JP2026000916A5 - - Google Patents
Info
- Publication number
- JP2026000916A5 JP2026000916A5 JP2025140269A JP2025140269A JP2026000916A5 JP 2026000916 A5 JP2026000916 A5 JP 2026000916A5 JP 2025140269 A JP2025140269 A JP 2025140269A JP 2025140269 A JP2025140269 A JP 2025140269A JP 2026000916 A5 JP2026000916 A5 JP 2026000916A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- pharmaceutically acceptable
- substituted
- compound according
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263343959P | 2022-05-19 | 2022-05-19 | |
| US63/343,959 | 2022-05-19 | ||
| PCT/US2023/022914 WO2023225302A1 (en) | 2022-05-19 | 2023-05-19 | Aza-tetracyclic oxazepine compounds and uses thereof |
| JP2024568561A JP7735594B2 (ja) | 2022-05-19 | 2023-05-19 | アザ四環式オキサゼピン化合物及びその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024568561A Division JP7735594B2 (ja) | 2022-05-19 | 2023-05-19 | アザ四環式オキサゼピン化合物及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2026000916A JP2026000916A (ja) | 2026-01-06 |
| JP2026000916A5 true JP2026000916A5 (enExample) | 2026-05-22 |
Family
ID=86895902
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024568561A Active JP7735594B2 (ja) | 2022-05-19 | 2023-05-19 | アザ四環式オキサゼピン化合物及びその使用 |
| JP2025140269A Pending JP2026000916A (ja) | 2022-05-19 | 2025-08-26 | アザ四環式オキサゼピン化合物及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024568561A Active JP7735594B2 (ja) | 2022-05-19 | 2023-05-19 | アザ四環式オキサゼピン化合物及びその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20240025919A1 (enExample) |
| EP (1) | EP4526309A1 (enExample) |
| JP (2) | JP7735594B2 (enExample) |
| KR (1) | KR20250013185A (enExample) |
| CN (1) | CN119365467A (enExample) |
| AR (1) | AR129388A1 (enExample) |
| AU (1) | AU2023272945A1 (enExample) |
| CA (1) | CA3257445A1 (enExample) |
| CL (1) | CL2024003491A1 (enExample) |
| CO (1) | CO2024017330A2 (enExample) |
| CR (1) | CR20240508A (enExample) |
| IL (1) | IL316696A (enExample) |
| MX (1) | MX2024014176A (enExample) |
| PE (1) | PE20250752A1 (enExample) |
| TW (1) | TW202400170A (enExample) |
| WO (1) | WO2023225302A1 (enExample) |
| ZA (1) | ZA202408076B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119569702A (zh) | 2018-04-04 | 2025-03-07 | 阿尔维纳斯运营股份有限公司 | 蛋白水解调节剂及相关使用方法 |
| CA3220929A1 (en) * | 2021-06-21 | 2022-12-29 | Xin Li | Fused tetracyclic compound, preparation method therefor and application thereof in medicine |
| KR20240029051A (ko) * | 2021-07-02 | 2024-03-05 | 상하이 드 노보 파마테크 컴퍼니 리미티드 | Kras g12d 억제제 및 이의 용도 |
| TW202315626A (zh) * | 2021-08-31 | 2023-04-16 | 大陸商勁方醫藥科技(上海)有限公司 | 嘧啶并環類化合物及其製法和用途 |
| CR20240508A (es) | 2022-05-19 | 2024-12-20 | Genentech Inc | Compuestos aza-tetracíclicos de oxazepina y usos de los mismos |
| TW202409051A (zh) * | 2022-07-27 | 2024-03-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠環類化合物、其製備方法及其在醫藥上的應用 |
| KR20250060956A (ko) | 2022-08-05 | 2025-05-07 | 컴쿼트 바이오사이언시즈 인크. | 헤테로환 화합물 및 이의 용도 |
| CN121419983A (zh) | 2023-01-26 | 2026-01-27 | 阿尔维纳斯运营股份有限公司 | 基于小脑蛋白的kras降解protac及其相关用途 |
| AU2024241633A1 (en) | 2023-03-30 | 2025-11-06 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
| CN121712509A (zh) | 2023-05-04 | 2026-03-20 | 锐新医药公司 | 用于ras相关疾病或病症的组合疗法 |
| WO2024243186A2 (en) * | 2023-05-22 | 2024-11-28 | Board Of Regents, The University Of Texas System | Heterocyclic compounds as nras inhibitors |
| TW202504599A (zh) | 2023-06-30 | 2025-02-01 | 美商必治妥美雅史谷比公司 | Kras抑制劑 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| AU2024333376A1 (en) * | 2023-08-31 | 2026-02-12 | Suzhou Zanrong Pharma Limited | Kras inhibitors and uses thereof |
| IL327306A (en) | 2023-10-12 | 2026-05-01 | Revolution Medicines Inc | Macrocyclic RAS inhibitors |
| TW202540122A (zh) * | 2023-11-22 | 2025-10-16 | 美商建南德克公司 | Ｋｒａｓ－ｇ１２ｄ之氮雜－四環氧氮呯抑制劑的多晶型物及合成方法 |
| WO2025123007A1 (en) * | 2023-12-08 | 2025-06-12 | Kestrel Therapeutics Inc. | Ras inhibitors and methods of use thereof |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202600562A (zh) | 2024-03-15 | 2026-01-01 | 美商建南德克公司 | 線性取代之氧氮呯－５－酮ｋｒａｓ－ｇ１２ｄ抑制劑 |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026011344A1 (en) * | 2024-07-10 | 2026-01-15 | Nikang Therapeutics, Inc. | Bifunctional compounds for degrading kras-12d via ubiquitin proteasome pathway |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026035945A1 (en) | 2024-08-07 | 2026-02-12 | Tesseract Medicines Us, Llc | Covalent-induced drug conjugates targeting kras and comprising a topoisomerase payload |
| WO2026035947A1 (en) | 2024-08-07 | 2026-02-12 | Tesseract Medicines Us, Llc | Kras-targeting covalent-induced drug conjugates comprising a topoisomerase payload |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026064520A1 (en) | 2024-09-19 | 2026-03-26 | Tesseract Medicines Us, Llc | Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload |
| WO2026064527A1 (en) | 2024-09-19 | 2026-03-26 | Tesseract Medicines Us, Llc | Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026073024A1 (en) * | 2024-09-30 | 2026-04-02 | Gilead Sciences, Inc. | Kras g12d inhibitors for the treatment of cancer |
| WO2026080548A1 (en) | 2024-10-10 | 2026-04-16 | Genentech, Inc. | Method of treating cancer using the kras g12d inhibitor gcd-7035 |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| CN121108144A (zh) * | 2025-09-02 | 2025-12-12 | 领泰生物医药(绍兴)有限公司 | 一种含氮杂多环化合物的制备方法及其中间体 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| AR111776A1 (es) * | 2017-05-11 | 2019-08-21 | Astrazeneca Ab | Heteroarilos inhibidores de las proteínas ras mutantes de g12c |
| TW202012415A (zh) | 2018-05-08 | 2020-04-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
| ES3004042T3 (en) | 2018-11-09 | 2025-03-11 | Hoffmann La Roche | Fused ring compounds |
| CA3148745A1 (en) * | 2019-08-29 | 2021-03-04 | Xiaolun Wang | Kras g12d inhibitors |
| EP4065231A1 (en) | 2019-11-27 | 2022-10-05 | Revolution Medicines, Inc. | Covalent ras inhibitors and uses thereof |
| US20230174518A1 (en) | 2020-04-24 | 2023-06-08 | Taiho Pharmaceutical Co., Ltd. | Kras g12d protein inhibitors |
| CN116867792A (zh) | 2021-02-09 | 2023-10-10 | 基因泰克公司 | 四环氧氮杂䓬化合物及其用途 |
| WO2022188729A1 (en) | 2021-03-07 | 2022-09-15 | Jacobio Pharmaceuticals Co., Ltd. | Fused ring derivatives useful as kras g12d inhibitors |
| JP2024510022A (ja) | 2021-03-17 | 2024-03-05 | ▲勁▼方医▲薬▼科技（上海）有限公司 | ピリミジン縮合環系化合物、その製造方法、及び使用 |
| WO2022199587A1 (zh) * | 2021-03-24 | 2022-09-29 | 南京明德新药研发有限公司 | 嘧啶并杂环类化合物及其应用 |
| WO2022206723A1 (zh) | 2021-03-30 | 2022-10-06 | 浙江海正药业股份有限公司 | 杂环类衍生物、其制备方法及其医药上的用途 |
| CA3220929A1 (en) * | 2021-06-21 | 2022-12-29 | Xin Li | Fused tetracyclic compound, preparation method therefor and application thereof in medicine |
| KR20240029051A (ko) | 2021-07-02 | 2024-03-05 | 상하이 드 노보 파마테크 컴퍼니 리미티드 | Kras g12d 억제제 및 이의 용도 |
| CN117677624A (zh) | 2021-07-19 | 2024-03-08 | 上海艾力斯医药科技股份有限公司 | 新型吡啶并嘧啶衍生物 |
| EP4373827A4 (en) * | 2021-07-23 | 2025-06-04 | Suzhou Zanrong Pharma Limited | KRAS G12D inhibitors and uses thereof |
| JP2024532735A (ja) | 2021-08-10 | 2024-09-10 | アムジエン・インコーポレーテツド | 複素環式化合物及び使用方法 |
| TW202330529A (zh) | 2021-08-10 | 2023-08-01 | 美商安進公司 | 雜環化合物及使用方法 |
| TW202315626A (zh) * | 2021-08-31 | 2023-04-16 | 大陸商勁方醫藥科技(上海)有限公司 | 嘧啶并環類化合物及其製法和用途 |
| CN117794930A (zh) | 2021-09-03 | 2024-03-29 | 苏州亚盛药业有限公司 | Kras抑制剂 |
| EP4408851A4 (en) | 2021-09-27 | 2025-09-17 | Jacobio Pharmaceuticals Co Ltd | POLYCYCLIC FUSED RING DERIVATIVES AND THEIR USE |
| CN116199703A (zh) | 2021-12-01 | 2023-06-02 | 江苏恒瑞医药股份有限公司 | 稠合四环杂环化合物、其制备方法及其在医药上的应用 |
| WO2023103906A1 (zh) | 2021-12-07 | 2023-06-15 | 贝达药业股份有限公司 | Kras g12d抑制剂及其在医药上的应用 |
| CN116332948A (zh) | 2021-12-22 | 2023-06-27 | 翰森生物有限责任公司 | 一种含氮四环化合物及其制备方法和药用用途 |
| EP4471037A1 (en) | 2022-01-30 | 2024-12-04 | Shanghai Pharmaceuticals Holding Co., Ltd. | Quinoline compound and use thereof |
| CR20240451A (es) | 2022-04-21 | 2024-12-04 | Gilead Sciences Inc | Compuestos de modulación de kras g12d |
| CA3247639A1 (en) | 2022-05-06 | 2023-11-09 | PAQ Therapeutics Inc. | CHIMERAS TARGET KRAS-G12D PROTEOLYSIS |
| CR20240508A (es) | 2022-05-19 | 2024-12-20 | Genentech Inc | Compuestos aza-tetracíclicos de oxazepina y usos de los mismos |
| TW202409051A (zh) | 2022-07-27 | 2024-03-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠環類化合物、其製備方法及其在醫藥上的應用 |
| CN117462688A (zh) | 2022-07-28 | 2024-01-30 | 江苏恒瑞医药股份有限公司 | 一种包含kras g12d抑制剂的组合物 |
| CN119384279A (zh) | 2022-07-29 | 2025-01-28 | 江苏恒瑞医药股份有限公司 | 一种包含kras g12d抑制剂的药物组合物 |
| CN119698418A (zh) | 2022-08-11 | 2025-03-25 | 百济神州(苏州)生物科技有限公司 | 杂环化合物、其组合物及用其进行治疗的方法 |
| WO2024041573A1 (en) | 2022-08-25 | 2024-02-29 | Zai Lab (Shanghai) Co., Ltd. | Fused multi-heterocyclic compounds as kras g12d modulators and uses thereof |
| CN117771378A (zh) | 2022-09-29 | 2024-03-29 | 贝达药业股份有限公司 | 提高kras抑制剂生物利用度的药物组合及其应用 |
| CN119947725A (zh) | 2022-09-30 | 2025-05-06 | 应世生物科技(南京)有限公司 | Fak抑制剂及诱导免疫原性细胞死亡的物质的药物组合及用途 |
| TW202430182A (zh) | 2022-12-14 | 2024-08-01 | 大陸商上海科州藥物研發有限公司 | 作為ｋｒａｓ抑制劑的雜環化合物，及其製備和治療用途 |
| CN118221699A (zh) | 2022-12-20 | 2024-06-21 | 江苏恒瑞医药股份有限公司 | 一种kras g12d抑制剂的可药用盐、晶型及其制备方法 |
| JP2026500533A (ja) | 2022-12-20 | 2026-01-07 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | Ｋｒａｓ ｇ１２ｄ阻害剤の結晶形及び調製方法 |
-
2023
- 2023-05-19 CR CR20240508A patent/CR20240508A/es unknown
- 2023-05-19 KR KR1020247041569A patent/KR20250013185A/ko active Pending
- 2023-05-19 EP EP23732731.7A patent/EP4526309A1/en active Pending
- 2023-05-19 TW TW112118800A patent/TW202400170A/zh unknown
- 2023-05-19 PE PE2024002607A patent/PE20250752A1/es unknown
- 2023-05-19 WO PCT/US2023/022914 patent/WO2023225302A1/en not_active Ceased
- 2023-05-19 CN CN202380041256.4A patent/CN119365467A/zh active Pending
- 2023-05-19 AR ARP230101266A patent/AR129388A1/es unknown
- 2023-05-19 AU AU2023272945A patent/AU2023272945A1/en active Pending
- 2023-05-19 JP JP2024568561A patent/JP7735594B2/ja active Active
- 2023-05-19 US US18/199,449 patent/US20240025919A1/en not_active Abandoned
- 2023-05-19 IL IL316696A patent/IL316696A/en unknown
- 2023-05-19 CA CA3257445A patent/CA3257445A1/en active Pending
-
2024
- 2024-05-28 US US18/676,200 patent/US12338256B2/en active Active
- 2024-10-25 ZA ZA2024/08076A patent/ZA202408076B/en unknown
- 2024-11-14 CL CL2024003491A patent/CL2024003491A1/es unknown
- 2024-11-15 MX MX2024014176A patent/MX2024014176A/es unknown
- 2024-12-17 CO CONC2024/0017330A patent/CO2024017330A2/es unknown
-
2025
- 2025-04-25 US US19/190,368 patent/US20260062425A1/en active Pending
- 2025-08-26 JP JP2025140269A patent/JP2026000916A/ja active Pending
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