JP4161017B2 - ベロ細胞に適応させた弱毒化日本脳炎ウィルスおよび日本脳炎ワクチン - Google Patents

ベロ細胞に適応させた弱毒化日本脳炎ウィルスおよび日本脳炎ワクチン Download PDF

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JP4161017B2
JP4161017B2 JP2000508774A JP2000508774A JP4161017B2 JP 4161017 B2 JP4161017 B2 JP 4161017B2 JP 2000508774 A JP2000508774 A JP 2000508774A JP 2000508774 A JP2000508774 A JP 2000508774A JP 4161017 B2 JP4161017 B2 JP 4161017B2
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virus
japanese encephalitis
vaccine
attenuated
vaccines
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JP2001514844A (ja
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キム、ヒュン、スー
ヨー、ワン、ドン
キム、ソー、オク
リー、スン、ヒー
ムーン、サン、ブム
ホン、スン、ピョ
シン、ヨン、チェオル
チュン、ヨン、ジュ
エッケルス、ケネス、エイチ
イニス、ブルース
プットナック、ジョセフ、アール
ビン、レオナルド、エヌ
スリバスタバ、アショック、ケイ
デュボイス、ドリア、アール
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Walter Reed Army Institute of Research
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Walter Reed Army Institute of Research
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2770/24011Flaviviridae
    • C12N2770/24111Flavivirus, e.g. yellow fever virus, dengue, JEV
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    • C12N2770/24011Flaviviridae
    • C12N2770/24111Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24151Methods of production or purification of viral material
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  • Proteomics, Peptides & Aminoacids (AREA)
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JP2000508774A 1997-08-28 1998-08-25 ベロ細胞に適応させた弱毒化日本脳炎ウィルスおよび日本脳炎ワクチン Expired - Lifetime JP4161017B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR19970042002 1997-08-28
KR1997/42001 1997-08-28
KR19970042001 1997-08-28
KR1997/42002 1997-08-28
PCT/KR1998/000259 WO1999011762A1 (en) 1997-08-28 1998-08-25 An attenuated japanese encephalitis virus adapted to vero cell and a japanese encephalitis vaccine

Publications (2)

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JP2001514844A JP2001514844A (ja) 2001-09-18
JP4161017B2 true JP4161017B2 (ja) 2008-10-08

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JP2000508774A Expired - Lifetime JP4161017B2 (ja) 1997-08-28 1998-08-25 ベロ細胞に適応させた弱毒化日本脳炎ウィルスおよび日本脳炎ワクチン

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US (1) US6309650B1 (US06559137-20030506-C00021.png)
EP (2) EP1025209B1 (US06559137-20030506-C00021.png)
JP (1) JP4161017B2 (US06559137-20030506-C00021.png)
KR (1) KR100314404B1 (US06559137-20030506-C00021.png)
CN (1) CN1142271C (US06559137-20030506-C00021.png)
AU (1) AU748730B2 (US06559137-20030506-C00021.png)
CA (1) CA2301000C (US06559137-20030506-C00021.png)
DE (2) DE69837211T2 (US06559137-20030506-C00021.png)
DK (2) DK1604685T3 (US06559137-20030506-C00021.png)
ES (2) ES2382946T3 (US06559137-20030506-C00021.png)
FR (1) FR09C0037I2 (US06559137-20030506-C00021.png)
MY (1) MY129773A (US06559137-20030506-C00021.png)
NL (1) NL300391I2 (US06559137-20030506-C00021.png)
NZ (1) NZ503522A (US06559137-20030506-C00021.png)
WO (1) WO1999011762A1 (US06559137-20030506-C00021.png)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000083657A (ja) * 1998-07-13 2000-03-28 Chemo Sero Therapeut Res Inst 日本脳炎ウイルスワクチン
JP4371343B2 (ja) 1998-10-05 2009-11-25 財団法人阪大微生物病研究会 日本脳炎ウイルス群感染症に対する不活化ワクチンのための増強免疫原およびその製造方法
JP4778620B2 (ja) * 1999-04-22 2011-09-21 ユナイテッド ステイツ デパートメント オブ アグリカルチャー 分離株ja−142に基づく、豚繁殖・呼吸障害症候群ワクチン
AU4472801A (en) * 2000-04-07 2001-10-23 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Inactivated japanese B encephalitis vaccine and process for producing the same
CN1253220C (zh) * 2001-06-29 2006-04-26 贝克顿迪肯森公司 通过微管在真皮内输入疫苗和基因治疗剂
JP2007068401A (ja) * 2003-08-07 2007-03-22 Chemo Sero Therapeut Res Inst 西ナイルウイルスワクチン
NZ548495A (en) * 2004-02-23 2009-05-31 Crucell Holland Bv Virus purification methods
CN100340596C (zh) * 2004-05-20 2007-10-03 佛山市顺德区汉达精密电子科技有限公司 回收聚碳酸酯/丙烯腈-丁二烯-苯乙烯共聚物及其回收方法
DK1869171T4 (en) * 2005-04-11 2016-01-18 Crucell Holland Bv Virus cleaning using ultrafiltration
US8591916B2 (en) * 2007-01-31 2013-11-26 Sanofi Pasteur Biologics, Llc Flavivirus vaccine vector against influenza virus
CA2710611C (en) * 2007-12-26 2016-12-20 The Kitasato Institute Method of producing japanese encephalitis vaccine stably storable over long time and use of the vaccine
JP5511660B2 (ja) * 2008-06-04 2014-06-04 一般財団法人化学及血清療法研究所 不活化日本脳炎ウイルス粒子をアジュバントとして使用する方法
JP5744517B2 (ja) * 2008-07-30 2015-07-08 久光製薬株式会社 マイクロニードルデバイスおよびマイクロニードルデバイスによる日本脳炎ウイルス抗原の奏功性を上昇させる方法
KR20120027381A (ko) * 2009-05-25 2012-03-21 파나세아 바이오테크 리미티드 일본뇌염 백신 및 그것의 제조 방법
KR101144993B1 (ko) * 2009-06-18 2012-06-27 대한민국 돼지 일본뇌염 바이러스의 고농축 혈구응집용 항원
SI3106176T1 (en) 2011-12-06 2018-04-30 Valneva Austria Gmbh Aluminum compounds for use in therapeutics and vaccines
AU2014338520B2 (en) * 2013-09-14 2019-12-05 Bharat Biotech International Limited A viral vaccine and methods of manufacture thereof
CN105695424B (zh) * 2015-04-01 2019-06-14 中国食品药品检定研究院 乙型脑炎减毒活疫苗株sa14-14-2在人二倍体细胞2bs上的适应株及其疫苗
FI3393510T3 (fi) 2015-12-23 2023-03-22 Valneva Austria Gmbh Zika-virusrokote
AU2017207076B2 (en) * 2016-01-15 2021-04-29 Km Biologics Co., Ltd. Vaccine containing immobilized virus particles
US11033615B2 (en) 2016-05-31 2021-06-15 The Government of the United States, As Represented by the Secretary of the Army Fort Detrick, Maryland Zika virus vaccine and methods of production
WO2019057793A1 (en) 2017-09-21 2019-03-28 Valneva Se PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL COMPOSITIONS COMPRISING THE IMMUNOGENIC VIRUS OF CHIKUNGUNYA CHIKV-DELTA5NSP3
WO2019090228A2 (en) 2017-11-03 2019-05-09 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
CN111601885A (zh) 2017-11-30 2020-08-28 武田疫苗股份有限公司 用于将寨卡病毒灭活的方法和相关方法
CN110684747B (zh) * 2018-07-06 2024-05-24 厦门大学 灭活及保存呼吸道合胞病毒的方法
CN112601815A (zh) * 2018-08-27 2021-04-02 迈凯恩技术有限公司 使用永生化单核细胞和诱导细胞的抗感染药物、疫苗等的评价方法
EP3895729A1 (en) 2020-03-01 2021-10-20 Valneva Austria GmbH Cpg-adjuvanted sars-cov-2 virus vaccine
JP2023515908A (ja) 2020-03-01 2023-04-14 ヴァルネヴァ・オーストリア・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング CpGアジュバント化SARS-CoV-2ウイルスワクチン
TW202203967A (zh) 2020-04-06 2022-02-01 奧地利商瓦爾尼瓦奧地利有限責任公司 不活化SARS—CoV—2病毒疫苗
WO2023148256A1 (en) 2022-02-02 2023-08-10 Valneva Austria Gmbh Inactivated sars-cov-2 virus vaccine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2704258B2 (ja) * 1987-10-31 1998-01-26 日本臓器製薬株式会社 組み換えワクチニアウイルス
GB8821656D0 (en) * 1988-09-15 1988-10-12 Health Lab Service Board Pharmaceutical compositions for eliciting immunostimulant effect
JPH085803B2 (ja) * 1988-11-10 1996-01-24 武田薬品工業株式会社 日本脳炎ワクチンの製造法
EP0562136A1 (en) * 1992-03-24 1993-09-29 Division Of Microbiology, Kyoto Biken Laboratories, Inc. Live vaccine to getah virus infectious disease, and trivalent live vaccine to Japanese encephalitis virus, porcine parvovirus and getah virus infectious diseases
US6010894A (en) * 1997-06-13 2000-01-04 Research Development Foundation Method of screening for attenuating viruses

Also Published As

Publication number Publication date
EP1604685A3 (en) 2006-07-05
NL300391I1 (nl) 2009-08-03
EP1025209B1 (en) 2007-02-28
DK1025209T3 (da) 2007-06-25
NZ503522A (en) 2001-06-29
AU748730B2 (en) 2002-06-13
DE122009000037I2 (de) 2011-06-16
CN1272879A (zh) 2000-11-08
DE69837211D1 (de) 2007-04-12
CA2301000C (en) 2003-07-08
ES2382946T3 (es) 2012-06-14
CA2301000A1 (en) 1999-03-11
KR100314404B1 (ko) 2002-10-12
DE122009000037I1 (de) 2009-11-05
FR09C0037I2 (fr) 2021-11-05
ES2281929T3 (es) 2007-10-01
AU9004798A (en) 1999-03-22
US6309650B1 (en) 2001-10-30
EP1604685B1 (en) 2012-02-22
MY129773A (en) 2007-04-30
DK1604685T3 (da) 2012-06-18
EP1025209A1 (en) 2000-08-09
EP1604685A2 (en) 2005-12-14
NL300391I2 (nl) 2009-11-02
WO1999011762A1 (en) 1999-03-11
KR19990023955A (ko) 1999-03-25
JP2001514844A (ja) 2001-09-18
CN1142271C (zh) 2004-03-17
FR09C0037I1 (US06559137-20030506-C00021.png) 2009-09-25
DE69837211T2 (de) 2007-12-06

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