CN113613679A - 基于甘氨酸的接头的转谷氨酰胺酶缀合方法 - Google Patents

基于甘氨酸的接头的转谷氨酰胺酶缀合方法 Download PDF

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Publication number
CN113613679A
CN113613679A CN202080022652.9A CN202080022652A CN113613679A CN 113613679 A CN113613679 A CN 113613679A CN 202080022652 A CN202080022652 A CN 202080022652A CN 113613679 A CN113613679 A CN 113613679A
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antibody
linker
payload
gly
conjugate
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Chinese (zh)
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罗杰·席比利
罗杰·贝赫
菲利普·斯派克
朱莉娅·弗雷
约里·魏姆勒
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Scherrer Paul Institut
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Scherrer Paul Institut
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    • A—HUMAN NECESSITIES
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202080022652.9A 2019-03-19 2020-03-19 基于甘氨酸的接头的转谷氨酰胺酶缀合方法 Pending CN113613679A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19163810.5 2019-03-19
EP19163810 2019-03-19
PCT/EP2020/057697 WO2020188061A1 (en) 2019-03-19 2020-03-19 Transglutaminase conjugation method with a glycine based linker

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CN113613679A true CN113613679A (zh) 2021-11-05

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US (1) US20220133904A1 (https=)
EP (1) EP3941526A1 (https=)
JP (2) JP7629902B2 (https=)
KR (1) KR20220144753A (https=)
CN (1) CN113613679A (https=)
AU (1) AU2020243056A1 (https=)
CA (1) CA3128571A1 (https=)
WO (1) WO2020188061A1 (https=)

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CN116406302A (zh) * 2020-09-18 2023-07-07 阿拉里斯生物技术股份公司 用基于氨基酸的接头的谷氨酰胺转胺酶缀合方法

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US11744876B2 (en) * 2019-06-10 2023-09-05 Sutro Biopharma, Inc. Immunomodulator antibody drug conjugates and uses thereof
AU2021213421B2 (en) 2020-01-31 2025-02-06 Innate Pharma Treatment of cancer
US20230095053A1 (en) * 2020-03-03 2023-03-30 Sutro Biopharma, Inc. Antibodies comprising site-specific glutamine tags, methods of their preparation and methods of their use
CN116801910A (zh) * 2020-10-25 2023-09-22 阿拉里斯生物技术股份公司 生产抗体-接头偶联物的手段和方法
CA3196218A1 (en) * 2020-10-25 2022-04-28 Philipp SPYCHER Means and methods for producing antibody-linker conjugates
CA3196198A1 (en) 2020-11-25 2022-06-02 Manel KRAIEM Treatment of cancer
CA3199925A1 (en) * 2020-11-30 2022-06-02 Menotti Ruvo Multi-specific human albumin nanoparticles decorated with antibody fragments and loaded with cytotoxics
US20230181754A1 (en) 2021-07-09 2023-06-15 Bright Peak Therapeutics Ag Modified checkpoint inhibitors and uses thereof
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US20230201365A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Modified cd20 antibodies and uses thereof
WO2023281485A1 (en) 2021-07-09 2023-01-12 Bright Peak Therapeutics Ag Modified il-2 polypeptides for treatment of inflammatory and autoimmune diseases
US20230201364A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Antibody conjugates and manufacture thereof
AU2023223557A1 (en) * 2022-02-22 2024-10-03 Adc Therapeutics Sa Conjugation method involving a transglutaminase at the fc region comprising a trimmed n-glycan
KR20240150807A (ko) 2022-02-22 2024-10-16 아라리스 바이오테크 아게 2개 이상의 페이로드를 포함하는 펩티드 링커
JP2025508823A (ja) 2022-02-23 2025-04-10 ブライト ピーク セラピューティクス エージー 免疫抗原特異的ｉｌ－１８免疫サイトカイン及びその使用
AR128745A1 (es) 2022-03-09 2024-06-12 Merck Patent Gmbh Anticuerpos y conjugados anti-ceacam5 y usos de los mismos
CA3245954A1 (en) 2022-05-25 2023-11-30 Innate Pharma NECTIN-4 LIAISON OFFICERS
EP4568997A1 (en) 2022-08-08 2025-06-18 ATB Therapeutics Humanized antibodies against cd79b
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US20240424127A1 (en) 2023-01-11 2024-12-26 Bright Peak Therapeutics Ag Il-7 polypeptides, immunocytokines comprising same, and uses thereof
US20240417436A1 (en) 2023-01-11 2024-12-19 Bright Peak Therapeutics Ag Conditionally activated immunocytokines and methods of use
WO2025041102A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Targeted immune activation with il-18 immunocytokines
WO2025041101A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Activatable il-18 immunocytokines and uses thereof
WO2025082990A1 (en) 2023-10-15 2025-04-24 Araris Biotech Ag Antibody-drug conjugates using two different types of topoisomerase i inhibitors
WO2025192692A1 (ja) * 2024-03-14 2025-09-18 東レ株式会社 癌の治療及び／又は予防用医薬組成物
WO2026008881A1 (en) 2024-07-05 2026-01-08 Synaffix B.V. Extracellular vesicles comprising biomolecule-conjugates
WO2026013234A1 (en) 2024-07-10 2026-01-15 Araris Biotech Ag Triple-payload antibody-drug conjugates (adcs)
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