JP4190079B2 - 血液浄化用中空糸膜および中空糸膜型人工腎臓 - Google Patents
血液浄化用中空糸膜および中空糸膜型人工腎臓 Download PDFInfo
- Publication number
- JP4190079B2 JP4190079B2 JP06572799A JP6572799A JP4190079B2 JP 4190079 B2 JP4190079 B2 JP 4190079B2 JP 06572799 A JP06572799 A JP 06572799A JP 6572799 A JP6572799 A JP 6572799A JP 4190079 B2 JP4190079 B2 JP 4190079B2
- Authority
- JP
- Japan
- Prior art keywords
- hollow fiber
- fiber membrane
- membrane
- weight
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012528 membrane Substances 0.000 title claims description 100
- 239000012510 hollow fiber Substances 0.000 title claims description 80
- 210000004369 blood Anatomy 0.000 title claims description 38
- 239000008280 blood Substances 0.000 title claims description 38
- 238000000746 purification Methods 0.000 title claims description 19
- 210000003734 kidney Anatomy 0.000 title claims description 17
- 229920001600 hydrophobic polymer Polymers 0.000 claims description 26
- 239000011550 stock solution Substances 0.000 claims description 26
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 18
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 18
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 18
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
- 229920002492 poly(sulfone) Polymers 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 239000003146 anticoagulant agent Substances 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- 230000002785 anti-thrombosis Effects 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 239000011709 vitamin E Substances 0.000 claims description 6
- 235000019165 vitamin E Nutrition 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 229960004676 antithrombotic agent Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 37
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 30
- 229920001477 hydrophilic polymer Polymers 0.000 description 26
- 239000002158 endotoxin Substances 0.000 description 22
- 238000005406 washing Methods 0.000 description 20
- 238000005345 coagulation Methods 0.000 description 11
- 230000015271 coagulation Effects 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 230000035699 permeability Effects 0.000 description 7
- 238000001179 sorption measurement Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000004833 X-ray photoelectron spectroscopy Methods 0.000 description 4
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 238000004033 diameter control Methods 0.000 description 3
- 238000002615 hemofiltration Methods 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 229940118019 malondialdehyde Drugs 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- -1 polytetramethylene Polymers 0.000 description 3
- 238000002166 wet spinning Methods 0.000 description 3
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
- 238000004820 blood count Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000921 elemental analysis Methods 0.000 description 2
- 210000003617 erythrocyte membrane Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000001631 haemodialysis Methods 0.000 description 2
- 230000000322 hemodialysis Effects 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- 229920002284 Cellulose triacetate Polymers 0.000 description 1
- GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 description 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 description 1
- 229940066595 beta tocopherol Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000010389 delta-tocopherol Nutrition 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 238000000578 dry spinning Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 238000011013 endotoxin removal Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000010382 gamma-tocopherol Nutrition 0.000 description 1
- 238000001891 gel spinning Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 229940105631 nembutal Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001230 polyarylate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP06572799A JP4190079B2 (ja) | 1999-03-12 | 1999-03-12 | 血液浄化用中空糸膜および中空糸膜型人工腎臓 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP06572799A JP4190079B2 (ja) | 1999-03-12 | 1999-03-12 | 血液浄化用中空糸膜および中空糸膜型人工腎臓 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000254222A JP2000254222A (ja) | 2000-09-19 |
| JP2000254222A5 JP2000254222A5 (enrdf_load_stackoverflow) | 2008-09-18 |
| JP4190079B2 true JP4190079B2 (ja) | 2008-12-03 |
Family
ID=13295353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP06572799A Expired - Lifetime JP4190079B2 (ja) | 1999-03-12 | 1999-03-12 | 血液浄化用中空糸膜および中空糸膜型人工腎臓 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4190079B2 (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013015046A1 (ja) * | 2011-07-27 | 2013-01-31 | 旭化成メディカル株式会社 | 中空糸膜型血液浄化装置 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003014394A1 (fr) * | 2001-08-03 | 2003-02-20 | Asahi Medical Co., Ltd. | Methode d'evaluation de la biocompatibilite |
| WO2003031533A1 (fr) | 2001-10-04 | 2003-04-17 | Toray Industries, Inc. | Matiere hydrophile et son procede de production |
| ES2737433T3 (es) * | 2002-08-21 | 2020-01-14 | Toray Industries | Sustrato de membrana modificado con adsorción reducida de plaquetas |
| JP3594032B1 (ja) | 2003-08-29 | 2004-11-24 | 東洋紡績株式会社 | 高透水性中空糸膜型血液浄化器 |
| JP3551971B1 (ja) | 2003-11-26 | 2004-08-11 | 東洋紡績株式会社 | ポリスルホン系選択透過性中空糸膜 |
| JP3580314B1 (ja) | 2003-12-09 | 2004-10-20 | 東洋紡績株式会社 | ポリスルホン系選択透過性中空糸膜束およびその製造方法 |
| JP3642065B1 (ja) * | 2004-03-22 | 2005-04-27 | 東洋紡績株式会社 | 選択透過性分離膜および選択透過性分離膜の製造方法 |
| JP4666248B2 (ja) * | 2004-05-27 | 2011-04-06 | 東洋紡績株式会社 | 高強度高透水性中空糸膜型血液浄化器 |
| JP2005334428A (ja) * | 2004-05-28 | 2005-12-08 | Toyobo Co Ltd | 血液適合性に優れた高透水性中空糸膜型血液浄化器 |
| JP4706194B2 (ja) * | 2004-06-01 | 2011-06-22 | 東洋紡績株式会社 | 高透水性中空糸膜型血液浄化器 |
| WO2006016573A1 (ja) | 2004-08-10 | 2006-02-16 | Toyo Boseki Kabushiki Kaisha | ポリスルホン系選択透過性中空糸膜モジュール及びその製造方法 |
| JP4839631B2 (ja) * | 2005-02-22 | 2011-12-21 | 東洋紡績株式会社 | ポリスルホン系選択透過性中空糸膜束および血液浄化器 |
| TWI374038B (en) | 2007-05-25 | 2012-10-11 | Asahi Kasei Medical Co Ltd | A polysulphone-based membrane for the blood treatment and its manufacturing method |
| WO2012169529A1 (ja) * | 2011-06-09 | 2012-12-13 | 旭化成メディカル株式会社 | 血液処理用中空糸膜及び中空糸膜型血液処理装置 |
| WO2013187396A1 (ja) * | 2012-06-11 | 2013-12-19 | 旭化成メディカル株式会社 | 血液処理用分離膜及びその膜を組み込んだ血液処理器 |
| JP6236255B2 (ja) * | 2012-08-31 | 2017-11-22 | 旭化成メディカル株式会社 | 基材及びデバイス |
| JP5614470B2 (ja) * | 2013-04-15 | 2014-10-29 | 東洋紡株式会社 | 大量液置換特性に優れた血液浄化器 |
| JP6323702B2 (ja) * | 2015-12-15 | 2018-05-16 | 東洋紡株式会社 | 細胞培養用中空糸膜および中空糸モジュール |
| JP7435017B2 (ja) * | 2020-02-26 | 2024-02-21 | ニプロ株式会社 | 透析装置、透析患者の心拍出量の測定方法、算出装置及びコンピュータプログラム |
-
1999
- 1999-03-12 JP JP06572799A patent/JP4190079B2/ja not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013015046A1 (ja) * | 2011-07-27 | 2013-01-31 | 旭化成メディカル株式会社 | 中空糸膜型血液浄化装置 |
| JP5638138B2 (ja) * | 2011-07-27 | 2014-12-10 | 旭化成メディカル株式会社 | 中空糸膜型血液浄化装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000254222A (ja) | 2000-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4190079B2 (ja) | 血液浄化用中空糸膜および中空糸膜型人工腎臓 | |
| US5496637A (en) | High efficiency removal of low density lipoprotein-cholesterol from whole blood | |
| KR102431427B1 (ko) | 혈액 정화를 위한 멤브레인 | |
| US5418061A (en) | Microporous polysulfone supports suitable for removal of low density lipoprotein-cholesterol | |
| AU2013349977A1 (en) | Liver support system | |
| JP6497318B2 (ja) | 血小板浮遊液洗浄用の中空糸膜モジュール | |
| JPWO2002087735A1 (ja) | 非対称多孔質膜およびその製造方法 | |
| JP4061798B2 (ja) | 血液処理用半透膜およびそれを用いた血液処理用透析器 | |
| WO2009040123A1 (en) | Hydrophilic membranes with a non-ionic surfactant | |
| JP4992104B2 (ja) | 血液濾過または血液濾過透析用のモジュール | |
| JP6817240B2 (ja) | 中空糸膜型血液浄化器 | |
| JP7035537B2 (ja) | 分離膜モジュール | |
| JP5633277B2 (ja) | 分離膜モジュール | |
| JPH10230148A (ja) | 半透膜 | |
| JP3934340B2 (ja) | 血液浄化器 | |
| JP2001170172A (ja) | 血液処理用透析器 | |
| JP2703266B2 (ja) | ポリスルホン中空繊維膜およびその製法 | |
| JP2000300663A (ja) | 選択分離膜 | |
| JP4352709B2 (ja) | ポリスルホン系半透膜およびそれを用いた人工腎臓 | |
| EP0570232A2 (en) | Microporous polysulfone supports suitable for removal of low density lipoprotein-cholesterol | |
| JP4190361B2 (ja) | 中空糸型の体液処理器、これに用いる中空糸束およびそれらの製造方法 | |
| JP5196509B2 (ja) | 血液浄化用中空糸膜及びその製造方法 | |
| JP4381058B2 (ja) | 血液適合性に優れた中空糸型血液浄化器 | |
| Irfan et al. | Recent Development of Hemodialysis Membrane Materials | |
| JP3489372B2 (ja) | 選択透過性分離膜 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060313 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080805 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20080912 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20080916 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110926 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110926 Year of fee payment: 3 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110926 Year of fee payment: 3 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110926 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120926 Year of fee payment: 4 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130926 Year of fee payment: 5 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130926 Year of fee payment: 5 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| EXPY | Cancellation because of completion of term |