JP4335529B2 - ジヒドロピロンの連続的製造方法 - Google Patents

ジヒドロピロンの連続的製造方法 Download PDF

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Publication number
JP4335529B2
JP4335529B2 JP2002567917A JP2002567917A JP4335529B2 JP 4335529 B2 JP4335529 B2 JP 4335529B2 JP 2002567917 A JP2002567917 A JP 2002567917A JP 2002567917 A JP2002567917 A JP 2002567917A JP 4335529 B2 JP4335529 B2 JP 4335529B2
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Japan
Prior art keywords
formula
acetoacetate
process according
compound
alkyl
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Expired - Fee Related
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JP2002567917A
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English (en)
Japanese (ja)
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JP2004522784A5 (enExample
JP2004522784A (ja
Inventor
マルクス ザウター
オーリヴァー マイヤー
マルーク ゲーリッヒ
Original Assignee
ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト
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Publication of JP2004522784A publication Critical patent/JP2004522784A/ja
Publication of JP2004522784A5 publication Critical patent/JP2004522784A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002567917A 2001-02-22 2002-02-20 ジヒドロピロンの連続的製造方法 Expired - Fee Related JP4335529B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2001108471 DE10108471C1 (de) 2001-02-22 2001-02-22 Kontinuierliches Verfahren zur Herstellung von 5,6-Dihydro-4-hydroxy-2-pyronen
PCT/EP2002/001772 WO2002068403A1 (de) 2001-02-22 2002-02-20 Kontinuierliches verfahren zur herstellung von dihydropyronen

Publications (3)

Publication Number Publication Date
JP2004522784A JP2004522784A (ja) 2004-07-29
JP2004522784A5 JP2004522784A5 (enExample) 2005-12-22
JP4335529B2 true JP4335529B2 (ja) 2009-09-30

Family

ID=7675073

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002567917A Expired - Fee Related JP4335529B2 (ja) 2001-02-22 2002-02-20 ジヒドロピロンの連続的製造方法

Country Status (6)

Country Link
EP (1) EP1368331B1 (enExample)
JP (1) JP4335529B2 (enExample)
CA (1) CA2438878C (enExample)
DE (1) DE10108471C1 (enExample)
MX (1) MXPA03007531A (enExample)
WO (1) WO2002068403A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10257761A1 (de) 2002-12-10 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung optisch aktiver Dihydropyrone
DE10303581A1 (de) * 2003-01-30 2004-08-12 Clariant Gmbh Acetoacetylierung von Alkoholen, Thiolen und Aminen im Mikroreaktor
DE10333174A1 (de) * 2003-07-22 2005-02-17 Cpc Cellular Process Chemistry Systems Gmbh Verfahren zur Durchführung einer In-Situ-Quench Reaktion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1142887T1 (en) 1993-11-19 2004-08-31 Parke, Davis & Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US5834506A (en) 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
DE19708472C2 (de) 1997-02-20 1999-02-18 Atotech Deutschland Gmbh Herstellverfahren für chemische Mikroreaktoren
US6380400B1 (en) 1998-09-11 2002-04-30 Victor Fedij Methods of making dihydropyrone HIV protease inhibitors
DE19935691A1 (de) 1999-07-29 2001-02-01 Merck Patent Gmbh Friedel-Crafts-Acylierung im statischen Mikromischer
DE10001317A1 (de) 2000-01-14 2001-07-19 Merck Patent Gmbh Reaktion von Carbonylverbindungen mit metallorganischen Reagenzien

Also Published As

Publication number Publication date
CA2438878A1 (en) 2002-09-06
CA2438878C (en) 2010-05-04
EP1368331B1 (de) 2014-04-09
WO2002068403A1 (de) 2002-09-06
EP1368331A1 (de) 2003-12-10
MXPA03007531A (es) 2003-12-04
JP2004522784A (ja) 2004-07-29
DE10108471C1 (de) 2002-11-21

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