JPH11509844A5 - - Google Patents

Info

Publication number
JPH11509844A5
JPH11509844A5 JP1997506964A JP50696497A JPH11509844A5 JP H11509844 A5 JPH11509844 A5 JP H11509844A5 JP 1997506964 A JP1997506964 A JP 1997506964A JP 50696497 A JP50696497 A JP 50696497A JP H11509844 A5 JPH11509844 A5 JP H11509844A5
Authority
JP
Japan
Prior art keywords
nmda
sulfate
response
5β3βs
5β3αs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1997506964A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11509844A (ja
JP4313435B2 (ja
Filing date
Publication date
Priority claimed from US08/559,442 external-priority patent/US5888996A/en
Application filed filed Critical
Priority claimed from PCT/US1996/012198 external-priority patent/WO1997003677A1/en
Publication of JPH11509844A publication Critical patent/JPH11509844A/ja
Publication of JPH11509844A5 publication Critical patent/JPH11509844A5/ja
Application granted granted Critical
Publication of JP4313435B2 publication Critical patent/JP4313435B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP50696497A 1995-07-24 1996-07-24 プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制 Expired - Fee Related JP4313435B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US143995P 1995-07-24 1995-07-24
US60/001,439 1995-07-24
US50775795A 1995-07-26 1995-07-26
US08/507,757 1995-07-26
US08/559,442 US5888996A (en) 1995-07-26 1995-11-15 Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
US08/559,442 1995-11-15
PCT/US1996/012198 WO1997003677A1 (en) 1995-07-24 1996-07-24 Inhibition of nmda receptor activity by pregnenolone sulfate derivatives

Publications (3)

Publication Number Publication Date
JPH11509844A JPH11509844A (ja) 1999-08-31
JPH11509844A5 true JPH11509844A5 (enExample) 2009-05-07
JP4313435B2 JP4313435B2 (ja) 2009-08-12

Family

ID=27356924

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50696497A Expired - Fee Related JP4313435B2 (ja) 1995-07-24 1996-07-24 プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制

Country Status (4)

Country Link
US (1) US6083941A (enExample)
EP (1) EP0840612A1 (enExample)
JP (1) JP4313435B2 (enExample)
WO (1) WO1997003677A1 (enExample)

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JP2002529416A (ja) * 1998-11-10 2002-09-10 メディモド・リサーチ・インスティチュート・ゲーエムベーハー 嗜癖の治療のためのグルココルチコステロイド・レセプターおよび／またはミネラルコルチコステロイド・レセプターのアゴニスト、特にコルチコステロイドの使用
FR2786102B1 (fr) * 1998-11-20 2001-02-16 Monique Vincens Utilisation de sulfate de dehydroepiandrosterone pour augmenter le nombre de recepteurs nmda chez un mammifere
GB9917822D0 (en) * 1999-07-29 1999-09-29 Imperial College Nmda antagonist
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US6623933B1 (en) 1999-08-31 2003-09-23 Trustees Of Boston University Methods for identifying a subunit specific modulator of N-methyl-D-asparate receptor
GB0003524D0 (en) * 2000-02-15 2000-04-05 Btg Int Ltd Cytoprotective steroids (II)
GB2363983A (en) 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 7-hydroxyepiandrosterone
WO2002036128A1 (en) * 2000-11-06 2002-05-10 Trustees Of Boston University Neuroactive steroid derivatives and methods of use
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JP2005506292A (ja) * 2001-03-08 2005-03-03 エモリー　ユニバーシティ ｐＨに依存するＮＭＤＡレセプターアンタゴニスト
ATE327744T1 (de) * 2001-03-20 2006-06-15 Sanol Arznei Schwarz Gmbh Neue verwendung von peptidverbindungen bei der behandlung von nicht-neuropathischem entzündungsschmerz
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AUPR731901A0 (en) * 2001-08-28 2001-09-20 Goodchild, Colin Stanley Method of treatment
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US7067504B2 (en) * 2004-01-15 2006-06-27 Warner Chilcott Company, Inc. Di-steroidal prodrugs of ethinyl estradiol
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US20100256179A1 (en) * 2004-03-26 2010-10-07 Ucb Pharma Gmbh Combination therapy for pain in painful diabetic neuropathy
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KR20070007931A (ko) 2004-04-16 2007-01-16 쉬바르츠파르마에이지 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도
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EP1604656A1 (en) * 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
PL1781276T3 (pl) * 2004-08-27 2010-11-30 Ucb Pharma Gmbh Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy
US20060252749A1 (en) * 2005-01-28 2006-11-09 Srz Properties, Inc. Lacosamide for add-on therapy of psychosis
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JP4382735B2 (ja) * 2005-10-06 2009-12-16 独立行政法人科学技術振興機構 神経因性疼痛治療剤
TR201708352T4 (tr) * 2005-10-28 2018-11-21 Univ Industry Cooperation Group Kyung Hee Univ Dioscoreaceae familyasına ait özüt ve periferik nöropatinin önlenmesi veya tedavi edilmesi için bunu içeren bileşim.
EA019757B1 (ru) 2006-06-15 2014-06-30 ЮСиБи ФАРМА ГМБХ Фармацевтическая композиция с синергетическим противосудорожным эффектом
CN101466390B (zh) * 2006-06-15 2014-03-12 优时比制药有限公司 用于治疗难治性癫痫持续状态的肽类化合物
US20090203658A1 (en) * 2007-01-08 2009-08-13 Duke University Neuroactive steroid compositions and methods of use therefor
KR20100045983A (ko) 2007-06-29 2010-05-04 에모리 유니버시티 신경보호를 위한 ｎｍｄａ 수용체 길항물질
EP2403501A4 (en) * 2008-12-09 2012-09-19 King Faisal Specialist Hospital & Res Ct PREGNENOLONSULFATE FOR THE TREATMENT OF NEUROLOGICAL DISEASES
HUE062616T2 (hu) * 2011-09-08 2023-11-28 Sage Therapeutics Inc Neuroaktív szteroidok, készítmények és alkalmazásaik
US10478505B2 (en) 2011-09-23 2019-11-19 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
SG10201606063RA (en) 2012-01-23 2016-09-29 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
FR2992645B1 (fr) * 2012-07-02 2014-08-01 Univ Claude Bernard Lyon Nouveaux derives de pyrrolidine
RS62761B1 (sr) 2012-08-21 2022-01-31 Sage Therapeutics Inc Alopregnanolon za lečenje refraktornog epileptičkog statusa
US20150313915A1 (en) 2012-11-30 2015-11-05 The Regents Of The University Of California Anticonvulsant activity of steroids
FI3932932T3 (fi) 2013-03-13 2025-10-15 Sage Therapeutics Inc Neuroaktiivisia steroideja ja niiden käyttömenetelmiä
JP6628745B2 (ja) 2014-06-18 2020-01-15 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびその使用方法
CZ305733B6 (cs) 2014-08-26 2016-02-24 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Amfifilní sloučeniny s neuroprotektivními účinky
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
PT3319611T (pt) 2015-07-06 2021-04-22 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
DK3812392T3 (da) 2015-07-06 2025-07-21 Sage Therapeutics Inc Oxysteroler og fremgangsmåder til anvendelse deraf
PH12018501923B1 (en) 2016-03-08 2024-06-28 Sage Therapeutics Inc Neuroactive steroids, compositions, and uses thereof
ES2921010T3 (es) 2016-04-01 2022-08-16 Sage Therapeutics Inc Oxisteroles y procedimientos de uso de los mismos
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
WO2018009867A1 (en) * 2016-07-07 2018-01-11 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MA46351A (fr) 2016-09-30 2021-06-02 Sage Therapeutics Inc Oxystérols substitués en c7 et procédés en tant que modulateurs nmda
DK3529257T3 (da) 2016-10-18 2023-08-07 Sage Therapeutics Inc Oxysteroler og fremgangsmåder til anvendelse deraf
KR102521573B1 (ko) 2016-10-18 2023-04-14 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
EP3988096A1 (en) * 2020-10-26 2022-04-27 Universidad Pablo de Olavide OTRI Sulfated c19 steroid hormones to treat and/or prevent proteotoxicity in protein-aggregation diseases

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US5212167A (en) * 1991-09-12 1993-05-18 Trustees Of Boston University Modulation of receptor-mediated ion transport
CA2118938A1 (en) * 1991-09-13 1993-04-01 Kelvin W. Gee Novel gabaa receptor with steroid binding sites
JP4008024B2 (ja) * 1993-05-24 2007-11-14 パーデュー、ファーマ、リミテッド、パートナーシップ Ｇａｂａａレセプター複合体と相互作用させるための化合物

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