JP2025016545A5 - - Google Patents
Info
- Publication number
- JP2025016545A5 JP2025016545A5 JP2024186222A JP2024186222A JP2025016545A5 JP 2025016545 A5 JP2025016545 A5 JP 2025016545A5 JP 2024186222 A JP2024186222 A JP 2024186222A JP 2024186222 A JP2024186222 A JP 2024186222A JP 2025016545 A5 JP2025016545 A5 JP 2025016545A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- linker
- payload conjugate
- payload
- heavy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19163810 | 2019-03-19 | ||
| EP19163810.5 | 2019-03-19 | ||
| PCT/EP2020/057697 WO2020188061A1 (en) | 2019-03-19 | 2020-03-19 | Transglutaminase conjugation method with a glycine based linker |
| JP2022504337A JP7629902B2 (ja) | 2019-03-19 | 2020-03-19 | グリシンベースリンカーを用いたトランスグルタミナーゼコンジュゲーション法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022504337A Division JP7629902B2 (ja) | 2019-03-19 | 2020-03-19 | グリシンベースリンカーを用いたトランスグルタミナーゼコンジュゲーション法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025016545A JP2025016545A (ja) | 2025-02-04 |
| JP2025016545A5 true JP2025016545A5 (https=) | 2025-10-21 |
Family
ID=65903991
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022504337A Active JP7629902B2 (ja) | 2019-03-19 | 2020-03-19 | グリシンベースリンカーを用いたトランスグルタミナーゼコンジュゲーション法 |
| JP2024186222A Pending JP2025016545A (ja) | 2019-03-19 | 2024-10-22 | グリシンベースリンカーを用いたトランスグルタミナーゼコンジュゲーション法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022504337A Active JP7629902B2 (ja) | 2019-03-19 | 2020-03-19 | グリシンベースリンカーを用いたトランスグルタミナーゼコンジュゲーション法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220133904A1 (https=) |
| EP (1) | EP3941526A1 (https=) |
| JP (2) | JP7629902B2 (https=) |
| KR (1) | KR20220144753A (https=) |
| CN (1) | CN113613679A (https=) |
| AU (1) | AU2020243056A1 (https=) |
| CA (1) | CA3128571A1 (https=) |
| WO (1) | WO2020188061A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ762376A (en) | 2017-09-19 | 2022-08-26 | Scherrer Inst Paul | Transglutaminase conjugation method and linker |
| JP7590354B2 (ja) * | 2019-06-10 | 2024-11-26 | ストロ バイオファーマ インコーポレーテッド | 免疫調節物質抗体薬物コンジュゲートおよびその使用 |
| EP4096717B1 (en) | 2020-01-31 | 2024-12-11 | Innate Pharma | Treatment of cancer |
| US20230095053A1 (en) * | 2020-03-03 | 2023-03-30 | Sutro Biopharma, Inc. | Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use |
| KR20230069211A (ko) * | 2020-09-18 | 2023-05-18 | 아라리스 바이오테크 아게 | 아미노산-기반 링커를 사용한 트란스글루타미나제 접합 방법 |
| KR20230096052A (ko) * | 2020-10-25 | 2023-06-29 | 아라리스 바이오테크 아게 | 항체-링커 접합체를 생성하기 위한 수단 및 방법 |
| CN116801910A (zh) * | 2020-10-25 | 2023-09-22 | 阿拉里斯生物技术股份公司 | 生产抗体-接头偶联物的手段和方法 |
| MX2023005873A (es) | 2020-11-25 | 2023-06-05 | Innate Pharma | Tratamiento del cancer. |
| KR20230142455A (ko) * | 2020-11-30 | 2023-10-11 | 앤비션 에스.알.엘. | 항체 단편으로 수식되고 세포독성 물질이 탑재된 다중특이인간 알부민 나노입자 |
| US20230201364A1 (en) | 2021-07-09 | 2023-06-29 | Bright Peak Therapeutics Ag | Antibody conjugates and manufacture thereof |
| AU2022306974A1 (en) | 2021-07-09 | 2024-01-04 | Bright Peak Therapeutics Ag | Modified il-2 polypeptides for treatment of inflammatory and autoimmune diseases |
| WO2023281480A1 (en) | 2021-07-09 | 2023-01-12 | Bright Peak Therapeutics Ag | Conjugates of checkpoint inhibitors with il-2, and uses thereof |
| EP4366781A1 (en) | 2021-07-09 | 2024-05-15 | Bright Peak Therapeutics AG | Checkpoint inhibitors conjugated to il-2, and uses thereof |
| US20230201365A1 (en) | 2021-07-09 | 2023-06-29 | Bright Peak Therapeutics Ag | Modified cd20 antibodies and uses thereof |
| KR20240150807A (ko) | 2022-02-22 | 2024-10-16 | 아라리스 바이오테크 아게 | 2개 이상의 페이로드를 포함하는 펩티드 링커 |
| JP2025505835A (ja) * | 2022-02-22 | 2025-02-28 | アーデーセー セラピューティクス ソシエテ アノニム | トリミングされたｎ－グリカンを含むｆｃ領域でのトランスグルタミナーゼを伴うコンジュゲーション方法 |
| AU2023226512A1 (en) | 2022-02-23 | 2024-08-29 | Bright Peak Therapeutics Ag | Immune antigen specific il-18 immunocytokines and uses thereof |
| US20250179210A1 (en) | 2022-03-09 | 2025-06-05 | Merck Patent Gmbh | Anti-ceacam5 antibodies and conjugates and uses thereof |
| JP2025517476A (ja) | 2022-05-25 | 2025-06-05 | イナート・ファルマ・ソシエテ・アノニム | ネクチン－４結合剤 |
| EP4568997A1 (en) | 2022-08-08 | 2025-06-18 | ATB Therapeutics | Humanized antibodies against cd79b |
| CN115814111B (zh) * | 2022-12-05 | 2025-03-28 | 复旦大学附属中山医院 | 一种近红外荧光adc免疫制剂及其制备方法与应用 |
| US20240417436A1 (en) | 2023-01-11 | 2024-12-19 | Bright Peak Therapeutics Ag | Conditionally activated immunocytokines and methods of use |
| US20240424127A1 (en) | 2023-01-11 | 2024-12-26 | Bright Peak Therapeutics Ag | Il-7 polypeptides, immunocytokines comprising same, and uses thereof |
| CN116077676B (zh) * | 2023-02-03 | 2025-09-12 | 南京大学 | 蛋白质靶向降解嵌合体及其制备方法和应用 |
| WO2025041102A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Targeted immune activation with il-18 immunocytokines |
| WO2025041101A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Activatable il-18 immunocytokines and uses thereof |
| WO2025082990A1 (en) | 2023-10-15 | 2025-04-24 | Araris Biotech Ag | Antibody-drug conjugates using two different types of topoisomerase i inhibitors |
| WO2025192692A1 (ja) * | 2024-03-14 | 2025-09-18 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
| WO2026008881A1 (en) | 2024-07-05 | 2026-01-08 | Synaffix B.V. | Extracellular vesicles comprising biomolecule-conjugates |
| WO2026013234A1 (en) | 2024-07-10 | 2026-01-15 | Araris Biotech Ag | Triple-payload antibody-drug conjugates (adcs) |
| WO2026069134A1 (en) | 2024-09-26 | 2026-04-02 | Bright Peak Therapeutics Ag | Human therapy with il-18 immunocytokines |
| WO2026083295A1 (en) | 2024-10-16 | 2026-04-23 | Bright Peak Therapeutics Ag | Trispecific compositions comprising il-2, vegf binding domains, and pd-1 binding domains |
| WO2026083296A1 (en) | 2024-10-16 | 2026-04-23 | Bright Peak Therapeutics Ag | Trispecific compositions comprising il-18, vegf binding domains, and pd-1 binding domains |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
| JPS5562090A (en) | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS5566585A (en) | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS55164685A (en) | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4309428A (en) | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6660510B2 (en) | 2001-12-17 | 2003-12-09 | Food Industry Research And Development | Transglutaminase gene of Streptoverticillium ladakanum and the transglutaminase encoded therefrom |
| US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| AU2008215422B2 (en) | 2007-02-15 | 2011-07-14 | Ajinomoto Co., Inc. | Transglutaminase having disulfide bond introduced therein |
| US20100087371A1 (en) | 2007-02-22 | 2010-04-08 | Sean Hu | Transglutaminase Variants with Improved Specificity |
| CA2813411C (en) * | 2010-11-05 | 2016-08-02 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| EP2793947B1 (en) | 2011-12-23 | 2021-02-03 | Innate Pharma | Enzymatic conjugation of polypeptides |
| EP2777714A1 (en) * | 2013-03-15 | 2014-09-17 | NBE-Therapeutics LLC | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
| WO2015015448A2 (en) | 2013-07-31 | 2015-02-05 | Rinat Neuroscience Corp. | Engineered polypeptide conjugates |
| PT3134127T (pt) * | 2014-04-25 | 2020-04-09 | Rinat Neuroscience Corp | Conjugados de anticorpo-fármaco com alta carga de fármaco |
| WO2015191883A1 (en) * | 2014-06-12 | 2015-12-17 | Dophen Biomedical | Homogenous antibody drug conjugates via enzymatic methods |
| CN107257802B (zh) | 2014-12-19 | 2021-11-23 | 豪夫迈·罗氏有限公司 | 转谷氨酰胺酶底物的鉴别及其用途 |
| WO2016100735A1 (en) | 2014-12-19 | 2016-06-23 | Roche Nimblegen, Inc. | Microbial transglutaminases, substrates therefor and methods for the use thereof |
| EP3256166A1 (en) * | 2015-02-09 | 2017-12-20 | NBE Therapeutics AG | Maytansine-drug conjugates of her- 2 specific binding proteins generated by site specific sortase-enzyme mediated conjugation |
| JP2018510864A (ja) | 2015-03-10 | 2018-04-19 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体 |
| ES2855998T3 (es) | 2015-08-07 | 2021-09-27 | Merck Patent Gmbh | Etiqueta transglutamina para bioconjugación específica de sitio eficiente |
| KR20230008269A (ko) * | 2017-08-07 | 2023-01-13 | 엔비이-테라퓨틱스 아게 | 생체 내 내성이 높은 항체 약물 결합체 |
-
2020
- 2020-03-19 CA CA3128571A patent/CA3128571A1/en active Pending
- 2020-03-19 WO PCT/EP2020/057697 patent/WO2020188061A1/en not_active Ceased
- 2020-03-19 US US17/435,356 patent/US20220133904A1/en active Pending
- 2020-03-19 CN CN202080022652.9A patent/CN113613679A/zh active Pending
- 2020-03-19 EP EP20711197.2A patent/EP3941526A1/en active Pending
- 2020-03-19 AU AU2020243056A patent/AU2020243056A1/en active Pending
- 2020-03-19 JP JP2022504337A patent/JP7629902B2/ja active Active
- 2020-03-19 KR KR1020217033833A patent/KR20220144753A/ko active Pending
-
2024
- 2024-10-22 JP JP2024186222A patent/JP2025016545A/ja active Pending
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