DE19542499A1 - Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung - Google Patents
Verfahren und Vorrichtung zur Herstellung einer parenteralen ArzneistoffzubereitungInfo
- Publication number
- DE19542499A1 DE19542499A1 DE19542499A DE19542499A DE19542499A1 DE 19542499 A1 DE19542499 A1 DE 19542499A1 DE 19542499 A DE19542499 A DE 19542499A DE 19542499 A DE19542499 A DE 19542499A DE 19542499 A1 DE19542499 A1 DE 19542499A1
- Authority
- DE
- Germany
- Prior art keywords
- dispersion
- nozzle
- homogenizing
- bar
- homogenizing nozzle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 17
- 239000003814 drug Substances 0.000 title claims abstract description 4
- 238000002360 preparation method Methods 0.000 title claims description 6
- 229940079593 drug Drugs 0.000 title description 2
- 239000006185 dispersion Substances 0.000 claims abstract description 35
- 239000002502 liposome Substances 0.000 claims abstract description 18
- 229910000831 Steel Inorganic materials 0.000 claims abstract description 14
- 239000010959 steel Substances 0.000 claims abstract description 14
- 239000000919 ceramic Substances 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 238000009472 formulation Methods 0.000 claims abstract description 6
- 239000000126 substance Substances 0.000 claims abstract description 6
- 239000013543 active substance Substances 0.000 claims abstract 2
- 239000002245 particle Substances 0.000 claims description 17
- 239000004480 active ingredient Substances 0.000 claims description 8
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims description 3
- 238000011144 upstream manufacturing Methods 0.000 claims description 3
- 229910001928 zirconium oxide Inorganic materials 0.000 claims description 3
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 claims description 2
- 229910010271 silicon carbide Inorganic materials 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 150000003904 phospholipids Chemical class 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000010276 construction Methods 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 229910052594 sapphire Inorganic materials 0.000 description 2
- 239000010980 sapphire Substances 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229960000715 nimodipine Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 230000021715 photosynthesis, light harvesting Effects 0.000 description 1
- PHJVBZVDUNTGNR-UHFFFAOYSA-N propan-2-yl 2-amino-5-cyano-6-methyl-4-(3-phenylquinolin-5-yl)-1,4-dihydropyridine-3-carboxylate Chemical compound CC(C)OC(=O)C1=C(N)NC(C)=C(C#N)C1C1=CC=CC2=NC=C(C=3C=CC=CC=3)C=C12 PHJVBZVDUNTGNR-UHFFFAOYSA-N 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/46—Homogenising or emulsifying nozzles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/70—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming
- B01F33/71—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming working at super-atmospheric pressure, e.g. in pressurised vessels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19542499A DE19542499A1 (de) | 1995-11-15 | 1995-11-15 | Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung |
| DK96938066T DK0861068T3 (da) | 1995-11-15 | 1996-11-04 | Fremgangsmåde og apparat til fremstilling af et lægemiddel til parenteral indgivelse |
| ES96938066T ES2180807T3 (es) | 1995-11-15 | 1996-11-04 | Procedimiento y dispositivo para la obtencion de una preparacion medicamentosa parenteral. |
| CA002237554A CA2237554C (en) | 1995-11-15 | 1996-11-04 | A method and apparatus for producing liposomal parenteral medicaments via high pressure homogenization |
| PT96938066T PT861068E (pt) | 1995-11-15 | 1996-11-04 | Processo e dispositivo para a producao de um preparado medicinal de administracao por via parenterica |
| JP51854497A JP4049391B2 (ja) | 1995-11-15 | 1996-11-04 | 非経口的薬剤の製造のための方法及び装置 |
| EP96938066A EP0861068B1 (de) | 1995-11-15 | 1996-11-04 | Verfahren und vorrichtung zur herstellung einer parenteralen arzneistoff-zubereitung |
| US09/068,812 US6331314B1 (en) | 1995-11-15 | 1996-11-04 | Method and device for producing a parenteral medicament |
| AT96938066T ATE222097T1 (de) | 1995-11-15 | 1996-11-04 | Verfahren und vorrichtung zur herstellung einer parenteralen arzneistoff-zubereitung |
| DE59609564T DE59609564D1 (de) | 1995-11-15 | 1996-11-04 | Verfahren und vorrichtung zur herstellung einer parenteralen arzneistoff-zubereitung |
| PCT/EP1996/004795 WO1997017946A2 (de) | 1995-11-15 | 1996-11-04 | Verfahren und vorrichtung zur herstellung einer parenteralen arzneistoff-zubereitung |
| MX9803633A MX9803633A (es) | 1995-11-15 | 1998-05-07 | Procedimiento y dispositivo para la produccion de un preparado farmaceutico parenteral. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19542499A DE19542499A1 (de) | 1995-11-15 | 1995-11-15 | Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19542499A1 true DE19542499A1 (de) | 1997-05-22 |
Family
ID=7777475
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19542499A Withdrawn DE19542499A1 (de) | 1995-11-15 | 1995-11-15 | Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung |
| DE59609564T Expired - Lifetime DE59609564D1 (de) | 1995-11-15 | 1996-11-04 | Verfahren und vorrichtung zur herstellung einer parenteralen arzneistoff-zubereitung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59609564T Expired - Lifetime DE59609564D1 (de) | 1995-11-15 | 1996-11-04 | Verfahren und vorrichtung zur herstellung einer parenteralen arzneistoff-zubereitung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6331314B1 (enExample) |
| EP (1) | EP0861068B1 (enExample) |
| JP (1) | JP4049391B2 (enExample) |
| AT (1) | ATE222097T1 (enExample) |
| CA (1) | CA2237554C (enExample) |
| DE (2) | DE19542499A1 (enExample) |
| DK (1) | DK0861068T3 (enExample) |
| ES (1) | ES2180807T3 (enExample) |
| MX (1) | MX9803633A (enExample) |
| PT (1) | PT861068E (enExample) |
| WO (1) | WO1997017946A2 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1008380A3 (en) * | 1998-12-07 | 2000-12-13 | F. Hoffmann-La Roche Ag | Process and apparatus for mixing or dispersing liquids |
| EP1222957A1 (en) * | 2000-12-22 | 2002-07-17 | Société des Produits Nestlé S.A. | Process and device for producing a food grade oil-in-water emulsion |
| US8678184B2 (en) | 2009-12-03 | 2014-03-25 | Novartis Ag | Methods for producing vaccine adjuvants |
| US8778275B2 (en) | 2009-12-03 | 2014-07-15 | Novartis Ag | Methods for producing vaccine adjuvants |
| US8871816B2 (en) | 2009-12-03 | 2014-10-28 | Novartis Ag | Methods for producing vaccine adjuvants |
| US8895629B2 (en) | 2009-12-03 | 2014-11-25 | Novartis Ag | Circulation of components during homogenization of emulsions |
| USRE46906E1 (en) | 2009-12-03 | 2018-06-26 | Novartis Ag | Methods for producing vaccine adjuvants |
| US10213383B2 (en) | 2009-12-03 | 2019-02-26 | Novartis Ag | Hydrophilic filtration during manufacture of vaccine adjuvants |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020119188A1 (en) * | 2000-02-08 | 2002-08-29 | Susan Niemiec | Method of manufacturing liposomes |
| DE102004055507A1 (de) * | 2004-11-17 | 2006-05-18 | Basf Ag | Verfahren zur Herstellung feinteiliger flüssig-flüssig Formulierungen und Vorrichtung zur Herstellung feinteiliger flüssig-flüssig Formulierungen |
| WO2007111937A1 (en) * | 2006-03-23 | 2007-10-04 | Applera Corporation | Directed enrichment of genomic dna for high-throughput sequencing |
| US7985058B2 (en) * | 2007-01-12 | 2011-07-26 | Mark Gray | Method and apparatus for making uniformly sized particles |
| US7491856B2 (en) * | 2007-06-27 | 2009-02-17 | H R D Corporation | Method of making alkylene glycols |
| US7479576B1 (en) * | 2007-06-27 | 2009-01-20 | H R D Corporation | Method of hydrogenating aldehydes and ketones |
| US8304584B2 (en) * | 2007-06-27 | 2012-11-06 | H R D Corporation | Method of making alkylene glycols |
| US7652175B2 (en) * | 2007-06-27 | 2010-01-26 | H R D Corporation | High shear process for the production of acetaldehyde |
| PL2158028T3 (pl) * | 2007-06-28 | 2013-04-30 | Procter & Gamble | Urządzenie i sposób mieszania poprzez wytworzenie ścinania i kawitacji w płynie |
| US8322910B2 (en) | 2008-07-25 | 2012-12-04 | The Procter & Gamble Company | Apparatus and method for mixing by producing shear and/or cavitation, and components for apparatus |
| CN101617990B (zh) * | 2009-07-31 | 2013-01-23 | 中国人民解放军第三军医大学 | 脂质体制备装置以及使用该装置制备脂质体的方法 |
| JP5771366B2 (ja) * | 2009-09-02 | 2015-08-26 | 株式会社バイオメッドコア | リポソーム製造装置及び方法 |
| EP4651984A1 (en) * | 2023-01-17 | 2025-11-26 | DSM IP Assets B.V. | Liquid dispersion preparation processes |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529561A (en) * | 1978-03-24 | 1985-07-16 | The Regents Of The University Of California | Method for producing liposomes in selected size range |
| EP0185756B1 (en) * | 1984-06-20 | 1990-08-29 | The Liposome Company, Inc. | Extrusion techniques for producing liposomes |
| DE4207481A1 (de) * | 1992-03-10 | 1993-09-16 | Bayer Ag | Liposomale wirkstoff-formulierungen und verfahren zu ihrer herstellung |
| DE4328331A1 (de) * | 1993-08-18 | 1995-02-23 | Andreas Dr Sachse | Kontinuierliches Hochdruckextrusionsverfahren zur Herstellung von Liposomen und Emulsionen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0082877A1 (en) * | 1981-07-06 | 1983-07-06 | Rush-Presbyterian-St.Luke's Medical Center | Preparation of synthetic erythrocytes |
| DE3515335C2 (de) | 1985-04-27 | 1995-01-26 | Bayer Ag | Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung |
| CA2146963A1 (en) * | 1992-10-16 | 1994-04-28 | Andreas Sachse | Process and device for producing liquid, dispersed systems |
-
1995
- 1995-11-15 DE DE19542499A patent/DE19542499A1/de not_active Withdrawn
-
1996
- 1996-11-04 DK DK96938066T patent/DK0861068T3/da active
- 1996-11-04 JP JP51854497A patent/JP4049391B2/ja not_active Expired - Fee Related
- 1996-11-04 EP EP96938066A patent/EP0861068B1/de not_active Expired - Lifetime
- 1996-11-04 PT PT96938066T patent/PT861068E/pt unknown
- 1996-11-04 DE DE59609564T patent/DE59609564D1/de not_active Expired - Lifetime
- 1996-11-04 CA CA002237554A patent/CA2237554C/en not_active Expired - Fee Related
- 1996-11-04 ES ES96938066T patent/ES2180807T3/es not_active Expired - Lifetime
- 1996-11-04 WO PCT/EP1996/004795 patent/WO1997017946A2/de not_active Ceased
- 1996-11-04 AT AT96938066T patent/ATE222097T1/de not_active IP Right Cessation
- 1996-11-04 US US09/068,812 patent/US6331314B1/en not_active Expired - Lifetime
-
1998
- 1998-05-07 MX MX9803633A patent/MX9803633A/es unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529561A (en) * | 1978-03-24 | 1985-07-16 | The Regents Of The University Of California | Method for producing liposomes in selected size range |
| EP0185756B1 (en) * | 1984-06-20 | 1990-08-29 | The Liposome Company, Inc. | Extrusion techniques for producing liposomes |
| DE4207481A1 (de) * | 1992-03-10 | 1993-09-16 | Bayer Ag | Liposomale wirkstoff-formulierungen und verfahren zu ihrer herstellung |
| DE4328331A1 (de) * | 1993-08-18 | 1995-02-23 | Andreas Dr Sachse | Kontinuierliches Hochdruckextrusionsverfahren zur Herstellung von Liposomen und Emulsionen |
Non-Patent Citations (1)
| Title |
|---|
| GREGORIADIS,Gregory: Liposome Technology 2nd Edition, Vol.I, Liposome Preparation and Related Techniques, CRC Press, Boca Raton, Ann Arbor, London, Tokyo, 1993, S.49-63 * |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1008380A3 (en) * | 1998-12-07 | 2000-12-13 | F. Hoffmann-La Roche Ag | Process and apparatus for mixing or dispersing liquids |
| US6530684B1 (en) | 1998-12-07 | 2003-03-11 | Roche Vitamins Inc. | Preparation of liquid dispersions |
| US6536940B1 (en) | 1998-12-07 | 2003-03-25 | Roche Vitamins Inc. | Preparation of liquid dispersions |
| US6722780B2 (en) | 1998-12-07 | 2004-04-20 | Roche Vitamins Inc. | Preparation of liquid dispersions |
| EP1222957A1 (en) * | 2000-12-22 | 2002-07-17 | Société des Produits Nestlé S.A. | Process and device for producing a food grade oil-in-water emulsion |
| US8895629B2 (en) | 2009-12-03 | 2014-11-25 | Novartis Ag | Circulation of components during homogenization of emulsions |
| US9750690B2 (en) | 2009-12-03 | 2017-09-05 | Novartis Ag | Circulation of components during microfluidization and/or homogenization of emulsions |
| US8871816B2 (en) | 2009-12-03 | 2014-10-28 | Novartis Ag | Methods for producing vaccine adjuvants |
| US8678184B2 (en) | 2009-12-03 | 2014-03-25 | Novartis Ag | Methods for producing vaccine adjuvants |
| US9463240B2 (en) | 2009-12-03 | 2016-10-11 | Novartis Ag | Arranging interaction and back pressure chambers for microfluidization |
| USRE46441E1 (en) | 2009-12-03 | 2017-06-20 | Novartis Ag | Circulation of components during homogenization of emulsions |
| US9700616B2 (en) | 2009-12-03 | 2017-07-11 | Novartis Ag | Arranging interaction and back pressure chambers for microfluidization |
| US8778275B2 (en) | 2009-12-03 | 2014-07-15 | Novartis Ag | Methods for producing vaccine adjuvants |
| USRE46906E1 (en) | 2009-12-03 | 2018-06-26 | Novartis Ag | Methods for producing vaccine adjuvants |
| US10213383B2 (en) | 2009-12-03 | 2019-02-26 | Novartis Ag | Hydrophilic filtration during manufacture of vaccine adjuvants |
| US10463615B2 (en) | 2009-12-03 | 2019-11-05 | Novartis Ag | Circulation of components during microfluidization and/or homogenization of emulsions |
| US10799454B2 (en) | 2009-12-03 | 2020-10-13 | Novartis Ag | Hydrophilic filtration during manufacture of vaccine adjuvants |
| DE102009056884B4 (de) * | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
| US11141376B2 (en) | 2009-12-03 | 2021-10-12 | Novartis Ag | Circulation of components during microfluidization and/or homogenization of emulsions |
Also Published As
| Publication number | Publication date |
|---|---|
| DK0861068T3 (da) | 2002-12-02 |
| EP0861068B1 (de) | 2002-08-14 |
| CA2237554C (en) | 2007-01-09 |
| PT861068E (pt) | 2002-12-31 |
| CA2237554A1 (en) | 1997-05-22 |
| MX9803633A (es) | 1998-09-30 |
| WO1997017946A3 (de) | 1997-09-12 |
| DE59609564D1 (de) | 2002-09-19 |
| JP2000500146A (ja) | 2000-01-11 |
| ATE222097T1 (de) | 2002-08-15 |
| WO1997017946A2 (de) | 1997-05-22 |
| US6331314B1 (en) | 2001-12-18 |
| ES2180807T3 (es) | 2003-02-16 |
| EP0861068A2 (de) | 1998-09-02 |
| JP4049391B2 (ja) | 2008-02-20 |
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