JP4278562B2 - アレルゲン抑制剤 - Google Patents
アレルゲン抑制剤 Download PDFInfo
- Publication number
- JP4278562B2 JP4278562B2 JP2004154942A JP2004154942A JP4278562B2 JP 4278562 B2 JP4278562 B2 JP 4278562B2 JP 2004154942 A JP2004154942 A JP 2004154942A JP 2004154942 A JP2004154942 A JP 2004154942A JP 4278562 B2 JP4278562 B2 JP 4278562B2
- Authority
- JP
- Japan
- Prior art keywords
- allergen
- inhibitor
- allergen inhibitor
- fiber
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Description
レルゲン抑制剤のアレルゲン抑制効果が発現しないことがある一方、多いと、アレルゲン対象物を痛めることがあるので、アレルゲン対象物100重量部に対して0.1〜300重量部が好ましく、0.2〜100重量部がより好ましく、0.5〜50重量部が特に好ましい。
基を持つセルロース誘導体(例えば、メルカプトエチルセルロースなど)を用いてグラフト重合を行う方法。c)オゾンや過酸化物を酸化し、ラジカルを生成させる方法でグラフト重合を行う方法。d)アリルエーテル、ビニルエーテルまたはメタクリル酸エステルなどの二重結合を、セルロースの側鎖に導入してグラフト重合を行う方法。e)アントラキノン−2,7−ジスルホン酸ナトリウムなどを光増感剤として用い、繊維に紫外線を照射してグラフト重合を行う方法。f)カソードの周りに繊維を巻き、希硫酸中に、アレルゲン抑制剤の原料となる単量体を加えて外部電圧を加えることにより電気化学的にグラフト重合を行う方法。
に対する置換反応(ハロゲン化、ニトロ化、スルホン化、クロルメチル化)などが挙げられる。
各実施例ごとにアレルゲン抑制剤として表1に示したように、フェノール樹脂(1)(新日本石油化学社製 商品名「PP−700−300」)、フェノール樹脂(2)(新日本石油化学社製 商品名「PP−1000−240」)、フェノール樹脂(3)(新日本石油化学社製 商品名「DPP−L」)又はポリ−4−ビニルフェノール(アルドリッチ社製 重量平均分子量:8000)をジメチルホルムアミドに10重量%、1重量%、0.1重量%又は0.01重量%となるように溶解させてアレルゲン抑制剤溶液を作製した。なお、フェノール樹脂(1)(2)は構造式(1)で、フェノール樹脂(3)は構造式(2)で示される。
アレルゲン抑制剤としてフェノール樹脂(1)5重量部及びポリビニルピロリドン(和
光純薬社製 商品名「K30」、重量平均分子量:40000)4重量部をジメチルホルムアミド100重量部に溶解させてアレルゲン抑制剤溶液を作製した。
アレルゲン抑制剤としてフェノール樹脂(1)3重量部、ポリオキシメチレン(和光純薬社製、重量平均分子量:7500)2重量部及びポリアクリル酸ナトリウム(アルドリッチ社製、重量平均分子量:2100)2重量部をジメチルホルムアミド水溶液(ジメチルホルムアミド:90重量%)100重量部に溶解させてアレルゲン抑制剤溶液を作製した。
ポリビニルピロリドンを用いなかったこと以外は実施例4と同様にしてアレルゲン抑制不織布を得た。
ジメチルホルムアミドにアレルゲン抑制剤を溶解させることなく用いた。
実施例4で用いた不織布にアレルゲン抑制剤溶液を噴霧させることなく用いた。
フェノール樹脂(1)を用いなかったこと以外は実施例4と同様にしてジメチルホルムアミド溶液を作製した。このジメチルホルムアミド溶液を不織布(綿:80重量%、ポリエステル繊維:20重量%、目付:100g/m2 )に20マイクロリットル/cm2 となるように噴霧して50℃で15時間に亘って放置して乾燥させた。
フェノール樹脂(1)を用いなかったこと以外は実施例5と同様にしてジメチルホルムアミド溶液を作製した。このジメチルホルムアミド溶液を不織布(綿:80重量%、ポリエステル繊維:20重量%、目付:100g/m2 )に20マイクロリットル/cm2 となるように噴霧して50℃で15時間に亘って放置して乾燥させた。
フェノール樹脂(1)の代わりにポリ4−ビニルフェノール(アルドリッチ社製 重量平均分子量:8000)を用いたこと以外は、実施例5と同様にしてアレルゲン抑制不織布を得た。
アレルゲン抑制剤としてポリ4−ビニルフェノール(アルドリッチ社製 重量平均分子量:8000)20重量部及びポリビニルピロリドン(和光純薬社製 商品名「K30」、重量平均分子量:40000)8重量部をジメチルホルムアミド100重量部に溶解させてアレルゲン抑制剤溶液を作製した。このアレルゲン抑制剤溶液を用いて実施例4と同
様の要領でアレルゲン抑制不織布を得た。
アレルゲンの冷結乾燥粉末(コスモ・バイオ社製 商品名「Mite Extract-Dp」 )をタンパク量が8ng/ミリリットルになるようにリン酸バッファー(pH7.6)に溶解させてアレルゲン溶液を作製した。
3・・・アレルゲンタンパク濃度:4ng/ミリリットル
2・・・アレルゲンタンパク濃度:2ng/ミリリットル
1・・・アレルゲンタンパク濃度:1ng/ミリリットル
実施例4〜6及び比較例3〜7で作製された不織布から一辺が10cmの平面正方形状の試験片を各不織布ごとに5枚づつ切り出した。そして、エチルアルコール90重量部及び精製水10重量部を混合してなる液に塵ゴミ(Der p1アレルゲン:10μg/g含有)1重量部を分散させてなるアレルゲン溶液液を作製し、このアレルゲン溶液を各試験片に5ミリリットル振り撒いた後、50℃のオーブンで5分間乾燥させた。
アレルゲン抑制率(%)=100×(1−W2 /W1 )
実施例4〜6及び比較例3〜7で作製された不織布から一辺が10cmの平面正方形状の試験片を各不織布ごとに5枚づつ切り出した。そして、採取したスギ花粉を0.125Mの重炭酸アンモニウムで抽出し、得られた抽出液のCryj1濃度が40g/ミリリットルとなるように、リン酸バッファー溶液(pH:7.6)で希釈してアレルゲン溶液とした。
アレルゲン抑制率(%)=100×(1−W3/40)
実施例4〜6及び比較例4〜7の不織布を素手で触り、比較例3の不織布の手触りと比較し、下記の基準に基づいて判断した。
4・・・比較例3の不織布と殆ど違いが感じられなかった。
3・・・比較例3の不織布よりも少し硬く感じられた。
2・・・比較例3の不織布より硬く感じられた。
1・・・比較例3の不織布に比して硬過ぎて使用に問題があった。
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