JP4082463B2 - 部位特異的結合システム、影像組成物及び方法 - Google Patents

部位特異的結合システム、影像組成物及び方法 Download PDF

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Publication number
JP4082463B2
JP4082463B2 JP50338097A JP50338097A JP4082463B2 JP 4082463 B2 JP4082463 B2 JP 4082463B2 JP 50338097 A JP50338097 A JP 50338097A JP 50338097 A JP50338097 A JP 50338097A JP 4082463 B2 JP4082463 B2 JP 4082463B2
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emulsion
biotinylated
avidin
acoustic
ligand
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JP2001527509A (ja
JP2001527509A5 (https=
Inventor
エム． ラーンツァー，グレゴリー
エイ． ウィックライン，サミュエル
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バーンズジューイッシュ ホスピタル ディー／ビー／エイ
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Priority claimed from US08/488,743 external-priority patent/US5690907A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Hydrogenated Pyridines (AREA)
JP50338097A 1995-06-08 1996-06-06 部位特異的結合システム、影像組成物及び方法 Expired - Fee Related JP4082463B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/488,743 US5690907A (en) 1995-06-08 1995-06-08 Avidin-biotin conjugated emulsions as a site specific binding system
US08/488,743 1996-05-23
US08/647,277 US5780010A (en) 1995-06-08 1996-05-23 Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system
US08/647,277 1996-05-23
PCT/US1996/010425 WO1996041647A1 (en) 1995-06-08 1996-06-06 Site specific binding system, imaging compositions and methods

Publications (3)

Publication Number Publication Date
JP2001527509A JP2001527509A (ja) 2001-12-25
JP2001527509A5 JP2001527509A5 (https=) 2004-07-29
JP4082463B2 true JP4082463B2 (ja) 2008-04-30

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JP50338097A Expired - Fee Related JP4082463B2 (ja) 1995-06-08 1996-06-06 部位特異的結合システム、影像組成物及び方法

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Country Link
US (2) US5780010A (https=)
EP (1) EP0831933B1 (https=)
JP (1) JP4082463B2 (https=)
AU (1) AU710837B2 (https=)
CA (1) CA2222544C (https=)
DE (1) DE69635516T2 (https=)
ES (1) ES2252755T3 (https=)
WO (1) WO1996041647A1 (https=)

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Also Published As

Publication number Publication date
US5780010A (en) 1998-07-14
DE69635516D1 (de) 2006-01-05
AU6179196A (en) 1997-01-09
WO1996041647A1 (en) 1996-12-27
CA2222544C (en) 2008-07-22
EP0831933A4 (en) 2001-05-30
US5989520A (en) 1999-11-23
EP0831933B1 (en) 2005-11-30
CA2222544A1 (en) 1996-12-27
AU710837B2 (en) 1999-09-30
JP2001527509A (ja) 2001-12-25
EP0831933A1 (en) 1998-04-01
ES2252755T3 (es) 2006-05-16
DE69635516T2 (de) 2006-08-10

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