PT861068E - Processo e dispositivo para a producao de um preparado medicinal de administracao por via parenterica - Google Patents

Processo e dispositivo para a producao de um preparado medicinal de administracao por via parenterica

Info

Publication number
PT861068E
PT861068E PT96938066T PT96938066T PT861068E PT 861068 E PT861068 E PT 861068E PT 96938066 T PT96938066 T PT 96938066T PT 96938066 T PT96938066 T PT 96938066T PT 861068 E PT861068 E PT 861068E
Authority
PT
Portugal
Prior art keywords
production
parenterica
administration
homogenizer
bar
Prior art date
Application number
PT96938066T
Other languages
English (en)
Inventor
Klinksiek Dipl Ing Bernd
Hans-Jurgen Hamann
Said Mahiout
Ricarda-Christine Nothelle
Jurgen Sdebik
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PT861068E publication Critical patent/PT861068E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/46—Homogenising or emulsifying nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/70—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming
    • B01F33/71—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming working at super-atmospheric pressure, e.g. in pressurised vessels
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
PT96938066T 1995-11-15 1996-11-04 Processo e dispositivo para a producao de um preparado medicinal de administracao por via parenterica PT861068E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19542499A DE19542499A1 (de) 1995-11-15 1995-11-15 Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung

Publications (1)

Publication Number Publication Date
PT861068E true PT861068E (pt) 2002-12-31

Family

ID=7777475

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96938066T PT861068E (pt) 1995-11-15 1996-11-04 Processo e dispositivo para a producao de um preparado medicinal de administracao por via parenterica

Country Status (11)

Country Link
US (1) US6331314B1 (pt)
EP (1) EP0861068B1 (pt)
JP (1) JP4049391B2 (pt)
AT (1) ATE222097T1 (pt)
CA (1) CA2237554C (pt)
DE (2) DE19542499A1 (pt)
DK (1) DK0861068T3 (pt)
ES (1) ES2180807T3 (pt)
MX (1) MX9803633A (pt)
PT (1) PT861068E (pt)
WO (1) WO1997017946A2 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69915434T2 (de) 1998-12-07 2005-03-03 Dsm Ip Assets B.V. Verfahren und Vorrichtung zum Mischen oder Dispergieren von Flüssigkeiten
US20020119188A1 (en) * 2000-02-08 2002-08-29 Susan Niemiec Method of manufacturing liposomes
EP1222957A1 (en) * 2000-12-22 2002-07-17 Société des Produits Nestlé S.A. Process and device for producing a food grade oil-in-water emulsion
DE102004055507A1 (de) * 2004-11-17 2006-05-18 Basf Ag Verfahren zur Herstellung feinteiliger flüssig-flüssig Formulierungen und Vorrichtung zur Herstellung feinteiliger flüssig-flüssig Formulierungen
WO2007111937A1 (en) * 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
US7985058B2 (en) * 2007-01-12 2011-07-26 Mark Gray Method and apparatus for making uniformly sized particles
US7479576B1 (en) * 2007-06-27 2009-01-20 H R D Corporation Method of hydrogenating aldehydes and ketones
US8304584B2 (en) * 2007-06-27 2012-11-06 H R D Corporation Method of making alkylene glycols
US7652175B2 (en) * 2007-06-27 2010-01-26 H R D Corporation High shear process for the production of acetaldehyde
US7491856B2 (en) 2007-06-27 2009-02-17 H R D Corporation Method of making alkylene glycols
CN101687153A (zh) * 2007-06-28 2010-03-31 宝洁公司 通过产生剪切和/或气穴进行混合的设备和方法以及用于设备的组件
US8322910B2 (en) 2008-07-25 2012-12-04 The Procter & Gamble Company Apparatus and method for mixing by producing shear and/or cavitation, and components for apparatus
CN101617990B (zh) * 2009-07-31 2013-01-23 中国人民解放军第三军医大学 脂质体制备装置以及使用该装置制备脂质体的方法
JP5771366B2 (ja) 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
CN104688687A (zh) 2009-12-03 2015-06-10 诺华股份有限公司 疫苗佐剂制备中的亲水过滤
DE102009056871A1 (de) 2009-12-03 2011-06-22 Novartis AG, 4056 Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
KR101523215B1 (ko) 2009-12-03 2015-05-27 노파르티스 아게 에멀션 미세 액화 및/또는 균질화 동안 성분들의 순환
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CL2012001399A1 (es) 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
WO2024153700A1 (en) * 2023-01-17 2024-07-25 Dsm Ip Assets B.V. Liquid dispersion preparation processes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
WO1983000089A1 (en) 1981-07-06 1983-01-20 Rush Presbyterian St Luke Preparation of synthetic erythrocytes
CA1264668C (en) * 1984-06-20 1990-01-23 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES
DE3515335C2 (de) 1985-04-27 1995-01-26 Bayer Ag Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
DE4207481A1 (de) * 1992-03-10 1993-09-16 Bayer Ag Liposomale wirkstoff-formulierungen und verfahren zu ihrer herstellung
WO1994008626A1 (de) * 1992-10-16 1994-04-28 Andreas Sachse Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme
DE4328331A1 (de) * 1993-08-18 1995-02-23 Andreas Dr Sachse Kontinuierliches Hochdruckextrusionsverfahren zur Herstellung von Liposomen und Emulsionen

Also Published As

Publication number Publication date
US6331314B1 (en) 2001-12-18
MX9803633A (es) 1998-09-30
DE59609564D1 (de) 2002-09-19
CA2237554C (en) 2007-01-09
DK0861068T3 (da) 2002-12-02
ES2180807T3 (es) 2003-02-16
EP0861068A2 (de) 1998-09-02
EP0861068B1 (de) 2002-08-14
ATE222097T1 (de) 2002-08-15
DE19542499A1 (de) 1997-05-22
JP2000500146A (ja) 2000-01-11
WO1997017946A2 (de) 1997-05-22
JP4049391B2 (ja) 2008-02-20
WO1997017946A3 (de) 1997-09-12
CA2237554A1 (en) 1997-05-22

Similar Documents

Publication Publication Date Title
PT861068E (pt) Processo e dispositivo para a producao de um preparado medicinal de administracao por via parenterica
TW347339B (en) Oral delivery of discrete units
AR013442A1 (es) Proceso para preparar una dispersion de politetrafluroetileno.
DE69505677D1 (de) Liposomales verabreichungssystem für biologisch aktive stoffe
NZ335133A (en) Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof for treating cancer
HUP0000520A2 (hu) Új vizes gyógyszerkészítmények hajtógázmentes aeroszolokhoz
AR032132A1 (es) Composicion farmaceutica que comprende una combinacion de un compuesto de tramadol y una droga anticonvulsiva y uso de la combinacion para preparar un medicamento
ATE307676T1 (de) Eine verpackungseinheit für die medikamentverabreichung in der olfaktorischen region
DE69422921D1 (de) Vorrichtung zum verabreichen von pharmazeutischen substanzen
EP0788346A4 (en) EMULSION DRUG DELIVERY SYSTEMS
DE50108380D1 (de) Hautbehandlungsmittel
BR9407748A (pt) Formulação farmacéutica processo para preparação da mesma e processo para a prevenção e/ou o tratamento de neurodegeneração ou para a obtenção de um efeito anti-convulsivo ou sedação em um paciente
AU1079701A (en) Oral transmucosal drug dosage using solid solution
ES2154737T3 (es) Proceso para preparar formas de dosificacion farmaceutica solidas de substancias hidrofobicas.
BR9608723A (pt) Dispositivo de inalação e processo de dispersar uma substância ativa para inalação
BR9912356A (pt) Regime de tratamento para a administração de fenilacetilglutamina, fenilacetilisoglutamina, e/ou fenilacetato
IL150528A0 (en) Ibuprofen containing active agent preparation
ATE289801T1 (de) Verabreichungssystem für wasserunlösliche arzneistoffe
DK0945136T3 (da) Topisk lægemiddel indeholdende ciclosporin
GR3029386T3 (en) Process and device for producing a flat dry-administration form with a preparation containing active medical agents
ZA987480B (en) Process for preparing contrast agents.
EP0797429B1 (de) Osmotische vorrichtung zur kontinuierlichen freisetzung von wirkstoffen in die flüssigkeiten des gastrointestinaltraktes
EP1288311A3 (en) Method for testing small pharmaceutically active molecules in the activation of Pax4 and production of insulin producing beta-cells
EP0896536A1 (en) Use of lofexidine in the manufacture of a medicament for treating attention deficit hyperactive disorder
WO2024064748A3 (en) Compositions and methods related to exosomal delivery of therapeutic agents