JP3342471B2 - 新規方法及び中間体 - Google Patents

新規方法及び中間体

Info

Publication number
JP3342471B2
JP3342471B2 JP2000179880A JP2000179880A JP3342471B2 JP 3342471 B2 JP3342471 B2 JP 3342471B2 JP 2000179880 A JP2000179880 A JP 2000179880A JP 2000179880 A JP2000179880 A JP 2000179880A JP 3342471 B2 JP3342471 B2 JP 3342471B2
Authority
JP
Japan
Prior art keywords
formula
compound
mixture
organic layer
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000179880A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001039949A (ja
Inventor
キース・マイケル・デヴリーズ
ダーレル・ユージーン・フォックス
フィリップ・ディートリック・ハンメン
ジェフリー・ブライアン・ジョージェンセン
デニス・ジェイ・フーヴァー
Original Assignee
ファイザー・プロダクツ・インク
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ファイザー・プロダクツ・インク filed Critical ファイザー・プロダクツ・インク
Publication of JP2001039949A publication Critical patent/JP2001039949A/ja
Application granted granted Critical
Publication of JP3342471B2 publication Critical patent/JP3342471B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2000179880A 1999-06-18 2000-06-15 新規方法及び中間体 Expired - Fee Related JP3342471B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13999799P 1999-06-18 1999-06-18
US60/139997 1999-06-18

Publications (2)

Publication Number Publication Date
JP2001039949A JP2001039949A (ja) 2001-02-13
JP3342471B2 true JP3342471B2 (ja) 2002-11-11

Family

ID=22489263

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000179880A Expired - Fee Related JP3342471B2 (ja) 1999-06-18 2000-06-15 新規方法及び中間体

Country Status (18)

Country Link
US (1) US6410750B1 (enExample)
EP (1) EP1061074A1 (enExample)
JP (1) JP3342471B2 (enExample)
KR (1) KR20010049559A (enExample)
CN (1) CN1283615A (enExample)
AU (1) AU4089200A (enExample)
BR (1) BR0002686A (enExample)
CA (1) CA2311872A1 (enExample)
CZ (1) CZ20002242A3 (enExample)
HU (1) HUP0002285A3 (enExample)
ID (1) ID26385A (enExample)
IL (1) IL136726A0 (enExample)
IN (1) IN188853B (enExample)
PL (1) PL340866A1 (enExample)
RU (1) RU2195450C2 (enExample)
TR (1) TR200001781A2 (enExample)
YU (1) YU38000A (enExample)
ZA (1) ZA200002987B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1838695A2 (en) * 2005-01-06 2007-10-03 Shering Corporation Preparation of ketone amides
ES2699773T3 (es) * 2011-05-31 2019-02-12 Theravance Biopharma R&D Ip Llc Inhibidores de neprilisina

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9709875A (es) 1995-06-06 1998-03-31 Pfizer N-(indol-2-carbonil)-glicinamidas substituidas y derivados como inhibidores de glicogeno fosforilasa, composiciones que las contienen y uso de las mismas.
US6297269B1 (en) 1995-06-06 2001-10-02 Pfizer Inc. Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors

Also Published As

Publication number Publication date
PL340866A1 (en) 2001-01-02
TR200001781A2 (tr) 2001-01-22
CN1283615A (zh) 2001-02-14
HU0002285D0 (en) 2000-08-28
EP1061074A1 (en) 2000-12-20
KR20010049559A (ko) 2001-06-15
AU4089200A (en) 2000-12-21
CZ20002242A3 (cs) 2002-01-16
RU2195450C2 (ru) 2002-12-27
HUP0002285A3 (en) 2002-09-30
ZA200002987B (en) 2001-12-14
HUP0002285A2 (en) 2001-03-28
YU38000A (sh) 2003-02-28
BR0002686A (pt) 2001-08-21
IN188853B (enExample) 2002-11-16
US6410750B1 (en) 2002-06-25
ID26385A (id) 2000-12-21
JP2001039949A (ja) 2001-02-13
IL136726A0 (en) 2001-06-14
CA2311872A1 (en) 2000-12-18

Similar Documents

Publication Publication Date Title
JP5802242B2 (ja) オピオイド調節物質の製造方法
MX2012005526A (es) Pirrolidin-2-carboxamida sustituida.
JP3258334B2 (ja) インドリルマレイミドの合成
US5859261A (en) Synthesis of indolylmaleimides
JP2001039949A (ja) 新規方法及び中間体
CN114106089A (zh) 一种经由碳氢活化芳基化合成β2AR别构调节剂化合物的方法
US20050234242A1 (en) Process for cross coupling indoles
CN102471239A (zh) 光学活性的1-氨基-2-乙烯基环丙甲酸酯的制造方法
EP0145459A2 (en) Process for the production of chemical compounds
US10457690B2 (en) Process for preparing substituted tetracyclic heterocycle compounds
JP2945957B2 (ja) 含フッ素一級アミンの製造法
CN100422170C (zh) 喹诺酮羧酸衍生物的制备方法
JP2004526735A (ja) ベナゼプリルの製造方法
MXPA00006046A (en) Novel process and intermediates
CN102791696A (zh) 氨基醇衍生物及其治疗活性
US20020151718A1 (en) Synthesis of pyrrole amides
CN120398833A (zh) 一类3-(哌啶-4-基)喹啉-2(1h)-酮类衍生物及其用途
JP2871556B2 (ja) プロペノン誘導体及びその製造法
KR20220143094A (ko) 키랄 벤조디아제피논 유도체의 제조 방법
JPH0940645A (ja) インドール−２−カルボン酸誘導体
CN111170927A (zh) 一种沙格列汀中间体的制备方法
CN110799493A (zh) 制备α-甲基-L-脯氨酸的方法
JP2005194266A (ja) インドール類の合成方法および合成中間体
JP2007119399A (ja) Ｎ−保護−２−アミノペンタン酸誘導体の製造方法
JP2001328993A (ja) 光学活性ホスフィン化合物

Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees