JP2778832B2 - Ｇａｂａ−ｂアンタゴニストとしての２−置換モルホリンおよびチオモルホリン誘導体 - Google Patents
Ｇａｂａ−ｂアンタゴニストとしての２−置換モルホリンおよびチオモルホリン誘導体Info
- Publication number
- JP2778832B2 JP2778832B2 JP6522103A JP52210394A JP2778832B2 JP 2778832 B2 JP2778832 B2 JP 2778832B2 JP 6522103 A JP6522103 A JP 6522103A JP 52210394 A JP52210394 A JP 52210394A JP 2778832 B2 JP2778832 B2 JP 2778832B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- group
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
- C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3858493A | 1993-03-26 | 1993-03-26 | |
| US038,584 | 1993-03-26 | ||
| US08/038,584 | 1993-03-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08503229A JPH08503229A (ja) | 1996-04-09 |
| JP2778832B2 true JP2778832B2 (ja) | 1998-07-23 |
Family
ID=21900746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6522103A Expired - Fee Related JP2778832B2 (ja) | 1993-03-26 | 1994-03-23 | Ｇａｂａ−ｂアンタゴニストとしての２−置換モルホリンおよびチオモルホリン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5929236A (enExample) |
| EP (1) | EP0690850B1 (enExample) |
| JP (1) | JP2778832B2 (enExample) |
| AT (1) | ATE160143T1 (enExample) |
| AU (1) | AU6408894A (enExample) |
| CA (1) | CA2158952C (enExample) |
| DE (1) | DE69406779T2 (enExample) |
| DK (1) | DK0690850T3 (enExample) |
| ES (1) | ES2109683T3 (enExample) |
| GR (1) | GR3025950T3 (enExample) |
| IL (1) | IL109111A (enExample) |
| TW (1) | TW280817B (enExample) |
| WO (1) | WO1994022843A1 (enExample) |
| ZA (1) | ZA942090B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2229036A1 (en) * | 1995-09-07 | 1997-03-13 | Stuart Norman Lile Bennett | Substituted phosphinic compounds and their use as pharmaceuticals |
| WO1998028313A1 (en) * | 1996-12-24 | 1998-07-02 | Novartis Ag | (thio)morpholine-substituted carboxylic and phosphinic acids |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| US20070112017A1 (en) * | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス，インコーポレイティド | ４−アシルアミノピリジン誘導体を含む組み合わせ |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889857A (en) * | 1987-10-12 | 1989-12-26 | Yoshitomi Pharmaceutical Industries, Ltd. | Quinolonecarboxylic acid compounds and pharmaceutical use thereof |
| NZ233503A (en) * | 1989-05-15 | 1991-06-25 | Janssen Pharmaceutica Nv | Substituted (thio)morpholinyl and piperazinyl alkylphenol ethers |
| JPH04270272A (ja) * | 1991-02-25 | 1992-09-25 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
-
1994
- 1994-03-23 JP JP6522103A patent/JP2778832B2/ja not_active Expired - Fee Related
- 1994-03-23 AT AT94911608T patent/ATE160143T1/de not_active IP Right Cessation
- 1994-03-23 EP EP94911608A patent/EP0690850B1/en not_active Expired - Lifetime
- 1994-03-23 WO PCT/US1994/002803 patent/WO1994022843A1/en not_active Ceased
- 1994-03-23 ES ES94911608T patent/ES2109683T3/es not_active Expired - Lifetime
- 1994-03-23 US US08/525,795 patent/US5929236A/en not_active Expired - Fee Related
- 1994-03-23 DK DK94911608.1T patent/DK0690850T3/da active
- 1994-03-23 DE DE69406779T patent/DE69406779T2/de not_active Expired - Lifetime
- 1994-03-23 CA CA002158952A patent/CA2158952C/en not_active Expired - Fee Related
- 1994-03-23 AU AU64088/94A patent/AU6408894A/en not_active Abandoned
- 1994-03-24 IL IL10911194A patent/IL109111A/en not_active IP Right Cessation
- 1994-03-24 ZA ZA942090A patent/ZA942090B/xx unknown
- 1994-03-24 TW TW083102586A patent/TW280817B/zh active
-
1998
- 1998-01-20 GR GR980400120T patent/GR3025950T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0690850T3 (da) | 1998-02-09 |
| GR3025950T3 (en) | 1998-04-30 |
| CA2158952A1 (en) | 1994-10-13 |
| TW280817B (enExample) | 1996-07-11 |
| JPH08503229A (ja) | 1996-04-09 |
| ES2109683T3 (es) | 1998-01-16 |
| AU6408894A (en) | 1994-10-24 |
| CA2158952C (en) | 1999-05-18 |
| WO1994022843A1 (en) | 1994-10-13 |
| US5929236A (en) | 1999-07-27 |
| EP0690850B1 (en) | 1997-11-12 |
| ATE160143T1 (de) | 1997-11-15 |
| ZA942090B (en) | 1994-09-26 |
| DE69406779D1 (en) | 1997-12-18 |
| IL109111A (en) | 1999-07-14 |
| EP0690850A1 (en) | 1996-01-10 |
| IL109111A0 (en) | 1994-06-24 |
| DE69406779T2 (de) | 1998-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69633607T2 (de) | Piperidinderivate mit tachykinin-antagonistischer wirkung | |
| EP0699199B1 (en) | Heteroatom substituted alkyl benzylaminoquinuclidines as substance p antagonists | |
| DE69333143T2 (de) | Substituierte chinuclidine als substanz p antagonisten | |
| JP3534765B2 (ja) | 喘息治療用のニューロキニン２受容体拮抗薬としての新規な４−ピペリジニル置換ラクタム | |
| DE60319951T2 (de) | Aminocyclische substituierte pyrrolopyrimidinderivate und pyrrolopyridinderivate | |
| DE69107250T2 (de) | Neue 4-Aminobuttersäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneizubereitungen. | |
| DE60309057T2 (de) | Azabicycloderivate als antagonisten des muscarinischen rezeptors | |
| DE69631784T2 (de) | 3-(4-subst.-piperidinyl-1)-1-(3,4-dichlorophenyl)propylcarbamate und -harnstoffe und andere derivative als neue neurokinin-antagonisten | |
| PL171921B1 (pl) | Sposób wytwarzania nowych pochodnych podstawionej 3-aminochinuklidyny PL PL PL PL PL | |
| EP0338331A1 (de) | 1,3-Disubstituierte Pyrrolidine | |
| DE69210875T2 (de) | Piperidinderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung | |
| JP2778832B2 (ja) | Ｇａｂａ−ｂアンタゴニストとしての２−置換モルホリンおよびチオモルホリン誘導体 | |
| EP0271795A2 (de) | Octahydro-10-oxo-6H-pyridazo [1,2-a] [1,2] diazepin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel | |
| DE69323322T2 (de) | Verwendung dimethylbenzofuran und dimethylbenzopyran derivate als 5-ht3 antagoniste | |
| DE69622569T2 (de) | Quinoneverbindung, seine herstellung und anwendung. | |
| DE68925173T2 (de) | 4-Methyl und 4-Ethyl substituierte Pyrrolidin-2-one | |
| DE3320102C2 (enExample) | ||
| EP0389425B1 (de) | Neue Benzothiopyranylamine | |
| DE3888811T2 (de) | Tricyclische Carbamate, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung. | |
| DE69827614T2 (de) | Chinoxalindionen | |
| EP0266308B1 (de) | Indolo-pyrazino-benzodiazepin-Derivate | |
| DE69515402T2 (de) | Oxazolochinolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel | |
| US4826869A (en) | N-(lower alkyl)-2-(3'ureidobenzyl)pyrrolidines | |
| EP1963299B1 (de) | Oxaphenanthren-derivate | |
| EP0187619A2 (de) | 1,3-disubstituierte Tetrahydropyridine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090508 Year of fee payment: 11 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090508 Year of fee payment: 11 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100508 Year of fee payment: 12 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110508 Year of fee payment: 13 |
|
| LAPS | Cancellation because of no payment of annual fees |