JP4025727B2 - Ｐｅｇ化およびジグリコシル化されたエリスロポエチン - Google Patents
Ｐｅｇ化およびジグリコシル化されたエリスロポエチン Download PDFInfo
- Publication number
- JP4025727B2 JP4025727B2 JP2003532536A JP2003532536A JP4025727B2 JP 4025727 B2 JP4025727 B2 JP 4025727B2 JP 2003532536 A JP2003532536 A JP 2003532536A JP 2003532536 A JP2003532536 A JP 2003532536A JP 4025727 B2 JP4025727 B2 JP 4025727B2
- Authority
- JP
- Japan
- Prior art keywords
- erythropoietin
- mutein
- epo
- terminal
- glycosylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01122555 | 2001-09-25 | ||
| PCT/EP2002/010556 WO2003029291A2 (en) | 2001-09-25 | 2002-09-20 | Pegylated and diglycosylated erythropoietin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005509609A JP2005509609A (ja) | 2005-04-14 |
| JP2005509609A5 JP2005509609A5 (enExample) | 2005-11-17 |
| JP4025727B2 true JP4025727B2 (ja) | 2007-12-26 |
Family
ID=8178675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003532536A Expired - Lifetime JP4025727B2 (ja) | 2001-09-25 | 2002-09-20 | Ｐｅｇ化およびジグリコシル化されたエリスロポエチン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6930086B2 (enExample) |
| EP (1) | EP1432802B1 (enExample) |
| JP (1) | JP4025727B2 (enExample) |
| CN (1) | CN100365117C (enExample) |
| AR (1) | AR036575A1 (enExample) |
| AU (1) | AU2002338743A1 (enExample) |
| CA (1) | CA2460489C (enExample) |
| DE (1) | DE60224415T2 (enExample) |
| ES (1) | ES2298402T3 (enExample) |
| WO (1) | WO2003029291A2 (enExample) |
Families Citing this family (127)
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|---|---|---|---|---|
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| US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| WO2004022593A2 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US20060183671A1 (en) * | 2003-07-17 | 2006-08-17 | Anne Angelillo-Scherrer | Treatment of anemia |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| CN1897959A (zh) * | 2003-09-29 | 2007-01-17 | 沃伦药品公司 | 用于治疗和预防脓毒病和粘连形成的组织保护细胞因子 |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| WO2005084364A2 (en) * | 2004-03-03 | 2005-09-15 | The Kenneth S. Warren Institue, Inc. | Long acting tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| EP1814573B1 (en) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| CA2593682C (en) | 2005-01-10 | 2016-03-22 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
| CA2595676A1 (en) * | 2005-01-25 | 2006-08-03 | Apollo Life Sciences Limited | Molecules and chimeric molecules thereof |
| US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| US9585932B2 (en) * | 2005-04-29 | 2017-03-07 | Peter C. Dowling | Use of EPO-derived peptide fragments for the treatment of neurodegenerative disorders |
| US9988427B2 (en) | 2005-05-13 | 2018-06-05 | Charite Universitaetsmedizen-Berlin | Erythropoietin variants |
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| CN102351791B (zh) | 2006-01-27 | 2014-10-29 | 菲布罗根有限公司 | 使低氧诱导因子(hif)稳定的氰基异喹啉化合物 |
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| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| DK2081956T3 (da) | 2006-11-13 | 2013-06-24 | Charite Universitaetsmedizin | FREMGANGSMÅDE TIL CELLEDYRKNING OG FREMGANGSMÅDE TIL BEHANDLING OMFATTENDE EN vEPO-PROTEINVARIANT |
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| AR067537A1 (es) * | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Purificacion de polipeptidos pegilados |
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| EP3958934B1 (en) | 2019-04-24 | 2025-04-09 | Amgen Inc. | Syringe sterilization verification assemblies and methods |
| US20220273887A1 (en) | 2019-08-23 | 2022-09-01 | Amgen Inc. | Drug delivery device with configurable needle shield engagement components and related methods |
| BR112023024278A2 (pt) | 2021-05-21 | 2024-01-30 | Amgen Inc | Método de otimizar uma receita de enchimento para um recipiente de fármacos |
| JP2025536587A (ja) | 2022-11-02 | 2025-11-07 | エフ． ホフマン－ラ ロシュ アーゲー | 糖タンパク質組成物を生産するための方法 |
| WO2026030152A1 (en) | 2024-07-29 | 2026-02-05 | Amgen Inc. | System and method for assessing transferability of a fill recipe |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin |
| DE3923963A1 (de) | 1989-07-20 | 1991-01-31 | Behringwerke Ag | Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung |
| DE3924746A1 (de) | 1989-07-26 | 1991-01-31 | Behringwerke Ag | Erythropoietin (epo)-peptide und dagegen gerichtete antikoerper |
| IL110669A (en) * | 1993-08-17 | 2008-11-26 | Kirin Amgen Inc | Erythropoietin analogs |
| DE19535571A1 (de) | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
| JP2002531089A (ja) | 1998-11-30 | 2002-09-24 | イーライ・リリー・アンド・カンパニー | 赤血球産生性化合物 |
| PE20010288A1 (es) | 1999-07-02 | 2001-03-07 | Hoffmann La Roche | Derivados de eritropoyetina |
-
2002
- 2002-09-11 US US10/241,356 patent/US6930086B2/en not_active Expired - Lifetime
- 2002-09-20 ES ES02777160T patent/ES2298402T3/es not_active Expired - Lifetime
- 2002-09-20 EP EP02777160A patent/EP1432802B1/en not_active Expired - Lifetime
- 2002-09-20 JP JP2003532536A patent/JP4025727B2/ja not_active Expired - Lifetime
- 2002-09-20 CN CNB028187520A patent/CN100365117C/zh not_active Expired - Lifetime
- 2002-09-20 AU AU2002338743A patent/AU2002338743A1/en not_active Abandoned
- 2002-09-20 CA CA2460489A patent/CA2460489C/en not_active Expired - Lifetime
- 2002-09-20 DE DE60224415T patent/DE60224415T2/de not_active Expired - Lifetime
- 2002-09-20 WO PCT/EP2002/010556 patent/WO2003029291A2/en not_active Ceased
- 2002-09-23 AR ARP020103572A patent/AR036575A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN100365117C (zh) | 2008-01-30 |
| CA2460489A1 (en) | 2003-04-10 |
| WO2003029291A2 (en) | 2003-04-10 |
| DE60224415D1 (de) | 2008-02-14 |
| WO2003029291A3 (en) | 2003-07-24 |
| CA2460489C (en) | 2011-12-06 |
| AU2002338743A1 (en) | 2003-04-14 |
| EP1432802A2 (en) | 2004-06-30 |
| AR036575A1 (es) | 2004-09-15 |
| US6930086B2 (en) | 2005-08-16 |
| EP1432802B1 (en) | 2008-01-02 |
| CN1558952A (zh) | 2004-12-29 |
| DE60224415T2 (de) | 2008-12-18 |
| US20030077753A1 (en) | 2003-04-24 |
| ES2298402T3 (es) | 2008-05-16 |
| JP2005509609A (ja) | 2005-04-14 |
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