|
US4151042A
(en)
|
1977-03-31 |
1979-04-24 |
Takeda Chemical Industries, Ltd. |
Method for producing maytansinol and its derivatives
|
|
US4137230A
(en)
|
1977-11-14 |
1979-01-30 |
Takeda Chemical Industries, Ltd. |
Method for the production of maytansinoids
|
|
US4265814A
(en)
|
1978-03-24 |
1981-05-05 |
Takeda Chemical Industries |
Matansinol 3-n-hexadecanoate
|
|
JPS5562090A
(en)
|
1978-10-27 |
1980-05-10 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS5566585A
(en)
|
1978-11-14 |
1980-05-20 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164687A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS55164685A
(en)
|
1979-06-08 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164686A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
US4309428A
(en)
|
1979-07-30 |
1982-01-05 |
Takeda Chemical Industries, Ltd. |
Maytansinoids
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
US6660510B2
(en)
|
2001-12-17 |
2003-12-09 |
Food Industry Research And Development |
Transglutaminase gene of Streptoverticillium ladakanum and the transglutaminase encoded therefrom
|
|
WO2004043493A1
(en)
|
2002-11-14 |
2004-05-27 |
Syntarga B.V. |
Prodrugs built as multiple self-elimination-release spacers
|
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
CA2556752C
(en)
|
2004-02-23 |
2016-02-02 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
AU2008215422B2
(en)
|
2007-02-15 |
2011-07-14 |
Ajinomoto Co., Inc. |
Transglutaminase having disulfide bond introduced therein
|
|
US20100087371A1
(en)
|
2007-02-22 |
2010-04-08 |
Sean Hu |
Transglutaminase Variants with Improved Specificity
|
|
WO2009072004A2
(en)
|
2007-09-26 |
2009-06-11 |
Gemin X Pharmaceuticals Canada, Inc. |
Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor
|
|
ES2784829T3
(es)
|
2009-04-08 |
2020-10-01 |
Faulstich Heinz Dr |
Componentes de unión a la superficie de células terapéuticas provistos de amatoxina diseñados para terapia de tumores
|
|
AU2010234335A1
(en)
|
2009-04-08 |
2011-10-13 |
Deutsches Krebsforschungszentrum |
Amatoxin-armed target-binding moieties for the treatment of cancer
|
|
AR082886A1
(es)
|
2010-09-03 |
2013-01-16 |
Forma Therapeutics Inc |
Compuestos y composiciones farmaceuticas que los contienen
|
|
ES2402254T3
(es)
|
2010-09-30 |
2013-04-30 |
Heidelberg Pharma Ag |
Conjugados de amatoxinas con ligadores mejorados
|
|
CA2813411C
(en)
*
|
2010-11-05 |
2016-08-02 |
Rinat Neuroscience Corporation |
Engineered polypeptide conjugates and methods for making thereof using transglutaminase
|
|
EP2497499A1
(en)
|
2011-03-10 |
2012-09-12 |
Heidelberg Pharma GmbH |
Amatoxin-conjugates with improved linkages
|
|
EP2793947B1
(en)
|
2011-12-23 |
2021-02-03 |
Innate Pharma |
Enzymatic conjugation of polypeptides
|
|
EP2774624A1
(en)
|
2013-03-04 |
2014-09-10 |
Heidelberg Pharma GmbH |
Amatoxin derivatives
|
|
WO2015015448A2
(en)
|
2013-07-31 |
2015-02-05 |
Rinat Neuroscience Corp. |
Engineered polypeptide conjugates
|
|
EP3055304A1
(en)
|
2013-10-09 |
2016-08-17 |
Eli Lilly and Company |
Novel pyridyloxyacetyl tetrahydroisoquinoline compounds useful as nampt inhibitors
|
|
WO2015191883A1
(en)
*
|
2014-06-12 |
2015-12-17 |
Dophen Biomedical |
Homogenous antibody drug conjugates via enzymatic methods
|
|
JP2018510864A
(ja)
*
|
2015-03-10 |
2018-04-19 |
ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ |
トランスグルタミナーゼによって結合可能な抗体およびそれによって製造される結合体
|
|
EP3069734A1
(en)
|
2015-03-17 |
2016-09-21 |
Exiris S.r.l. |
Cryptophycin-based antibody-drug conjugates with novel self-immolative linkers
|
|
ES2855998T3
(es)
|
2015-08-07 |
2021-09-27 |
Merck Patent Gmbh |
Etiqueta transglutamina para bioconjugación específica de sitio eficiente
|
|
NZ762376A
(en)
*
|
2017-09-19 |
2022-08-26 |
Scherrer Inst Paul |
Transglutaminase conjugation method and linker
|
|
CA3128571A1
(en)
*
|
2019-03-19 |
2020-09-24 |
Paul Scherrer Institut |
Transglutaminase conjugation method with a glycine based linker
|