1009407B1 (en) * | 1997-09-04 | 2004-04-28 | Novoneuron, Inc. | Noribogaine in the treatment of pain and drug addiction |
| US20070083185A1 (en) * | 2005-09-30 | 2007-04-12 | Darrick Carter | Iontophoretic device and method of delivery of active agents to biological interface |
| WO2008021896A2 (en) * | 2006-08-08 | 2008-02-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Therapeutic methods for neuropathic pain |
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8362007B1 (en) | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
| US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| UA111065C2 (uk) | 2010-07-23 | 2016-03-25 | Демеркс, Інк. | Композиції норибогаїну |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| US20130096170A1 (en) | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
| JP2015500833A (ja) | 2011-12-09 | 2015-01-08 | デメレックス， インコーポレイテッド | ノルイボガインのリン酸エステル |
| US8242158B1 (en) * | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
| US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| WO2013112673A1 (en) | 2012-01-25 | 2013-08-01 | Demerx, Inc. | Synthetic voacangine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| EP2934541A4 (en) | 2012-12-20 | 2016-08-03 | Demerx Inc | NORIBOGAINE SUBSTITUTE |
| US9550789B2 (en) | 2014-06-18 | 2017-01-24 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
| MX2020002147A (es) * | 2017-08-25 | 2022-10-03 | The Board Of Supervisors Of Louisiana State Univ And Agricultural And Mechanical College | Composiciones útiles para la mejora del dolor. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3700773A (en) * | 1969-06-25 | 1972-10-24 | Merck & Co Inc | Substituted phenylsulfamyl salicyclic acids and derivatives thereof in the treatment of inflammation |
| DE4010536A1 (de) * | 1990-04-02 | 1991-10-10 | Boehringer Mannheim Gmbh | Pharmazeutische waessrige loesung von 4-(2-(benzolsulfonylamino)-ethyl)-phenoxyessigsaeure |
| US5554636A (en) | 1995-04-21 | 1996-09-10 | Lsu Medical Center Foundation | N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them |
| JP2000103778A (ja) * | 1997-05-15 | 2000-04-11 | Ono Pharmaceut Co Ltd | ベンゼンスルフォンアミド化合物、それらの製造方法およびそれらを有効成分として含有するプロスタグランジンｅ２受容体拮抗剤 |
| IL138686A0 (en) * | 1999-10-01 | 2001-10-31 | Pfizer Prod Inc | α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS |
| TWI239942B (en) * | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
-
2003
- 2003-10-09 US US10/682,744 patent/US6806291B1/en not_active Expired - Lifetime
-
2004
- 2004-10-12 DE DE602004020494T patent/DE602004020494D1/de not_active Expired - Lifetime
- 2004-10-12 EP EP04794857A patent/EP1682496B1/en not_active Expired - Lifetime
- 2004-10-12 WO PCT/US2004/033609 patent/WO2005035485A2/en not_active Ceased
- 2004-10-12 JP JP2006534463A patent/JP4568726B2/ja not_active Expired - Fee Related
- 2004-10-12 AT AT04794857T patent/ATE427931T1/de not_active IP Right Cessation
- 2004-10-12 ES ES04794857T patent/ES2325163T3/es not_active Expired - Lifetime
- 2004-10-12 CA CA2544648A patent/CA2544648C/en not_active Expired - Fee Related
- 2004-10-12 AU AU2004279880A patent/AU2004279880B2/en not_active Ceased
-
2010
- 2010-05-31 JP JP2010124856A patent/JP2010195826A/ja not_active Withdrawn
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