JP4025727B2 - Ｐｅｇ化およびジグリコシル化されたエリスロポエチン - Google Patents
Ｐｅｇ化およびジグリコシル化されたエリスロポエチン Download PDFInfo
- Publication number
- JP4025727B2 JP4025727B2 JP2003532536A JP2003532536A JP4025727B2 JP 4025727 B2 JP4025727 B2 JP 4025727B2 JP 2003532536 A JP2003532536 A JP 2003532536A JP 2003532536 A JP2003532536 A JP 2003532536A JP 4025727 B2 JP4025727 B2 JP 4025727B2
- Authority
- JP
- Japan
- Prior art keywords
- erythropoietin
- mutein
- epo
- terminal
- glycosylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01122555 | 2001-09-25 | ||
| PCT/EP2002/010556 WO2003029291A2 (en) | 2001-09-25 | 2002-09-20 | Pegylated and diglycosylated erythropoietin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005509609A JP2005509609A (ja) | 2005-04-14 |
| JP2005509609A5 JP2005509609A5 (enExample) | 2005-11-17 |
| JP4025727B2 true JP4025727B2 (ja) | 2007-12-26 |
Family
ID=8178675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532536A Expired - Lifetime JP4025727B2 (ja) | 2001-09-25 | 2002-09-20 | Ｐｅｇ化およびジグリコシル化されたエリスロポエチン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6930086B2 (enExample) |
| EP (1) | EP1432802B1 (enExample) |
| JP (1) | JP4025727B2 (enExample) |
| CN (1) | CN100365117C (enExample) |
| AR (1) | AR036575A1 (enExample) |
| AU (1) | AU2002338743A1 (enExample) |
| CA (1) | CA2460489C (enExample) |
| DE (1) | DE60224415T2 (enExample) |
| ES (1) | ES2298402T3 (enExample) |
| WO (1) | WO2003029291A2 (enExample) |
Families Citing this family (127)
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|---|---|---|---|---|
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| US7767643B2 (en) | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| CA2498319A1 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| NZ542586A (en) | 2003-04-09 | 2009-11-27 | Biogenerix Ag | Method of forming a covalent conjugate between a G-CSF peptide and PEG |
| US20060183671A1 (en) * | 2003-07-17 | 2006-08-17 | Anne Angelillo-Scherrer | Treatment of anemia |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| JP2007517769A (ja) * | 2003-09-29 | 2007-07-05 | ウォーレン ファーマシューティカルズ，インコーポレーテッド | 敗血症および癒着形成の治療および予防のための組織保護性サイトカイン |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| WO2005084364A2 (en) * | 2004-03-03 | 2005-09-15 | The Kenneth S. Warren Institue, Inc. | Long acting tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| EP3061461A1 (en) | 2004-10-29 | 2016-08-31 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| JP2008527980A (ja) * | 2005-01-25 | 2008-07-31 | アポロ ライフ サイエンシズ リミテッド | 分子およびそのキメラ分子 |
| EP1871795A4 (en) | 2005-04-08 | 2010-03-31 | Biogenerix Ag | COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE |
| US9585932B2 (en) * | 2005-04-29 | 2017-03-07 | Peter C. Dowling | Use of EPO-derived peptide fragments for the treatment of neurodegenerative disorders |
| US9988427B2 (en) | 2005-05-13 | 2018-06-05 | Charite Universitaetsmedizen-Berlin | Erythropoietin variants |
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| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| EP2081956B1 (en) | 2006-11-13 | 2013-03-20 | Charité - Universitätsmedizin Berlin | Method of cell culture and method of treatment comprising a vepo protein variant |
| EP2120998B1 (en) | 2006-11-28 | 2013-08-07 | HanAll Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
| AR065083A1 (es) * | 2007-02-02 | 2009-05-13 | Amgen Inc | Hepcidina, antagonistas de la hepcidina y metodos de uso |
| CN101796063B (zh) | 2007-04-03 | 2017-03-22 | 拉蒂奥法姆有限责任公司 | 使用糖聚乙二醇化g‑csf的治疗方法 |
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| CL2008002054A1 (es) * | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
| CL2008002053A1 (es) | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion. |
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| TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
| AU2020263289B2 (en) | 2019-04-24 | 2025-05-22 | Amgen Inc. | Syringe sterilization verification assemblies and methods |
| MX2022002149A (es) | 2019-08-23 | 2022-03-17 | Amgen Inc | Dispositivo de suministro de farmacos con componentes de acoplamiento de capuchon de aguja configurable y metodos relacionados. |
| MX2023013640A (es) | 2021-05-21 | 2023-11-30 | Amgen Inc | Metodo de optimizacion de una receta de llenado para un contenedor de medicamento. |
| KR20250099137A (ko) | 2022-11-02 | 2025-07-01 | 에프. 호프만-라 로슈 아게 | 당단백질 조성물의 생산 방법 |
| WO2026030152A1 (en) | 2024-07-29 | 2026-02-05 | Amgen Inc. | System and method for assessing transferability of a fill recipe |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin |
| DE3923963A1 (de) | 1989-07-20 | 1991-01-31 | Behringwerke Ag | Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung |
| DE3924746A1 (de) | 1989-07-26 | 1991-01-31 | Behringwerke Ag | Erythropoietin (epo)-peptide und dagegen gerichtete antikoerper |
| IL192290A0 (en) | 1993-08-17 | 2008-12-29 | Kirin Amgen Inc | Erythropoietin analogs |
| DE19535571A1 (de) | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
| CA2352538A1 (en) | 1998-11-30 | 2000-06-08 | Eli Lilly And Company | Erythropoietic compounds |
| JO2291B1 (en) | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythropoietin derivatives |
-
2002
- 2002-09-11 US US10/241,356 patent/US6930086B2/en not_active Expired - Lifetime
- 2002-09-20 WO PCT/EP2002/010556 patent/WO2003029291A2/en not_active Ceased
- 2002-09-20 DE DE60224415T patent/DE60224415T2/de not_active Expired - Lifetime
- 2002-09-20 EP EP02777160A patent/EP1432802B1/en not_active Expired - Lifetime
- 2002-09-20 AU AU2002338743A patent/AU2002338743A1/en not_active Abandoned
- 2002-09-20 JP JP2003532536A patent/JP4025727B2/ja not_active Expired - Lifetime
- 2002-09-20 CA CA2460489A patent/CA2460489C/en not_active Expired - Lifetime
- 2002-09-20 CN CNB028187520A patent/CN100365117C/zh not_active Expired - Lifetime
- 2002-09-20 ES ES02777160T patent/ES2298402T3/es not_active Expired - Lifetime
- 2002-09-23 AR ARP020103572A patent/AR036575A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60224415T2 (de) | 2008-12-18 |
| DE60224415D1 (de) | 2008-02-14 |
| US20030077753A1 (en) | 2003-04-24 |
| CA2460489C (en) | 2011-12-06 |
| WO2003029291A3 (en) | 2003-07-24 |
| WO2003029291A2 (en) | 2003-04-10 |
| US6930086B2 (en) | 2005-08-16 |
| AU2002338743A1 (en) | 2003-04-14 |
| CN1558952A (zh) | 2004-12-29 |
| ES2298402T3 (es) | 2008-05-16 |
| JP2005509609A (ja) | 2005-04-14 |
| EP1432802A2 (en) | 2004-06-30 |
| CN100365117C (zh) | 2008-01-30 |
| CA2460489A1 (en) | 2003-04-10 |
| EP1432802B1 (en) | 2008-01-02 |
| AR036575A1 (es) | 2004-09-15 |
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