JP2025510623A5 - - Google Patents
Info
- Publication number
- JP2025510623A5 JP2025510623A5 JP2024554796A JP2024554796A JP2025510623A5 JP 2025510623 A5 JP2025510623 A5 JP 2025510623A5 JP 2024554796 A JP2024554796 A JP 2024554796A JP 2024554796 A JP2024554796 A JP 2024554796A JP 2025510623 A5 JP2025510623 A5 JP 2025510623A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody conjugate
- conjugate according
- pharmaceutically acceptable
- antibody
- fuc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22163924 | 2022-03-23 | ||
| EP22163924.8 | 2022-03-23 | ||
| PCT/EP2023/057560 WO2023180484A1 (en) | 2022-03-23 | 2023-03-23 | Antibody-conjugates for targeting of tumours expressing ptk7 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025510623A JP2025510623A (ja) | 2025-04-15 |
| JP2025510623A5 true JP2025510623A5 (https=) | 2026-03-31 |
Family
ID=81308370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024554796A Pending JP2025510623A (ja) | 2022-03-23 | 2023-03-23 | Ｐｔｋ７を発現する腫瘍を標的化するための抗体コンジュゲート |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12440573B2 (https=) |
| EP (1) | EP4496592A1 (https=) |
| JP (1) | JP2025510623A (https=) |
| KR (1) | KR20250024742A (https=) |
| CN (1) | CN120826241A (https=) |
| AU (1) | AU2023237619A1 (https=) |
| CA (1) | CA3254479A1 (https=) |
| IL (1) | IL315366A (https=) |
| MX (1) | MX2024011518A (https=) |
| WO (1) | WO2023180484A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113260384A (zh) | 2018-11-05 | 2021-08-13 | 西纳福克斯股份有限公司 | 用于靶向表达trop-2的肿瘤的抗体缀合物 |
| CN119997983A (zh) * | 2022-10-14 | 2025-05-13 | 四川科伦博泰生物医药股份有限公司 | 抗体药物偶联物及其制备方法和用途 |
| EP4737483A1 (en) * | 2023-06-30 | 2026-05-06 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate production method including purification step using activated carbon material |
| EP4566631A1 (en) * | 2023-12-06 | 2025-06-11 | Heidelberg Pharma Research GmbH | New antibody drug conjugate as well as methods of production and uses thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939255A (en) | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| EA017812B1 (ru) | 2005-12-08 | 2013-03-29 | Медарекс, Инк. | Выделенное моноклональное антитело или его антигенсвязывающий участок, которые связываются с протеинтирозинкиназой 7 ( ptk7) человека, и их применение |
| DK3438131T3 (da) | 2006-02-10 | 2022-04-11 | Life Technologies Corp | Oligosaccharidmodifikation og mærkning af proteiner |
| CL2008003527A1 (es) * | 2007-11-30 | 2009-10-09 | Medarex Inc | Conjugado de anticuerpo o porcion de union de antigeno del mismo, que se une a la proteina tirosina quinasa 7 (ptk-7/cck4); composicion que lo comprende; acido nulceico cidificante del anticuerpo; vector y celula huesped; uso del conjugado para tratar o prevenir una enfermedad de celulas tumorales que expresan ptk7 |
| US20090162359A1 (en) * | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| WO2009102820A2 (en) | 2008-02-11 | 2009-08-20 | Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services | Modified sugar substrates and methods of use |
| CN105142672B (zh) | 2012-10-23 | 2019-04-05 | 西纳福克斯股份有限公司 | 经修饰的抗体、抗体-缀合物及其制备方法 |
| AU2014371934B2 (en) | 2013-12-25 | 2020-01-23 | Daiichi Sankyo Company, Limited | Anti-TROP2 antibody-drug conjugate |
| RU2708075C2 (ru) | 2014-04-30 | 2019-12-04 | Пфайзер Инк. | Конъюгаты анти-ртк7 антитело-лекарственное средство |
| EP4148138A1 (en) | 2014-08-04 | 2023-03-15 | SynAffix B.V. | Process for the modification of a glycoprotein using a beta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof |
| CN107106701B (zh) | 2014-10-03 | 2020-11-06 | 西纳福克斯股份有限公司 | 磺酰胺接头、其缀合物及制备方法 |
| WO2016170186A1 (en) | 2015-04-23 | 2016-10-27 | Synaffix B.V. | PROCESS FOR THE MODIFICATION OF A GLYCOPROTEIN USING A GLYCOSYLTRANSFERASE THAT IS OR IS DERIVED FROM A β(1,4)-N-ACETYLGALACTOSAMINYLTRANSFERASE |
| EP3413920A1 (en) * | 2016-02-08 | 2018-12-19 | Synaffix B.V. | Bioconjugates containing sulfamide linkers for use in treatment |
| WO2017137457A1 (en) * | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| WO2017137458A1 (en) * | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| CA3026651A1 (en) | 2016-06-09 | 2017-12-14 | Blinkbio, Inc. | Silanol based therapeutic payloads |
| CN110121365A (zh) | 2016-12-29 | 2019-08-13 | 财团法人生物技术开发中心 | 制备糖蛋白-药物偶联物的方法 |
| EP3720504A1 (en) | 2017-12-06 | 2020-10-14 | Synaffix B.V. | Enediyne conjugates |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| CN113260384A (zh) | 2018-11-05 | 2021-08-13 | 西纳福克斯股份有限公司 | 用于靶向表达trop-2的肿瘤的抗体缀合物 |
| CA3118830A1 (en) * | 2018-11-07 | 2020-05-14 | Crispr Therapeutics Ag | Anti-ptk7 immune cell cancer therapy |
| MX2021011812A (es) | 2019-03-29 | 2021-10-22 | Medimmune Ltd | Compuestos y conjugados de estos. |
| SG11202110922QA (en) | 2019-04-26 | 2021-10-28 | Immunogen Inc | Camptothecin derivatives |
| KR20230021018A (ko) | 2020-06-05 | 2023-02-13 | 재단법인 생물기술개발중심 | 항-메조텔린 항체를 함유하는 항체-약물 컨쥬게이트 및 이의 용도 |
| JP2023541637A (ja) | 2020-09-15 | 2023-10-03 | シンアフィックス ビー．ブイ． | 抗体－エクサテカンコンジュゲート |
| NL2026947B1 (en) | 2020-11-20 | 2022-07-01 | Synaffix Bv | Tyrosine-based antibody conjugates |
| CN113816969B (zh) | 2021-04-30 | 2024-01-16 | 联宁（苏州）生物制药有限公司 | 依喜替康类化合物、其抗体药物偶联物及其应用 |
| KR20230015301A (ko) | 2021-07-19 | 2023-01-31 | 맙플렉스 인터내셔널 컴퍼니 리미티드 | 2성분 독소가 부하된 항체-약물 접합체 및 그의 용도 |
| KR20250024741A (ko) | 2022-03-23 | 2025-02-19 | 시나픽스 비.브이. | 암배아성 항원을 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트 |
| CA3253220A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | ANTIBODIES CONJUGATED FOR TARGETING TUMORS EXPRESSING TROP-2 |
-
2023
- 2023-03-23 IL IL315366A patent/IL315366A/en unknown
- 2023-03-23 CA CA3254479A patent/CA3254479A1/en active Pending
- 2023-03-23 JP JP2024554796A patent/JP2025510623A/ja active Pending
- 2023-03-23 KR KR1020247034724A patent/KR20250024742A/ko active Pending
- 2023-03-23 MX MX2024011518A patent/MX2024011518A/es unknown
- 2023-03-23 EP EP23713892.0A patent/EP4496592A1/en active Pending
- 2023-03-23 WO PCT/EP2023/057560 patent/WO2023180484A1/en not_active Ceased
- 2023-03-23 CN CN202380028783.1A patent/CN120826241A/zh active Pending
- 2023-03-23 AU AU2023237619A patent/AU2023237619A1/en active Pending
-
2024
- 2024-09-20 US US18/892,253 patent/US12440573B2/en active Active
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