JP3457014B2 - α−グリコシル カテコールアミン類とその製造方法並びに用途 - Google Patents

α−グリコシル カテコールアミン類とその製造方法並びに用途

Info

Publication number
JP3457014B2
JP3457014B2 JP10154292A JP10154292A JP3457014B2 JP 3457014 B2 JP3457014 B2 JP 3457014B2 JP 10154292 A JP10154292 A JP 10154292A JP 10154292 A JP10154292 A JP 10154292A JP 3457014 B2 JP3457014 B2 JP 3457014B2
Authority
JP
Japan
Prior art keywords
methyldopa
glucosyl
catecholamines
weight
glycosylcatecholamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP10154292A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05255371A (ja
Inventor
哲也 仲田
倫夫 久保田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hayashibara Seibutsu Kagaku Kenkyujo KK
Original Assignee
Hayashibara Seibutsu Kagaku Kenkyujo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hayashibara Seibutsu Kagaku Kenkyujo KK filed Critical Hayashibara Seibutsu Kagaku Kenkyujo KK
Priority to JP10154292A priority Critical patent/JP3457014B2/ja
Priority to TW082101555A priority patent/TW270120B/zh
Priority to DE69327813T priority patent/DE69327813D1/de
Priority to EP93301668A priority patent/EP0564099B1/en
Priority to KR1019930003481A priority patent/KR930019686A/ko
Priority to US08/057,915 priority patent/US5380837A/en
Publication of JPH05255371A publication Critical patent/JPH05255371A/ja
Priority to US08/297,527 priority patent/US5656460A/en
Priority to US08/483,260 priority patent/US5618794A/en
Priority to US08/483,268 priority patent/US5672587A/en
Application granted granted Critical
Publication of JP3457014B2 publication Critical patent/JP3457014B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP10154292A 1992-03-09 1992-03-09 α−グリコシル カテコールアミン類とその製造方法並びに用途 Expired - Fee Related JP3457014B2 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP10154292A JP3457014B2 (ja) 1992-03-09 1992-03-09 α−グリコシル カテコールアミン類とその製造方法並びに用途
TW082101555A TW270120B (enExample) 1992-03-09 1993-03-03
EP93301668A EP0564099B1 (en) 1992-03-09 1993-03-05 Alpha-glucosyl derivative of catecholamine or its salt, and its preparation and uses
DE69327813T DE69327813D1 (de) 1992-03-09 1993-03-05 Alpha-Glucosyl-Catecholaminderivate, ihre Salze, Herstellung und Verwendung
KR1019930003481A KR930019686A (ko) 1992-03-09 1993-03-09 카테콜아민의 α-글리코실 유도체와 그 염 및 그 제조 방법과 용도
US08/057,915 US5380837A (en) 1992-03-09 1993-05-07 α-glycosyl derivative of catecholamine or its salt, and its preparation and uses
US08/297,527 US5656460A (en) 1992-03-09 1994-08-26 α-glycosyl derivative of the catecholamine or its salt, and its preparation and uses
US08/483,260 US5618794A (en) 1992-03-09 1995-06-07 α-glycosyl derivative of catecholamine or its salt, and its preparation and uses
US08/483,268 US5672587A (en) 1992-03-09 1995-06-07 α-Glycosyl derivative of catecholamine or its salt, and its preparation and uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10154292A JP3457014B2 (ja) 1992-03-09 1992-03-09 α−グリコシル カテコールアミン類とその製造方法並びに用途

Publications (2)

Publication Number Publication Date
JPH05255371A JPH05255371A (ja) 1993-10-05
JP3457014B2 true JP3457014B2 (ja) 2003-10-14

Family

ID=14303328

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10154292A Expired - Fee Related JP3457014B2 (ja) 1992-03-09 1992-03-09 α−グリコシル カテコールアミン類とその製造方法並びに用途

Country Status (6)

Country Link
US (4) US5380837A (enExample)
EP (1) EP0564099B1 (enExample)
JP (1) JP3457014B2 (enExample)
KR (1) KR930019686A (enExample)
DE (1) DE69327813D1 (enExample)
TW (1) TW270120B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3457014B2 (ja) * 1992-03-09 2003-10-14 株式会社林原生物化学研究所 α−グリコシル カテコールアミン類とその製造方法並びに用途
US5710133A (en) * 1993-05-07 1998-01-20 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo α-glycosyl derivative of catecholamine or its salt, and its preparation and uses
ES2159484B1 (es) * 1999-12-22 2002-05-01 Consejo Superior Investigacion Derivados de glicosil-diacil dopamina y sus sales como agentes potenciales de reposicion de dopamina en cerebro y su procedimiento de obtencion.
US9302982B2 (en) 2000-04-12 2016-04-05 Glycon Llc Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
US7345031B2 (en) * 2000-04-12 2008-03-18 International Medical Innovations, Inc. Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
US20060189547A1 (en) * 2000-04-12 2006-08-24 Christian Samuel T Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use
JP2002193990A (ja) * 2000-12-25 2002-07-10 Mitsui Chemicals Inc ハイドロカルコン配糖体および該配糖体を有効成分として配合した化粧料
WO2006056604A1 (en) * 2004-11-25 2006-06-01 Evolva Ag Levodopa glycosyl derivatives, methods of preparation and use
US20060280907A1 (en) * 2005-06-08 2006-12-14 Whitaker Robert H Novel mineral composition
US7651559B2 (en) * 2005-11-04 2010-01-26 Franklin Industrial Minerals Mineral composition
US20070104923A1 (en) * 2005-11-04 2007-05-10 Whitaker Robert H Novel mineral composition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4311706A (en) * 1980-01-22 1982-01-19 Interx Research Corporation Novel dopa/dopamine prodrugs
US4337207A (en) * 1980-09-04 1982-06-29 Regents Of The University Of California Biologically active catecholamine derivatives
JP3457014B2 (ja) * 1992-03-09 2003-10-14 株式会社林原生物化学研究所 α−グリコシル カテコールアミン類とその製造方法並びに用途

Also Published As

Publication number Publication date
KR930019686A (ko) 1993-10-18
US5672587A (en) 1997-09-30
TW270120B (enExample) 1996-02-11
EP0564099A1 (en) 1993-10-06
US5618794A (en) 1997-04-08
JPH05255371A (ja) 1993-10-05
DE69327813D1 (de) 2000-03-16
EP0564099B1 (en) 2000-02-09
US5656460A (en) 1997-08-12
US5380837A (en) 1995-01-10

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