JP2024543934A5 - - Google Patents
Info
- Publication number
- JP2024543934A5 JP2024543934A5 JP2024531628A JP2024531628A JP2024543934A5 JP 2024543934 A5 JP2024543934 A5 JP 2024543934A5 JP 2024531628 A JP2024531628 A JP 2024531628A JP 2024531628 A JP2024531628 A JP 2024531628A JP 2024543934 A5 JP2024543934 A5 JP 2024543934A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- groups
- compound
- tautomer
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163284166P | 2021-11-30 | 2021-11-30 | |
| US63/284,166 | 2021-11-30 | ||
| US202163286165P | 2021-12-06 | 2021-12-06 | |
| US63/286,165 | 2021-12-06 | ||
| US202263310832P | 2022-02-16 | 2022-02-16 | |
| US63/310,832 | 2022-02-16 | ||
| PCT/US2022/051364 WO2023102022A1 (en) | 2021-11-30 | 2022-11-30 | 4-phenyl-2-(1h-1,2,3-triazol-4-yl)piperidin-4-ol derivatives as inhibitors of apol1 and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024543934A JP2024543934A (ja) | 2024-11-26 |
| JP2024543934A5 true JP2024543934A5 (https=) | 2025-11-06 |
Family
ID=84981152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024531628A Pending JP2024543934A (ja) | 2021-11-30 | 2022-11-30 | Ａｐｏｌ１の阻害剤としての４－フェニル－２－（１ｈ－１，２，３－トリアゾール－４－イル）ピペリジン－４－オール誘導体、およびそれを使用する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US12612379B2 (https=) |
| EP (1) | EP4441032A1 (https=) |
| JP (1) | JP2024543934A (https=) |
| KR (1) | KR20240131345A (https=) |
| AU (1) | AU2022402839A1 (https=) |
| CA (1) | CA3239394A1 (https=) |
| CL (1) | CL2024001586A1 (https=) |
| CO (1) | CO2024006736A2 (https=) |
| CR (1) | CR20240261A (https=) |
| DO (1) | DOP2024000104A (https=) |
| EC (1) | ECSP24050151A (https=) |
| GE (1) | GEAP202416543A (https=) |
| IL (1) | IL312747A (https=) |
| JO (1) | JOP20240120A1 (https=) |
| MX (1) | MX2024006473A (https=) |
| PE (1) | PE20241628A1 (https=) |
| TW (1) | TW202329951A (https=) |
| UY (1) | UY40047A (https=) |
| WO (1) | WO2023102022A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618746B2 (en) | 2018-12-17 | 2023-04-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of APOL1 and methods of using same |
| WO2021154997A1 (en) | 2020-01-29 | 2021-08-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
| CN115867543A (zh) | 2020-06-12 | 2023-03-28 | 弗特克斯药品有限公司 | Apol1抑制剂的固体形式及其使用方法 |
| CA3185604A1 (en) | 2020-06-12 | 2021-12-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and use of the same |
| CN116547287B (zh) | 2020-08-26 | 2025-09-26 | 弗特克斯药品有限公司 | Apol1的抑制剂及其使用方法 |
| MX2024008868A (es) | 2022-01-18 | 2024-09-23 | Maze Therapeutics Inc | Inhibidores de la apolipoproteína l1 (apol1) y métodos de uso. |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4039676A (en) | 1975-06-23 | 1977-08-02 | Ciba-Geigy Corporation | 2-piperidinoalkyl-1,4-benzodioxans |
| US6518423B1 (en) | 1996-08-09 | 2003-02-11 | Eisai Co., Ltd. | Benzopiperidine derivatives |
| FR2793246B1 (fr) | 1999-05-03 | 2001-06-29 | Adir | Nouveaux derives de 1-aza-2-alkyl-6-aryl-cycloalcanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU7514700A (en) | 1999-09-07 | 2001-04-10 | Syngenta Participations Ag | Cyanopiperidines |
| FR2801585B1 (fr) | 1999-11-25 | 2002-02-15 | Fournier Ind & Sante | Nouveaux antagonistes des recepteurs de l'ii-8 |
| AU2002211828A1 (en) | 2000-10-02 | 2002-04-15 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| FR2824827B1 (fr) | 2001-05-17 | 2004-02-13 | Fournier Lab Sa | Nouveaux derives de 5-phenyl-1h-indole antagoniste des recepteurs de l'interleukine-8 |
| FR2824826B1 (fr) | 2001-05-17 | 2003-11-07 | Fournier Lab Sa | Nouveaux derives de 5-cyano-1h-indole antagonistes des recepteurs de l'interleukine-8 |
| WO2003104180A1 (en) | 2002-06-05 | 2003-12-18 | Natco Pharma Limited | Process for the preparation of 4-(4-fluorobenzoyl) butyric acid |
| JP2007504221A (ja) | 2003-09-03 | 2007-03-01 | ガラパゴス・エヌブイ | 新規な４−ピペリジンカルボキシアミドおよび５ｈｔ２ａ受容体関連障害に対する薬剤の製造のためのその使用 |
| BRPI0507657A (pt) | 2004-03-03 | 2007-07-10 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, método para tratar um distúrbio, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo |
| AR048523A1 (es) | 2004-04-07 | 2006-05-03 | Kalypsys Inc | Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos |
| JP5406722B2 (ja) | 2006-10-16 | 2014-02-05 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ブラジキニン１受容体モジュレータとしての置換されたスルホンアミド誘導体 |
| PT2118074E (pt) | 2007-02-01 | 2014-03-20 | Resverlogix Corp | Compostos para a prevenção e tratamento de doenças cardiovasculares |
| DK2178870T3 (en) | 2007-08-17 | 2018-10-22 | Lg Chemical Ltd | INDOLE AND INDAZOLIC COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSE |
| CN105254557A (zh) | 2009-05-29 | 2016-01-20 | 拉夸里亚创药株式会社 | 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物 |
| WO2012025155A1 (en) | 2010-08-26 | 2012-03-01 | Novartis Ag | Hydroxamate-based inhibitors of deacetylases |
| BR102012024778A2 (pt) | 2012-09-28 | 2014-08-19 | Cristalia Prod Quimicos Farm | Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica |
| US10130632B2 (en) | 2012-11-27 | 2018-11-20 | Beth Israel Deaconess Medical Center, Inc. | Methods for treating renal disease |
| EP3049405A4 (en) | 2013-09-26 | 2017-03-08 | Pharmakea Inc. | Autotaxin inhibitor compounds |
| EP3186225A4 (en) | 2014-08-27 | 2018-02-28 | The Governing Council of the University of Toronto | Cannabinoid type 1 receptor modulators |
| US10654838B2 (en) | 2014-10-08 | 2020-05-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Aminopyridine compounds useful as inhibitors of protein prenylation |
| HUE053705T2 (hu) | 2015-08-27 | 2021-07-28 | Pfizer | Biciklusos kondenzált heteroaril- vagy aril- vegyületek IRAK4 modulátorokként |
| CN106749330A (zh) | 2016-12-29 | 2017-05-31 | 长春海谱润斯科技有限公司 | 一种杂环衍生物及使用该杂环衍生物的有机发光器件 |
| EP3787669A4 (en) | 2018-04-30 | 2022-03-30 | The Trustees of Indiana University | COMPOUNDS FOR MODULATION OF LEVELS OF DDAH AND ADMA AND METHODS OF USE THEM TO TREAT DISEASES |
| US11618746B2 (en) | 2018-12-17 | 2023-04-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of APOL1 and methods of using same |
| US20220144838A1 (en) | 2019-03-13 | 2022-05-12 | Nanjing Immunophage Biotech Co., Ltd. | Compounds as Inhibitors of Macrophage Migration Inhibitory Factor |
| WO2021154997A1 (en) | 2020-01-29 | 2021-08-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
| US20210246121A1 (en) | 2020-02-04 | 2021-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of apol1 inhibitor and methods of using same |
| IL296035A (en) | 2020-03-06 | 2022-10-01 | Vertex Pharma | Methods of treating apol-1 dependent focal segmental glomerulosclerosis |
| IL296423A (en) | 2020-04-22 | 2022-11-01 | Anima Biotech Inc | Collagen 1 translation inhibitors and methods of use thereof |
| JP2023524563A (ja) | 2020-05-07 | 2023-06-12 | ラムバム メド－テック リミテッド | Ａｐｏｌ１－関連疾患の治療に使用するための組成物 |
| CN115867532A (zh) | 2020-06-12 | 2023-03-28 | 弗特克斯药品有限公司 | Apol1的抑制剂及其用途 |
| CA3185604A1 (en) | 2020-06-12 | 2021-12-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and use of the same |
| CN115867543A (zh) | 2020-06-12 | 2023-03-28 | 弗特克斯药品有限公司 | Apol1抑制剂的固体形式及其使用方法 |
| CN116547287B (zh) | 2020-08-26 | 2025-09-26 | 弗特克斯药品有限公司 | Apol1的抑制剂及其使用方法 |
| US20230119114A1 (en) | 2021-08-26 | 2023-04-20 | Vertex Pharmaceuticals Incorporated | Solid forms of apol1 inhibitors and methods of using same |
| EP4440697A1 (en) | 2021-11-30 | 2024-10-09 | Vertex Pharmaceuticals Incorporated | Spirocyclic inhibitors of apol1 and methods of using same |
| CN119212986A (zh) | 2022-02-08 | 2024-12-27 | 弗特克斯药品有限公司 | 作为apol1的抑制剂的螺哌啶衍生物及其使用方法 |
| AU2023219516A1 (en) | 2022-02-08 | 2024-08-22 | Vertex Pharmaceuticals Incorporated | 2-methyl-4-phenylpiperidin-4-ol derivatives as inhibitors of apol1 and methods of using same |
| EP4476228A1 (en) | 2022-02-08 | 2024-12-18 | Vertex Pharmaceuticals Incorporated | 4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] derivatives as inhibitors of apol1 and methods of using same |
| CA3251050A1 (en) | 2022-02-08 | 2023-08-17 | Vertex Pharmaceuticals Incorporated | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES USED AS APOL1 INHIBITORS AND THEIR METHODS OF USE |
-
2022
- 2022-11-29 US US18/071,153 patent/US12612379B2/en active Active
- 2022-11-30 EP EP22843923.8A patent/EP4441032A1/en active Pending
- 2022-11-30 IL IL312747A patent/IL312747A/en unknown
- 2022-11-30 WO PCT/US2022/051364 patent/WO2023102022A1/en not_active Ceased
- 2022-11-30 JP JP2024531628A patent/JP2024543934A/ja active Pending
- 2022-11-30 UY UY0001040047A patent/UY40047A/es unknown
- 2022-11-30 GE GEAP202416543A patent/GEAP202416543A/en unknown
- 2022-11-30 MX MX2024006473A patent/MX2024006473A/es unknown
- 2022-11-30 PE PE2024001215A patent/PE20241628A1/es unknown
- 2022-11-30 KR KR1020247021706A patent/KR20240131345A/ko active Pending
- 2022-11-30 CA CA3239394A patent/CA3239394A1/en active Pending
- 2022-11-30 TW TW111145764A patent/TW202329951A/zh unknown
- 2022-11-30 AU AU2022402839A patent/AU2022402839A1/en active Pending
- 2022-11-30 CR CR20240261A patent/CR20240261A/es unknown
-
2024
- 2024-05-27 DO DO2024000104A patent/DOP2024000104A/es unknown
- 2024-05-27 CO CONC2024/0006736A patent/CO2024006736A2/es unknown
- 2024-05-28 JO JOJO/P/2024/0120A patent/JOP20240120A1/ar unknown
- 2024-05-28 CL CL2024001586A patent/CL2024001586A1/es unknown
- 2024-06-27 EC ECSENADI202450151A patent/ECSP24050151A/es unknown
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