JP4521121B2 - マイクロタイタプレートとともに用いるための光学オートフォーカス - Google Patents

マイクロタイタプレートとともに用いるための光学オートフォーカス Download PDF

Info

Publication number
JP4521121B2
JP4521121B2 JP2000597622A JP2000597622A JP4521121B2 JP 4521121 B2 JP4521121 B2 JP 4521121B2 JP 2000597622 A JP2000597622 A JP 2000597622A JP 2000597622 A JP2000597622 A JP 2000597622A JP 4521121 B2 JP4521121 B2 JP 4521121B2
Authority
JP
Japan
Prior art keywords
well
light
microplate
focal spot
intensity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000597622A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002541430A5 (https=
JP2002541430A (ja
Inventor
マニアン，バラ・エス
ヘッフェルフィンガー，デイビッド・エム
ゴールドバーグ，エドワード・エム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BD Biosciences Systems and Reagents Inc
Original Assignee
BD Biosciences Systems and Reagents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BD Biosciences Systems and Reagents Inc filed Critical BD Biosciences Systems and Reagents Inc
Publication of JP2002541430A publication Critical patent/JP2002541430A/ja
Publication of JP2002541430A5 publication Critical patent/JP2002541430A5/ja
Application granted granted Critical
Publication of JP4521121B2 publication Critical patent/JP4521121B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Automatic Focus Adjustment (AREA)
  • Length Measuring Devices By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2000597622A 1999-02-05 1999-05-03 マイクロタイタプレートとともに用いるための光学オートフォーカス Expired - Fee Related JP4521121B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/245,782 1999-02-05
US09/245,782 US6130745A (en) 1999-01-07 1999-02-05 Optical autofocus for use with microtiter plates
PCT/US1999/009699 WO2000046590A1 (en) 1999-02-05 1999-05-03 Optical autofocus for use with microtiter plates

Publications (3)

Publication Number Publication Date
JP2002541430A JP2002541430A (ja) 2002-12-03
JP2002541430A5 JP2002541430A5 (https=) 2006-06-01
JP4521121B2 true JP4521121B2 (ja) 2010-08-11

Family

ID=22928053

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000597622A Expired - Fee Related JP4521121B2 (ja) 1999-02-05 1999-05-03 マイクロタイタプレートとともに用いるための光学オートフォーカス

Country Status (5)

Country Link
US (2) US6130745A (https=)
EP (2) EP1942333B1 (https=)
JP (1) JP4521121B2 (https=)
DE (2) DE69938512T2 (https=)
WO (1) WO2000046590A1 (https=)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030030797A1 (en) * 1999-09-24 2003-02-13 Henry Palladino Solid state fluorescence and absorption spectroscopy
US6586257B1 (en) * 1999-10-12 2003-07-01 Vertex Pharmaceuticals Incorporated Multiwell scanner and scanning method
US6814933B2 (en) 2000-09-19 2004-11-09 Aurora Biosciences Corporation Multiwell scanner and scanning method
FR2801977B1 (fr) * 1999-12-02 2002-05-17 Commissariat Energie Atomique Amplification d'un signal de fluorescence emis par un echantillon surfacique
WO2002063367A1 (en) * 2001-02-02 2002-08-15 Cellomics, Inc. Method for estimating the best initial focus position
FR2820828B1 (fr) * 2001-02-09 2003-05-02 Commissariat Energie Atomique Dispositif d'observation d'echantillons par fluorescence, notamment de facon sequentielle
US6979530B2 (en) * 2001-05-21 2005-12-27 Applera Corporation Peptide conjugates and fluorescence detection methods for intracellular caspase assay
DE10141544A1 (de) * 2001-08-24 2003-03-13 Eppendorf Ag Vorrichtung zur Behandlung von Flüssigkeiten und Verfahren zum Betreiben der Vorrichtung
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
DE10157511A1 (de) * 2001-11-23 2003-06-12 Evotec Ag Verfahren und Vorrichtung zur Korrektur der Größe und/oder Form eines Messvolumens in einer chemischen und/oder biologischen Probe
JP4497923B2 (ja) * 2001-12-05 2010-07-07 ザ ジェイ． デビッド グラッドストーン インスティテューツ ロボット顕微鏡検査システム
FR2833718A1 (fr) * 2001-12-13 2003-06-20 Commissariat Energie Atomique Dispositif d'observation d'objets, notamment pour plaques de microtitration
US7205154B2 (en) * 2002-01-31 2007-04-17 Agilent Technologies, Inc. Calibrating array scanners
US6770892B2 (en) * 2002-02-28 2004-08-03 Agilent Technologies, Inc. Method and system for automated focus-distance determination for molecular array scanners
IL148664A0 (en) * 2002-03-13 2002-09-12 Yeda Res & Dev Auto-focusing method and device
WO2003095986A1 (en) 2002-05-14 2003-11-20 Amersham Biosciences Niagara, Inc. System and methods for rapid and automated screening of cells
US9157860B2 (en) * 2002-05-16 2015-10-13 Applied Biosystems, Llc Achromatic lens array
US6982166B2 (en) * 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
JPWO2004027085A1 (ja) * 2002-09-05 2006-01-19 日東電工株式会社 固体表面の微生物試験用粘着シートおよびキット
JPWO2004022774A1 (ja) * 2002-09-05 2005-12-22 富士電機システムズ株式会社 微生物または細胞の検出方法
DE10244618A1 (de) * 2002-09-25 2004-04-08 Olympus Biosystems Gmbh Einrichtung und Verfahren zur optischen Objektuntersuchung oder/und Erfassung oder/und Untersuchung von Schichten
EP1585978A4 (en) * 2002-12-30 2009-12-16 Pelikan Technologies Inc METHOD AND APPARATUS FOR USING OPTICAL TECHNIQUES FOR MEASURING ANALYTE RATES
US20040150217A1 (en) * 2003-01-23 2004-08-05 Heffelfinger David M. Identifying indicia and focusing target
US7522762B2 (en) * 2003-04-16 2009-04-21 Inverness Medical-Biostar, Inc. Detection, resolution, and identification of arrayed elements
US6853454B1 (en) 2004-01-15 2005-02-08 Alpha Innotech Corporation Optical analysis systems
US20050157299A1 (en) * 2004-01-15 2005-07-21 Heffelfinger David M. Optical analysis systems
US6995901B2 (en) * 2004-01-15 2006-02-07 Alpha Innotech Corporation Optical analysis systems
EP1760455A4 (en) * 2004-06-21 2016-12-21 Olympus Corp MEASURING DEVICE
FI20055043A0 (fi) * 2005-01-31 2005-01-31 Wallac Oy Sovitelma mikrotiterkaivojen kuvausjärjestelmässä
JP4701781B2 (ja) * 2005-03-28 2011-06-15 カシオ計算機株式会社 生体高分子分析装置及び生体高分子分析方法
US7718131B2 (en) 2005-07-06 2010-05-18 Genetix Limited Methods and apparatus for imaging and processing of samples in biological sample containers
EP1930717B1 (en) * 2005-09-29 2019-06-19 Olympus Corporation Focal position determining method and apparatus
FR2898363B1 (fr) * 2006-03-10 2008-06-13 Biofilm Control Sarl Prodede de releves d'images, notamment pour l'etude du developpement d'un biofilm dans un milieu de culture
CN101438147B (zh) 2006-05-31 2011-09-28 奥林巴斯株式会社 生物试样摄像方法及生物试样摄像装置
JP2008267842A (ja) * 2007-04-17 2008-11-06 Yokogawa Electric Corp 生物観察容器並びにこれを用いる生物顕微鏡及び生物観察装置
JP5152622B2 (ja) * 2007-05-23 2013-02-27 横河電機株式会社 創薬スクリーニング装置及びこの装置を用いた創薬スクリーニング方法
US7646482B2 (en) * 2007-05-31 2010-01-12 Genetix Limited Methods and apparatus for optical analysis of samples in biological sample containers
US7535556B2 (en) * 2007-05-31 2009-05-19 Genetix Limited Methods and apparatus for optical analysis of samples in biological sample containers
EP2110696B1 (en) 2008-04-15 2013-10-16 Sensovation AG Method and apparatus for autofocus
FR2931966A1 (fr) * 2008-05-30 2009-12-04 Novacyt Procede d'analyse cellulaire d'un prelevement au moyen d'une plaque d'analyse virtuelle
DE202009003288U1 (de) 2009-03-11 2009-06-25 Sensovation Ag Autofokuseinrichtung
WO2010103389A1 (de) 2009-03-11 2010-09-16 Sensovation Ag Autofokusverfahren und autofokuseinrichtung
DE102009012293A1 (de) 2009-03-11 2010-09-16 Sensovation Ag Autofokusverfahren und Autofokuseinrichtung
JP5167194B2 (ja) * 2009-04-28 2013-03-21 株式会社日立エンジニアリング・アンド・サービス 微生物検査装置
US7952799B2 (en) * 2009-06-19 2011-05-31 Corning Incorporated Extreme broadband compact optical system with multiple fields of view
US8304704B2 (en) * 2009-07-27 2012-11-06 Sensovation Ag Method and apparatus for autofocus using a light source pattern and means for masking the light source pattern
US9360659B2 (en) * 2011-08-10 2016-06-07 Molecular Devices, Llc Method for presenting and evaluation of images of micro-titer plate properties
JP2012159854A (ja) * 2012-04-04 2012-08-23 Olympus Corp 倒立顕微鏡システム
EP2769204B1 (en) 2012-05-02 2016-02-17 Charles River Laboratories, Inc. Cell capture system and use thereof
EP2780707B1 (en) 2012-05-02 2016-02-24 Charles River Laboratories, Inc. Method of detecting viable cells in a cell sample
AU2013256174B2 (en) 2012-05-02 2017-03-02 Charles River Laboratories, Inc. Viability staining method
US20140168402A1 (en) * 2012-12-13 2014-06-19 Vala Sciences, Inc. Continuous-Scanning Image Acquisition in Automated Microscopy Using Reflective Autofocus
EP2932425B1 (en) 2012-12-14 2025-01-29 The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone Automated robotic microscopy systems
US9279750B2 (en) * 2013-03-15 2016-03-08 Iris International, Inc. Method and composition for staining and sample processing
JP6523245B2 (ja) 2013-03-15 2019-05-29 アイリス インターナショナル， インコーポレイテッド 血液試料における粒子分析のためのシース液システム及び方法
US9857361B2 (en) * 2013-03-15 2018-01-02 Iris International, Inc. Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples
DE102013103971A1 (de) 2013-04-19 2014-11-06 Sensovation Ag Verfahren zum Erzeugen eines aus mehreren Teilbildern zusammengesetzten Gesamtbilds eines Objekts
FR3012131B1 (fr) * 2013-10-18 2018-01-19 Centre National De La Recherche Scientifique Supports amplificateurs de contraste pour l'observation d'un echantillon, leur procedes de fabrication et leurs utilisations
US10007102B2 (en) 2013-12-23 2018-06-26 Sakura Finetek U.S.A., Inc. Microscope with slide clamping assembly
JP6673198B2 (ja) * 2014-05-30 2020-03-25 株式会社ニコン 顕微鏡
US10941435B2 (en) 2016-06-23 2021-03-09 Life Technologies Corporation Methods and compositions for detecting or measuring caspases or apoptosis
EP3287829A1 (en) * 2016-08-25 2018-02-28 Deutsches Krebsforschungszentrum Method of and microscope with installation for focus stabilization
US11280803B2 (en) 2016-11-22 2022-03-22 Sakura Finetek U.S.A., Inc. Slide management system
ES2924275T3 (es) * 2017-01-19 2022-10-05 Otsuka Pharma Co Ltd Método de detección de posición y dispositivo de detección de posición para un chip sensor en un sistema óptico de detección de muestras
JP6853728B2 (ja) * 2017-04-28 2021-03-31 株式会社Ｓｃｒｅｅｎホールディングス 試料容器およびこれを用いる撮像方法
JP7212028B2 (ja) 2017-07-13 2023-01-24 グライナー バイオ‐ワン ノース アメリカ，インコーポレイテッド 撮像用の培養プレート
CN108519332B (zh) * 2018-04-28 2019-12-03 南通市肺科医院（南通市第六人民医院） 全自动微孔板系统及用于该系统的计算机可读介质
WO2019244275A1 (ja) * 2018-06-20 2019-12-26 株式会社日立ハイテクノロジーズ 観察装置
GB201816687D0 (en) * 2018-10-12 2018-11-28 Clinspec Diagnostics Ltd Sample container
EP4251974A4 (en) * 2020-11-25 2024-11-20 Mabtech Ab APPARATUS AND METHOD FOR FOCUSING A LASER SCANNING CYTOMETER USING THE REFLECTION OF THE LASER
EP4198604B1 (en) * 2021-12-17 2025-10-29 Thermo Electron Scientific Instruments LLC Method and system for positioning a sample
WO2024101416A1 (ja) * 2022-11-10 2024-05-16 キヤノン株式会社 走査方法、走査システム及び位置情報取得方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI790692A7 (fi) * 1979-03-01 1980-09-02 Suovaniemi Finnpipette Mikrokyvettenhet
JPS5827755U (ja) * 1981-08-19 1983-02-22 オリンパス光学工業株式会社 マイクロプレ−ト
JPS5891164U (ja) * 1981-12-15 1983-06-20 オリンパス光学工業株式会社 粒子凝集反応容器
AU585033B2 (en) * 1986-07-04 1989-06-08 Tosoh Corporation Quantitative dispenser for a liquid
JPS63193350U (https=) * 1987-05-30 1988-12-13
US4844617A (en) * 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
JP2717730B2 (ja) * 1991-01-09 1998-02-25 富士写真フイルム株式会社 液面レベル検出装置
US5355215A (en) * 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
US5556764A (en) * 1993-02-17 1996-09-17 Biometric Imaging, Inc. Method and apparatus for cell counting and cell classification
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
EP0695941B1 (en) * 1994-06-08 2002-07-31 Affymetrix, Inc. Method and apparatus for packaging a chip
JP2852190B2 (ja) * 1994-09-02 1999-01-27 浜松ホトニクス株式会社 微小位置測定装置
US5499097A (en) * 1994-09-19 1996-03-12 Neopath, Inc. Method and apparatus for checking automated optical system performance repeatability
IL111229A (en) * 1994-10-10 1998-06-15 Nova Measuring Instr Ltd Autofocusing microscope
US5589351A (en) * 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
US5548392A (en) * 1995-01-31 1996-08-20 Kabushikikaisha Wacom Optical position detector having scale pattern spot-illuminated to increase resolution
JPH08219812A (ja) * 1995-02-15 1996-08-30 Canon Inc 変位情報検出装置、変位情報検出用スケール及びこれを用いたドライブ制御装置
US5784152A (en) * 1995-03-16 1998-07-21 Bio-Rad Laboratories Tunable excitation and/or tunable detection microplate reader
US5776674A (en) * 1995-06-05 1998-07-07 Seq, Ltd Chemical biochemical and biological processing in thin films
US5764272A (en) * 1995-09-12 1998-06-09 Eastman Kodak Company Autofocus mechanism for laser imager
JP3291995B2 (ja) * 1995-09-13 2002-06-17 富士通株式会社 変動液面高さ測定装置及び方法
US5774214A (en) * 1996-12-12 1998-06-30 Photometrics, Ltd. Multi-mode imaging apparatus for radiation-emitting or absorbing samples
WO1998038490A1 (en) * 1997-02-27 1998-09-03 Cellomics, Inc. A system for cell-based screening
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6081487A (en) * 1998-02-13 2000-06-27 International Business Machines Corporation System for creating, reading and writing on rotatable information storage media, an apparatus for controlling laser positioning
FR2784189B3 (fr) * 1998-10-05 2000-11-03 Commissariat Energie Atomique Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire

Also Published As

Publication number Publication date
US6130745A (en) 2000-10-10
EP1942333A1 (en) 2008-07-09
EP1169632A4 (en) 2007-07-18
DE69938512T2 (de) 2009-04-30
DE69941236D1 (de) 2009-09-17
EP1942333B1 (en) 2009-08-05
DE69938512D1 (de) 2008-05-21
EP1169632B1 (en) 2008-04-09
EP1169632A1 (en) 2002-01-09
WO2000046590A1 (en) 2000-08-10
US6441894B1 (en) 2002-08-27
JP2002541430A (ja) 2002-12-03

Similar Documents

Publication Publication Date Title
JP4521121B2 (ja) マイクロタイタプレートとともに用いるための光学オートフォーカス
US7016110B2 (en) Microscope suitable for high-throughput screening having an autofocusing apparatus
US7646482B2 (en) Methods and apparatus for optical analysis of samples in biological sample containers
JP4945025B2 (ja) 軸方向高解像度を有する走査型顕微鏡方法
EP2483701B1 (en) A biosensor system for single particle detection
EP1215481B1 (en) Emission fluorometer
US8867029B2 (en) Systems for and methods of facilitating focusing an optical scanner
US7535556B2 (en) Methods and apparatus for optical analysis of samples in biological sample containers
EP1726940A1 (en) Light measurement apparatus and light measurement method
US7247825B2 (en) Method and apparatus for scanning a specimen using an optical imaging system
AU2020366521B2 (en) Virtual fiducials
CN111788473B (zh) 用于检测结合亲和力的装置
WO2002097408A1 (en) Fluorescence reader
US6819437B2 (en) Apparatus for handling liquids and a process for operating the device
JP4217061B2 (ja) 蛍光読み取り装置
JP4346442B2 (ja) 化学的及び／または生物学的試料の測定体積のサイズ及び／または形状を補正するための方法並びに装置
JPH0552896B2 (https=)
HK40037086A (en) Device for use in the detection of binding affinities
JPH07325030A (ja) 走査型レーザーサイトメータに用いられる側方散乱光検出装置

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060406

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060406

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090414

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090713

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090721

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090811

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20091110

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20091110

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20091119

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20091125

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20091125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100202

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100421

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100518

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100524

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130528

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees