JP3181919B2 - アミノチアゾール誘導体、それを含有する医薬及び該化合物の製造中間体 - Google Patents

アミノチアゾール誘導体、それを含有する医薬及び該化合物の製造中間体

Info

Publication number
JP3181919B2
JP3181919B2 JP53470396A JP53470396A JP3181919B2 JP 3181919 B2 JP3181919 B2 JP 3181919B2 JP 53470396 A JP53470396 A JP 53470396A JP 53470396 A JP53470396 A JP 53470396A JP 3181919 B2 JP3181919 B2 JP 3181919B2
Authority
JP
Japan
Prior art keywords
group
amino
thiazole
nmr
brs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP53470396A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO1996036619A1 (ja
Inventor
正明 長澤
正和 村田
裕康 西岡
忠 栗本
茂 上木
治 北川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Original Assignee
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharmaceutical Co Ltd filed Critical Zeria Pharmaceutical Co Ltd
Publication of JPWO1996036619A1 publication Critical patent/JPWO1996036619A1/ja
Application granted granted Critical
Publication of JP3181919B2 publication Critical patent/JP3181919B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP53470396A 1995-05-18 1996-05-16 アミノチアゾール誘導体、それを含有する医薬及び該化合物の製造中間体 Expired - Lifetime JP3181919B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP7-142399 1995-05-18
JP14239995 1995-05-18
PCT/JP1996/001297 WO1996036619A1 (en) 1995-05-18 1996-05-16 Aminothiazole derivatives, drug containing the same and intermediate in the production of the compounds

Publications (2)

Publication Number Publication Date
JPWO1996036619A1 JPWO1996036619A1 (ja) 1998-07-21
JP3181919B2 true JP3181919B2 (ja) 2001-07-03

Family

ID=15314454

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53470396A Expired - Lifetime JP3181919B2 (ja) 1995-05-18 1996-05-16 アミノチアゾール誘導体、それを含有する医薬及び該化合物の製造中間体

Country Status (14)

Country Link
US (1) US5981557A (enExample)
EP (1) EP0870765B1 (enExample)
JP (1) JP3181919B2 (enExample)
KR (1) KR100424933B1 (enExample)
CN (1) CN1063442C (enExample)
AT (1) ATE254609T1 (enExample)
AU (1) AU699008B2 (enExample)
CA (1) CA2219747C (enExample)
DE (1) DE69630806T2 (enExample)
DK (1) DK0870765T3 (enExample)
ES (1) ES2210366T3 (enExample)
PT (1) PT870765E (enExample)
TW (1) TW445260B (enExample)
WO (1) WO1996036619A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011020957A (ja) * 2009-07-16 2011-02-03 Zeria Pharmaceutical Co Ltd アルツハイマー病治療薬

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DE69718498T2 (de) * 1996-10-24 2003-10-09 Zeria Pharmaceutical Co., Ltd. Substituierte benzoylthiazolderivate und sie enthaltende medikamente
EP0994108B1 (en) * 1997-06-24 2003-05-14 Zeria Pharmaceutical Co., Ltd. Process for producing 2-hydroxybenzamide derivatives
CA2312484A1 (en) 1997-12-11 1999-06-17 Smithkline Beecham Corporation Hepatitis c virus ns5b truncated protein and methods thereof to identify antiviral compounds
SE9803773D0 (sv) * 1998-11-05 1998-11-05 Astra Pharma Prod Compounds
AU2001256685B2 (en) 2000-09-08 2005-12-22 Zeria Pharmaceutical Co., Ltd. Pharmaceutical compositions containing aminothiazole derivatives for the treatment of colonic motor dysfunctions
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
JP5281226B2 (ja) * 2002-04-08 2013-09-04 ゼリア新薬工業株式会社 胃食物受容能障害治療薬
US6986901B2 (en) * 2002-07-15 2006-01-17 Warner-Lambert Company Llc Gastrointestinal compositions
US20040010035A1 (en) * 2002-07-15 2004-01-15 Ciociola Arthur A. Gastrointestinal compositions
CA2491797A1 (en) * 2002-07-10 2004-01-22 Warner-Lambert Company Llc Gastrointestinal compositions
GB0412468D0 (en) * 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
AU2011244991B2 (en) * 2004-08-23 2012-08-23 Zeria Pharmaceutical Co., Ltd. Method for producing aminothiazole derivative and production intermediate
PT2269975E (pt) 2004-08-23 2015-09-24 Zeria Pharm Co Ltd Processo para a produção de derivado de aminotiazole e intermediário de produção
US8586761B2 (en) 2004-08-23 2013-11-19 Zeria Pharmaceutical Co., Ltd. Method for producing aminothiazole derivative and production intermediate
EP1797084A1 (en) * 2004-09-20 2007-06-20 4Sc Ag NOVEL HETEROCYCLIC NF-kB INHIBITORS
WO2006032273A1 (en) 2004-09-22 2006-03-30 H. Lundbeck A/S 2-acylaminothiazole derivatives
US7552781B2 (en) 2004-10-20 2009-06-30 Black & Decker Inc. Power tool anti-kickback system with rotational rate sensor
US7674912B2 (en) 2005-04-25 2010-03-09 H. Lundbeck A/S Pro-drugs of N-thiazol-2-yl-benzamide derivatives
JP4651714B2 (ja) 2005-07-09 2011-03-16 アストラゼネカ アクチボラグ 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
NZ588971A (en) * 2005-07-29 2012-06-29 4Sc Discovery Gmbh Novel heterocyclic NF-kappaB inhibitors
JP2007119416A (ja) * 2005-10-31 2007-05-17 Bayer Cropscience Ag 殺虫性２−アシルアミノチアゾール−４−カルボキサミド類
WO2007116901A1 (ja) * 2006-04-05 2007-10-18 Banyu Pharmaceutical Co., Ltd. 新規アリールアミド誘導体
US8418778B2 (en) 2010-01-07 2013-04-16 Black & Decker Inc. Power screwdriver having rotary input control
US9266178B2 (en) 2010-01-07 2016-02-23 Black & Decker Inc. Power tool having rotary input control
JP2013516335A (ja) 2010-01-07 2013-05-13 ブラック アンド デッカー インク 回転入力制御機能を有する動力スクリュードライバ
US9475180B2 (en) 2010-01-07 2016-10-25 Black & Decker Inc. Power tool having rotary input control
CN103204824B (zh) * 2012-01-12 2015-04-08 清华大学深圳研究生院 2-氨基噻唑-4-酰胺类衍生物及其制备方法与应用
EP2631035B1 (en) 2012-02-24 2019-10-16 Black & Decker Inc. Power tool
CN103387552B (zh) * 2012-05-10 2016-06-08 常州市第四制药厂有限公司 制备盐酸阿考替胺的方法
CN104447612A (zh) * 2013-09-16 2015-03-25 天津市汉康医药生物技术有限公司 阿考替胺水合物晶型及其制备方法和用途
CN103896873B (zh) * 2013-10-23 2015-11-25 山东诚创医药技术开发有限公司 一种盐酸阿考替胺的精制方法
CN104592147A (zh) * 2013-10-30 2015-05-06 江苏豪森药业股份有限公司 盐酸阿考替胺中间体的制备方法
CN103665023B (zh) * 2013-12-23 2017-05-24 华润赛科药业有限责任公司 一种盐酸阿考替胺的合成方法
CN103980226A (zh) * 2014-05-10 2014-08-13 杭州新博思生物医药有限公司 盐酸阿考替胺水合物晶型及其制备方法
CN104031001B (zh) * 2014-06-30 2015-09-30 山东诚创医药技术开发有限公司 一锅烩制备2-[n-(2,4,5-三甲氧基苯甲胺基)氨基]-4-乙氧羰基-1,3-噻唑的方法
CN104130207B (zh) * 2014-07-07 2016-08-24 湖北华世通生物医药科技有限公司 阿考替胺氢溴酸盐水合物及其晶型的制备方法
CN105439977A (zh) * 2014-09-26 2016-03-30 广州朗圣药业有限公司 一种阿考替胺及其盐酸盐的制备方法
CN105924406B (zh) * 2016-05-04 2018-04-10 河北国龙制药有限公司 一种盐酸阿考替胺三水合物的制备方法
US10589413B2 (en) 2016-06-20 2020-03-17 Black & Decker Inc. Power tool with anti-kickback control system
KR102453655B1 (ko) * 2017-10-25 2022-10-12 (주)헥사파마텍 아코티아미드의 개선된 제조방법
CN108358867A (zh) * 2018-05-05 2018-08-03 邳州易萨新型材料有限公司 一种盐酸阿考替胺的合成方法
CN109776447B (zh) * 2019-02-28 2021-03-02 常州市阳光药业有限公司 盐酸阿考替胺工业化生产方法
CN109988121B (zh) * 2019-04-28 2023-01-03 梯尔希（南京）药物研发有限公司 一种阿考替胺衍生物的制备方法
CN111518052A (zh) * 2020-05-27 2020-08-11 廊坊市泽康医药科技有限公司 一种阿考替胺盐酸盐杂质的制备方法
TW202440087A (zh) 2023-03-15 2024-10-16 日商志瑞亞新藥工業股份有限公司 排尿障礙改善劑

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JP2011020957A (ja) * 2009-07-16 2011-02-03 Zeria Pharmaceutical Co Ltd アルツハイマー病治療薬

Also Published As

Publication number Publication date
PT870765E (pt) 2004-03-31
DE69630806D1 (de) 2003-12-24
TW445260B (en) 2001-07-11
CN1184471A (zh) 1998-06-10
CA2219747A1 (en) 1996-11-21
KR19990008282A (ko) 1999-01-25
CA2219747C (en) 2008-11-25
EP0870765A4 (enExample) 1998-10-14
KR100424933B1 (ko) 2004-07-27
AU5702496A (en) 1996-11-29
EP0870765B1 (en) 2003-11-19
US5981557A (en) 1999-11-09
DE69630806T2 (de) 2004-04-15
EP0870765A1 (en) 1998-10-14
ES2210366T3 (es) 2004-07-01
CN1063442C (zh) 2001-03-21
DK0870765T3 (da) 2004-02-23
WO1996036619A1 (en) 1996-11-21
AU699008B2 (en) 1998-11-19
ATE254609T1 (de) 2003-12-15

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