CA2460489C - Pegylated and diglycosylated erythropoietin - Google Patents

Pegylated and diglycosylated erythropoietin Download PDF

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Publication number
CA2460489C
CA2460489C CA2460489A CA2460489A CA2460489C CA 2460489 C CA2460489 C CA 2460489C CA 2460489 A CA2460489 A CA 2460489A CA 2460489 A CA2460489 A CA 2460489A CA 2460489 C CA2460489 C CA 2460489C
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CA
Canada
Prior art keywords
erythropoietin
mutein
terminal
epo
glycosylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2460489A
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English (en)
French (fr)
Other versions
CA2460489A1 (en
Inventor
Wilhelm Tischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2460489A1 publication Critical patent/CA2460489A1/en
Application granted granted Critical
Publication of CA2460489C publication Critical patent/CA2460489C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/505Erythropoietin [EPO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2460489A 2001-09-25 2002-09-20 Pegylated and diglycosylated erythropoietin Expired - Lifetime CA2460489C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01122555.4 2001-09-25
EP01122555 2001-09-25
PCT/EP2002/010556 WO2003029291A2 (en) 2001-09-25 2002-09-20 Pegylated and diglycosylated erythropoietin

Publications (2)

Publication Number Publication Date
CA2460489A1 CA2460489A1 (en) 2003-04-10
CA2460489C true CA2460489C (en) 2011-12-06

Family

ID=8178675

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2460489A Expired - Lifetime CA2460489C (en) 2001-09-25 2002-09-20 Pegylated and diglycosylated erythropoietin

Country Status (10)

Country Link
US (1) US6930086B2 (enExample)
EP (1) EP1432802B1 (enExample)
JP (1) JP4025727B2 (enExample)
CN (1) CN100365117C (enExample)
AR (1) AR036575A1 (enExample)
AU (1) AU2002338743A1 (enExample)
CA (1) CA2460489C (enExample)
DE (1) DE60224415T2 (enExample)
ES (1) ES2298402T3 (enExample)
WO (1) WO2003029291A2 (enExample)

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Also Published As

Publication number Publication date
EP1432802B1 (en) 2008-01-02
JP4025727B2 (ja) 2007-12-26
CN1558952A (zh) 2004-12-29
EP1432802A2 (en) 2004-06-30
CA2460489A1 (en) 2003-04-10
WO2003029291A2 (en) 2003-04-10
AU2002338743A1 (en) 2003-04-14
DE60224415T2 (de) 2008-12-18
US6930086B2 (en) 2005-08-16
DE60224415D1 (de) 2008-02-14
ES2298402T3 (es) 2008-05-16
JP2005509609A (ja) 2005-04-14
WO2003029291A3 (en) 2003-07-24
US20030077753A1 (en) 2003-04-24
CN100365117C (zh) 2008-01-30
AR036575A1 (es) 2004-09-15

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