JP2025510700A5 - - Google Patents
Info
- Publication number
- JP2025510700A5 JP2025510700A5 JP2024556005A JP2024556005A JP2025510700A5 JP 2025510700 A5 JP2025510700 A5 JP 2025510700A5 JP 2024556005 A JP2024556005 A JP 2024556005A JP 2024556005 A JP2024556005 A JP 2024556005A JP 2025510700 A5 JP2025510700 A5 JP 2025510700A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antibody conjugate
- linker
- hetero
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22163943 | 2022-03-23 | ||
| EP22163943.8 | 2022-03-23 | ||
| PCT/EP2023/057561 WO2023180485A1 (en) | 2022-03-23 | 2023-03-23 | Antibody-conjugates for targeting of tumours expressing trop-2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025510700A JP2025510700A (ja) | 2025-04-15 |
| JP2025510700A5 true JP2025510700A5 (https=) | 2026-03-31 |
Family
ID=81308125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024556005A Pending JP2025510700A (ja) | 2022-03-23 | 2023-03-23 | Ｔｒｏｐ－２を発現する腫瘍を標的化するための抗体コンジュゲート |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250090679A1 (https=) |
| EP (1) | EP4496594A1 (https=) |
| JP (1) | JP2025510700A (https=) |
| KR (1) | KR20250024743A (https=) |
| CN (1) | CN119212731A (https=) |
| AU (1) | AU2023241225A1 (https=) |
| CA (1) | CA3253220A1 (https=) |
| IL (1) | IL315207A (https=) |
| MX (1) | MX2024011520A (https=) |
| WO (1) | WO2023180485A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113260384A (zh) | 2018-11-05 | 2021-08-13 | 西纳福克斯股份有限公司 | 用于靶向表达trop-2的肿瘤的抗体缀合物 |
| IL315366A (en) | 2022-03-23 | 2024-11-01 | Synaffix Bv | Antibody pairs for targeting PTK7-expressing tumors |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939255A (en) | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| EP0856054B1 (en) | 1995-10-19 | 2004-04-28 | Bristol-Myers Squibb Company | Monoclonal antibody br110 and uses thereof |
| US9745380B2 (en) | 2002-03-01 | 2017-08-29 | Immunomedics, Inc. | RS7 antibodies |
| CA2478047C (en) | 2002-03-01 | 2014-01-21 | Immunomedics, Inc. | Rs7 antibodies |
| DK3438131T3 (da) | 2006-02-10 | 2022-04-11 | Life Technologies Corp | Oligosaccharidmodifikation og mærkning af proteiner |
| US7420040B2 (en) | 2006-02-24 | 2008-09-02 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
| US20080131428A1 (en) | 2006-02-24 | 2008-06-05 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
| WO2009102820A2 (en) | 2008-02-11 | 2009-08-20 | Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services | Modified sugar substrates and methods of use |
| CA2750038C (en) | 2009-02-05 | 2016-10-04 | Oncoxx S.R.L. | Anti-trop-2 monoclonal antibodies and uses thereof in the treatment and diagnosis of tumors |
| WO2011155579A1 (ja) | 2010-06-10 | 2011-12-15 | 北海道公立大学法人札幌医科大学 | 抗Ｔｒｏｐ－２抗体 |
| TWI495644B (zh) | 2011-11-11 | 2015-08-11 | Rinat Neuroscience Corp | 營養層細胞表面抗原（Ｔｒｏｐ－２）之專一性抗體類及彼等之用途 |
| US9427464B2 (en) | 2011-11-22 | 2016-08-30 | Chiome Bioscience Inc. | Anti-human TROP-2 antibody having an antitumor activity in vivo |
| CN105142672B (zh) | 2012-10-23 | 2019-04-05 | 西纳福克斯股份有限公司 | 经修饰的抗体、抗体-缀合物及其制备方法 |
| WO2015012904A2 (en) | 2012-12-13 | 2015-01-29 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| AU2014371934B2 (en) | 2013-12-25 | 2020-01-23 | Daiichi Sankyo Company, Limited | Anti-TROP2 antibody-drug conjugate |
| EP4148138A1 (en) | 2014-08-04 | 2023-03-15 | SynAffix B.V. | Process for the modification of a glycoprotein using a beta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof |
| CN107106701B (zh) | 2014-10-03 | 2020-11-06 | 西纳福克斯股份有限公司 | 磺酰胺接头、其缀合物及制备方法 |
| WO2016170186A1 (en) | 2015-04-23 | 2016-10-27 | Synaffix B.V. | PROCESS FOR THE MODIFICATION OF A GLYCOPROTEIN USING A GLYCOSYLTRANSFERASE THAT IS OR IS DERIVED FROM A β(1,4)-N-ACETYLGALACTOSAMINYLTRANSFERASE |
| CA3026651A1 (en) | 2016-06-09 | 2017-12-14 | Blinkbio, Inc. | Silanol based therapeutic payloads |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| CN113260384A (zh) * | 2018-11-05 | 2021-08-13 | 西纳福克斯股份有限公司 | 用于靶向表达trop-2的肿瘤的抗体缀合物 |
| MX2021011812A (es) | 2019-03-29 | 2021-10-22 | Medimmune Ltd | Compuestos y conjugados de estos. |
| SG11202110922QA (en) | 2019-04-26 | 2021-10-28 | Immunogen Inc | Camptothecin derivatives |
| KR20230021018A (ko) | 2020-06-05 | 2023-02-13 | 재단법인 생물기술개발중심 | 항-메조텔린 항체를 함유하는 항체-약물 컨쥬게이트 및 이의 용도 |
| NL2026947B1 (en) | 2020-11-20 | 2022-07-01 | Synaffix Bv | Tyrosine-based antibody conjugates |
| CN113816969B (zh) | 2021-04-30 | 2024-01-16 | 联宁（苏州）生物制药有限公司 | 依喜替康类化合物、其抗体药物偶联物及其应用 |
| KR20230015301A (ko) | 2021-07-19 | 2023-01-31 | 맙플렉스 인터내셔널 컴퍼니 리미티드 | 2성분 독소가 부하된 항체-약물 접합체 및 그의 용도 |
-
2023
- 2023-03-23 CA CA3253220A patent/CA3253220A1/en active Pending
- 2023-03-23 EP EP23714682.4A patent/EP4496594A1/en active Pending
- 2023-03-23 CN CN202380028866.0A patent/CN119212731A/zh active Pending
- 2023-03-23 IL IL315207A patent/IL315207A/en unknown
- 2023-03-23 WO PCT/EP2023/057561 patent/WO2023180485A1/en not_active Ceased
- 2023-03-23 AU AU2023241225A patent/AU2023241225A1/en active Pending
- 2023-03-23 JP JP2024556005A patent/JP2025510700A/ja active Pending
- 2023-03-23 KR KR1020247034725A patent/KR20250024743A/ko active Pending
-
2024
- 2024-09-19 MX MX2024011520A patent/MX2024011520A/es unknown
- 2024-09-20 US US18/892,270 patent/US20250090679A1/en active Pending
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