ES2180807T3 - Procedimiento y dispositivo para la obtencion de una preparacion medicamentosa parenteral. - Google Patents
Procedimiento y dispositivo para la obtencion de una preparacion medicamentosa parenteral.Info
- Publication number
- ES2180807T3 ES2180807T3 ES96938066T ES96938066T ES2180807T3 ES 2180807 T3 ES2180807 T3 ES 2180807T3 ES 96938066 T ES96938066 T ES 96938066T ES 96938066 T ES96938066 T ES 96938066T ES 2180807 T3 ES2180807 T3 ES 2180807T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- obtaining
- homogenizer
- bar
- medicinal preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/46—Homogenising or emulsifying nozzles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/70—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming
- B01F33/71—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming working at super-atmospheric pressure, e.g. in pressurised vessels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
EN EL PROCEDIMIENTO PARA LA PRODUCCION DE UNA PREPARACION DE MEDICAMENTO APLICABLE POR VIA PARENTERAL, SE UTILIZA UNA DISPERSION DE LIPOSOMAS COMO VEHICULO PARA UNA SUSTANCIA ACTIVA FARMACEUTICA. PARA LA PRODUCCION DE UNA DISPERSION DE LIPOSOMAS SE INTRODUCE UNA PREDISPERSION ACUOSA DE UNA O MAS SUSTANCIAS ANFIFILICAS EN UN HOMOGENEIZADOR DE ALTA PRESION, EN EL QUE LA PREDISPERSION SE BOMBEA A UNA PRESION DE ENTRE 600 BAR Y 900 BAR A TRAVES DE UNA BOQUILLA PULVERIZADORA HOMOGENEIZADORA, CON UN DIAMETRO DE ENTRE 0,1 Y 5 MM. LA BOQUILLA PULVERIZADORA HOMOGENEIZADORA PRESENTA UN CANAL DE ALIMENTACION Y UN CANAL DE DESCARGA Y CONSTA DE UNA PLACA DE CERAMICA DURA EN LA QUE SE ENCUENTRA LA ABERTURA Y QUE ESTA ENCAJADA A PRESION EN UN CUERPO DE ACERO. EL CANAL DE ALIMENTACION Y EL CANAL DE DESCARGA ESTAN TAMBIEN INCORPORADOS EN EL CUERPO DE ACERO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19542499A DE19542499A1 (de) | 1995-11-15 | 1995-11-15 | Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2180807T3 true ES2180807T3 (es) | 2003-02-16 |
Family
ID=7777475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96938066T Expired - Lifetime ES2180807T3 (es) | 1995-11-15 | 1996-11-04 | Procedimiento y dispositivo para la obtencion de una preparacion medicamentosa parenteral. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6331314B1 (es) |
EP (1) | EP0861068B1 (es) |
JP (1) | JP4049391B2 (es) |
AT (1) | ATE222097T1 (es) |
CA (1) | CA2237554C (es) |
DE (2) | DE19542499A1 (es) |
DK (1) | DK0861068T3 (es) |
ES (1) | ES2180807T3 (es) |
MX (1) | MX9803633A (es) |
PT (1) | PT861068E (es) |
WO (1) | WO1997017946A2 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2216423T3 (es) | 1998-12-07 | 2004-10-16 | Dsm Ip Assets B.V. | Metodo y dispositivo para mezclar o dispersar liquidos. |
US20020119188A1 (en) * | 2000-02-08 | 2002-08-29 | Susan Niemiec | Method of manufacturing liposomes |
EP1222957A1 (en) * | 2000-12-22 | 2002-07-17 | Société des Produits Nestlé S.A. | Process and device for producing a food grade oil-in-water emulsion |
DE102004055507A1 (de) * | 2004-11-17 | 2006-05-18 | Basf Ag | Verfahren zur Herstellung feinteiliger flüssig-flüssig Formulierungen und Vorrichtung zur Herstellung feinteiliger flüssig-flüssig Formulierungen |
WO2007111937A1 (en) * | 2006-03-23 | 2007-10-04 | Applera Corporation | Directed enrichment of genomic dna for high-throughput sequencing |
US7985058B2 (en) * | 2007-01-12 | 2011-07-26 | Mark Gray | Method and apparatus for making uniformly sized particles |
US7479576B1 (en) * | 2007-06-27 | 2009-01-20 | H R D Corporation | Method of hydrogenating aldehydes and ketones |
US7652175B2 (en) * | 2007-06-27 | 2010-01-26 | H R D Corporation | High shear process for the production of acetaldehyde |
US8304584B2 (en) | 2007-06-27 | 2012-11-06 | H R D Corporation | Method of making alkylene glycols |
US7491856B2 (en) | 2007-06-27 | 2009-02-17 | H R D Corporation | Method of making alkylene glycols |
PL2158028T3 (pl) * | 2007-06-28 | 2013-04-30 | Procter & Gamble | Urządzenie i sposób mieszania poprzez wytworzenie ścinania i kawitacji w płynie |
US8322910B2 (en) | 2008-07-25 | 2012-12-04 | The Procter & Gamble Company | Apparatus and method for mixing by producing shear and/or cavitation, and components for apparatus |
CN101617990B (zh) * | 2009-07-31 | 2013-01-23 | 中国人民解放军第三军医大学 | 脂质体制备装置以及使用该装置制备脂质体的方法 |
JP5771366B2 (ja) * | 2009-09-02 | 2015-08-26 | 株式会社バイオメッドコア | リポソーム製造装置及び方法 |
CL2012001399A1 (es) | 2009-12-03 | 2013-03-08 | Novartis Ag | Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion. |
DE102009056883B4 (de) | 2009-12-03 | 2012-08-16 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
DE102009056871A1 (de) | 2009-12-03 | 2011-06-22 | Novartis AG, 4056 | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
KR101625623B1 (ko) | 2009-12-03 | 2016-05-31 | 노파르티스 아게 | 백신 보조제 제조 중의 친수성 여과 |
SG10201501611QA (en) | 2009-12-03 | 2015-04-29 | Novartis Ag | Circulation of components during microfluidization and/or homogenization emulsions |
DE102009056884B4 (de) * | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
WO2024153700A1 (en) * | 2023-01-17 | 2024-07-25 | Dsm Ip Assets B.V. | Liquid dispersion preparation processes |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4529561A (en) * | 1978-03-24 | 1985-07-16 | The Regents Of The University Of California | Method for producing liposomes in selected size range |
WO1983000089A1 (en) | 1981-07-06 | 1983-01-20 | Rush Presbyterian St Luke | Preparation of synthetic erythrocytes |
CA1264668A (en) * | 1984-06-20 | 1990-01-23 | Pieter R. Cullis | Extrusion techniques for producing liposomes |
DE3515335C2 (de) | 1985-04-27 | 1995-01-26 | Bayer Ag | Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung |
DE4207481A1 (de) * | 1992-03-10 | 1993-09-16 | Bayer Ag | Liposomale wirkstoff-formulierungen und verfahren zu ihrer herstellung |
DE4328331A1 (de) * | 1993-08-18 | 1995-02-23 | Andreas Dr Sachse | Kontinuierliches Hochdruckextrusionsverfahren zur Herstellung von Liposomen und Emulsionen |
WO1994008626A1 (de) | 1992-10-16 | 1994-04-28 | Andreas Sachse | Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme |
-
1995
- 1995-11-15 DE DE19542499A patent/DE19542499A1/de not_active Withdrawn
-
1996
- 1996-11-04 CA CA002237554A patent/CA2237554C/en not_active Expired - Fee Related
- 1996-11-04 JP JP51854497A patent/JP4049391B2/ja not_active Expired - Fee Related
- 1996-11-04 AT AT96938066T patent/ATE222097T1/de not_active IP Right Cessation
- 1996-11-04 DE DE59609564T patent/DE59609564D1/de not_active Expired - Lifetime
- 1996-11-04 US US09/068,812 patent/US6331314B1/en not_active Expired - Lifetime
- 1996-11-04 WO PCT/EP1996/004795 patent/WO1997017946A2/de active IP Right Grant
- 1996-11-04 EP EP96938066A patent/EP0861068B1/de not_active Expired - Lifetime
- 1996-11-04 ES ES96938066T patent/ES2180807T3/es not_active Expired - Lifetime
- 1996-11-04 DK DK96938066T patent/DK0861068T3/da active
- 1996-11-04 PT PT96938066T patent/PT861068E/pt unknown
-
1998
- 1998-05-07 MX MX9803633A patent/MX9803633A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ATE222097T1 (de) | 2002-08-15 |
JP4049391B2 (ja) | 2008-02-20 |
DE19542499A1 (de) | 1997-05-22 |
CA2237554A1 (en) | 1997-05-22 |
WO1997017946A3 (de) | 1997-09-12 |
EP0861068B1 (de) | 2002-08-14 |
EP0861068A2 (de) | 1998-09-02 |
US6331314B1 (en) | 2001-12-18 |
DK0861068T3 (da) | 2002-12-02 |
MX9803633A (es) | 1998-09-30 |
WO1997017946A2 (de) | 1997-05-22 |
JP2000500146A (ja) | 2000-01-11 |
CA2237554C (en) | 2007-01-09 |
PT861068E (pt) | 2002-12-31 |
DE59609564D1 (de) | 2002-09-19 |
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