JP4481011B2 - リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体 - Google Patents

リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体 Download PDF

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JP4481011B2
JP4481011B2 JP2003574195A JP2003574195A JP4481011B2 JP 4481011 B2 JP4481011 B2 JP 4481011B2 JP 2003574195 A JP2003574195 A JP 2003574195A JP 2003574195 A JP2003574195 A JP 2003574195A JP 4481011 B2 JP4481011 B2 JP 4481011B2
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alkylene
phenyl
aryl
phenoxy
mmol
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Expired - Lifetime
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Japanese (ja)
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JP2005525378A5 (https=
JP2005525378A (ja
Inventor
アドナン エム． エム． ムジャリ、
ロバート シー． アンドリューズ、
ラメッシュ ゴパラスワミー、
アニサ ハリ、
クワシ アヴォア、
ガッサン カバジャ、
シャオ−チュアン グオ、
スパーナ グプタ、
デビッド アール． ジョーンズ、
シン チェン、
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vTv Therapeutics LLC
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vTvx Holdings I LLC
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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JP2003574195A 2002-03-05 2003-03-05 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体 Expired - Lifetime JP4481011B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36198302P 2002-03-05 2002-03-05
PCT/US2003/006749 WO2003075921A2 (en) 2002-03-05 2003-03-05 Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage

Related Child Applications (1)

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JP2008271566A Division JP2009096806A (ja) 2002-03-05 2008-10-22 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体

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JP2005525378A JP2005525378A (ja) 2005-08-25
JP2005525378A5 JP2005525378A5 (https=) 2007-12-06
JP4481011B2 true JP4481011B2 (ja) 2010-06-16

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JP2003574195A Expired - Lifetime JP4481011B2 (ja) 2002-03-05 2003-03-05 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体
JP2008271566A Pending JP2009096806A (ja) 2002-03-05 2008-10-22 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体

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JP2008271566A Pending JP2009096806A (ja) 2002-03-05 2008-10-22 リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体

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US (5) US7361678B2 (https=)
EP (2) EP2324830A1 (https=)
JP (2) JP4481011B2 (https=)
CN (3) CN101613321A (https=)
AT (1) ATE529110T1 (https=)
AU (2) AU2007202350B2 (https=)
CA (1) CA2476594C (https=)
DK (1) DK1482931T3 (https=)
ES (1) ES2373875T3 (https=)
WO (1) WO2003075921A2 (https=)

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EP2324830A1 (en) 2011-05-25
EP1482931A2 (en) 2004-12-08
AU2009202814B2 (en) 2011-07-14
AU2007202350A1 (en) 2007-06-14
US20100256119A1 (en) 2010-10-07
US7737285B2 (en) 2010-06-15
CN1633290A (zh) 2005-06-29
WO2003075921A2 (en) 2003-09-18
ATE529110T1 (de) 2011-11-15
US20040082542A1 (en) 2004-04-29
WO2003075921A3 (en) 2003-12-04
DK1482931T3 (da) 2011-12-19
AU2003217943A1 (en) 2003-09-22
CN100525763C (zh) 2009-08-12
HK1069549A1 (en) 2005-05-27
JP2009096806A (ja) 2009-05-07
JP2005525378A (ja) 2005-08-25
US7361678B2 (en) 2008-04-22
US20070213347A1 (en) 2007-09-13
US20120088778A1 (en) 2012-04-12
US7714013B2 (en) 2010-05-11
CN101597262A (zh) 2009-12-09
AU2009202814A1 (en) 2009-08-06
CA2476594C (en) 2012-10-09
CN101613321A (zh) 2009-12-30
ES2373875T3 (es) 2012-02-09
AU2007202350B2 (en) 2009-07-30
CA2476594A1 (en) 2003-09-18
EP1482931B1 (en) 2011-10-19

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