JP4313435B2 - プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制 - Google Patents
プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制 Download PDFInfo
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- JP4313435B2 JP4313435B2 JP50696497A JP50696497A JP4313435B2 JP 4313435 B2 JP4313435 B2 JP 4313435B2 JP 50696497 A JP50696497 A JP 50696497A JP 50696497 A JP50696497 A JP 50696497A JP 4313435 B2 JP4313435 B2 JP 4313435B2
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| US143995P | 1995-07-24 | 1995-07-24 | |
| US60/001,439 | 1995-07-24 | ||
| US50775795A | 1995-07-26 | 1995-07-26 | |
| US08/507,757 | 1995-07-26 | ||
| US08/559,442 US5888996A (en) | 1995-07-26 | 1995-11-15 | Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity |
| US08/559,442 | 1995-11-15 | ||
| PCT/US1996/012198 WO1997003677A1 (en) | 1995-07-24 | 1996-07-24 | Inhibition of nmda receptor activity by pregnenolone sulfate derivatives |
Publications (3)
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| JPH11509844A JPH11509844A (ja) | 1999-08-31 |
| JPH11509844A5 JPH11509844A5 (enExample) | 2009-05-07 |
| JP4313435B2 true JP4313435B2 (ja) | 2009-08-12 |
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| US (1) | US6083941A (enExample) |
| EP (1) | EP0840612A1 (enExample) |
| JP (1) | JP4313435B2 (enExample) |
| WO (1) | WO1997003677A1 (enExample) |
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| US20010051599A1 (en) * | 1997-05-02 | 2001-12-13 | Michael Z. Kagan | Pregnan-3-ol-20-ones |
| JP2002529416A (ja) * | 1998-11-10 | 2002-09-10 | メディモド・リサーチ・インスティチュート・ゲーエムベーハー | 嗜癖の治療のためのグルココルチコステロイド・レセプターおよび／またはミネラルコルチコステロイド・レセプターのアゴニスト、特にコルチコステロイドの使用 |
| FR2786102B1 (fr) * | 1998-11-20 | 2001-02-16 | Monique Vincens | Utilisation de sulfate de dehydroepiandrosterone pour augmenter le nombre de recepteurs nmda chez un mammifere |
| GB9917822D0 (en) * | 1999-07-29 | 1999-09-29 | Imperial College | Nmda antagonist |
| US20040204490A1 (en) * | 1999-08-31 | 2004-10-14 | Farb David H. | Effect of steroids on NMDA receptors depends on subunit composition |
| US6623933B1 (en) | 1999-08-31 | 2003-09-23 | Trustees Of Boston University | Methods for identifying a subunit specific modulator of N-methyl-D-asparate receptor |
| GB0003524D0 (en) * | 2000-02-15 | 2000-04-05 | Btg Int Ltd | Cytoprotective steroids (II) |
| GB2363983A (en) | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 7-hydroxyepiandrosterone |
| WO2002036128A1 (en) * | 2000-11-06 | 2002-05-10 | Trustees Of Boston University | Neuroactive steroid derivatives and methods of use |
| US20030013692A1 (en) * | 2001-01-19 | 2003-01-16 | Gullans Steven R. | Methods of treating neurological disorders |
| JP2005506292A (ja) * | 2001-03-08 | 2005-03-03 | エモリー ユニバーシティ | ｐＨに依存するＮＭＤＡレセプターアンタゴニスト |
| ATE327744T1 (de) * | 2001-03-20 | 2006-06-15 | Sanol Arznei Schwarz Gmbh | Neue verwendung von peptidverbindungen bei der behandlung von nicht-neuropathischem entzündungsschmerz |
| DE60100055T2 (de) * | 2001-03-21 | 2003-07-24 | Schwarz Pharma Ag | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
| US7790404B2 (en) * | 2001-08-20 | 2010-09-07 | Sanford-Burnham Medical Research Institute | Excitatory glycine receptors and methods |
| AUPR731901A0 (en) * | 2001-08-28 | 2001-09-20 | Goodchild, Colin Stanley | Method of treatment |
| FR2850023B1 (fr) * | 2003-01-17 | 2007-04-06 | Mapreg | Medicaments pour le systeme nerveux |
| IL154318A (en) * | 2003-02-06 | 2010-05-31 | Sarah Herzog Memorial Hospital | Pharmaceutical compositions for the treatment of movement disorders |
| EP1621199B8 (en) * | 2003-04-18 | 2011-01-19 | Advanced Medicine Research Institute | Remedies for diseases to be applied to eye |
| US7794987B2 (en) * | 2003-12-02 | 2010-09-14 | Ucb Pharma Gmbh | Method for treating central neuropathic pain |
| US7067504B2 (en) * | 2004-01-15 | 2006-06-27 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of ethinyl estradiol |
| WO2005070949A1 (en) * | 2004-01-15 | 2005-08-04 | Warner Chilcott Company, Inc. | Di-steroidal prodrugs of estradiol |
| US20100256179A1 (en) * | 2004-03-26 | 2010-10-07 | Ucb Pharma Gmbh | Combination therapy for pain in painful diabetic neuropathy |
| US20070042969A1 (en) * | 2004-03-26 | 2007-02-22 | Srz Properties, Inc. | Combination therapy for pain in painful diabetic neuropathy |
| KR20070007931A (ko) | 2004-04-16 | 2007-01-16 | 쉬바르츠파르마에이지 | 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도 |
| EP1604655A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| EP1604656A1 (en) * | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| PL1781276T3 (pl) * | 2004-08-27 | 2010-11-30 | Ucb Pharma Gmbh | Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy |
| US20060252749A1 (en) * | 2005-01-28 | 2006-11-09 | Srz Properties, Inc. | Lacosamide for add-on therapy of psychosis |
| EP1910402A2 (en) * | 2005-07-12 | 2008-04-16 | Warner Chilcott Company, Inc. | 3-ester prodrugs of estradiol |
| CA2610475C (en) * | 2005-07-12 | 2013-09-17 | Warner Chilcott Company, Inc. | Derivative prodrugs of ethinyl estradiol |
| US20070048372A1 (en) * | 2005-08-18 | 2007-03-01 | Srz Properties, Inc. | Method for treating non-inflammatory osteoarthritic pain |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| JP4382735B2 (ja) * | 2005-10-06 | 2009-12-16 | 独立行政法人科学技術振興機構 | 神経因性疼痛治療剤 |
| TR201708352T4 (tr) * | 2005-10-28 | 2018-11-21 | Univ Industry Cooperation Group Kyung Hee Univ | Dioscoreaceae familyasına ait özüt ve periferik nöropatinin önlenmesi veya tedavi edilmesi için bunu içeren bileşim. |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
| CN101466390B (zh) * | 2006-06-15 | 2014-03-12 | 优时比制药有限公司 | 用于治疗难治性癫痫持续状态的肽类化合物 |
| US20090203658A1 (en) * | 2007-01-08 | 2009-08-13 | Duke University | Neuroactive steroid compositions and methods of use therefor |
| KR20100045983A (ko) | 2007-06-29 | 2010-05-04 | 에모리 유니버시티 | 신경보호를 위한 ｎｍｄａ 수용체 길항물질 |
| EP2403501A4 (en) * | 2008-12-09 | 2012-09-19 | King Faisal Specialist Hospital & Res Ct | PREGNENOLONSULFATE FOR THE TREATMENT OF NEUROLOGICAL DISEASES |
| HUE062616T2 (hu) * | 2011-09-08 | 2023-11-28 | Sage Therapeutics Inc | Neuroaktív szteroidok, készítmények és alkalmazásaik |
| US10478505B2 (en) | 2011-09-23 | 2019-11-19 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
| SG10201606063RA (en) | 2012-01-23 | 2016-09-29 | Sage Therapeutics Inc | Neuroactive steroid formulations and methods of treating cns disorders |
| FR2992645B1 (fr) * | 2012-07-02 | 2014-08-01 | Univ Claude Bernard Lyon | Nouveaux derives de pyrrolidine |
| RS62761B1 (sr) | 2012-08-21 | 2022-01-31 | Sage Therapeutics Inc | Alopregnanolon za lečenje refraktornog epileptičkog statusa |
| US20150313915A1 (en) | 2012-11-30 | 2015-11-05 | The Regents Of The University Of California | Anticonvulsant activity of steroids |
| FI3932932T3 (fi) | 2013-03-13 | 2025-10-15 | Sage Therapeutics Inc | Neuroaktiivisia steroideja ja niiden käyttömenetelmiä |
| JP6628745B2 (ja) | 2014-06-18 | 2020-01-15 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびその使用方法 |
| CZ305733B6 (cs) | 2014-08-26 | 2016-02-24 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | Amfifilní sloučeniny s neuroprotektivními účinky |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| PT3319611T (pt) | 2015-07-06 | 2021-04-22 | Sage Therapeutics Inc | Oxisteróis e métodos de utilização dos mesmos |
| DK3812392T3 (da) | 2015-07-06 | 2025-07-21 | Sage Therapeutics Inc | Oxysteroler og fremgangsmåder til anvendelse deraf |
| PH12018501923B1 (en) | 2016-03-08 | 2024-06-28 | Sage Therapeutics Inc | Neuroactive steroids, compositions, and uses thereof |
| ES2921010T3 (es) | 2016-04-01 | 2022-08-16 | Sage Therapeutics Inc | Oxisteroles y procedimientos de uso de los mismos |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2018009867A1 (en) * | 2016-07-07 | 2018-01-11 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| MA46351A (fr) | 2016-09-30 | 2021-06-02 | Sage Therapeutics Inc | Oxystérols substitués en c7 et procédés en tant que modulateurs nmda |
| DK3529257T3 (da) | 2016-10-18 | 2023-08-07 | Sage Therapeutics Inc | Oxysteroler og fremgangsmåder til anvendelse deraf |
| KR102521573B1 (ko) | 2016-10-18 | 2023-04-14 | 세이지 테라퓨틱스, 인크. | 옥시스테롤 및 그의 사용 방법 |
| EP3988096A1 (en) * | 2020-10-26 | 2022-04-27 | Universidad Pablo de Olavide OTRI | Sulfated c19 steroid hormones to treat and/or prevent proteotoxicity in protein-aggregation diseases |
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|---|---|---|---|---|
| US5212167A (en) * | 1991-09-12 | 1993-05-18 | Trustees Of Boston University | Modulation of receptor-mediated ion transport |
| CA2118938A1 (en) * | 1991-09-13 | 1993-04-01 | Kelvin W. Gee | Novel gabaa receptor with steroid binding sites |
| JP4008024B2 (ja) * | 1993-05-24 | 2007-11-14 | パーデュー、ファーマ、リミテッド、パートナーシップ | Ｇａｂａａレセプター複合体と相互作用させるための化合物 |
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- 1996-07-24 EP EP96926768A patent/EP0840612A1/en not_active Withdrawn
- 1996-07-24 WO PCT/US1996/012198 patent/WO1997003677A1/en not_active Ceased
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1998
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|---|---|
| EP0840612A1 (en) | 1998-05-13 |
| JPH11509844A (ja) | 1999-08-31 |
| US6083941A (en) | 2000-07-04 |
| WO1997003677A1 (en) | 1997-02-06 |
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