JP3790284B2 - 血液の処理装置および方法 - Google Patents
血液の処理装置および方法 Download PDFInfo
- Publication number
- JP3790284B2 JP3790284B2 JP19083595A JP19083595A JP3790284B2 JP 3790284 B2 JP3790284 B2 JP 3790284B2 JP 19083595 A JP19083595 A JP 19083595A JP 19083595 A JP19083595 A JP 19083595A JP 3790284 B2 JP3790284 B2 JP 3790284B2
- Authority
- JP
- Japan
- Prior art keywords
- filter
- chamber
- membrane
- sweep
- clogging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008280 blood Substances 0.000 title claims abstract description 65
- 210000004369 blood Anatomy 0.000 title claims abstract description 65
- 238000000034 method Methods 0.000 title claims abstract description 37
- 238000012545 processing Methods 0.000 title claims description 45
- 239000012528 membrane Substances 0.000 claims abstract description 117
- 239000007788 liquid Substances 0.000 claims abstract description 98
- 238000001914 filtration Methods 0.000 claims abstract description 34
- 238000012544 monitoring process Methods 0.000 claims abstract description 18
- 238000000502 dialysis Methods 0.000 claims description 47
- 239000000385 dialysis solution Substances 0.000 claims description 42
- 238000000746 purification Methods 0.000 claims description 27
- 230000004087 circulation Effects 0.000 claims description 24
- 238000011144 upstream manufacturing Methods 0.000 claims description 16
- 230000010412 perfusion Effects 0.000 claims description 15
- 238000000108 ultra-filtration Methods 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 12
- 238000004140 cleaning Methods 0.000 claims description 11
- 238000006073 displacement reaction Methods 0.000 claims description 11
- 238000010408 sweeping Methods 0.000 claims description 11
- 238000001631 haemodialysis Methods 0.000 claims description 10
- 230000000322 hemodialysis Effects 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- 230000017531 blood circulation Effects 0.000 claims description 7
- 230000006870 function Effects 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 6
- 230000003134 recirculating effect Effects 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000012535 impurity Substances 0.000 description 5
- 239000002510 pyrogen Substances 0.000 description 5
- 238000011109 contamination Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 230000001698 pyrogenic effect Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000002052 anaphylactic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1672—Apparatus for preparing dialysates using membrane filters, e.g. for sterilising the dialysate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
- A61M1/3465—Substitution fluids using dialysate as substitution fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
- A61M2205/707—Testing of filters for clogging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7554—General characteristics of the apparatus with filters with means for unclogging or regenerating filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7563—General characteristics of the apparatus with filters with means preventing clogging of filters
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9409499A FR2723002B1 (fr) | 1994-07-26 | 1994-07-26 | Dispositif et procede pour preparer un liquide de traitement par filtration |
| FR9409499 | 1994-07-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0866474A JPH0866474A (ja) | 1996-03-12 |
| JP3790284B2 true JP3790284B2 (ja) | 2006-06-28 |
Family
ID=9465939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19083595A Expired - Lifetime JP3790284B2 (ja) | 1994-07-26 | 1995-07-26 | 血液の処理装置および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5702597A (enExample) |
| EP (2) | EP1300167B2 (enExample) |
| JP (1) | JP3790284B2 (enExample) |
| AT (2) | ATE255924T1 (enExample) |
| CA (1) | CA2154629C (enExample) |
| DE (2) | DE69534830T3 (enExample) |
| ES (2) | ES2260389T5 (enExample) |
| FR (1) | FR2723002B1 (enExample) |
Families Citing this family (129)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2723002B1 (fr) * | 1994-07-26 | 1996-09-06 | Hospal Ind | Dispositif et procede pour preparer un liquide de traitement par filtration |
| SE510127C2 (sv) * | 1996-06-13 | 1999-04-19 | Althin Medical Ab | Hemodiafiltrationsset av engångstyp |
| FR2749761B1 (fr) * | 1996-06-18 | 1998-07-31 | Hospal Ind | Procede de desinfection pour une machine de dialyse |
| US6378907B1 (en) | 1996-07-12 | 2002-04-30 | Mykrolis Corporation | Connector apparatus and system including connector apparatus |
| US5888401A (en) * | 1996-09-16 | 1999-03-30 | Union Camp Corporation | Method and apparatus for reducing membrane fouling |
| DE19700466A1 (de) * | 1997-01-09 | 1998-07-16 | Polaschegg Hans Dietrich Dr | Einrichtung und Verfahren zur Hämodiafiltration |
| US20040243047A1 (en) * | 1997-02-14 | 2004-12-02 | Brugger James M. | Single step fluid circuit engagement device and method |
| US6852090B2 (en) | 1997-02-14 | 2005-02-08 | Nxstage Medical, Inc. | Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge |
| IT1293309B1 (it) * | 1997-07-09 | 1999-02-16 | Sis Ter Spa | Apparecchiatura per il trattamento del sangue con dispositivo di scambio a membrana |
| DE19801768C2 (de) | 1998-01-19 | 2001-04-19 | Fresenius Medical Care De Gmbh | Verfahren und Vorrichtung zur Bereitstellung betriebsbereiter Dialysierflüssigkeit |
| DE69940608D1 (de) | 1998-07-31 | 2009-04-30 | Nephros Inc | Vorrichtung zur effizienten hämodiafiltration |
| ATE346677T1 (de) * | 1998-10-30 | 2006-12-15 | Nephros Inc | Anlage zur nicht-isosmotischen diafiltration |
| US6783898B2 (en) | 1999-02-12 | 2004-08-31 | Corning Incorporated | Projection lithography photomask blanks, preforms and method of making |
| US6877713B1 (en) | 1999-07-20 | 2005-04-12 | Deka Products Limited Partnership | Tube occluder and method for occluding collapsible tubes |
| US6406631B1 (en) | 1999-07-30 | 2002-06-18 | Nephros, Inc. | Two stage diafiltration method and apparatus |
| IT1310659B1 (it) * | 1999-07-30 | 2002-02-19 | Hospal Dasco Spa | Metodo di controllo di una macchina per dialisi avente un filtrosemipermeabile. |
| US7780619B2 (en) | 1999-11-29 | 2010-08-24 | Nxstage Medical, Inc. | Blood treatment apparatus |
| US6733477B2 (en) * | 1999-12-07 | 2004-05-11 | Medrad, Inc. | Syringes, syringe tubing and fluid transfer systems |
| US20030176838A1 (en) * | 1999-12-06 | 2003-09-18 | Medrad, Inc. | Syringes, syringe tubing and fluid transfer systems |
| WO2001051185A1 (en) | 2000-01-11 | 2001-07-19 | Nephros, Inc. | Thermally enhanced dialysis/diafiltration system |
| US7067060B2 (en) * | 2000-01-11 | 2006-06-27 | Nephros, Inc. | Ionic enhanced dialysis/diafiltration system |
| JP4649092B2 (ja) | 2000-05-12 | 2011-03-09 | ポール・コーポレーション | ろ過装置およびろ過装置のための接続構造体 |
| KR100826622B1 (ko) | 2000-05-12 | 2008-05-02 | 폴 코포레이션 | 필터 |
| EP1322395B1 (en) | 2000-09-13 | 2011-02-23 | Entegris, Inc. | Liquid filtration device |
| IL155408A0 (en) | 2000-10-30 | 2003-11-23 | Nephros Inc | Dual-stage filtration cartridge |
| MXPA03007068A (es) * | 2001-02-07 | 2003-11-18 | Nephros Inc | Metodo y aparato para un modulo de administracion de hemodiafiltracion. |
| US20050010158A1 (en) * | 2001-05-24 | 2005-01-13 | Brugger James M. | Drop-in blood treatment cartridge with filter |
| US20030083901A1 (en) * | 2001-06-22 | 2003-05-01 | Bosch Juan P. | Process for providing dialysis and other treatments |
| US6649063B2 (en) | 2001-07-12 | 2003-11-18 | Nxstage Medical, Inc. | Method for performing renal replacement therapy including producing sterile replacement fluid in a renal replacement therapy unit |
| US20030010717A1 (en) * | 2001-07-13 | 2003-01-16 | Nx Stage Medical, Inc. | Systems and methods for handling air and/or flushing fluids in a fluid circuit |
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| JP4890761B2 (ja) | 2002-07-19 | 2012-03-07 | バクスター・インターナショナル・インコーポレイテッド | 腹膜透析を実施するためのシステムおよび方法 |
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-
1994
- 1994-07-26 FR FR9409499A patent/FR2723002B1/fr not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/462,435 patent/US5702597A/en not_active Expired - Lifetime
- 1995-07-24 ES ES02080290.6T patent/ES2260389T5/es not_active Expired - Lifetime
- 1995-07-24 ES ES95420216T patent/ES2211894T3/es not_active Expired - Lifetime
- 1995-07-24 DE DE69534830.2T patent/DE69534830T3/de not_active Expired - Lifetime
- 1995-07-24 EP EP02080290.6A patent/EP1300167B2/fr not_active Expired - Lifetime
- 1995-07-24 DE DE69532258T patent/DE69532258T2/de not_active Expired - Lifetime
- 1995-07-24 AT AT95420216T patent/ATE255924T1/de not_active IP Right Cessation
- 1995-07-24 AT AT02080290T patent/ATE319492T1/de not_active IP Right Cessation
- 1995-07-24 EP EP95420216A patent/EP0694312B1/fr not_active Expired - Lifetime
- 1995-07-25 CA CA002154629A patent/CA2154629C/en not_active Expired - Lifetime
- 1995-07-26 JP JP19083595A patent/JP3790284B2/ja not_active Expired - Lifetime
-
1997
- 1997-09-22 US US08/934,903 patent/US6039877A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE319492T1 (de) | 2006-03-15 |
| DE69534830T3 (de) | 2014-07-31 |
| DE69532258T2 (de) | 2004-09-16 |
| ATE255924T1 (de) | 2003-12-15 |
| EP1300167A2 (fr) | 2003-04-09 |
| EP0694312B1 (fr) | 2003-12-10 |
| CA2154629C (en) | 2005-11-29 |
| ES2260389T3 (es) | 2006-11-01 |
| EP1300167B1 (fr) | 2006-03-08 |
| EP0694312A2 (fr) | 1996-01-31 |
| US5702597A (en) | 1997-12-30 |
| EP1300167A3 (fr) | 2003-12-17 |
| FR2723002B1 (fr) | 1996-09-06 |
| DE69534830T2 (de) | 2006-10-19 |
| DE69534830D1 (de) | 2006-05-04 |
| FR2723002A1 (fr) | 1996-02-02 |
| DE69532258D1 (de) | 2004-01-22 |
| CA2154629A1 (en) | 1996-01-27 |
| JPH0866474A (ja) | 1996-03-12 |
| EP0694312A3 (enExample) | 1996-03-13 |
| US6039877A (en) | 2000-03-21 |
| EP1300167B2 (fr) | 2014-03-19 |
| ES2260389T5 (es) | 2014-06-10 |
| ES2211894T3 (es) | 2004-07-16 |
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