JP3945703B2 - 口腔表面に美容及び/又は治療活性物質を一体型キャリアを用いて送達するためのシステム - Google Patents
口腔表面に美容及び/又は治療活性物質を一体型キャリアを用いて送達するためのシステム Download PDFInfo
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- JP3945703B2 JP3945703B2 JP2002572983A JP2002572983A JP3945703B2 JP 3945703 B2 JP3945703 B2 JP 3945703B2 JP 2002572983 A JP2002572983 A JP 2002572983A JP 2002572983 A JP2002572983 A JP 2002572983A JP 3945703 B2 JP3945703 B2 JP 3945703B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
- A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Description
本出願は、2001年3月19日出願の米国仮出願第60/276,977号の利益を請求するものである。
本発明は、一つの実施形態において材料のストリップである、一体型キャリアによって歯に低分子量のポリブテンを適用することにより、美容及び治療の効果を口腔に送達するためのシステムに関する。
本明細書で使用する時、用語「歯」とは、天然の歯、義歯、歯板、詰め物、かぶせた物、クラウン、ブリッジ、人工歯根など及び口腔内に永久的に又は一時的のいずれかにおいて固定されている、その他の硬い表面をもつ歯科補綴物を包含することを意味する。
本発明の第一層は、口腔内での美容及び治療活性物質のデリバリーシステムにおける一体型キャリアを含み、これは一つの実施形態においては材料のストリップである。
(ポリブテン)
ポリブテンは、イソブチレンとブテンモノマーの粘稠なコポリマーである。本明細書で使用する時、「ポリブテン」は、ポリマーの水素添加(CAS #68937−10−0)及び非水素添加(CAS #9003−29−6)の両方の形態を意味する。ポリブテンは、粘稠な、無色の、不乾性液体ポリマーである。ポリブテンは、流動性液体からほぼ半固体状態までの範囲に分布する。ポリブテンは、透明、無臭で、化学的に安定しており、光及び熱による酸化に抵抗力があり、毒性がなく、無害である。
歯に一旦適用されると、ポリブテンは非常に滑らかで、すべすべした質感を有し、消費者が望ましく清潔な感じとして知覚する。ポリブテンは硬い表面の潤滑剤として作用し、舌がこれらの表面に滑って触れた場合に普通生成される摩擦を減少させる。
本発明は、美容及び治療活性物質をそれらが、含まれる一体型キャリアと共にポリブテンを使用することにより歯及び口腔に送達するシステムに関する。一つの実施形態では、デリバリーシステムは:材料のストリップの第一層;前記ストリップ材料に放出可能なように結合された分子量約300〜約3000を有するポリブテンを含む第二層;及び第二層に結合された美容又は治療活性物質を含む。本発明の第二層の組成物は、一つ以上の美容及び/又は治療活性物質を1回用量形態の中に含有してもよく、その場合は、指示された使用において、装着者の求める効果は高められる。これらの活性物質が対処する口腔の状態の例には、ホワイトニング、染みの漂白、染みの除去、その他の歯の外観の変化及び構造変化、及び歯垢、歯石、虫歯、炎症を起こした歯茎及び/又は出血する歯茎、歯肉炎、カンジダ症のようなカビ感染症、粘膜の創傷、損傷、潰瘍、アフター性潰瘍、ヘルペス、歯の膿瘍の治療及び予防、及び上記の状態及び微生物の増殖のようなその他の原因の結果として生じる口臭の除去が挙げられるが、これらに限定されない。
一つ以上の口腔ケアキャリアを、第二層の組成物に添加することは望ましい可能性がある。水は第二層の組成物中に組み込まれてもよく、好ましくは低イオン含有量でなくてはならず及び有機不純物を含んではならない。
放出ライナーは、第二層の組成物がそれ自体に対して、及び第一層の材料のストリップに対して示す親和性より小さい親和性を、第二層の組成物に対して示すいかなる材料から形成されてもよい。放出ライナーは、硬い材料のシート、例えばポリエチレン、紙、ポリエステル、又はその他の材料を含んでもよく、これは次に非粘着型の物質によりコーティングされる。放出ライナーは材料のストリップと実質的に同じ大きさ及び形状に切断されてもよいし、又は材料をストリップから分離するのに容易に利用できる手段を提供するために、放出ライナーは材料のストリップより大きく切断されてもよい。放出ライナーはストリップを曲げた時に亀裂が入る脆性材料から、又は複数の材料から、又は切れ目の付いた材料から形成されてもよい。あるいは、放出ライナーは、典型的な粘着性包帯のデザインのような、二片が重なり合ったものであってもよい。放出剤として好適な物質の記述は、カーク・オスマー(Kirk-Othmer)の、工業化学百科事典(Encyclopedia of Chemical Technology)、第四版、21巻、207〜218頁に見出され、これは参考として本明細書に組み入れられる。
上記のデリバリーシステムにおいて、第二層の組成物は次のようにして好適に製作される:ポリブテンと美容又は治療活性物質を、混合容器の中に入れて混ぜ合わせ、当該技術分野において既知のいかなる手段、例えばスパチュラ又は混合桟により、よく混合する。所望であれば、組成物を加熱し、混合を促進する。均一になるまで組成物の混合を続ける。美容又は治療活性物質が固体の粒子状形態に含まれる場合には、シリカのような粘度変性剤の添加は、粒子状物質を組成物内において分散及び懸濁した状態に保つために適切である。風味剤又は甘味剤及びその他の口腔ケアキャリアもまた、所望のように混合することにより、第二層の組成物に添加されてもよい。
一体型キャリアが材料のストリップである場合、第二層の組成物は材料のストリップ上にコーティングされてもよいし、又はユーザーにより材料のストリップに適用されてもよいし、又はユーザーにより歯に適用され、次いでコーティングされた歯の上に材料のストリップが設置されてもよい。材料のストリップ又は歯に適用される第二層の組成物の量は、材料片の大きさ及び容量、活性物質の濃度、及び所望の効果に依存する。一般に、1グラム未満の物質が必要とされ、好ましくは約0.05グラム〜約0.5g、及びより好ましくは約0.1グラム〜約0.4gの物質が使用される。材料の1平方センチメートル(cm)当たりの組成物の量は、約1g/cm2未満であり、好ましくは約0.2g/cm2未満であり、より好ましくは0.005g/cm2〜約0.1g/cm2であり、及び更により好ましくは約0.01g/cm2〜約0.04g/cm2である。
上記のデリバリーシステムは、一以上のストリップ手段、及び使用のための指示を含むキットの中に組み合わされてもよい。
Claims (8)
- 口腔表面に口腔ケア活性物質を送達するためのデリバリーシステムであって、これは:
a)口腔表面上で曲線状の形状を形成するのに十分な柔軟性を有する材料の柔軟ストリップの形態である一体型キャリア、及び
b)分子量300〜3000を有するポリブテンと、抗結石剤、フッ化物イオン供給源、第一スズイオン供給源、ホワイトニング剤、抗微生物剤、抗歯垢剤、抗炎症剤、栄養素、酸化防止剤、抗ウイルス剤、抗カビ剤、鎮痛剤、麻酔剤、H−2拮抗剤、重曹、グラス−H、芳香剤、感覚剤、色素、着色剤及びそれらの混合物から成る群から選択される一以上の口腔的に許容可能な活性物質の1回用量とを含む組成物
を含み;該組成物が放出可能なように該柔軟ストリップに適用されているデリバリーシステム。 - 前記組成物の量が、前記柔軟ストリップ1平方センチメートル当たり0.2g未満である請求項1に記載のデリバリーシステム。
- 前記デリバリーシステムが該口腔表面に対して設置された場合に、該材料のストリップが永久的に変形することなく該口腔表面に一致し、該材料の柔軟ストリップが第一の側面及び第二の側面を含み、前記組成物が該材料の柔軟ストリップの該第二の側面に適用される請求項1又は2に記載のデリバリーシステム。
- 前記材料の柔軟ストリップが複数のポケットを更に含む請求項3に記載のデリバリーシステム。
- 前記材料の柔軟ストリップが、0.5〜4センチメートルの幅、2〜12センチメートルの長さ及び1ミリメートル未満の厚さを有する請求項3又は4に記載のデリバリーシステム。
- 前記ポリブテンが、分子量750〜1500を有する請求項1に記載のデリバリーシステム。
- 前記口腔的に許容可能な活性物質が、トリクロサン、重曹、フッ化ナトリウム、硝酸カリウム、硝酸ナトリウム、ナイスタチン、グレープフルーツ種子抽出物、フッ化第一スズ、ピロリン酸四ナトリウム、モノフルオロホスフェート、オパティントD&Cレッド27(Opatint D&C Red 27)、ポリホスフェート、過酸化カルバミド及び塩化セチルピリジニウムから成る群から選択される請求項1に記載のデリバリーシステム。
- 口腔ケア製品であって、これは:
a)包装;及び
b)口腔表面に口腔ケア活性物質を送達するための一つ以上のデリバリーシステムを含み、この一つ以上のデリバリーシステムは、口腔表面上で曲線状の形状を形成するのに十分な柔軟性を有する材料の柔軟ストリップの形態である一体型キャリア及び組成物を含み、この組成物は、分子量300〜3000を有するポリブテン及び一つ以上の口腔的に許容可能な活性物質を含み、放出可能なように該柔軟ストリップに適用されており、前記包装内に配置されていることを含む口腔ケア製品。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27697701P | 2001-03-19 | 2001-03-19 | |
PCT/US2002/008139 WO2002074275A2 (en) | 2001-03-19 | 2002-03-15 | Systems for delivering a cosmetic and/or therapeutic active to oral surfaces |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004535372A JP2004535372A (ja) | 2004-11-25 |
JP3945703B2 true JP3945703B2 (ja) | 2007-07-18 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2002572983A Expired - Fee Related JP3945703B2 (ja) | 2001-03-19 | 2002-03-15 | 口腔表面に美容及び/又は治療活性物質を一体型キャリアを用いて送達するためのシステム |
Country Status (16)
Country | Link |
---|---|
US (2) | US6514484B2 (ja) |
EP (1) | EP1370228B1 (ja) |
JP (1) | JP3945703B2 (ja) |
KR (1) | KR100648022B1 (ja) |
CN (1) | CN1236754C (ja) |
AT (1) | ATE415135T1 (ja) |
AU (1) | AU2002247356B2 (ja) |
CA (1) | CA2441860C (ja) |
DE (1) | DE60230021D1 (ja) |
ES (1) | ES2316548T3 (ja) |
HK (1) | HK1066476A1 (ja) |
HU (1) | HUP0303525A3 (ja) |
MX (1) | MXPA03008496A (ja) |
PL (1) | PL204658B1 (ja) |
RU (1) | RU2257888C2 (ja) |
WO (1) | WO2002074275A2 (ja) |
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- 2002-03-15 EP EP02715139A patent/EP1370228B1/en not_active Expired - Lifetime
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- 2002-03-15 ES ES02715139T patent/ES2316548T3/es not_active Expired - Lifetime
- 2002-03-15 KR KR1020037012187A patent/KR100648022B1/ko not_active IP Right Cessation
- 2002-03-15 RU RU2003130734/15A patent/RU2257888C2/ru not_active IP Right Cessation
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- 2002-03-15 PL PL364141A patent/PL204658B1/pl not_active IP Right Cessation
- 2002-03-15 HU HU0303525A patent/HUP0303525A3/hu unknown
- 2002-03-15 AT AT02715139T patent/ATE415135T1/de not_active IP Right Cessation
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ES2316548T3 (es) | 2009-04-16 |
ATE415135T1 (de) | 2008-12-15 |
US6514484B2 (en) | 2003-02-04 |
CA2441860C (en) | 2008-11-04 |
CA2441860A1 (en) | 2002-09-26 |
CN1503658A (zh) | 2004-06-09 |
RU2003130734A (ru) | 2005-03-10 |
KR100648022B1 (ko) | 2006-11-23 |
MXPA03008496A (es) | 2003-12-08 |
PL364141A1 (en) | 2004-12-13 |
CN1236754C (zh) | 2006-01-18 |
US20030113276A1 (en) | 2003-06-19 |
US6719995B2 (en) | 2004-04-13 |
WO2002074275A3 (en) | 2003-06-05 |
AU2002247356B2 (en) | 2005-05-26 |
HUP0303525A2 (hu) | 2004-03-01 |
KR20030087647A (ko) | 2003-11-14 |
RU2257888C2 (ru) | 2005-08-10 |
EP1370228A2 (en) | 2003-12-17 |
HK1066476A1 (en) | 2005-03-24 |
US20020176827A1 (en) | 2002-11-28 |
HUP0303525A3 (en) | 2006-11-28 |
WO2002074275A2 (en) | 2002-09-26 |
DE60230021D1 (de) | 2009-01-08 |
EP1370228B1 (en) | 2008-11-26 |
PL204658B1 (pl) | 2010-01-29 |
JP2004535372A (ja) | 2004-11-25 |
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