ATE478337T1 - Methoden zum nachweis analyten in proben - Google Patents

Methoden zum nachweis analyten in proben

Info

Publication number
ATE478337T1
ATE478337T1 AT07123477T AT07123477T ATE478337T1 AT E478337 T1 ATE478337 T1 AT E478337T1 AT 07123477 T AT07123477 T AT 07123477T AT 07123477 T AT07123477 T AT 07123477T AT E478337 T1 ATE478337 T1 AT E478337T1
Authority
AT
Austria
Prior art keywords
analyte
marker
methods
binding material
samples
Prior art date
Application number
AT07123477T
Other languages
English (en)
Inventor
Antje Baeumner
Original Assignee
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc
Application granted granted Critical
Publication of ATE478337T1 publication Critical patent/ATE478337T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
AT07123477T 2002-05-31 2003-05-30 Methoden zum nachweis analyten in proben ATE478337T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38514602P 2002-05-31 2002-05-31

Publications (1)

Publication Number Publication Date
ATE478337T1 true ATE478337T1 (de) 2010-09-15

Family

ID=29712137

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03756301T ATE382861T1 (de) 2002-05-31 2003-05-30 Universeller biosensor und verfahren zur verwendung
AT07123477T ATE478337T1 (de) 2002-05-31 2003-05-30 Methoden zum nachweis analyten in proben

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03756301T ATE382861T1 (de) 2002-05-31 2003-05-30 Universeller biosensor und verfahren zur verwendung

Country Status (7)

Country Link
US (1) US7718388B2 (de)
EP (2) EP1939627B1 (de)
AT (2) ATE382861T1 (de)
AU (1) AU2003243348B2 (de)
CA (1) CA2485942A1 (de)
DE (2) DE60318435T2 (de)
WO (1) WO2003102541A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005084404A2 (en) * 2004-03-03 2005-09-15 Cornell Research Foundation, Inc. Microfluidic biosensor and methods of use
DE102005037436A1 (de) * 2005-08-04 2007-02-15 Siemens Ag Verfahren und System zur Konzentrationsbestimmung eines Analyt-Enzym-Komplexes oder Analyt-Enzym-Konjugats, insbesondere zur elektrochemischen Detektion des Analyten, und zugehörige Messvorrichtung
WO2010058059A1 (en) * 2008-11-18 2010-05-27 University Of Jyväskylä A method for detecting specific nucleotide sequences
JP2011047923A (ja) * 2009-07-27 2011-03-10 Panasonic Corp リポソーム組成物及びその製造方法並びにそれを用いたアナライトの分析方法
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
WO2012081940A2 (ko) * 2010-12-16 2012-06-21 한국생명공학연구원 프린팅을 이용한 멤브레인 상 전극 및 이를 활용한 생체물질 검출
KR101335246B1 (ko) * 2010-12-16 2013-11-29 한국생명공학연구원 프린팅을 이용한 멤브레인 상 전극 및 이를 활용한 생체물질 검출
WO2013074796A1 (en) 2011-11-15 2013-05-23 The Board Of Trustees Of The University Of Illinois Thermal control of droplets by nanoscale field effect transistors
CN102680705A (zh) * 2012-05-15 2012-09-19 南昌大学 一种基于量子点荧光定量检测过敏原α-乳白蛋白的方法
EP2986987B1 (de) 2013-04-15 2018-08-08 Nanyang Technological University Elektrochemischer lateral-flow-bioassay und biosensor
CN105675678B (zh) * 2016-02-29 2018-01-05 北京农业质量标准与检测技术研究中心 基于电化学适体dna生物传感器的乙醇胺检测方法
WO2020003087A1 (en) * 2018-06-26 2020-01-02 Tdk Corporation Kit and method for detecting dna
CN110531074B (zh) * 2019-09-06 2022-07-05 齐鲁工业大学 一种检测空肠弯曲杆菌的方法
GB2604367A (en) * 2021-03-03 2022-09-07 Biotip Ltd Devices and methods for performing lateral flow tests

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4048298A (en) 1975-02-25 1977-09-13 Rohm And Haas Company Solid phase double-antibody radioimmunoassay procedure
US4172770A (en) 1978-03-27 1979-10-30 Technicon Instruments Corporation Flow-through electrochemical system analytical method
US4225410A (en) 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
US4235601A (en) 1979-01-12 1980-11-25 Thyroid Diagnostics, Inc. Test device and method for its use
ES8103174A1 (es) 1979-01-18 1981-02-16 Unilever Nv Un metodo y su correspondiente equipo para la deteccion o determinacion de una incognita analizable.
US4342826A (en) 1980-02-04 1982-08-03 Collaborative Research, Inc. Immunoassay products and methods
US4668619A (en) 1980-10-30 1987-05-26 Miles Laboratories, Inc. Multilayer homogeneous specific binding assay device
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4517303A (en) 1982-10-20 1985-05-14 E. I. Du Pont De Nemours And Company Specific binding assays utilizing analyte-cytolysin conjugates
US4571543A (en) 1983-03-28 1986-02-18 Southwest Medical Products, Inc. Specific material detection and measuring device
US4636479A (en) 1983-04-20 1987-01-13 Cooper-Lipotech, Inc. Enhanced agglutination method and kit
US4605630A (en) 1983-07-27 1986-08-12 Cooper Lipotech Inc. Large-liposome agglutination reagent and method
US4594327A (en) 1983-11-02 1986-06-10 Syntex (U.S.A.) Inc. Assay method for whole blood samples
US4695554A (en) 1984-02-14 1987-09-22 Becton Dickinson And Company Sac or liposome containing dye (sulforhodamine) for immunoassay
US4703017C1 (en) 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
US4708933A (en) 1984-06-12 1987-11-24 Leaf Huang Immunoliposome assay-methods and products
US5141868A (en) 1984-06-13 1992-08-25 Internationale Octrooi Maatschappij "Octropa" Bv Device for use in chemical test procedures
US4880635B1 (en) 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
JPH076984B2 (ja) 1985-05-31 1995-01-30 株式会社日立製作所 複数項目分析方法
US5047245A (en) 1985-07-26 1991-09-10 The Liposome Company, Inc. Novel composition for targeting, storing and loading of liposomes
US4806311A (en) 1985-08-28 1989-02-21 Miles Inc. Multizone analytical element having labeled reagent concentration zone
US4752572A (en) 1985-08-30 1988-06-21 Eastman Kodak Company Lipid vesicles containing labeled species and their analytical uses
JPH0650315B2 (ja) 1985-11-08 1994-06-29 株式会社日立製作所 免疫分析用試薬および免疫分析方法
US4822566A (en) 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
US5501949A (en) * 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
CA1291031C (en) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4874710A (en) 1986-02-20 1989-10-17 Becton Dickinson And Company Assay and product in which binder and liposomes are supported on a solid support
US5039818A (en) 1986-02-27 1991-08-13 Syntex (U.S.A.) Inc. Squaraine dye
US4960692A (en) * 1986-03-18 1990-10-02 Fisher Scientific Company Assay employing binding pair members on particles and on a filter or membrane
US5137827A (en) * 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US5085987A (en) 1986-09-05 1992-02-04 Syntex (U.S.A.) Inc. Immunoseparating strip
US5310650A (en) 1986-09-29 1994-05-10 Abbott Laboratoires Method and device for improved reaction kinetics in nucleic acid hybridizations
US5169789A (en) 1986-12-03 1992-12-08 New Horizons Diagnostics Corporation Device and method for self contained solid phase immunodiffusion assay
GB2200448B (en) 1987-01-23 1991-01-16 Univ London Targetted liposomes and their use in immunoassay
US4920046A (en) 1987-02-20 1990-04-24 Becton, Dickinson And Company Process, test device, and test kit for a rapid assay having a visible readout
US5089181A (en) 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
CA1303983C (en) 1987-03-27 1992-06-23 Robert W. Rosenstein Solid phase assay
ES2050704T5 (es) 1987-04-27 2004-04-16 Inverness Medical Switzerland Gmbh Inmunoensayos y dispositivos para su realizacion.
DE3880429T2 (de) 1987-05-06 1993-09-02 Teijin Ltd Verfahren und satz fuer eine immunanalyse unter verwendung von liposomen.
US4855240A (en) 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
US5001048A (en) 1987-06-05 1991-03-19 Aurthur D. Little, Inc. Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film
IT1223295B (it) 1987-08-14 1990-09-19 Boehringer Biochemia Srl Dispositivo e metodo immunodiagnostico
US5459041A (en) 1988-02-18 1995-10-17 Enteric Research Laboratories, Inc. Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection
US5389523A (en) 1988-05-31 1995-02-14 The United States Of Americas, As Represented By The Secretary Of Commerce Liposome immunoanalysis by flow injection assay
US5141751A (en) 1988-06-29 1992-08-25 Daiichi Pharmaceutical Co., Ltd. Lipid membrane structures
US5006473A (en) 1988-08-09 1991-04-09 Abbott Laboratories Electrophoresis method using vesicles
US5096629A (en) 1988-08-29 1992-03-17 501 Nippon Fine Chemical Co., Ltd. Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes
US5130257A (en) 1988-09-29 1992-07-14 Hewlett-Packard Company Chemical sensor utilizing a surface transverse wave device
ATE107502T1 (de) 1988-10-05 1994-07-15 Vestar Inc Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens.
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5208143A (en) 1988-11-17 1993-05-04 Becton, Dickinson And Company Immunoassay on a preblocked solid surface
US5312762A (en) 1989-03-13 1994-05-17 Guiseppi Elie Anthony Method of measuring an analyte by measuring electrical resistance of a polymer film reacting with the analyte
EP0387696B1 (de) 1989-03-17 1997-08-27 Abbott Laboratories Verfahren und Vorrichtung zur Hybridisierung von Nukleinsäure mit verbesserter Reaktionskinetik
JPH02308800A (ja) 1989-05-24 1990-12-21 Toshiba Corp 遺伝子診断方法
US5198367A (en) 1989-06-09 1993-03-30 Masuo Aizawa Homogeneous amperometric immunoassay
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5045285A (en) 1989-09-05 1991-09-03 United States Of America As Represented By The Secretary Of The Air Force Gaseous component identification with polymeric film sensor
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
EP0437092A1 (de) 1989-12-25 1991-07-17 Kabushiki Kaisha Toshiba Gendiagnose
GB2244135B (en) 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
WO1992012428A1 (en) 1991-01-11 1992-07-23 Quidel Corporation A one-step lateral flow nonbibulous assay
US5155022A (en) 1991-02-08 1992-10-13 Becton, Dickinson And Company Assay for lyme disease
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US5567591A (en) 1991-06-24 1996-10-22 Becton Dickinson And Company Amplified assay for analyte
US5248590A (en) 1991-07-22 1993-09-28 Becton, Dickinson And Company Surface modified liposomes
WO1993010226A1 (en) 1991-11-19 1993-05-27 North Carolina State University Immunodiagnostic assay using liposomes carrying labels thereof on outer liposome surface
US5965132A (en) * 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US5670328A (en) 1992-06-09 1997-09-23 Yamasa Corporation Monoclonal antibodies to human pulmonary surfactant apoprotein D and use thereof
US5399500A (en) 1992-06-26 1995-03-21 Becton Dickinson And Company Two step process for coating of antibodies to a solid phase
US5369036A (en) 1992-07-02 1994-11-29 Becton, Dickinson And Company Enhancement of signal in immunoassays using microparticles which contain different detectable substances
EP0651752A1 (de) 1992-07-20 1995-05-10 Behringwerke Ag Chemilumineszierende derivate und methoden deren anwendung
US5354692A (en) 1992-09-08 1994-10-11 Pacific Biotech, Inc. Analyte detection device including a hydrophobic barrier for improved fluid flow
AU670108B2 (en) 1992-09-11 1996-07-04 Becton Dickinson & Company Improved antibodies to plasmodium falciparum
US5308775A (en) 1992-09-15 1994-05-03 Abbott Laboratories Assay devices for concurrently detecting an analyte and confirming the test result
US5384264A (en) 1992-11-05 1995-01-24 Syntron Bioresearch, Inc. Method and apparatus for single step assays of ligand-containing fluids
IL107628A0 (en) 1992-11-18 1994-02-27 Calypte Inc Immunoassays for microorganisms associated with sexually transmitted diseases
FI92882C (fi) 1992-12-29 1995-01-10 Medix Biochemica Ab Oy Kertakäyttöinen testiliuska ja menetelmä sen valmistamiseksi
US5393527A (en) 1993-01-04 1995-02-28 Becton, Dickinson And Company Stabilized microspheres and methods of preparation
US5532133A (en) 1993-06-02 1996-07-02 New York University Plasmodium vivax blood stage antigens, PvESP-1, antibodies, and diagnostic assays
US6103127A (en) 1993-06-08 2000-08-15 Cortex Biochem, Inc. Methods for removing hazardous organic molecules from liquid waste
JP3267000B2 (ja) 1993-09-13 2002-03-18 株式会社ニコン 非球面ミラー製造方法
US5756362A (en) 1993-10-12 1998-05-26 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
US5789154A (en) 1993-10-12 1998-08-04 Cornell Research Foundation, Inc. Liposome-enhanced immunoassay and test device
WO1995012125A1 (en) * 1993-10-26 1995-05-04 Mayo Foundation For Medical Education And Research Direct fluorescence-conjugated immunoassay for platelet activation
US5986076A (en) * 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US6589736B1 (en) * 1994-11-22 2003-07-08 The Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
DE4437274C2 (de) 1994-10-18 1998-11-05 Inst Chemo Biosensorik Analytselektiver Sensor
US5780010A (en) 1995-06-08 1998-07-14 Barnes-Jewish Hospital Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system
US5738868A (en) 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US5776487A (en) 1996-04-19 1998-07-07 Pasteur Sanofi Diagnostics Liposome reagents for immunoassays
US5756879A (en) 1996-07-25 1998-05-26 Hughes Electronics Volatile organic compound sensors
US6358752B1 (en) 1996-09-27 2002-03-19 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
US5958791A (en) 1996-09-27 1999-09-28 Innovative Biotechnologies, Inc. Interdigitated electrode arrays for liposome-enhanced immunoassay and test device
US6040195A (en) 1997-06-10 2000-03-21 Home Diagnostics, Inc. Diagnostic sanitary test strip
DE69932428T2 (de) * 1998-05-21 2007-02-08 Cornell Research Foundation, Inc. Mittels liposomen verbesserte testvorrichtung sowie verfahren
US6153411A (en) 1998-10-30 2000-11-28 American Water Works Company, Inc. Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
US20020102581A1 (en) * 1999-02-19 2002-08-01 Hageman Gregory S. Diagnostics and therapeutics for ocular disorders
EP1192466B1 (de) 1999-06-23 2004-08-11 Cornell Research Foundation, Inc. Entwässerung/rehydratisierung von markierten liposomen auf einer prüfeinrichtung
US6576460B1 (en) * 1999-10-28 2003-06-10 Cornell Research Foundation, Inc. Filtration-detection device and method of use
US6483705B2 (en) * 2001-03-19 2002-11-19 Harris Corporation Electronic module including a cooling substrate and related methods
WO2005084404A2 (en) * 2004-03-03 2005-09-15 Cornell Research Foundation, Inc. Microfluidic biosensor and methods of use

Also Published As

Publication number Publication date
WO2003102541A3 (en) 2004-02-19
EP1512010A2 (de) 2005-03-09
ATE382861T1 (de) 2008-01-15
DE60333876D1 (de) 2010-09-30
EP1939627A1 (de) 2008-07-02
AU2003243348B2 (en) 2009-12-03
US20100068696A1 (en) 2010-03-18
WO2003102541A2 (en) 2003-12-11
CA2485942A1 (en) 2003-12-11
DE60318435T2 (de) 2008-12-24
DE60318435D1 (de) 2008-02-14
EP1512010A4 (de) 2006-04-26
EP1939627B1 (de) 2010-08-18
US7718388B2 (en) 2010-05-18
AU2003243348A1 (en) 2003-12-19
EP1512010B1 (de) 2008-01-02

Similar Documents

Publication Publication Date Title
WO2003043487A3 (en) Method of using a non-antibody protein to detect and measure an analyte
ATE425266T1 (de) Aptamer-nanopartikelkonjugate und verwendungsverfahren zur detektion von zielanalyten
AU2002304640A1 (en) Method and diagnosis kit for selecting and or qualitative and/or quantitative detection of cells
WO2006126008A3 (en) Improved immunoassay methods
CA2566040A1 (en) Method for increasing the dynamic measuring range of test elements, especially immunological test elements, that are based on specific binding reactions
CY1113686T1 (el) Συσκευη bio-αισθητηρα και οι μεθοδοι χρησης της
DE69835893D1 (de) Diagnostische tests und kits für clostridium difficile
ATE478337T1 (de) Methoden zum nachweis analyten in proben
PT1044373E (pt) Metodo incluindo o uso de um novo calibrador e um dispositivo e kit de teste incluindo o calibrador
WO2003106964A3 (en) HIGH EFFICIENCY METHODS AND DEVICES FOR ASSAYING ANALYTES IN A FLUID SAMPLE
DK1513878T3 (da) Sammensætninger og fremgangsmåder til analyse af Apo B48 og Apo B100
DE60325107D1 (de) Verfahren und kit zum quantitativen und/oder qualitativen nachweis von komponenten in einer probe
DE602004015953D1 (de) Festphase immunochromatographische testverfahren
WO2003106649A3 (en) CONJUGATE TEST AND USES THEREOF
EP1138781A3 (de) Methode zur Quantifizierung der Bindeaktivität von DNA-bindenden Proteinen
DE69529691D1 (de) Differenziertes timingsverfahren zum nachweiss multiple analyte in eine testprobe
ATE421093T1 (de) Schnelle bestimmung verschiedener formen von hgf (heptocyte growth factor) in den körperflüssigkeiten
NO20016080D0 (no) Analyse
GB0304832D0 (en) Assay method
DE69920981D1 (de) Knorpelresorptionsassays
WO2005084404A3 (en) Microfluidic biosensor and methods of use
SE0003662D0 (sv) Assay method and kit therefor
WO2007015840A3 (en) Reagents for the detection of phosphorylated atr kinase (ser 428/ser 2317) and uses thereof
WO2003076654A3 (de) Verfahren zum nachweisen, quantifizieren und/oder charakterisieren eines analyten
DK1423708T3 (da) Sammensætninger og fremgangsmåder til bestemmelser af AA4RP

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties