JP2014500337A - アレルゲン不活性化剤組成物、物品、及び方法 - Google Patents
アレルゲン不活性化剤組成物、物品、及び方法 Download PDFInfo
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- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
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- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical class N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/22—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds
- C11D1/24—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds containing ester or ether groups directly attached to the nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D39/00—Filtering material for liquid or gaseous fluids
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/244—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing sulfur or phosphorus
- D06M13/248—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing sulfur or phosphorus with compounds containing sulfur
- D06M13/272—Unsaturated compounds containing sulfur atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/04—Additives and treatments of the filtering material
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
- Y10T442/2525—Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Textile Engineering (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
有効成分として式1の化合物を10重量%、クエン酸無水物を4.5重量%、EDTA塩を0.5重量%、エタノールを5重量%、及び水を80重量%含むアレルゲン不活性化剤を調製した。スパンボンド式不織布(重量:80g/sqm)をフィルタとして使用した。ドーピング工程及び乾燥工程によりアレルゲン不活性化剤をフィルタにコーティングして試験用サンプルを得た。この試験で使用したサンプルの寸法は5mm×5mmであった。
ELIZA試験で使用したアレルゲンは、
1)イエダニの残留物:Der p 1、Der f 1、Der p 2、及びDer f 2
2)花粉:Bet v 1(即ち、樺の木花粉)
3)ペットの残留物:Can f 1(即ち、ペットのふけ)
各抗原ごとにELISA試験キット(Inbio GmbH(Julich、Germany))を使用し、各抗原をPBSに溶解させて、250ng/mLの試験用アレルゲン溶液を準備した。ELISAキット製造業者の説明書に従って他の試薬を調製した。
各サンプルを5mm×5mmの寸法に切断した後、25℃のアレルゲン溶液(250ng/mL)300uLに1時間にわたって浸漬させた。1時間浸漬させた後、溶液(上澄み)100uLを、抗体でコーティングされた96ウェルマイクロプレートに注ぎ込んだ。マイクロプレートリーダーを使用してマイクロプレートの吸光度を405nmで測定した後、各サンプル中のアレルゲン濃度を測定した。
アレルゲン不活性化の効率を算出するため、マイクロプレートリーダーを405nmで使用して、サンプルの入った反応液中の各抗原の濃度を測定した。
実施例1〜6及び比較例1〜5:有効成分としての様々な種類の界面活性剤の試験
式1の様々な化合物をアレルゲン不活性化剤の有効成分として含むサンプル(実施例1〜6)、界面活性剤を有さないサンプル(比較例1)、及び式1の化合物の代わりに他の界面活性剤を含むサンプル(比較例2〜5)を使用して、Der p 1の除去効率を測定した。ここでは、サンプル中の有効成分のコーティング量は、1g/m2であった。
Der f 1を試験アレルゲンとし、次の成分を含むアレルゲン不活性化剤を使用して、アレルゲン不活性化効果を測定した。結果を表2に示す。
4種類のイエダニ(Der p 1、Der f 、Der p 2、及びDer f 2)、及びヘキサデシルジフェニルオキシド二スルホン酸二ナトリウムを有効成分として含むアレルゲン不活性化剤を使用して除去効率を測定し、試験は、サンプル中の全有効成分のコーティング量を変化させて(即ち、0.5、1、2、3、4、及び8g/m2)行った。結果を表3に示す。
Bet v 1及びCan f 1をタンパク質濃度250ng/mLで試験アレルゲンとして使用し、ヘキサデシルジフェニルオキシド二スルホン酸二ナトリウムを有効成分として含むアレルゲン不活性化剤を使用して除去効率を測定し、試験は、サンプル中の有効成分のコーティング量を変化させて(即ち、0.5、1、2、3、4、及び8g/m2)行った。結果を表4に示す。
サンプルシートを供給フィルタ(feefilter)に取り付けた後、RAP(空気清浄器)ユニットに取り付けた。空気清浄器を作動させた後、1g/m2の有効成分で処理した不織布シートを使用して、耐久性試験を1ヵ月にわたって実施した(実施例23)。Der p 1、Can f 1及びBet v 1を試験アレルゲンとして使用した。未処理サンプルに対しても同じ試験を行った。
Claims (20)
- クエン酸、リンゴ酸、酒石酸、安息香酸、乳酸、グリコール酸、アスコルビン酸、没食子酸、グルコン酸、及びマレイン酸からなる群から選択される少なくとも1つの有機酸を更に含む、請求項1に記載のアレルゲン不活性化剤。
- 前記有機酸がクエン酸である、請求項2に記載のアレルゲン不活性化剤。
- エチレンジアミン四酢酸の四ナトリウム塩(EDTA四ナトリウム)を更に含む、請求項1に記載のアレルゲン不活性化剤。
- エチレンジアミン四酢酸の四ナトリウム塩(EDTA四ナトリウム)と、
1つ以上のC1〜C6アルコールと、
水と、
を更に含む、請求項1又は2に記載のアレルゲン不活性化剤。 - 前記式1の化合物が、ヘキサデシルジフェニルオキシド二スルホン酸ナトリウムである、請求項1又は2に記載のアレルゲン不活性化剤。
- 前記組成物が、前記組成物100重量%に対して、
0.5〜50重量%の前記式1の化合物と、
0.5〜50重量%の前記有機酸と、
0.2〜2重量%のエチレンジアミン四酢酸の四ナトリウム塩(EDTA四ナトリウム)と、
1〜20重量%の1種以上のC1〜C6アルコールと、
バランス量の水と、
を含む、請求項2に記載のアレルゲン不活性化剤。 - 前記組成物が、前記組成物100重量%に対して、
5〜20重量%の前記式1の化合物と、
5〜20重量%の前記有機酸と、
0.5〜1重量%のEDTA四ナトリウムと、
4〜10重量%の1種以上のC1〜C6アルコールと、
バランス量の水と、
を含む、請求項7に記載のアレルゲン不活性化剤。 - 請求項1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用したフィルタ。
- 請求項1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用したスプレー。
- 請求項1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用した布地。
- 請求項1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用した不織布。
- 請求項1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用した繊維。
- 請求項1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用した洗剤。
- 請求項1〜8のいずれか一項に記載のアレルゲン不活性化剤の使用方法であって、
前記アレルゲン活性化剤を液体形態で準備する工程と、
前記アレルゲン活性化剤を基材の表面に適用する工程と、
を含む、方法。 - 前記基材を乾燥させて前記アレルゲン活性化剤の少なくとも一部を前記基材の表面から除去する工程を更に含む、請求項15に記載の方法。
- 前記基材を乾燥させて前記アレルゲン活性化剤の少なくとも一部を前記基材の表面から除去する工程が、前記基材を加熱することを含む、請求項16に記載の方法。
- 前記基材が、充填剤、繊維、布地、不織布物品、及びフィルタから選択される、請求項15〜17のいずれか一項に記載の方法。
- 前記基材がフィルタである、請求項18に記載の方法。
- 前記フィルタが、HVACフィルタ、乗物の室内エアフィルタ、又は個人向けエアフィルタ(呼吸用マスク)である、請求項19に記載の方法。
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JP2001328936A (ja) * | 2000-03-14 | 2001-11-27 | Shinto Fine Co Ltd | 抗アレルゲン組成物及びアレルゲン不活化方法 |
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