JP3229990B2 - β―立体配置をもつジオキソランヌクレオシドの合成のための方法および成分 - Google Patents

β―立体配置をもつジオキソランヌクレオシドの合成のための方法および成分

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Publication number
JP3229990B2
JP3229990B2 JP52157397A JP52157397A JP3229990B2 JP 3229990 B2 JP3229990 B2 JP 3229990B2 JP 52157397 A JP52157397 A JP 52157397A JP 52157397 A JP52157397 A JP 52157397A JP 3229990 B2 JP3229990 B2 JP 3229990B2
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Japan
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group
carbon atoms
atom
formula
hydrogen atom
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JP52157397A
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English (en)
Japanese (ja)
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JP2000501714A (ja
Inventor
マンサワ，タレク
シムポイア，アレックス
ベドナルスキ，クルジスズトフ
Original Assignee
バイオケム ファーマ インコーポレイテッド
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP52157397A 1995-12-14 1996-12-13 β―立体配置をもつジオキソランヌクレオシドの合成のための方法および成分 Expired - Lifetime JP3229990B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
GB9525606.1 1995-12-14
PCT/CA1996/000845 WO1997021706A1 (en) 1995-12-14 1996-12-13 METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Publications (2)

Publication Number Publication Date
JP2000501714A JP2000501714A (ja) 2000-02-15
JP3229990B2 true JP3229990B2 (ja) 2001-11-19

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52157397A Expired - Lifetime JP3229990B2 (ja) 1995-12-14 1996-12-13 β―立体配置をもつジオキソランヌクレオシドの合成のための方法および成分

Country Status (27)

Country Link
US (4) US5922867A (en:Method)
EP (1) EP0970074B1 (en:Method)
JP (1) JP3229990B2 (en:Method)
KR (1) KR100406159B1 (en:Method)
CN (1) CN1080263C (en:Method)
AP (1) AP879A (en:Method)
AT (1) ATE214699T1 (en:Method)
AU (1) AU706328B2 (en:Method)
BR (1) BR9612351A (en:Method)
CA (1) CA2237730C (en:Method)
DE (1) DE69620042T2 (en:Method)
DK (1) DK0970074T3 (en:Method)
EA (1) EA000844B1 (en:Method)
ES (1) ES2172697T3 (en:Method)
GB (1) GB9525606D0 (en:Method)
HU (1) HU224076B1 (en:Method)
IL (3) IL124663A (en:Method)
IN (1) IN187349B (en:Method)
MX (1) MX9804701A (en:Method)
NO (1) NO309901B1 (en:Method)
NZ (1) NZ323855A (en:Method)
OA (1) OA11094A (en:Method)
PL (1) PL188447B1 (en:Method)
PT (1) PT970074E (en:Method)
TW (1) TW341574B (en:Method)
WO (1) WO1997021706A1 (en:Method)
ZA (1) ZA9610544B (en:Method)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410546B1 (en) 1997-04-07 2002-06-25 Triangle Pharmaceuticals, Inc. Use of MKC-442 in combination with other antiviral agents
DE69921829T2 (de) 1998-08-12 2005-10-27 Gilead Sciences, Inc., Foster City Verfahren zur herstellung von 1,3-oxathiolannukleoside
US6979561B1 (en) * 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
JP2002533470A (ja) 1998-12-23 2002-10-08 シャイアー・バイオケム・インコーポレイテッド 抗ウイルス性ヌクレオシド類似体
CA2362570A1 (en) * 1999-02-11 2000-08-17 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
EP1214074B1 (en) * 1999-09-24 2004-06-16 Shire Biochem Inc. Dioxolane nucleoside analogs for the treatment or prevention of viral infection
CA2389745C (en) 1999-11-04 2010-03-23 Shire Biochem Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
US7038039B2 (en) * 2000-02-10 2006-05-02 Mitsui Chemicals, Inc. Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
WO2001058894A1 (en) * 2000-02-11 2001-08-16 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
WO2002070518A1 (en) * 2001-03-01 2002-09-12 Triangle Pharmaceuticals, Inc. Polymorphic and other crystalline forms of cis-ftc
AU2002329970A1 (en) * 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
AU2002336864B2 (en) * 2001-11-02 2006-08-17 Shire Biochem Inc. Pharmaceutical compositions for the treatment of leukemia comprising dioxolane nucleosides analogs
US7105527B2 (en) * 2001-12-14 2006-09-12 Otto Michael J N4-acylcytosine nucleosides for treatment of viral infections
JP4441265B2 (ja) * 2002-01-25 2010-03-31 シャー バイオケム インコーポレイティッド ジオキソランヌクレオシド類似体の製造方法
AU2003294212B2 (en) 2002-08-06 2010-01-07 Pharmasset Inc. Processes for preparing 1,3-dioxolane nucleosides
CN101724110B (zh) 2002-10-15 2013-03-27 埃克森美孚化学专利公司 用于烯烃聚合的多催化剂体系和由其生产的聚合物
DE10335061B4 (de) 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
KR101157468B1 (ko) * 2004-02-03 2012-07-06 에모리 유니버시티 1,3-디옥솔란 뉴클레오시드 제조방법
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (ja) * 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
CN1086519A (zh) * 1992-06-22 1994-05-11 伊莱利利公司 立体有择阴离子糖基化方法

Also Published As

Publication number Publication date
US20030060476A1 (en) 2003-03-27
NO982716D0 (no) 1998-06-12
EP0970074A1 (en) 2000-01-12
PL327443A1 (en) 1998-12-07
BR9612351A (pt) 1999-07-13
IL144155A0 (en) 2002-05-23
EP0970074B1 (en) 2002-03-20
EA199800555A1 (ru) 1999-02-25
DK0970074T3 (da) 2002-07-15
PL188447B1 (pl) 2005-02-28
US5922867A (en) 1999-07-13
KR100406159B1 (ko) 2004-11-16
IN187349B (en:Method) 2002-03-30
EA000844B1 (ru) 2000-06-26
TW341574B (en) 1998-10-01
GB9525606D0 (en) 1996-02-14
WO1997021706A1 (en) 1997-06-19
PT970074E (pt) 2002-09-30
CN1208414A (zh) 1999-02-17
US6069250A (en) 2000-05-30
IL124663A0 (en) 1998-12-06
CA2237730A1 (en) 1997-06-19
JP2000501714A (ja) 2000-02-15
HK1017886A1 (en) 1999-12-03
US20020058670A1 (en) 2002-05-16
DE69620042T2 (de) 2002-10-17
CA2237730C (en) 2001-12-04
CN1080263C (zh) 2002-03-06
AU706328B2 (en) 1999-06-17
ATE214699T1 (de) 2002-04-15
AP9801252A0 (en) 1998-06-30
DE69620042D1 (de) 2002-04-25
IL144155A (en) 2003-07-06
NO309901B1 (no) 2001-04-17
HUP9901050A2 (hu) 2001-04-28
AP879A (en) 2000-10-02
ES2172697T3 (es) 2002-10-01
HUP9901050A3 (en) 2001-05-28
HU224076B1 (hu) 2005-05-30
OA11094A (en) 2003-03-13
NZ323855A (en) 1999-11-29
NO982716L (no) 1998-06-12
IL124663A (en) 2001-10-31
ZA9610544B (en) 1997-07-29
AU1089397A (en) 1997-07-03
KR19990072141A (ko) 1999-09-27
MX9804701A (es) 1998-10-31

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