JP4538408B2 - 高い最終粘度を持つデンプンを合成する植物細胞及び植物 - Google Patents
高い最終粘度を持つデンプンを合成する植物細胞及び植物 Download PDFInfo
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- JP4538408B2 JP4538408B2 JP2005502564A JP2005502564A JP4538408B2 JP 4538408 B2 JP4538408 B2 JP 4538408B2 JP 2005502564 A JP2005502564 A JP 2005502564A JP 2005502564 A JP2005502564 A JP 2005502564A JP 4538408 B2 JP4538408 B2 JP 4538408B2
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Applications Claiming Priority (3)
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| EP02028530A EP1431393A1 (de) | 2002-12-19 | 2002-12-19 | Pflanzen, die eine Stärke mit erhöhter Endviskosität synthetisieren |
| EP03090275 | 2003-08-29 | ||
| PCT/EP2003/014840 WO2004056999A1 (en) | 2002-12-19 | 2003-12-19 | Plant cells and plants which synthesize a starch with an increased final viscosity |
Publications (3)
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| JP2006511235A JP2006511235A (ja) | 2006-04-06 |
| JP2006511235A5 JP2006511235A5 (enExample) | 2010-06-17 |
| JP4538408B2 true JP4538408B2 (ja) | 2010-09-08 |
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| JP (1) | JP4538408B2 (enExample) |
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| AT (1) | ATE405653T1 (enExample) |
| AU (1) | AU2003293991B2 (enExample) |
| CA (1) | CA2505776C (enExample) |
| CY (1) | CY1108510T1 (enExample) |
| DE (1) | DE60323149D1 (enExample) |
| DK (1) | DK1578973T3 (enExample) |
| ES (1) | ES2310256T3 (enExample) |
| PT (1) | PT1578973E (enExample) |
| SI (1) | SI1578973T1 (enExample) |
| WO (1) | WO2004056999A1 (enExample) |
Families Citing this family (193)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1649022B1 (en) | 2003-06-30 | 2011-07-27 | Commonwealth Scientific And Industrial Research Organisation | Wheat with altered branching enzyme activity and starch and starch containing products derived thereform |
| EP1710315A1 (de) | 2005-04-08 | 2006-10-11 | Bayer CropScience GmbH | Hoch Phosphat Stärke |
| EP1887079A1 (de) * | 2006-08-09 | 2008-02-13 | Bayer CropScience AG | Genetisch modifizierte Pflanzen, die eine Stärke mit erhöhtem Quellvermögen synthetisieren |
| CL2007003744A1 (es) | 2006-12-22 | 2008-07-11 | Bayer Cropscience Ag | Composicion que comprende un derivado 2-piridilmetilbenzamida y un compuesto insecticida; y metodo para controlar de forma curativa o preventiva hongos fitopatogenos de cultivos e insectos. |
| CL2007003743A1 (es) * | 2006-12-22 | 2008-07-11 | Bayer Cropscience Ag | Composicion que comprende fenamidona y un compuesto insecticida; y metodo para controlar de forma curativa o preventiva hongos fitopatogenos de cultivos e insectos. |
| EP1950303A1 (de) * | 2007-01-26 | 2008-07-30 | Bayer CropScience AG | Genetisch modifizierte Pflanzen, die eine Stärke mit geringem Amylosegehalt und erhöhtem Quellvermögen synthetisieren |
| EP2136627B1 (de) | 2007-03-12 | 2015-05-13 | Bayer Intellectual Property GmbH | Dihalogenphenoxyphenylamidine und deren verwendung als fungizide |
| EP1969930A1 (de) | 2007-03-12 | 2008-09-17 | Bayer CropScience AG | Phenoxyphenylamidine und deren Verwendung als Fungizide |
| EP1969929A1 (de) | 2007-03-12 | 2008-09-17 | Bayer CropScience AG | Substituierte Phenylamidine und deren Verwendung als Fungizide |
| EP1969934A1 (de) | 2007-03-12 | 2008-09-17 | Bayer CropScience AG | 4-Cycloalkyl-oder 4-arylsubstituierte Phenoxyphenylamidine und deren Verwendung als Fungizide |
| EP1969931A1 (de) | 2007-03-12 | 2008-09-17 | Bayer CropScience Aktiengesellschaft | Fluoalkylphenylamidine und deren Verwendung als Fungizide |
| US20100167926A1 (en) | 2007-03-12 | 2010-07-01 | Bayer Cropscience Ag | 3-substituted phenoxyphenylamidines and use thereof as fungicides |
| EP2120558B1 (de) | 2007-03-12 | 2016-02-10 | Bayer Intellectual Property GmbH | 3,4-Disubstituierte Phenoxyphenylamidin-Derivate und deren Verwendung als Fungizide |
| JP2010524869A (ja) | 2007-04-19 | 2010-07-22 | バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト | チアジアゾリルオキシフェニルアミジンおよび殺菌剤としてのこれらの使用 |
| DE102007045956A1 (de) | 2007-09-26 | 2009-04-09 | Bayer Cropscience Ag | Wirkstoffkombination mit insektiziden und akariziden Eigenschaften |
| DE102007045920B4 (de) | 2007-09-26 | 2018-07-05 | Bayer Intellectual Property Gmbh | Synergistische Wirkstoffkombinationen |
| DE102007045953B4 (de) | 2007-09-26 | 2018-07-05 | Bayer Intellectual Property Gmbh | Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften |
| DE102007045922A1 (de) | 2007-09-26 | 2009-04-02 | Bayer Cropscience Ag | Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften |
| DE102007045919B4 (de) | 2007-09-26 | 2018-07-05 | Bayer Intellectual Property Gmbh | Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften |
| EP2090168A1 (de) | 2008-02-12 | 2009-08-19 | Bayer CropScience AG | Methode zur Verbesserung des Pflanzenwachstums |
| WO2009047013A2 (en) * | 2007-10-12 | 2009-04-16 | Bayer Cropscience Ag | Process for producing transparent pasta by extrusion |
| EP2072506A1 (de) | 2007-12-21 | 2009-06-24 | Bayer CropScience AG | Thiazolyloxyphenylamidine oder Thiadiazolyloxyphenylamidine und deren Verwendung als Fungizide |
| EP2168434A1 (de) | 2008-08-02 | 2010-03-31 | Bayer CropScience AG | Verwendung von Azolen zur Steigerung der Resistenz von Pflanzen oder Pflanzenteilen gegenüber abiotischem Stress |
| CN102186809A (zh) | 2008-08-14 | 2011-09-14 | 拜尔农作物科学股份公司 | 杀虫性的4-苯基-1h-吡唑 |
| DE102008041695A1 (de) | 2008-08-29 | 2010-03-04 | Bayer Cropscience Ag | Methoden zur Verbesserung des Pflanzenwachstums |
| EP2201838A1 (de) | 2008-12-05 | 2010-06-30 | Bayer CropScience AG | Wirkstoff-Nützlings-Kombinationen mit insektiziden und akariziden Eigenschaften |
| EP2198709A1 (de) | 2008-12-19 | 2010-06-23 | Bayer CropScience AG | Verfahren zur Bekämpfung resistenter tierischer Schädlinge |
| EP2204094A1 (en) | 2008-12-29 | 2010-07-07 | Bayer CropScience AG | Method for improved utilization of the production potential of transgenic plants Introduction |
| EP2223602A1 (de) | 2009-02-23 | 2010-09-01 | Bayer CropScience AG | Verfahren zur verbesserten Nutzung des Produktionspotentials genetisch modifizierter Pflanzen |
| AU2009335333B2 (en) | 2008-12-29 | 2015-04-09 | Bayer Intellectual Property Gmbh | Method for improved use of the production potential of genetically modified plants |
| EP2039770A2 (en) | 2009-01-06 | 2009-03-25 | Bayer CropScience AG | Method for improved utilization of the production potential of transgenic plants |
| EP2039771A2 (en) | 2009-01-06 | 2009-03-25 | Bayer CropScience AG | Method for improved utilization of the production potential of transgenic plants |
| EP2039772A2 (en) | 2009-01-06 | 2009-03-25 | Bayer CropScience AG | Method for improved utilization of the production potential of transgenic plants introduction |
| KR20110106448A (ko) | 2009-01-19 | 2011-09-28 | 바이엘 크롭사이언스 아게 | 사이클릭 디온 및 살충제, 살비제 및/또는 살진균제로서의 그의 용도 |
| EP2227951A1 (de) | 2009-01-23 | 2010-09-15 | Bayer CropScience AG | Verwendung von Enaminocarbonylverbindungen zur Bekämpfung von durch Insekten übertragenen Viren |
| EP2391608B8 (en) | 2009-01-28 | 2013-04-10 | Bayer Intellectual Property GmbH | Fungicide n-cycloalkyl-n-bicyclicmethylene-carboxamide derivatives |
| AR075126A1 (es) | 2009-01-29 | 2011-03-09 | Bayer Cropscience Ag | Metodo para el mejor uso del potencial de produccion de plantas transgenicas |
| EP2218717A1 (en) | 2009-02-17 | 2010-08-18 | Bayer CropScience AG | Fungicidal N-((HET)Arylethyl)thiocarboxamide derivatives |
| WO2010094666A2 (en) | 2009-02-17 | 2010-08-26 | Bayer Cropscience Ag | Fungicidal n-(phenylcycloalkyl)carboxamide, n-(benzylcycloalkyl)carboxamide and thiocarboxamide derivatives |
| TW201031331A (en) | 2009-02-19 | 2010-09-01 | Bayer Cropscience Ag | Pesticide composition comprising a tetrazolyloxime derivative and a fungicide or an insecticide active substance |
| MA33140B1 (fr) | 2009-03-25 | 2012-03-01 | Bayer Cropscience Ag | Combinaisons d'agents actifs ayant des proprietes insecticides et acaricides |
| BRPI0924986A8 (pt) | 2009-03-25 | 2016-06-21 | Bayer Cropscience Ag | "combinações de substâncias ativas com propriedades inseticidas e acaricidas, seus usos e método para o controle de pragas animais". |
| EP2232995A1 (de) | 2009-03-25 | 2010-09-29 | Bayer CropScience AG | Verfahren zur verbesserten Nutzung des Produktionspotentials transgener Pflanzen |
| EP2410850A2 (de) | 2009-03-25 | 2012-02-01 | Bayer Cropscience AG | Synergistische wirkstoffkombinationen |
| CN102448304B (zh) | 2009-03-25 | 2015-03-11 | 拜尔农作物科学股份公司 | 具有杀昆虫和杀螨特性的活性成分结合物 |
| MX2011009372A (es) | 2009-03-25 | 2011-09-27 | Bayer Cropscience Ag | Combinaciones de principios activos con propiedades insecticidas y acaricidas. |
| EP2239331A1 (en) | 2009-04-07 | 2010-10-13 | Bayer CropScience AG | Method for improved utilization of the production potential of transgenic plants |
| US8835657B2 (en) | 2009-05-06 | 2014-09-16 | Bayer Cropscience Ag | Cyclopentanedione compounds and their use as insecticides, acaricides and/or fungicides |
| AR076839A1 (es) | 2009-05-15 | 2011-07-13 | Bayer Cropscience Ag | Derivados fungicidas de pirazol carboxamidas |
| EP2251331A1 (en) | 2009-05-15 | 2010-11-17 | Bayer CropScience AG | Fungicide pyrazole carboxamides derivatives |
| EP2255626A1 (de) | 2009-05-27 | 2010-12-01 | Bayer CropScience AG | Verwendung von Succinat Dehydrogenase Inhibitoren zur Steigerung der Resistenz von Pflanzen oder Pflanzenteilen gegenüber abiotischem Stress |
| BRPI1011983A2 (pt) | 2009-06-02 | 2015-09-22 | Bayer Cropscience Ag | utilização de inibidores de succinato desidrogenase para o controle sclerotinia ssp. |
| MX2012000566A (es) | 2009-07-16 | 2012-03-06 | Bayer Cropscience Ag | Combinaciones sinergicas de principios activos con feniltriazoles. |
| WO2011015524A2 (en) | 2009-08-03 | 2011-02-10 | Bayer Cropscience Ag | Fungicide heterocycles derivatives |
| EP2292094A1 (en) | 2009-09-02 | 2011-03-09 | Bayer CropScience AG | Active compound combinations |
| EP2343280A1 (en) | 2009-12-10 | 2011-07-13 | Bayer CropScience AG | Fungicide quinoline derivatives |
| EP2519516A2 (en) | 2009-12-28 | 2012-11-07 | Bayer CropScience AG | Fungicidal hydroximoyl-tetrazole derivatives |
| TW201138624A (en) | 2009-12-28 | 2011-11-16 | Bayer Cropscience Ag | Fungicide hydroximoyl-tetrazole derivatives |
| CN102725270B (zh) | 2009-12-28 | 2015-10-07 | 拜尔农科股份公司 | 杀真菌剂肟基-杂环衍生物 |
| CN102811617A (zh) | 2010-01-22 | 2012-12-05 | 拜耳知识产权有限责任公司 | 杀螨和/或杀虫活性物质结合物 |
| ES2523503T3 (es) | 2010-03-04 | 2014-11-26 | Bayer Intellectual Property Gmbh | 2-Amidobencimidazoles sustituidos con fluoroalquilo y su uso para el aumento de la tolerancia al estrés en plantas |
| AR080827A1 (es) | 2010-04-06 | 2012-05-09 | Bayer Cropscience Ag | Utilizacion del acido 4- fenil- butirico y/o de sus sales para el aumento de la tolerancia al estres en plantas |
| EP2555626A2 (de) | 2010-04-09 | 2013-02-13 | Bayer Intellectual Property GmbH | Verwendung von derivaten der (1-cyancyclopropyl)phenylphosphinsäure, deren ester und/oder deren salze zur steigerung der toleranz in pflanzen gegenüber abiotischem stress |
| BR112012027558A2 (pt) | 2010-04-28 | 2015-09-15 | Bayer Cropscience Ag | ''composto da fórmula (i), composição fungicida e método para o controle de fungos fitogênicos de colheitas'' |
| WO2011134913A1 (en) | 2010-04-28 | 2011-11-03 | Bayer Cropscience Ag | Fungicide hydroximoyl-heterocycles derivatives |
| WO2011134911A2 (en) | 2010-04-28 | 2011-11-03 | Bayer Cropscience Ag | Fungicide hydroximoyl-tetrazole derivatives |
| WO2011151369A1 (en) | 2010-06-03 | 2011-12-08 | Bayer Cropscience Ag | N-[(het)arylethyl)] pyrazole(thio)carboxamides and their heterosubstituted analogues |
| MX2012013896A (es) | 2010-06-03 | 2012-12-17 | Bayer Cropscience Ag | N-[(het)arilalquil)]pirazol(tio)carboxamidas y sus analogos heterosustituidos. |
| UA110703C2 (uk) | 2010-06-03 | 2016-02-10 | Байєр Кропсайнс Аг | Фунгіцидні похідні n-[(тризаміщений силіл)метил]-карбоксаміду |
| EP2580336B1 (en) | 2010-06-09 | 2017-05-10 | Bayer CropScience NV | Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering |
| SG185668A1 (en) | 2010-06-09 | 2012-12-28 | Bayer Cropscience Nv | Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering |
| US9598700B2 (en) | 2010-06-25 | 2017-03-21 | Agrivida, Inc. | Methods and compositions for processing biomass with elevated levels of starch |
| US10443068B2 (en) | 2010-06-25 | 2019-10-15 | Agrivida, Inc. | Plants with engineered endogenous genes |
| JP5750635B2 (ja) * | 2010-07-15 | 2015-07-22 | 公立大学法人秋田県立大学 | イネ変異体、澱粉の製造方法、澱粉、及びイネ変異体の製造方法 |
| EP2595961B1 (en) | 2010-07-20 | 2017-07-19 | Bayer Intellectual Property GmbH | Benzocycloalkenes as antifungal agents |
| CN103228141B (zh) | 2010-09-03 | 2016-04-20 | 拜耳知识产权有限责任公司 | 取代的稠合的嘧啶酮和二氢嘧啶酮 |
| EP2460406A1 (en) | 2010-12-01 | 2012-06-06 | Bayer CropScience AG | Use of fluopyram for controlling nematodes in nematode resistant crops |
| AU2011306893A1 (en) | 2010-09-22 | 2013-04-04 | Bayer Intellectual Property Gmbh | Use of biological or chemical control agents for controlling insects and nematodes in resistant crops |
| JP5977242B2 (ja) | 2010-10-07 | 2016-08-24 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | テトラゾリルオキシム誘導体とチアゾリルピペリジン誘導体を含んでいる殺菌剤組成物 |
| CA2815114A1 (en) | 2010-10-21 | 2012-04-26 | Juergen Benting | 1-(heterocyclic carbonyl) piperidines |
| JP2013541554A (ja) | 2010-10-21 | 2013-11-14 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | Ｎ−ベンジルヘテロ環式カルボキサミド類 |
| CN103298802B (zh) | 2010-11-02 | 2016-06-08 | 拜耳知识产权有限责任公司 | N-杂芳基甲基吡唑基羧酰胺 |
| WO2012065947A1 (en) | 2010-11-15 | 2012-05-24 | Bayer Cropscience Ag | 5-halogenopyrazolecarboxamides |
| JP5860471B2 (ja) | 2010-11-15 | 2016-02-16 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | Ｎ−アリールピラゾール（チオ）カルボキサミド類 |
| US20130231303A1 (en) | 2010-11-15 | 2013-09-05 | Bayer Intellectual Property Gmbh | 5-halogenopyrazole(thio)carboxamides |
| EP2460407A1 (de) | 2010-12-01 | 2012-06-06 | Bayer CropScience AG | Wirkstoffkombinationen umfassend Pyridylethylbenzamide und weitere Wirkstoffe |
| KR20180096815A (ko) | 2010-12-01 | 2018-08-29 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 작물에서 선충류를 구제하고 수확량을 증가시키기 위한 플루오피람의 용도 |
| EP2474542A1 (en) | 2010-12-29 | 2012-07-11 | Bayer CropScience AG | Fungicide hydroximoyl-tetrazole derivatives |
| JP2014502611A (ja) | 2010-12-29 | 2014-02-03 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 殺菌剤ヒドロキシモイル−テトラゾール誘導体 |
| EP2471363A1 (de) | 2010-12-30 | 2012-07-04 | Bayer CropScience AG | Verwendung von Aryl-, Heteroaryl- und Benzylsulfonamidocarbonsäuren, -carbonsäureestern, -carbonsäureamiden und -carbonitrilen oder deren Salze zur Steigerung der Stresstoleranz in Pflanzen |
| EP2494867A1 (de) | 2011-03-01 | 2012-09-05 | Bayer CropScience AG | Halogen-substituierte Verbindungen in Kombination mit Fungiziden |
| US20130345058A1 (en) | 2011-03-10 | 2013-12-26 | Wolfram Andersch | Use of lipochito-oligosaccharide compounds for safeguarding seed safety of treated seeds |
| JP2014509599A (ja) | 2011-03-14 | 2014-04-21 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 殺菌剤ヒドロキシモイル−テトラゾール誘導体 |
| EP2694494A1 (en) | 2011-04-08 | 2014-02-12 | Bayer Intellectual Property GmbH | Fungicide hydroximoyl-tetrazole derivatives |
| EP2511255A1 (de) | 2011-04-15 | 2012-10-17 | Bayer CropScience AG | Substituierte Prop-2-in-1-ol- und Prop-2-en-1-ol-Derivate |
| AR090010A1 (es) | 2011-04-15 | 2014-10-15 | Bayer Cropscience Ag | 5-(ciclohex-2-en-1-il)-penta-2,4-dienos y 5-(ciclohex-2-en-1-il)-pent-2-en-4-inos sustituidos como principios activos contra el estres abiotico de las plantas, usos y metodos de tratamiento |
| AR085568A1 (es) | 2011-04-15 | 2013-10-09 | Bayer Cropscience Ag | 5-(biciclo[4.1.0]hept-3-en-2-il)-penta-2,4-dienos y 5-(biciclo[4.1.0]hept-3-en-2-il)-pent-2-en-4-inos sustituidos como principios activos contra el estres abiotico de las plantas |
| AR085585A1 (es) | 2011-04-15 | 2013-10-09 | Bayer Cropscience Ag | Vinil- y alquinilciclohexanoles sustituidos como principios activos contra estres abiotico de plantas |
| PL2699093T3 (pl) | 2011-04-22 | 2016-04-29 | Bayer Cropscience Ag | Kombinacje związku aktywnego zawierające pochodną karboksyamidową i związek grzybobójczy |
| AU2012266597B2 (en) | 2011-06-06 | 2016-09-22 | Bayer Cropscience Nv | Methods and means to modify a plant genome at a preselected site |
| WO2013004652A1 (de) | 2011-07-04 | 2013-01-10 | Bayer Intellectual Property Gmbh | Verwendung substituierter isochinolinone, isochinolindione, isochinolintrione und dihydroisochinolinone oder jeweils deren salze als wirkstoffe gegen abiotischen pflanzenstress |
| US9265252B2 (en) | 2011-08-10 | 2016-02-23 | Bayer Intellectual Property Gmbh | Active compound combinations comprising specific tetramic acid derivatives |
| JP2014524455A (ja) | 2011-08-22 | 2014-09-22 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 殺真菌性ヒドロキシモイル−テトラゾール誘導体 |
| MX346439B (es) | 2011-08-22 | 2017-03-17 | Bayer Cropscience Nv | Métodos y medios para modificar un genoma vegetal. |
| EP2561759A1 (en) | 2011-08-26 | 2013-02-27 | Bayer Cropscience AG | Fluoroalkyl-substituted 2-amidobenzimidazoles and their effect on plant growth |
| EP2753177A1 (en) | 2011-09-09 | 2014-07-16 | Bayer Intellectual Property GmbH | Acyl-homoserine lactone derivatives for improving plant yield |
| WO2013037717A1 (en) | 2011-09-12 | 2013-03-21 | Bayer Intellectual Property Gmbh | Fungicidal 4-substituted-3-{phenyl[(heterocyclylmethoxy)imino]methyl}-1,2,4-oxadizol-5(4h)-one derivatives |
| CN103917097A (zh) | 2011-09-16 | 2014-07-09 | 拜耳知识产权有限责任公司 | 5-苯基-或5-苄基-2-异噁唑啉-3-甲酸酯用于改善植物产量的用途 |
| WO2013037955A1 (en) | 2011-09-16 | 2013-03-21 | Bayer Intellectual Property Gmbh | Use of acylsulfonamides for improving plant yield |
| WO2013037958A1 (en) | 2011-09-16 | 2013-03-21 | Bayer Intellectual Property Gmbh | Use of phenylpyrazolin-3-carboxylates for improving plant yield |
| BR112014006940A2 (pt) | 2011-09-23 | 2017-04-04 | Bayer Ip Gmbh | uso de derivados de ácido 1-fenilpirazol-3-carboxílico 4-substituído como agentes contra estresse abiótico em plantas |
| EA028662B1 (ru) | 2011-10-04 | 2017-12-29 | Байер Интеллекчуал Проперти Гмбх | Рнк-интерференция для борьбы с грибами и оомицетами путем ингибирования гена сахаропиндегидрогеназы |
| WO2013050324A1 (de) | 2011-10-06 | 2013-04-11 | Bayer Intellectual Property Gmbh | Abiotischen pflanzenstress-reduzierende kombination enthaltend 4- phenylbuttersäure (4-pba) oder eines ihrer salze (komponente (a)) und eine oder mehrere ausgewählte weitere agronomisch wirksame verbindungen (komponente(n) (b) |
| WO2013075817A1 (en) | 2011-11-21 | 2013-05-30 | Bayer Intellectual Property Gmbh | Fungicide n-[(trisubstitutedsilyl)methyl]-carboxamide derivatives |
| MX2014006350A (es) | 2011-11-30 | 2014-06-23 | Bayer Ip Gmbh | Derivados de n-bicicloalquil- y n-tricicloalquil-(tio)carboxamida fungicidas. |
| AU2012357896B9 (en) | 2011-12-19 | 2016-12-15 | Bayer Cropscience Ag | Use of anthranilic acid diamide derivatives for pest control in transgenic crops |
| KR102028903B1 (ko) | 2011-12-29 | 2019-10-07 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 살진균 3-[(피리딘-2-일메톡시이미노)(페닐)메틸]-2-치환-1,2,4-옥사디아졸-5(2h)-온 유도체 |
| TWI558701B (zh) | 2011-12-29 | 2016-11-21 | 拜耳知識產權公司 | 殺真菌之３－［（１，３－噻唑－４－基甲氧基亞胺）（苯基）甲基］－２－經取代之－１，２，４－二唑－５（２ｈ）－酮衍生物 |
| HUE036328T2 (hu) | 2012-02-22 | 2018-06-28 | Bayer Cropscience Ag | Fluopirám alkalmazása fabetegségek leküzdésére szõlõn |
| US9629367B2 (en) | 2012-02-27 | 2017-04-25 | Bayer Intellectual Property Gmbh | Active compound combinations containing a thiazoylisoxazoline and a fungicide |
| WO2013139949A1 (en) | 2012-03-23 | 2013-09-26 | Bayer Intellectual Property Gmbh | Compositions comprising a strigolactame compound for enhanced plant growth and yield |
| EP2836489B1 (en) | 2012-04-12 | 2016-06-29 | Bayer Cropscience AG | N-acyl-2-(cyclo) alkylpyrrolidines and piperidines useful as fungicides |
| MX374868B (es) | 2012-04-20 | 2025-03-06 | Bayer Cropscience Ag | Derivados de n-cicloalquil-n-[(heterociclilfenil)metilen]-(tio)carboxamida. |
| US20150080337A1 (en) | 2012-04-20 | 2015-03-19 | Bayer Cropscience | N-cycloalkyl-n-[(trisubstitutedsilylphenyl)methylene]-(thio)carboxamide derivatives |
| WO2013160230A1 (en) | 2012-04-23 | 2013-10-31 | Bayer Cropscience Nv | Targeted genome engineering in plants |
| EP2662360A1 (en) | 2012-05-09 | 2013-11-13 | Bayer CropScience AG | 5-Halogenopyrazole indanyl carboxamides |
| EP2662361A1 (en) | 2012-05-09 | 2013-11-13 | Bayer CropScience AG | Pyrazol indanyl carboxamides |
| US9375005B2 (en) | 2012-05-09 | 2016-06-28 | Bayer Cropscience Ag | 5-halogenopyrazole indanyl carboxamides |
| EP2662363A1 (en) | 2012-05-09 | 2013-11-13 | Bayer CropScience AG | 5-Halogenopyrazole biphenylcarboxamides |
| EP2662364A1 (en) | 2012-05-09 | 2013-11-13 | Bayer CropScience AG | Pyrazole tetrahydronaphthyl carboxamides |
| EP2662362A1 (en) | 2012-05-09 | 2013-11-13 | Bayer CropScience AG | Pyrazole indanyl carboxamides |
| MX2014013497A (es) | 2012-05-09 | 2015-02-10 | Bayer Cropscience Ag | Pirazol indanil carboxamidas. |
| EP2662370A1 (en) | 2012-05-09 | 2013-11-13 | Bayer CropScience AG | 5-Halogenopyrazole benzofuranyl carboxamides |
| AR091104A1 (es) | 2012-05-22 | 2015-01-14 | Bayer Cropscience Ag | Combinaciones de compuestos activos que comprenden un derivado lipo-quitooligosacarido y un compuesto nematicida, insecticida o fungicida |
| AU2013289301A1 (en) | 2012-07-11 | 2015-01-22 | Bayer Cropscience Ag | Use of fungicidal combinations for increasing the tolerance of a plant towards abiotic stress |
| CN104780764A (zh) | 2012-09-05 | 2015-07-15 | 拜尔农作物科学股份公司 | 取代的2-酰氨基苯并咪唑、2-酰氨基苯并噁唑和2-酰氨基苯并噻唑或其盐作为活性物质对抗非生物植物胁迫的用途 |
| JP6153619B2 (ja) | 2012-10-19 | 2017-06-28 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | カルボキサミド誘導体を含む活性化合物の組み合わせ |
| AU2013333845B2 (en) | 2012-10-19 | 2017-06-08 | Bayer Cropscience Ag | Method of plant growth promotion using carboxamide derivatives |
| MX381528B (es) | 2012-10-19 | 2025-03-12 | Bayer Cropscience Ag | Método para mejorar la tolerancia al estrés abiótico en plantas usando derivados de carboxamida o tiocarboxamida. |
| AU2013333847B2 (en) | 2012-10-19 | 2017-04-20 | Bayer Cropscience Ag | Method for treating plants against fungi resistant to fungicides using carboxamide or thiocarboxamide derivatives |
| ES2774426T3 (es) * | 2012-11-14 | 2020-07-21 | Agrivida Inc | Métodos y composiciones para procesar biomasa con niveles elevados de almidón |
| EP2735231A1 (en) | 2012-11-23 | 2014-05-28 | Bayer CropScience AG | Active compound combinations |
| WO2014079957A1 (de) | 2012-11-23 | 2014-05-30 | Bayer Cropscience Ag | Selektive inhibition der ethylensignaltransduktion |
| CN104918493B (zh) | 2012-11-30 | 2018-02-06 | 拜尔农作物科学股份公司 | 三元杀真菌和杀虫混合物 |
| UA117820C2 (uk) | 2012-11-30 | 2018-10-10 | Байєр Кропсайєнс Акцієнгезелльшафт | Подвійна фунгіцидна або пестицидна суміш |
| WO2014083031A2 (en) | 2012-11-30 | 2014-06-05 | Bayer Cropscience Ag | Binary pesticidal and fungicidal mixtures |
| US9943082B2 (en) | 2012-11-30 | 2018-04-17 | Bayer Cropscience Ag | Ternary fungicidal mixtures |
| EA201500580A1 (ru) | 2012-11-30 | 2016-01-29 | Байер Кропсайенс Акциенгезельшафт | Двойные фунгицидные смеси |
| EP2740356A1 (de) | 2012-12-05 | 2014-06-11 | Bayer CropScience AG | Substituierte (2Z)-5(1-Hydroxycyclohexyl)pent-2-en-4-insäure-Derivate |
| EP2740720A1 (de) | 2012-12-05 | 2014-06-11 | Bayer CropScience AG | Substituierte bicyclische- und tricyclische Pent-2-en-4-insäure -Derivate und ihre Verwendung zur Steigerung der Stresstoleranz in Pflanzen |
| WO2014086751A1 (de) | 2012-12-05 | 2014-06-12 | Bayer Cropscience Ag | Verwendung substituierter 1-(arylethinyl)-, 1-(heteroarylethinyl)-, 1-(heterocyclylethinyl)- und 1-(cyloalkenylethinyl)-cyclohexanole als wirkstoffe gegen abiotischen pflanzenstress |
| AR093909A1 (es) | 2012-12-12 | 2015-06-24 | Bayer Cropscience Ag | Uso de ingredientes activos para controlar nematodos en cultivos resistentes a nematodos |
| AR093996A1 (es) | 2012-12-18 | 2015-07-01 | Bayer Cropscience Ag | Combinaciones bactericidas y fungicidas binarias |
| WO2014095677A1 (en) | 2012-12-19 | 2014-06-26 | Bayer Cropscience Ag | Difluoromethyl-nicotinic- tetrahydronaphtyl carboxamides |
| US20140220218A1 (en) * | 2013-02-05 | 2014-08-07 | The Quaker Oats Company | Crunchy granola clusters and products prepared therefrom |
| WO2014135608A1 (en) | 2013-03-07 | 2014-09-12 | Bayer Cropscience Ag | Fungicidal 3-{phenyl[(heterocyclylmethoxy)imino]methyl}-heterocycle derivatives |
| WO2014161821A1 (en) | 2013-04-02 | 2014-10-09 | Bayer Cropscience Nv | Targeted genome engineering in eukaryotes |
| CA2909213A1 (en) | 2013-04-12 | 2014-10-16 | Bayer Cropscience Aktiengesellschaft | Novel triazole derivatives |
| WO2014167008A1 (en) | 2013-04-12 | 2014-10-16 | Bayer Cropscience Ag | Novel triazolinthione derivatives |
| BR112015026235A2 (pt) | 2013-04-19 | 2017-10-10 | Bayer Cropscience Ag | método para melhorar a utilização do potencial de produção de plantas transgênicas envolvendo a aplicação de um derivado de ftaldiamida |
| JP2016519687A (ja) | 2013-04-19 | 2016-07-07 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | バイナリー殺虫または農薬混合物 |
| WO2014177514A1 (en) | 2013-04-30 | 2014-11-06 | Bayer Cropscience Ag | Nematicidal n-substituted phenethylcarboxamides |
| TW201507722A (zh) | 2013-04-30 | 2015-03-01 | Bayer Cropscience Ag | 做為殺線蟲劑及殺體內寄生蟲劑的ｎ－（２－鹵素－２－苯乙基）－羧醯胺類 |
| CN105636939B (zh) | 2013-06-26 | 2018-08-31 | 拜耳作物科学股份公司 | N-环烷基-n-[(二环基苯基)亚甲基]-(硫代)甲酰胺衍生物 |
| AR096827A1 (es) | 2013-07-09 | 2016-02-03 | Bayer Cropscience Ag | Uso de piridoncarboxamidas seleccionadas o sus sales como ingredientes activos contra estrés abiótico en plantas |
| CN105873907B (zh) | 2013-12-05 | 2019-03-12 | 拜耳作物科学股份公司 | N-环烷基-n-{[2-(1-取代的环烷基)苯基]亚甲基}-(硫代)甲酰胺衍生物 |
| WO2015082586A1 (en) | 2013-12-05 | 2015-06-11 | Bayer Cropscience Ag | N-cycloalkyl-n-{[2-(1-substitutedcycloalkyl)phenyl]methylene}-(thio)carboxamide derivatives |
| AR101214A1 (es) | 2014-07-22 | 2016-11-30 | Bayer Cropscience Ag | Ciano-cicloalquilpenta-2,4-dienos, ciano-cicloalquilpent-2-en-4-inas, ciano-heterociclilpenta-2,4-dienos y ciano-heterociclilpent-2-en-4-inas sustituidos como principios activos contra el estrés abiótico de plantas |
| AR103024A1 (es) | 2014-12-18 | 2017-04-12 | Bayer Cropscience Ag | Piridoncarboxamidas seleccionadas o sus sales como sustancias activas contra estrés abiótico de las plantas |
| EP3283476B1 (en) | 2015-04-13 | 2019-08-14 | Bayer Cropscience AG | N-cycloalkyl-n-(biheterocyclyethylene)-(thio)carboxamide derivatives |
| AU2016279062A1 (en) | 2015-06-18 | 2019-03-28 | Omar O. Abudayyeh | Novel CRISPR enzymes and systems |
| CN105671042A (zh) * | 2016-03-28 | 2016-06-15 | 浙江师范大学 | 稻米直链淀粉含量微控基因ssiii-1分子标记及应用 |
| RU2019104918A (ru) | 2016-07-29 | 2020-08-28 | Байер Кропсайенс Акциенгезельшафт | Комбинации активных соединений и способы защиты материала размножения растений |
| CN106636179B (zh) * | 2016-08-19 | 2019-11-08 | 天津中医药大学 | 植物中间表达载体及其构建方法与应用 |
| BR112019005668A2 (pt) | 2016-09-22 | 2019-06-04 | Bayer Ag | novos derivados de triazol |
| BR112019005660A2 (pt) | 2016-09-22 | 2019-06-04 | Bayer Cropscience Ag | novos derivados de triazol e seu uso como fungicidas |
| US20190225974A1 (en) | 2016-09-23 | 2019-07-25 | BASF Agricultural Solutions Seed US LLC | Targeted genome optimization in plants |
| CA3041351A1 (en) | 2016-10-26 | 2018-05-03 | Bayer Cropscience Aktiengesellschaft | Use of pyraziflumid for controlling sclerotinia spp in seed treatment applications |
| CN110248547A (zh) | 2016-12-08 | 2019-09-17 | 拜耳农作物科学股份公司 | 杀虫剂用于控制金针虫的用途 |
| EP3332645A1 (de) | 2016-12-12 | 2018-06-13 | Bayer Cropscience AG | Verwendung substituierter pyrimidindione oder jeweils deren salze als wirkstoffe gegen abiotischen pflanzenstress |
| WO2018108627A1 (de) | 2016-12-12 | 2018-06-21 | Bayer Cropscience Aktiengesellschaft | Verwendung substituierter indolinylmethylsulfonamide oder deren salze zur steigerung der stresstoleranz in pflanzen |
| WO2018204777A2 (en) | 2017-05-05 | 2018-11-08 | The Broad Institute, Inc. | Methods for identification and modification of lncrna associated with target genotypes and phenotypes |
| US12297436B2 (en) | 2017-05-18 | 2025-05-13 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| WO2019025153A1 (de) | 2017-07-31 | 2019-02-07 | Bayer Cropscience Aktiengesellschaft | Verwendung von substituierten n-sulfonyl-n'-aryldiaminoalkanen und n-sulfonyl-n'-heteroaryldiaminoalkanen oder deren salzen zur steigerung der stresstoleranz in pflanzen |
| KR102338449B1 (ko) | 2017-09-21 | 2021-12-10 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물 |
| US20230193242A1 (en) | 2017-12-22 | 2023-06-22 | The Broad Institute, Inc. | Cas12b systems, methods, and compositions for targeted dna base editing |
| WO2019145544A1 (en) | 2018-01-26 | 2019-08-01 | Böhm-Nordkartoffel Agrarproduktion Gmbh & Co. Ohg | Altered starch producing plants |
| US10968257B2 (en) | 2018-04-03 | 2021-04-06 | The Broad Institute, Inc. | Target recognition motifs and uses thereof |
| BR112020024615A2 (pt) | 2018-06-04 | 2021-03-02 | Bayer Aktiengesellschaft | benzoilpirazóis bicíclicos de ação herbicida |
| WO2020131862A1 (en) | 2018-12-17 | 2020-06-25 | The Broad Institute, Inc. | Crispr-associated transposase systems and methods of use thereof |
| CN113755543B (zh) * | 2020-08-24 | 2024-02-20 | 中国科学院天津工业生物技术研究所 | 一种淀粉的生物合成方法 |
| CN113151318B (zh) * | 2021-03-17 | 2022-08-16 | 云南中烟工业有限责任公司 | 一种烟草淀粉分支酶基因NtGBE1及其应用 |
| CN114107368B (zh) * | 2021-11-29 | 2023-05-26 | 重庆大学 | 表达反式菊酸的联合表达载体及其在调控番茄vi型腺体腺毛合成反式菊酸中的应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034322A (en) * | 1983-01-17 | 1991-07-23 | Monsanto Company | Chimeric genes suitable for expression in plant cells |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| US4962028A (en) * | 1986-07-09 | 1990-10-09 | Dna Plant Technology Corporation | Plant promotors |
| ES2074999T3 (es) | 1987-05-20 | 1995-10-01 | Ciba Geigy Ag | Plantas de zea mays y plantas de zea mays transgenicas regeneradas de protoplastos o celulas derivadas de protoplastos. |
| MC2115A1 (fr) | 1987-12-15 | 1991-07-05 | Gene Shears Pty Ltd | Ribozynes |
| US5639952A (en) * | 1989-01-05 | 1997-06-17 | Mycogen Plant Science, Inc. | Dark and light regulated chlorophyll A/B binding protein promoter-regulatory system |
| IL95132A0 (en) | 1989-07-19 | 1991-06-10 | Calgene Inc | Fruit-specific transcriptional factors |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| DK0465875T3 (da) | 1990-06-23 | 1999-08-09 | Hoechst Schering Agrevo Gmbh | Fremgangsmåde til produktion af en calluskultur af Zea mays (L.) |
| SE467358B (sv) | 1990-12-21 | 1992-07-06 | Amylogene Hb | Genteknisk foeraendring av potatis foer bildning av staerkelse av amylopektintyp |
| JPH05199877A (ja) | 1991-10-03 | 1993-08-10 | Sumitomo Chem Co Ltd | バレイショおよびイネの誘導型植物防御遺伝子の制御領域、その用途およびアッセイ法 |
| DE4139611A1 (de) | 1991-11-30 | 1993-06-03 | Zahnradfabrik Friedrichshafen | Getriebe mit einer verdraengerpumpe |
| KR100386337B1 (ko) | 1993-12-09 | 2004-03-24 | 토마스 제퍼슨 대학교 | 진핵세포에서부위-특이적돌연변이를위한화합물과그방법 |
| US6274792B1 (en) * | 1995-06-20 | 2001-08-14 | Ming-Tang Chang | Plants and processes for obtaining them |
| US6825342B1 (en) | 1995-05-05 | 2004-11-30 | National Starch And Chemical Investment Holding Corporation | Plant starch composition |
| GB9514435D0 (en) | 1995-07-14 | 1995-09-13 | Danisco | Inhibition of gene expression |
| GB9514437D0 (en) | 1995-07-14 | 1995-09-13 | Danisco | Inhibition of gene expression |
| SE513209C2 (sv) | 1995-11-29 | 2000-07-31 | Lars Rask | Förfarande för produktion av transgena potatisar med ökad eller minskad grad av förgrening av amylopektinstärkelse |
| CA2239979C (en) * | 1995-12-20 | 2007-09-25 | E.I. Du Pont De Nemours And Company | Novel starches via modification of expression of starch biosynthetic enzyme genes |
| BR9808648A (pt) | 1997-02-21 | 2000-05-23 | Danisco | Inibição de senso intron da expressão de enzima de ramificação de amido |
| AU738272B2 (en) | 1997-02-21 | 2001-09-13 | Dupont Nutrition Biosciences Aps | Antisense intron inhibition of starch branching enzyme expression |
| EP1068311B2 (en) | 1998-04-08 | 2020-12-09 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
| WO1999066050A1 (en) | 1998-06-15 | 1999-12-23 | National Starch And Chemical Investment Holding Corporation | Improvements in or relating to plants and plant products |
| DE19836098A1 (de) | 1998-07-31 | 2000-02-03 | Hoechst Schering Agrevo Gmbh | Pflanzen, die eine modifizierte Stärke synthetisieren, Verfahren zur Herstellung der Pflanzen, ihre Verwendung sowie die modifizierte Stärke |
| GB9825242D0 (en) * | 1998-11-19 | 1999-01-13 | Cambridge Advanced Tech | Genetically modified plants with altered starch |
| AUPQ005299A0 (en) | 1999-04-29 | 1999-05-27 | Commonwealth Scientific And Industrial Research Organisation | Novel genes encoding wheat starch synthases and uses therefor |
| CA2470667A1 (en) * | 2001-12-21 | 2003-07-03 | Bayer Cropscience Gmbh | Pregelatinized starches and method for producing the same |
| JP2006034128A (ja) * | 2004-07-23 | 2006-02-09 | Japan Science & Technology Agency | イネ由来デンプン合成酵素ＳＳＩＩａを発現させたシアノバクテリアの形質転換体、これを用いたＳＳＩＩａの機能解析法、並びに同形質転換体によって生産される多糖 |
-
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- 2003-12-19 CN CN2003801065253A patent/CN1726282B/zh not_active Expired - Lifetime
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- 2003-12-19 DE DE60323149T patent/DE60323149D1/de not_active Expired - Lifetime
- 2003-12-19 ES ES03789405T patent/ES2310256T3/es not_active Expired - Lifetime
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- 2003-12-19 US US10/539,723 patent/US7714186B2/en not_active Expired - Lifetime
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| US20100292461A1 (en) | 2010-11-18 |
| DE60323149D1 (de) | 2008-10-02 |
| US20060130181A1 (en) | 2006-06-15 |
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| CA2505776A1 (en) | 2004-07-08 |
| AU2003293991B2 (en) | 2009-01-22 |
| CY1108510T1 (el) | 2014-04-09 |
| JP2006511235A (ja) | 2006-04-06 |
| US7714186B2 (en) | 2010-05-11 |
| CN1726282A (zh) | 2006-01-25 |
| PT1578973E (pt) | 2008-10-16 |
| CA2505776C (en) | 2013-04-02 |
| WO2004056999A1 (en) | 2004-07-08 |
| AU2003293991A1 (en) | 2004-07-14 |
| ATE405653T1 (de) | 2008-09-15 |
| EP1578973B1 (en) | 2008-08-20 |
| CN1726282B (zh) | 2012-09-26 |
| ES2310256T3 (es) | 2009-01-01 |
| SI1578973T1 (sl) | 2009-02-28 |
| EP1578973A1 (en) | 2005-09-28 |
| US8017832B2 (en) | 2011-09-13 |
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