KR20220144753A - 글리신 기반 링커를 사용한 트랜스글루타미나제 컨쥬게이션 방법 - Google Patents

글리신 기반 링커를 사용한 트랜스글루타미나제 컨쥬게이션 방법 Download PDF

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KR20220144753A
KR20220144753A KR1020217033833A KR20217033833A KR20220144753A KR 20220144753 A KR20220144753 A KR 20220144753A KR 1020217033833 A KR1020217033833 A KR 1020217033833A KR 20217033833 A KR20217033833 A KR 20217033833A KR 20220144753 A KR20220144753 A KR 20220144753A
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South Korea
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antibody
linker
payload
gly
conjugate
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Korean (ko)
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로저 쉬블리
로저 비히
필립 스파이쳐
줄리아 프레이
죄리 베어뮐러
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폴 슈레 앙스띠뛰
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020217033833A 2019-03-19 2020-03-19 글리신 기반 링커를 사용한 트랜스글루타미나제 컨쥬게이션 방법 Pending KR20220144753A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19163810 2019-03-19
PCT/EP2020/057697 WO2020188061A1 (en) 2019-03-19 2020-03-19 Transglutaminase conjugation method with a glycine based linker

Publications (1)

Publication Number Publication Date
KR20220144753A true KR20220144753A (ko) 2022-10-27

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KR1020217033833A Pending KR20220144753A (ko) 2019-03-19 2020-03-19 글리신 기반 링커를 사용한 트랜스글루타미나제 컨쥬게이션 방법

Country Status (8)

Country Link
US (1) US20220133904A1 (https=)
EP (1) EP3941526A1 (https=)
JP (2) JP7629902B2 (https=)
KR (1) KR20220144753A (https=)
CN (1) CN113613679A (https=)
AU (1) AU2020243056A1 (https=)
CA (1) CA3128571A1 (https=)
WO (1) WO2020188061A1 (https=)

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US20230201364A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Antibody conjugates and manufacture thereof
AU2023223557A1 (en) * 2022-02-22 2024-10-03 Adc Therapeutics Sa Conjugation method involving a transglutaminase at the fc region comprising a trimmed n-glycan
KR20240150807A (ko) 2022-02-22 2024-10-16 아라리스 바이오테크 아게 2개 이상의 페이로드를 포함하는 펩티드 링커
JP2025508823A (ja) 2022-02-23 2025-04-10 ブライト ピーク セラピューティクス エージー 免疫抗原特異的ｉｌ－１８免疫サイトカイン及びその使用
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US20240417436A1 (en) 2023-01-11 2024-12-19 Bright Peak Therapeutics Ag Conditionally activated immunocytokines and methods of use
CN116077676B (zh) * 2023-02-03 2025-09-12 南京大学 蛋白质靶向降解嵌合体及其制备方法和应用
WO2025041102A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Targeted immune activation with il-18 immunocytokines
WO2025041101A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Activatable il-18 immunocytokines and uses thereof
WO2025082990A1 (en) 2023-10-15 2025-04-24 Araris Biotech Ag Antibody-drug conjugates using two different types of topoisomerase i inhibitors
WO2025192692A1 (ja) * 2024-03-14 2025-09-18 東レ株式会社 癌の治療及び／又は予防用医薬組成物
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AU2020243056A1 (en) 2021-09-09
US20220133904A1 (en) 2022-05-05
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