JP4049391B2 - 非経口的薬剤の製造のための方法及び装置 - Google Patents

非経口的薬剤の製造のための方法及び装置 Download PDF

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Publication number
JP4049391B2
JP4049391B2 JP51854497A JP51854497A JP4049391B2 JP 4049391 B2 JP4049391 B2 JP 4049391B2 JP 51854497 A JP51854497 A JP 51854497A JP 51854497 A JP51854497 A JP 51854497A JP 4049391 B2 JP4049391 B2 JP 4049391B2
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nozzle
homogenizer
dispersion
steel body
cavity
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JP51854497A
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Japanese (ja)
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JP2000500146A (ja
JP2000500146A5 (enExample
Inventor
クリンクジーク，ベルント
マヒアウト，ザイト
ノテレ，リカルダ−クリステイネ
ハマン，ハンス−ユルゲン
スデビク，ユルゲン
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バイエル・アクチエンゲゼルシヤフト
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/46—Homogenising or emulsifying nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/70—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming
    • B01F33/71—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming working at super-atmospheric pressure, e.g. in pressurised vessels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Plant Substances (AREA)
JP51854497A 1995-11-15 1996-11-04 非経口的薬剤の製造のための方法及び装置 Expired - Fee Related JP4049391B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19542499A DE19542499A1 (de) 1995-11-15 1995-11-15 Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung
DE19542499.9 1995-11-15
PCT/EP1996/004795 WO1997017946A2 (de) 1995-11-15 1996-11-04 Verfahren und vorrichtung zur herstellung einer parenteralen arzneistoff-zubereitung

Publications (3)

Publication Number Publication Date
JP2000500146A JP2000500146A (ja) 2000-01-11
JP2000500146A5 JP2000500146A5 (enExample) 2004-07-15
JP4049391B2 true JP4049391B2 (ja) 2008-02-20

Family

ID=7777475

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51854497A Expired - Fee Related JP4049391B2 (ja) 1995-11-15 1996-11-04 非経口的薬剤の製造のための方法及び装置

Country Status (11)

Country Link
US (1) US6331314B1 (enExample)
EP (1) EP0861068B1 (enExample)
JP (1) JP4049391B2 (enExample)
AT (1) ATE222097T1 (enExample)
CA (1) CA2237554C (enExample)
DE (2) DE19542499A1 (enExample)
DK (1) DK0861068T3 (enExample)
ES (1) ES2180807T3 (enExample)
MX (1) MX9803633A (enExample)
PT (1) PT861068E (enExample)
WO (1) WO1997017946A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1008380T3 (da) 1998-12-07 2004-07-12 Dsm Ip Assets Bv Fremgangsmåde og indretning til blanding eller dispergering af væsker
US20020119188A1 (en) * 2000-02-08 2002-08-29 Susan Niemiec Method of manufacturing liposomes
EP1222957A1 (en) * 2000-12-22 2002-07-17 Société des Produits Nestlé S.A. Process and device for producing a food grade oil-in-water emulsion
DE102004055507A1 (de) * 2004-11-17 2006-05-18 Basf Ag Verfahren zur Herstellung feinteiliger flüssig-flüssig Formulierungen und Vorrichtung zur Herstellung feinteiliger flüssig-flüssig Formulierungen
US20070231823A1 (en) * 2006-03-23 2007-10-04 Mckernan Kevin J Directed enrichment of genomic DNA for high-throughput sequencing
US7985058B2 (en) * 2007-01-12 2011-07-26 Mark Gray Method and apparatus for making uniformly sized particles
US7491856B2 (en) * 2007-06-27 2009-02-17 H R D Corporation Method of making alkylene glycols
US7652175B2 (en) * 2007-06-27 2010-01-26 H R D Corporation High shear process for the production of acetaldehyde
US8304584B2 (en) 2007-06-27 2012-11-06 H R D Corporation Method of making alkylene glycols
US7479576B1 (en) 2007-06-27 2009-01-20 H R D Corporation Method of hydrogenating aldehydes and ketones
CN101687153A (zh) * 2007-06-28 2010-03-31 宝洁公司 通过产生剪切和/或气穴进行混合的设备和方法以及用于设备的组件
US8322910B2 (en) 2008-07-25 2012-12-04 The Procter & Gamble Company Apparatus and method for mixing by producing shear and/or cavitation, and components for apparatus
CN101617990B (zh) * 2009-07-31 2013-01-23 中国人民解放军第三军医大学 脂质体制备装置以及使用该装置制备脂质体的方法
JP5771366B2 (ja) * 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
US10213383B2 (en) 2009-12-03 2019-02-26 Novartis Ag Hydrophilic filtration during manufacture of vaccine adjuvants
DE102009056884B4 (de) * 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
EP4410306A3 (en) 2009-12-03 2024-11-13 Seqirus UK Limited Circulation of components during homogenization of emulsions
DE102009056871A1 (de) 2009-12-03 2011-06-22 Novartis AG, 4056 Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CL2012001399A1 (es) 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CN120529961A (zh) * 2023-01-17 2025-08-22 帝斯曼知识产权资产管理有限公司 液体分散体制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
WO1983000089A1 (en) * 1981-07-06 1983-01-20 Rush Presbyterian St Luke Preparation of synthetic erythrocytes
CA1264668A (en) * 1984-06-20 1990-01-23 Pieter R. Cullis Extrusion techniques for producing liposomes
DE3515335C2 (de) 1985-04-27 1995-01-26 Bayer Ag Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
DE4207481A1 (de) * 1992-03-10 1993-09-16 Bayer Ag Liposomale wirkstoff-formulierungen und verfahren zu ihrer herstellung
DE4328331A1 (de) * 1993-08-18 1995-02-23 Andreas Dr Sachse Kontinuierliches Hochdruckextrusionsverfahren zur Herstellung von Liposomen und Emulsionen
JPH08505312A (ja) * 1992-10-16 1996-06-11 ザックセ，アンドレアス 液状分散系を製造する方法及び装置

Also Published As

Publication number Publication date
WO1997017946A3 (de) 1997-09-12
JP2000500146A (ja) 2000-01-11
EP0861068A2 (de) 1998-09-02
MX9803633A (es) 1998-09-30
CA2237554A1 (en) 1997-05-22
DK0861068T3 (da) 2002-12-02
EP0861068B1 (de) 2002-08-14
DE59609564D1 (de) 2002-09-19
US6331314B1 (en) 2001-12-18
DE19542499A1 (de) 1997-05-22
WO1997017946A2 (de) 1997-05-22
CA2237554C (en) 2007-01-09
PT861068E (pt) 2002-12-31
ATE222097T1 (de) 2002-08-15
ES2180807T3 (es) 2003-02-16

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