DK1075462T3 - Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid. - Google Patents

Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid.

Info

Publication number
DK1075462T3
DK1075462T3 DK99924824T DK99924824T DK1075462T3 DK 1075462 T3 DK1075462 T3 DK 1075462T3 DK 99924824 T DK99924824 T DK 99924824T DK 99924824 T DK99924824 T DK 99924824T DK 1075462 T3 DK1075462 T3 DK 1075462T3
Authority
DK
Denmark
Prior art keywords
hydroxy
triiodo
oxopropyl
amino
benzenedicarboxamide
Prior art date
Application number
DK99924824T
Other languages
Danish (da)
English (en)
Inventor
Nicola Desantis
Salvatore Incandela
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of DK1075462T3 publication Critical patent/DK1075462T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
DK99924824T 1998-05-08 1999-04-26 Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid. DK1075462T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98MI001005A IT1299202B1 (it) 1998-05-08 1998-05-08 Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
PCT/EP1999/002804 WO1999058494A2 (en) 1998-05-08 1999-04-26 Process for the preparation of s- n,n'- bis[2- hydroxy-1- (hydroxymethyl) ethyl]-5- [(2- hydroxy-1- oxopropyl)- amino]- 2,4,6- triiodo- 1,3- benzenedicarboxamide

Publications (1)

Publication Number Publication Date
DK1075462T3 true DK1075462T3 (da) 2003-10-13

Family

ID=11379983

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99924824T DK1075462T3 (da) 1998-05-08 1999-04-26 Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid.

Country Status (15)

Country Link
EP (1) EP1075462B1 (enExample)
JP (1) JP4390389B2 (enExample)
KR (1) KR100612480B1 (enExample)
CN (1) CN100336800C (enExample)
AT (1) ATE243676T1 (enExample)
AU (1) AU749785B2 (enExample)
CA (1) CA2331660C (enExample)
CZ (1) CZ293801B6 (enExample)
DE (1) DE69909078T2 (enExample)
DK (1) DK1075462T3 (enExample)
ES (1) ES2201719T3 (enExample)
IT (1) IT1299202B1 (enExample)
NO (1) NO326203B1 (enExample)
PT (1) PT1075462E (enExample)
WO (1) WO1999058494A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101098553B1 (ko) * 2008-04-30 2011-12-26 주식회사 엘지생명과학 이오프로마이드의 신규한 제조방법
PL2365963T3 (pl) * 2008-11-18 2017-12-29 Bracco Imaging S.P.A Sposób przygotowywania jodowanych środków kontrastowych
EP2230227A1 (en) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
JP6694713B2 (ja) 2012-12-11 2020-05-20 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． （ｓ）−２−アセチルオキシプロピオン酸クロリドの連続製造方法
PT3066071T (pt) 2013-11-05 2018-06-25 Bracco Imaging Spa Processo para a preparação de iopamidol
US9963416B2 (en) 2014-06-10 2018-05-08 Bracco Imaging S.P.A. Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof
CN105272899B (zh) * 2015-11-17 2017-09-22 浙江海洲制药有限公司 一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法
CN110023279B (zh) * 2016-12-05 2022-03-11 伯拉考成像股份公司 放射照相剂中间体的机械化学合成
CN110687226B (zh) * 2019-10-18 2022-10-25 上海明捷医药科技有限公司 一种测定碘帕醇中2-氯丙酸含量的方法
CN118414325A (zh) 2021-12-20 2024-07-30 伯拉考成像股份公司 制备2,4,6-三碘间苯二甲酸双酰胺的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (enExample) * 1974-12-13 1978-12-29 Savac Ag
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1256163B (it) * 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio

Also Published As

Publication number Publication date
CN1302288A (zh) 2001-07-04
AU4135699A (en) 1999-11-29
CZ293801B6 (cs) 2004-08-18
JP2002517381A (ja) 2002-06-18
NO20005616L (no) 2000-11-07
DE69909078T2 (de) 2003-12-18
NO20005616D0 (no) 2000-11-07
ATE243676T1 (de) 2003-07-15
NO326203B1 (no) 2008-10-20
AU749785B2 (en) 2002-07-04
CN100336800C (zh) 2007-09-12
JP4390389B2 (ja) 2009-12-24
WO1999058494A3 (en) 2000-01-20
CA2331660A1 (en) 1999-11-18
KR100612480B1 (ko) 2006-08-16
IT1299202B1 (it) 2000-02-29
EP1075462B1 (en) 2003-06-25
ES2201719T3 (es) 2004-03-16
CZ20004124A3 (cs) 2002-03-13
EP1075462A2 (en) 2001-02-14
PT1075462E (pt) 2003-10-31
CA2331660C (en) 2008-07-08
ITMI981005A1 (it) 1999-11-08
KR20010071221A (ko) 2001-07-28
WO1999058494A2 (en) 1999-11-18
DE69909078D1 (de) 2003-07-31

Similar Documents

Publication Publication Date Title
ES2074734T5 (es) Utilizacion de composiciones a base de alcoholes grasos, para la preparacion de emulsiones; procedimiento de preparacion de emulsiones y emulsiones asi obtenidas.
DE69831401D1 (de) Poröser metall und verfahren zur herstellung
DK1075462T3 (da) Fremgangsmåde til fremstilling af S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiod-1,3-benzendicarboxamid.
IL160045A0 (en) Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
BR9610129A (pt) Processo para preparação de compostos alifáticos fluorados
PL295030A1 (en) Method of obtaining substituted derivatives of 2-cyclohexan-1-yl amine
PT1154986E (pt) Processo para a preparacao de iopamidol
HU216548B (hu) Eljárás benzoldikarbonsav-dikloridok előállítására, és a köztitermék
ATE238271T1 (de) Desformoterol und verfahren zu seiner herstellung
ITMI962545A0 (it) Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
DE69910609D1 (de) Verfahren zur herstellung von n,n'-bis,2,3-dihydroxypropyl]-5-[(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide
BR0114216A (pt) Composições de catalisadores de secagem por aspersão e métodos de secagem por aspersão
ES2136011A1 (es) Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados.
BR9908970A (pt) Processo para a preparação do composto, e, composto
ES2185196T3 (es) Un procedimiento para la preparacion de tetraazamacrociclos.
DE69906999D1 (de) Verfahren zur herstellung von s-n, n'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]- 5-[(2-hydroxy-1-oxopropyl)amino]-2, 4, 6-triiodo-1, 3-benzdicarboxamid
CO4700431A1 (es) Benzamidas para el tratamiento de desordenes neurodegenerativos
ATE17470T1 (de) Aliphatische ether des cyclododecen-2-ols, verfahren zu ihrer herstellung sowie ihre verwendung zur herstellung von riechstoffkompositionen.
ATE401298T1 (de) Verbessertes verfahren zur herstellung von 2s,3s- n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin
DE59107545D1 (de) Salicylaldehyd- und Salicylsäurederivate sowie deren Schwefelanaloge, Verfahren und Zwischenprodukte zu ihrer Herstellung
FR2697249B1 (fr) Procédé de préparation du bis(1,3-dihydroxypropylamide) d'acide L-5-(2-acétoxypropionylamino)-2,4,6-triiodo-isophtalique.
DE69717156D1 (de) Verfahren zur kritallisation von (s)-n-n'-bis [2-hydroxy-1-(hydroxymethyl) ethyl]-5-[(2-hydroxy-1-oxopropyl) amino]-2,4,6-triiodo-1,3-benzoldicarboxamid aus linearem oder verzweigtem (c5-c6) alkohol oder gemischen davon
ES518377A0 (es) Procedimiento para la preparacion de pirido (1,4) benzodiazepinas.
DE69503212D1 (de) Verfahren zur Herstellung von (1,1-Dichloromethyl)methylether und (1,1-Dichloromethyl)ethylether
BR0317297A (pt) Processo para preparação de polioxialquileno glicol, e, uso de um polietileno glicol