JP4390389B2 - Ｓ−ｎ，ｎ′−ビス〔２−ヒドロキシ−１−（ヒドロキシメチル）エチル〕−５−〔（２−ヒドロキシ−１−オキソプロピル）アミノ〕−２，４，６−トリヨード−１，３−ベンゼンジカルボキシアミドを製造する方法 - Google Patents

Ｓ−ｎ，ｎ′−ビス〔２−ヒドロキシ−１−（ヒドロキシメチル）エチル〕−５−〔（２−ヒドロキシ−１−オキソプロピル）アミノ〕−２，４，６−トリヨード−１，３−ベンゼンジカルボキシアミドを製造する方法 Download PDF

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Publication number
JP4390389B2
JP4390389B2 JP2000548298A JP2000548298A JP4390389B2 JP 4390389 B2 JP4390389 B2 JP 4390389B2 JP 2000548298 A JP2000548298 A JP 2000548298A JP 2000548298 A JP2000548298 A JP 2000548298A JP 4390389 B2 JP4390389 B2 JP 4390389B2
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JP
Japan
Prior art keywords
solvent
amino
triiodo
oxopropyl
hydroxy
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JP2000548298A
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Japanese (ja)
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JP2002517381A (ja
JP2002517381A5 (enExample
Inventor
デサンティス，ニコラ
インカンデラ，サルヴァトーレ
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Dibra SpA
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Dibra SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
JP2000548298A 1998-05-08 1999-04-26 Ｓ−ｎ，ｎ′−ビス〔２−ヒドロキシ−１−（ヒドロキシメチル）エチル〕−５−〔（２−ヒドロキシ−１−オキソプロピル）アミノ〕−２，４，６−トリヨード−１，３−ベンゼンジカルボキシアミドを製造する方法 Expired - Lifetime JP4390389B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT98MI001005A IT1299202B1 (it) 1998-05-08 1998-05-08 Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
IT98A001005 1998-05-08
PCT/EP1999/002804 WO1999058494A2 (en) 1998-05-08 1999-04-26 Process for the preparation of s- n,n'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide

Publications (3)

Publication Number Publication Date
JP2002517381A JP2002517381A (ja) 2002-06-18
JP2002517381A5 JP2002517381A5 (enExample) 2006-06-15
JP4390389B2 true JP4390389B2 (ja) 2009-12-24

Family

ID=11379983

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000548298A Expired - Lifetime JP4390389B2 (ja) 1998-05-08 1999-04-26 Ｓ−ｎ，ｎ′−ビス〔２−ヒドロキシ−１−（ヒドロキシメチル）エチル〕−５−〔（２−ヒドロキシ−１−オキソプロピル）アミノ〕−２，４，６−トリヨード−１，３−ベンゼンジカルボキシアミドを製造する方法

Country Status (15)

Country Link
EP (1) EP1075462B1 (enExample)
JP (1) JP4390389B2 (enExample)
KR (1) KR100612480B1 (enExample)
CN (1) CN100336800C (enExample)
AT (1) ATE243676T1 (enExample)
AU (1) AU749785B2 (enExample)
CA (1) CA2331660C (enExample)
CZ (1) CZ293801B6 (enExample)
DE (1) DE69909078T2 (enExample)
DK (1) DK1075462T3 (enExample)
ES (1) ES2201719T3 (enExample)
IT (1) IT1299202B1 (enExample)
NO (1) NO326203B1 (enExample)
PT (1) PT1075462E (enExample)
WO (1) WO1999058494A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101098553B1 (ko) * 2008-04-30 2011-12-26 주식회사 엘지생명과학 이오프로마이드의 신규한 제조방법
ES2637010T3 (es) * 2008-11-18 2017-10-10 Bracco Imaging S.P.A Proceso para la preparación de agente de contraste yodado
EP2230227A1 (en) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
US9926257B2 (en) 2012-12-11 2018-03-27 Bracco Imaging S.P.A. Continuous process for the preparation of (S)-2-acetyloxypropionic acid chloride
LT3066071T (lt) 2013-11-05 2018-09-10 Bracco Imaging S.P.A. Jopamidolio gamybos būdas
LT3154928T (lt) 2014-06-10 2020-05-11 Bracco Imaging S.P.A. (s)-2-acetiloksipropioninės rūgšties ir jos darinių gavimo būdas
CN105272899B (zh) * 2015-11-17 2017-09-22 浙江海洲制药有限公司 一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法
EP3548461B1 (en) * 2016-12-05 2021-02-03 Bracco Imaging SpA Mechanochemical synthesis of radiographic agents intermediates
CN110687226B (zh) * 2019-10-18 2022-10-25 上海明捷医药科技有限公司 一种测定碘帕醇中2-氯丙酸含量的方法
JP2024545278A (ja) 2021-12-20 2024-12-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ２，４，６－トリヨードイソフタル酸ビスアミドの製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (enExample) * 1974-12-13 1978-12-29 Savac Ag
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1256163B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio

Also Published As

Publication number Publication date
AU749785B2 (en) 2002-07-04
KR20010071221A (ko) 2001-07-28
DK1075462T3 (da) 2003-10-13
WO1999058494A3 (en) 2000-01-20
EP1075462A2 (en) 2001-02-14
CZ20004124A3 (cs) 2002-03-13
WO1999058494A2 (en) 1999-11-18
PT1075462E (pt) 2003-10-31
CN100336800C (zh) 2007-09-12
JP2002517381A (ja) 2002-06-18
NO20005616L (no) 2000-11-07
CN1302288A (zh) 2001-07-04
AU4135699A (en) 1999-11-29
NO326203B1 (no) 2008-10-20
ES2201719T3 (es) 2004-03-16
CZ293801B6 (cs) 2004-08-18
NO20005616D0 (no) 2000-11-07
CA2331660A1 (en) 1999-11-18
IT1299202B1 (it) 2000-02-29
KR100612480B1 (ko) 2006-08-16
ITMI981005A1 (it) 1999-11-08
ATE243676T1 (de) 2003-07-15
CA2331660C (en) 2008-07-08
DE69909078T2 (de) 2003-12-18
DE69909078D1 (de) 2003-07-31
EP1075462B1 (en) 2003-06-25

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